Full Text Journal Articles by
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Outbreak or pseudo-outbreak? Integrating SARS-CoV-2 sequencing to validate infection control practices in a dialysis facility.

Bridget L Pfaff, Craig S Richmond, Arick P Sabin, Deena M Athas, Jessica C Adams, Megan E Meller, Kumari Usha, Sarah A Schmitz, Brian J Simmons, Andrew J Borgert, Paraic A Kenny,

<h4>Background</h4>The COVID-19 pandemic poses a particularly high risk for End Stage Renal Disease (ESRD) patients so rapid identification of case clusters in ESRD facilities is essential. Nevertheless, with high community prevalence, a series of ESRD patients may test positive contemporaneously for reasons unrelated to their shared ESRD facility. Here we ... Read more >>

Am J Infect Control (American journal of infection control)
[2021, :]

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Primary estrogen receptor-positive lung adenocarcinoma identified by immunohistochemical investigation of rare cutaneous metastasis to the breast in a patient with presumed recurrent estrogen receptor-positive breast cancer.

Shu Ting Liang Amy, Chenin Ryan, Keegan O'Hern, Gabrielle E Duprat, Sarah A Donnell, Brian Simmons,

JAAD Case Rep (JAAD case reports)
[2021, 14:85-87]

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Novel heterozygous COL7A1 mutation in a patient with de-novo dominant dystrophic epidermolysis bullosa pruriginosa.

Tasya Rakasiwi, Shu Ting Liang, Brian J Simmons, M Shane Chapman,

JAAD Case Rep (JAAD case reports)
[2021, 11:112-114]

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Outbreak or pseudo-outbreak? Integrating SARS-CoV-2 sequencing to validate infection control practices in an end stage renal disease facility

Bridget Pfaff, Craig Richmond, Arick Sabin, Deena Athas, Jessica Adams, Megan Meller, Kumari Usha, Sarah Schmitz, Brian Simmons, Andrew Borgert, Paraic Kenny,

<h4>ABSTRACT</h4> <h4>Background</h4> The COVID-19 pandemic of 2020 poses a particularly high risk for End Stage Renal Disease (ESRD) patients and led to a need for facility-wide control plans to prevent introduction and spread of infection within ESRD facilities. Rapid identification of clusters of contemporaneous cases is essential, as these may ... Read more >>

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Paraneoplastic pemphigus with cicatricial nail involvement.

Brian J Simmons, Jennifer A Adams, Jeong Hee Cho-Vega, Antonella Tosti,

Cutis (Cutis)
[2020, 106(4):E4-E6]

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Localized reactive granulomatous dermatitis secondary to erythema migrans.

Dylan J Badin, Keegan O'Hern, Brian J Simmons, Julianne A Mann, Shabnam Momtahen,

JAAD Case Rep (JAAD case reports)
[2020, 6(12):1236-1238]

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Cutaneous leishmaniasis successfully treated with miltefosine.

Cynthia X Chan, Brian J Simmons, John E Call, Shaofeng Yan, Jonathan S Glass, M Shane Chapman,

Leishmaniasis is a neglected tropical disease with notable worldwide burden and increasing prevalence in the United States due to globalization. We describe 2 cases of cutaneous leishmaniasis in New England, United States, both caused by the New World subgenus Viannia, in adults returning from Central America. Both patients underutilized preventive ... Read more >>

Cutis (Cutis)
[2020, 106(4):206-209]

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Sarcoidosis with small syringotropic granulomas presenting clinically as a pigmented purpuric dermatosis: Inconspicuous clinical and histopathological clues to systemic illness.

Brian J Simmons, Xiaoying Liu, Marshall A Guill, Robert E LeBlanc,

Sarcoidosis is a multisystem granulomatous disease with a myriad of clinical manifestations and a predilection to involve the lungs, eyes, lymph nodes, and skin. A 38-year-old man presented to dermatology with a history of progressive dyspnea, pulmonary consolidations on chest X-ray, and hilar adenopathy on computed tomography scan. Skin exam ... Read more >>

J Cutan Pathol (Journal of cutaneous pathology)
[2020, 47(8):755-757]

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Absolute Bioavailability of Vemurafenib in Patients With BRAFV600 Mutation-Positive Malignancies.

