Full Text Journal Articles by
Author Brian L Grills

Advertisement

Find full text journal articles








Teaching students to explain the pathophysiology of diseases to lay audiences with a scaffold that supports student choice.

Louise Lexis, Debbi Weaver, Brian L Grills, Brianna L Julien,

Expert educators in science argue that science graduates are often lacking skills in effectively communicating scientific information to lay audiences. To address this, we designed a project, Communicating Disease, for final-year undergraduate human pathophysiology students. Students chose a disease, a relevant nonscientific target audience, and a mode of communication and ... Read more >>

Adv Physiol Educ (Advances in physiology education)
[2021, 45(2):281-289]

Cited: 0 times

View full text PDF listing >>



The TrkB agonist, 7,8-dihydroxyflavone, impairs fracture healing in mice.

Maddison R Johnstone, Rhys D Brady, Jarrod E Church, David Orr, Stuart J McDonald, Brian L Grills,

<h4>Objectives</h4>To study the effects of the selective TrkB agonist, 7,8-dihydroxyflavone (7,8-DHF), on fracture healing in mice and on an osteoprogenitor cell line, Kusa4b10, <i>in vitro</i>.<h4>Methods</h4>Mice received unilateral closed mid-shaft tibial fractures and treated for two weeks with vehicle or 5 mg/kg/day DHF and euthanised at 28 days post-fracture. Calluses were ... Read more >>

J Musculoskelet Neuronal Interact (Journal of musculoskeletal & neuronal interactions)
[2021, 21(2):263-271]

Cited: 0 times

View full text PDF listing >>



Advertisement

A novel rat model of heterotopic ossification after polytrauma with traumatic brain injury.

Rhys D Brady, Michael Z Zhao, Ker R Wong, Pablo M Casilla-Espinosa, Glenn R Yamakawa, Ryan C Wortman, Mujun Sun, Brian L Grills, Richelle Mychasiuk, Terence J O'Brien, Denes V Agoston, Peter V S Lee, Stuart J McDonald, Dale L Robinson, Sandy R Shultz,

Neurological heterotopic ossification (NHO) is characterized by abnormal bone growth in soft tissue and joints in response to injury to the central nervous system. The ectopic bone frequently causes pain, restricts mobility, and decreases the quality of life for those affected. NHO commonly develops in severe traumatic brain injury (TBI) ... Read more >>

Bone (Bone)
[2020, 133:115263]

Cited: 2 times

View full text PDF listing >>



Meta-Analysis of Grainyhead-Like Dependent Transcriptional Networks: A Roadmap for Identifying Novel Conserved Genetic Pathways.

Nishanthi Mathiyalagan, Lee B Miles, Peter J Anderson, Tomasz Wilanowski, Brian L Grills, Stuart J McDonald, M Cristina Keightley, Agata Charzynska, Michal Dabrowski, Sebastian Dworkin,

: The Drosophila grainyhead (grh) and vertebrate Grainyhead-like (Grhl) transcription factors are among the most critical genes for epithelial development, maintenance and homeostasis, and are remarkably well conserved from fungi to humans. Mutations affecting grh/Grhl function lead to a myriad of developmental and adult onset epithelial disease, such as aberrant ... Read more >>

Genes (Basel) (Genes)
[2019, 10(11):]

Cited: 0 times

View full text PDF listing >>



Treadmill Exercise before and during Pregnancy Improves Bone Deficits in Pregnant Growth Restricted Rats without the Exacerbated Effects of High Fat Diet.

Kristina Anevska, Dayana Mahizir, Jessica F Briffa, Andrew J Jefferies, John D Wark, Brian L Grills, Rhys D Brady, Stuart J McDonald, Mary E Wlodek, Tania Romano,

Growth restriction programs adult bone deficits and increases the risk of obesity, which may be exacerbated during pregnancy. We aimed to determine if high-fat feeding could exacerbate the bone deficits in pregnant growth restricted dams, and whether treadmill exercise would attenuate these deficits. Uteroplacental insufficiency was induced on embryonic day ... Read more >>

Nutrients (Nutrients)
[2019, 11(6):]

Cited: 0 times

View full text PDF listing >>



The selective TrkA agonist, gambogic amide, promotes osteoblastic differentiation and improves fracture healing in mice.