Weijiang Zhang, Dawn Colburn, Brian Simmons, Zsuzsanna Papai, Enric Bertran, Simone Schadt, Christophe Husser, Harper Forbes, Dieter Roethlisberger, Thomas Hartung,

Vemurafenib is a BRAF kinase inhibitor indicated for the treatment of patients with BRAFV600 mutation-positive unresectable or metastatic melanoma and Erdheim-Chester disease. This phase 1, open-label, single-arm study was designed to estimate absolute bioavailability of oral vemurafenib at steady state and to characterize the pharmacokinetics of a single intravenous microdose ... Read more >>

Clin Pharmacol Drug Dev (Clinical pharmacology in drug development)
[2020, 9(4):496-504]

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Entrectinib in ROS1 fusion-positive non-small-cell lung cancer: integrated analysis of three phase 1-2 trials.

Alexander Drilon, Salvatore Siena, Rafal Dziadziuszko, Fabrice Barlesi, Matthew G Krebs, Alice T Shaw, Filippo de Braud, Christian Rolfo, Myung-Ju Ahn, Jürgen Wolf, Takashi Seto, Byoung Chul Cho, Manish R Patel, Chao-Hua Chiu, Thomas John, Koichi Goto, Christos S Karapetis, Hendrick-Tobias Arkenau, Sang-We Kim, Yuichiro Ohe, Yu-Chung Li, Young K Chae, Christine H Chung, Gregory A Otterson, Haruyasu Murakami, Chia-Chi Lin, Daniel S W Tan, Hans Prenen, Todd Riehl, Edna Chow-Maneval, Brian Simmons, Na Cui, Ann Johnson, Susan Eng, Timothy R Wilson, Robert C Doebele, ,

<h4>Background</h4>Recurrent gene fusions, such as ROS1 fusions, are oncogenic drivers of various cancers, including non-small-cell lung cancer (NSCLC). Up to 36% of patients with ROS1 fusion-positive NSCLC have brain metastases at the diagnosis of advanced disease. Entrectinib is a ROS1 inhibitor that has been designed to effectively penetrate and remain ... Read more >>

Lancet Oncol (The Lancet. Oncology)
[2020, 21(2):261-270]

Cited: 50 times

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Entrectinib in patients with advanced or metastatic NTRK fusion-positive solid tumours: integrated analysis of three phase 1-2 trials.

Robert C Doebele, Alexander Drilon, Luis Paz-Ares, Salvatore Siena, Alice T Shaw, Anna F Farago, Collin M Blakely, Takashi Seto, Byung Chul Cho, Diego Tosi, Benjamin Besse, Sant P Chawla, Lyudmila Bazhenova, John C Krauss, Young Kwang Chae, Minal Barve, Ignacio Garrido-Laguna, Stephen V Liu, Paul Conkling, Thomas John, Marwan Fakih, Darren Sigal, Herbert H Loong, Gary L Buchschacher, Pilar Garrido, Jorge Nieva, Conor Steuer, Tobias R Overbeck, Daniel W Bowles, Elizabeth Fox, Todd Riehl, Edna Chow-Maneval, Brian Simmons, Na Cui, Ann Johnson, Susan Eng, Timothy R Wilson, George D Demetri, ,

BACKGROUND:Entrectinib is a potent inhibitor of tropomyosin receptor kinase (TRK) A, B, and C, which has been shown to have anti-tumour activity against NTRK gene fusion-positive solid tumours, including CNS activity due to its ability to penetrate the blood-brain barrier. We present an integrated efficacy and safety analysis of patients ... Read more >>

Lancet Oncol (The Lancet. Oncology)
[2020, 21(2):271-282]

Cited: 113 times

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Health-related quality of life in patients with fully resected BRAFV600 mutation-positive melanoma receiving adjuvant vemurafenib.

Dirk Schadendorf, Anna Maria Di Giacomo, Lev Demidov, Barbara Merelli, Igor Bondarenko, Paolo A Ascierto, Christopher Herbert, Andrzej Mackiewicz, Piotr Rutkowski, Alexander Guminski, Grant R Goodman, Brian Simmons, Chenglin Ye, Agnes Hong, Karl Lewis, ,

AIM OF STUDY:The aim of the study was to assess the impact of treatment with adjuvant vemurafenib monotherapy on health-related quality of life (HRQOL) in patients with resected stage IIC-IIIC melanoma. METHODS:The phase 3 BRIM8 study (NCT01667419) randomised patients with BRAFV600 mutation-positive resected stage IIC-IIIC melanoma to 960 mg of vemurafenib ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2019, 123:155-161]

Cited: 1 time

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The elusive nature of mucormycosis in an immunocompetent host and the role of a dermatology consult.

Dylan J Badin, Catherine Baker, Brian J Simmons, Shaofeng Yan, Kathryn A Zug,

Mucormycosis infection in the immunocompetent host typically occurs in the setting of trauma and presents a diagnostic challenge. The earliest signs of infection are often cutaneous, but can easily be misinterpreted, which can be a fatal mistake. Dermatology has tools to help recognize these infections and initiate earlier therapy. ... Read more >>

Clin Case Rep (Clinical case reports)
[2019, 7(11):2187-2189]

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Safety and efficacy of vismodegib in relapsed/refractory acute myeloid leukaemia: results of a phase Ib trial.

Dale Bixby, Richard Noppeney, Tara L Lin, Jorge Cortes, Jürgen Krauter, Karen Yee, Bruno C Medeiros, Alwin Krämer, Sarit Assouline, Walter Fiedler, Natalie Dimier, Brian P Simmons, Todd Riehl, Dawn Colburn,

Br J Haematol (British journal of haematology)
[2019, 185(3):595-598]

Cited: 5 times

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Intertriginous mastocytosis: a rare presentation of an uncommon disease.

Brian J Simmons, Robert E LeBlanc, Jonathan S Glass,

Int J Dermatol (International journal of dermatology)
[2019, 58(7):852-853]

Cited: 0 times

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Immunotherapy Bridge 2017 and Melanoma Bridge 2017: meeting abstracts

David Carbone, Michael Sharpnack, Kai He, Lisa H. Butterfield, Alexander M. M. Eggermont, Maria Gonzalez-Cao, Niki Karachaliou, Guillermo Crespo, Erika Aldeguer, Ana Drozdowskyj, Ana Giménez-Capitán, Cristina Teixidó, Miguel Angel Molina-Vila, Santiago Viteri Ramírez, Salvador Martin Algarra, Elisabeth Pérez-Ruiz, Iván Márquez-Rodas, Delvys Rodriguez-Abreu, Remei Blanco, Teresa Puértolas, Maria Angeles Royo, Rafael Rosell, Maria Libera Ascierto, Svetlana Hamm, Tanja Wulff, Kerstin Kronthaler, Sabine Schrepfer, Ulrike Parnitzke, Anne Catherine Bretz, Roland Baumgartner, Veronica Ferrucci, Francesco Paolo Pennino, Luisa Dassi, Fatemeh Asadzadeh, Roberto Siciliano, Marianeve Carotenuto, Daniela Spano, Cristina Maria Chiarolla, Adelaide Greco, Monica Cantile, Maurizio Di Bonito, Gerardo Botti, Vandenbussche Jonathan, Gevaert Kris, Massimo Zollo, Teresa Amaral, Ioanna Tampouri, Ulrike Keim, Thomas Eigentler, Claus Garbe, Andrea Forschner, Alessandra Cesano, Sarah Warren, Duane Moogk, Kaitao Li, Zhou Yuan, Shi Zhong, Zhiya Yu, Ivan Liadi, William Rittase, Victoria Fang, Janna Dougherty, Arianne Perez-Garcia, Iman Osman, Navin Varadarajan, Nicholas P. Restifo, Alan Frey, Cheng Zhu, Michelle Krogsgaard, Claire Vanpouille-Box, Silvia C. Formenti, Sandra Demaria, Cristiana Lo Nigro, Alexander Renziehausen, Andreas G. Tzakos, Hexiao Wang, Bhavya Rao, Rubeta Matin, Catherine Harwood, Daniela Vivenza, Federica Tonissi, Marcella Occelli, Lynda Weir, Su Li, Van Ren Sim, Kevin O’Neill, Alan Evans, Alastair Thompson, Peter Szlosarek, Colin Fleming, Charlotte Proby, Nelofer Syed, Marco Merlano, Tim Crook, Robert Ferguson, Danny Simpson, Carlos Martinez, Matjaz Vogelsang, Esther Kazlow, Melissa Wilson, Anna Pavlick, Jeffrey Weber, Ryan Sullivan, Keith Flaherty, Antoni Ribas, Tomas Kirchhoff, Antonio D’Avino, Licia Guida, Augusto Cosacco, Roberta D’Aniello, Piera Maiolino, Teresa Tramontano, Maria R. Sarno, Ida Palazzo, Angela Di Napoli, Gianclaudio Acunzo, Mariarosanna De Fina, Antonia Silvestri, Monica Specchia, Michela Musacchio, Gianfranco Giglio, Francesco Carrozza, Liberato Di Lullo, Gian Marco De Maddi, Adele Venturelli, Elisabetta Gambale, Alessia Gatta, Davide Brocco, Consiglia Carella, Michele De Tursi, Thomas F. Gajewski, Costanza M. Cristiani, Rossana Tallerico, Valeria Ventura, Mariaelena Capone, Gabriele Madonna, Domenico Mallardo, Eliska Selinger, Cinzia Garofalo, Elina Staaf, Ester Simeone, Antonio M. Grimaldi, Genny del Zotto, Elio Gulletta, Gennaro Ciliberto, Alessandro Moretta, Paolo A. Ascierto, Ennio Carbone, Susan Costantini, Angela Sorice, Francesca Capone, Gennaro Ciliberto, Alfredo Budillon, Carolina Cauchi, Grazia Sciancalepore, Cristiana Lo Nigro, Michela Rovera, Chiara Varamo, Zelda Seia, Stefania Palazzini, Fabiana Errico, Davide Basso, Laura Quaranta, Giuseppe Forte, Fulvio Lavagna, Silvia Violante, Paolo Bosio, Laura Lattanzio, Marco C Merlano, Mike Gowen, Jeremy Tchack, Hua Zhou, Keith Giles, Scott Paschke, Una Moran, David Fenyo, Aris Tsirigos, Michael Pacold, Silvana Morello, Claudia Sorrentino, Diana Giannarelli, Aldo Pinto, Federica Fratangelo, Rosaria Falcone, Vito Vanella, Dirk Schadendorf, Karl Lewis, Michele Maio, Lev Demidov, Mario Mandalà, Igor Bondarenko, Christopher Herbert, Andrzej Mackiewicz, Piotr Rutkowski, Alexander Guminski, Grant Goodman, Brian Simmons, Chenglin Ye, Gregory Hooper, Matthew J. Wongchenko, Yibing Yan, Frank Hermann, Astrid Ammendola, Svetlana Hamm, René Bartz, Bulotta Alessandra, Colombo Letizia, Mirabile Aurora, Lazzari Chiara, Mercuri Santo Raffaele, Parolini Danilo, Rizzo Nathalie, Martella Stefano, Modorati Giulio, Brianti Pina, Cestone Enza, Bellinzona Federica, Miserocchi Elisabetta, Gianni Luca, Gregorc Vanesa, Sanjiv Agarwala, B. Mark Smithers, Axel Haushild, Eric Watcher, Luigi Fattore, Ciro Francesco Ruggiero, Domenico Liguoro, Andrea Cerri, Maria Elena Pisanu, Rita Mancini,