Maddison R Johnstone, Rhys D Brady, Johannes A Schuijers, Jarrod E Church, David Orr, Julian M W Quinn, Stuart J McDonald, Brian L Grills,

OBJECTIVES:To study effects of the selective TrkA agonist, gambogic amide (GA), on fracture healing in mice and on an osteoprogenitor cell line in vitro. METHODS:Mice were given bilateral fibular fractures and treated for two weeks with vehicle or 1 mg/kg/day GA and euthanized at 14-, 21-, and 42-days post-fracture. Calluses ... Read more >>

J Musculoskelet Neuronal Interact (Journal of musculoskeletal & neuronal interactions)
[2019, 19(1):94-103]

Cited: 6 times

View full text PDF listing >>



Gambogic amide, a selective TrkA agonist, does not improve outcomes from traumatic brain injury in mice.

Maddison R Johnstone, Mujun Sun, Caroline J Taylor, Rhys D Brady, Brian L Grills, Jarrod E Church, Sandy R Shultz, Stuart J McDonald,

<h4>Objectives</h4>There is evidence that treatment with nerve growth factor (NGF) may reduce neuroinflammation and apoptosis after a traumatic brain injury (TBI). NGF is thought to exert its effects via binding to either TrkA or p75 neurotrophin receptors. This study aimed to investigate the effects of a selective TrkA agonist, gambogic ... Read more >>

Brain Inj (Brain injury)
[2018, 32(2):257-268]

Cited: 7 times

View full text PDF listing >>



Roles of neurotrophins in skeletal tissue formation and healing.

Yu-Wen Su, Xin-Fu Zhou, Bruce K Foster, Brian L Grills, Jiake Xu, Cory J Xian,

Neurotrophins and their receptors are key molecules that are known to be critical in regulating nervous system development and maintenance and have been recognized to be also involved in regulating tissue formation and healing in skeletal tissues. Studies have shown that neurotrophins and their receptors are widely expressed in skeletal ... Read more >>

J Cell Physiol (Journal of cellular physiology)
[2018, 233(3):2133-2145]

Cited: 18 times

View full text PDF listing >>



Experimental Traumatic Brain Injury Induces Bone Loss in Rats.

Rhys D Brady, Sandy R Shultz, Mujun Sun, Tania Romano, Chris van der Poel, David K Wright, John D Wark, Terence J O'Brien, Brian L Grills, Stuart J McDonald,

Few studies have investigated the influence of traumatic brain injury (TBI) on bone homeostasis; however, pathophysiological mechanisms involved in TBI have potential to be detrimental to bone. The current study assessed the effect of experimental TBI in rats on the quantity and quality of two different weight-bearing bones, the femur ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2016, 33(23):2154-2160]

Cited: 14 times

View full text PDF listing >>



Tibial fracture exacerbates traumatic brain injury outcomes and neuroinflammation in a novel mouse model of multitrauma.

Sandy R Shultz, Mujun Sun, David K Wright, Rhys D Brady, Shijie Liu, Sinead Beynon, Shannon F Schmidt, Andrew H Kaye, John A Hamilton, Terence J O'Brien, Brian L Grills, Stuart J McDonald,

Multitrauma is a common medical problem worldwide, and often involves concurrent traumatic brain injury (TBI) and bone fracture. Despite the high incidence of combined TBI and fracture, preclinical TBI research commonly employs independent injury models that fail to incorporate the pathophysiologic interactions occurring in multitrauma. Here, we developed a novel ... Read more >>

J Cereb Blood Flow Metab (Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism)
[2015, 35(8):1339-1347]

Cited: 33 times

View full text PDF listing >>



Osteoclast formation elicited by interleukin-33 stimulation is dependent upon the type of osteoclast progenitor.

Damien G Eeles, Jason M Hodge, Preetinder P Singh, Johannes A Schuijers, Brian L Grills, Matthew T Gillespie, Damian E Myers, Julian M W Quinn,

Osteoclasts are bone resorbing multinucleated cells (MNCs) derived from macrophage progenitors. IL-33 has been reported to drive osteoclastogenesis independently of receptor activator of NFκB ligand (RANKL) but this remains controversial as later studies did not confirm this. We found IL-33 clearly elicited functional dentine-resorbing osteoclast formation from human adult monocytes. ... Read more >>

Mol Cell Endocrinol (Molecular and cellular endocrinology)
[2015, 399:259-266]

Cited: 6 times

View full text PDF listing >>



Thymosin β4 administration enhances fracture healing in mice.