J Transl Med (Journal of translational medicine)
[2018, 16(Suppl 1):]

Cited: 0 times

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Adjuvant vemurafenib in resected, BRAFV600 mutation-positive melanoma (BRIM8): a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial.

Michele Maio, Karl Lewis, Lev Demidov, Mario Mandalà, Igor Bondarenko, Paolo A Ascierto, Christopher Herbert, Andrzej Mackiewicz, Piotr Rutkowski, Alexander Guminski, Grant R Goodman, Brian Simmons, Chenglin Ye, Yibing Yan, Dirk Schadendorf, ,

BACKGROUND:Systemic adjuvant treatment might mitigate the high risk of disease recurrence in patients with resected stage IIC-III melanoma. The BRIM8 study evaluated adjuvant vemurafenib monotherapy in patients with resected, BRAFV600 mutation-positive melanoma. METHODS:BRIM8 was a phase 3, international, double-blind, randomised, placebo-controlled study that enrolled 498 adults (aged ≥18 years) with ... Read more >>

Lancet Oncol (The Lancet. Oncology)
[2018, 19(4):510-520]

Cited: 37 times

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Urinary 11-dehydro-thromboxane B2 levels are associated with vascular inflammation and prognosis in atherosclerotic cardiovascular disease.

Nan Wang, Kimberly C Vendrov, Brian P Simmons, Robert N Schuck, George A Stouffer, Craig R Lee,

Cyclooxygenase-derived thromboxane (TxA2) and prostacyclin (PGI2) regulate atherogenesis in preclinical models. However, the relationship between TxA2 and PGI2 biosynthesis, vascular inflammation, and atherosclerotic cardiovascular disease (ASCVD) progression in humans remains unclear. The association between stable urine metabolites of thromboxane (TxA2-M) and prostacyclin (PGI2-M), circulating levels of cellular adhesion molecules (CAMs: ... Read more >>

Prostaglandins Other Lipid Mediat (Prostaglandins & other lipid mediators)
[2018, 134:24-31]

Cited: 3 times

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Laboratory Focus on Improving the Culture of Biosafety: Statewide Risk Assessment of Clinical Laboratories That Process Specimens for Microbiologic Analysis.

Erik Munson, Erin J Bowles, Richard Dern, Eric Beck, Raymond P Podzorski, Allen C Bateman, Timothy K Block, Joshua L Kropp, Tyler Radke, Karen Siebers, Brian Simmons, Mary A Smith, Frances Spray-Larson, David M Warshauer,

The Wisconsin State Laboratory of Hygiene challenged Wisconsin laboratories to examine their biosafety practices and improve their culture of biosafety. One hundred three clinical and public health laboratories completed a questionnaire-based, microbiology-focused biosafety risk assessment. Greater than 96% of the respondents performed activities related to specimen processing, direct microscopic examination, ... Read more >>

J Clin Microbiol (Journal of clinical microbiology)
[2018, 56(1):]

Cited: 3 times

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Significance of Objective Structured Clinical Examinations to Plastic Surgery Residency Training.

Brian J Simmons, Yasmina Zoghbi, Morad Askari, David J Birnbach, Ilya Shekhter, Seth R Thaller,

<h4>Introduction</h4>Objective structured clinical examinations (OSCEs) have proven to be a powerful tool. They possess more than a 30-year track record in assessing the competency of medical students, residents, and fellows. Objective structured clinical examinations have been used successfully in a variety of medical specialties, including surgery. They have recently found ... Read more >>

Ann Plast Surg (Annals of plastic surgery)
[2017, 79(3):312-319]

Cited: 1 time

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Sun protection for infants: parent behaviors and beliefs in Miami, Florida.

Fleta N Bray, Sebastian H Verne, Jessica Cervantes, Alexandra Balaban, Eric R Bray, Brian J Simmons, Keyvan Nouri,

Children who are not adequately protected from the sun have an increased risk for developing skin cancers later in life. The primary objective of this study was to determine the sun protection behaviors that black and Hispanic parents in Miami, Florida, employ in infants younger than 6 months. Secondary objectives ... Read more >>

Cutis (Cutis)
[2017, 99(5):339-341]

Cited: 0 times

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Pharmacokinetics and safety of vismodegib in patients with advanced solid malignancies and hepatic impairment.

Ghassan K Abou-Alfa, Lionel D Lewis, Patricia LoRusso, Michael Maitland, Priya Chandra, Sravanthi Cheeti, Dawn Colburn, Sarah Williams, Brian Simmons, Richard A Graham,

<h4>Purpose</h4>Vismodegib is a Hedgehog pathway inhibitor approved for the treatment of advanced basal cell carcinoma. Currently, the pharmacokinetics (PK) and safety of vismodegib in patients with hepatic dysfunction are unknown and are the objective of this study.<h4>Methods</h4>Patients with advanced solid malignancies and hepatic impairment were enrolled into one of four ... Read more >>

Cancer Chemother Pharmacol (Cancer chemotherapy and pharmacology)
[2017, 80(1):29-36]

Cited: 12 times

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A review on laser and light-based therapies for alopecia areata.

Stephanie Mlacker, Adam Souhail Aldahan, Brian James Simmons, Vidhi Shah, Colin Andrew McNamara, Sahal Samarkandy, Keyvan Nouri,

Alopecia areata is a form of non-scarring alopecia that results from a hyperactive immune response of T cells against hair follicles. Many patients with visible hair loss experience psychological and emotional distress, as a result of their cosmetic disfigurement, and frequently seek treatment. However, existing treatment methods, such as corticosteroids, ... Read more >>

J Cosmet Laser Ther (Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology)
[2017, 19(2):93-99]

Cited: 2 times

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Pyogenic granuloma association with isotretinoin treatment for acne.

Brian J Simmons, Lucy Chen, Shasa Hu,

Australas J Dermatol (The Australasian journal of dermatology)
[2016, 57(4):e144-e145]

Cited: 4 times

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A Review of the Efficacy of Thalidomide and Lenalidomide in the Treatment of Refractory Prurigo Nodularis.

Victoria M Lim, Eric L Maranda, Vivek Patel, Brian J Simmons, Joaquin J Jimenez,

Prurigo nodularis (PN) is a chronic dermatoses characterized by intensely pruritic, excoriated, or lichenified nodules. Standard therapy includes corticosteroids, antihistamines, and phototherapy; however, treatment results are often inadequate or transient. Thalidomide and its analogue lenalidomide are immunomodulatory drugs that have successfully been used to treat refractory cases of PN. A ... Read more >>

Dermatol Ther (Heidelb) (Dermatology and therapy)
[2016, 6(3):397-411]

Cited: 2 times

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