Rhys D Brady, Brian L Grills, Johannes A Schuijers, Alex R Ward, Brett A Tonkin, Nicole C Walsh, Stuart J McDonald,

Thymosin β4 (Tβ4 ) is a regenerative peptide that we hypothesized would promote healing of fractured bone. Mice received a bilateral fibular osteotomy and were given i.p. injections of either Tβ4 (6 mg/kg) or saline. Calluses from saline- and Tβ4 -treated mice were analyzed for: (1) biomechanical properties and (2) composition ... Read more >>

J Orthop Res (Journal of orthopaedic research : official publication of the Orthopaedic Research Society)
[2014, 32(10):1277-1282]

Cited: 10 times

View full text PDF listing >>



Transient expression of myofibroblast-like cells in rat rib fracture callus.

Stuart J McDonald, Philip C Dooley, Aaron C McDonald, Johannes A Schuijers, Alex R Ward, Brian L Grills,

<h4>Background and purpose</h4>We have previously shown that early fracture callus of rat rib has viscoelastic and contractile properties resembling those of smooth muscle. The cells responsible for this contractility have been hypothesized to be myofibroblast-like in nature. In soft-tissue healing, force generated by contraction of myofibroblasts promotes healing. Accordingly, we ... Read more >>

Acta Orthop (Acta orthopaedica)
[2012, 83(1):93-98]

Cited: 4 times

View full text PDF listing >>



α(1) adrenergic receptor agonist, phenylephrine, actively contracts early rat rib fracture callus ex vivo.

Stuart J McDonald, Philip C Dooley, Aaron C McDonald, Elvan Djouma, Johannes A Schuijers, Alex R Ward, Brian L Grills,

Early, soft fracture callus that links fracture ends together is smooth muscle-like in nature. We aimed to determine if early fracture callus could be induced to contract and relax ex vivo by similar pathways to smooth muscle, that is, contraction via α(1) adrenergic receptor (α(1) AR) activation with phenylephrine (PE) ... Read more >>

J Orthop Res (Journal of orthopaedic research : official publication of the Orthopaedic Research Society)
[2011, 29(5):740-745]

Cited: 6 times

View full text PDF listing >>



Early fracture callus displays smooth muscle-like viscoelastic properties ex vivo: implications for fracture healing.

Stuart J McDonald, Philip C Dooley, Aaron C McDonald, Johannes A Schuijers, Alex R Ward, Brian L Grills,

Cells of early, fibrous callus in bone fractures possess much alpha smooth muscle actin. This callus contracts and relaxes; however, active and passive components of its force production have yet to be defined. We aimed to establish whether passive viscoelastic properties of early soft fracture callus are smooth muscle-like in ... Read more >>

J Orthop Res (Journal of orthopaedic research : official publication of the Orthopaedic Research Society)
[2009, 27(11):1508-1513]

Cited: 7 times

View full text PDF listing >>



Early callus of fractured rib of rat contracts and relaxes ex vivo.

Philip C Dooley, Melissa L Howgate, Johannes A Schuijers, Brian L Grills,

<h4>Purpose</h4>Wound contraction is an essential process in early soft-tissue repair, yet contraction of callus in fracture repair has not been investigated previously. Fracture callus consists of several cell types, many of which may have the capacity to contract. Accordingly, the purpose of the present study was to (i) determine whether ... Read more >>

J Orthop Res (Journal of orthopaedic research : official publication of the Orthopaedic Research Society)
[2004, 22(5):1063-1071]

Cited: 4 times

View full text PDF listing >>



Expression of galanin and galanin receptor-1 in normal bone and during fracture repair in the rat.

Aaron C McDonald, John A Schuijers, Pei-Juan Shen, Andrew L Gundlach, Brian L Grills,

The neuropeptide galanin (GAL) has recognized physiological actions in the nervous system and other tissues, but there is no documented evidence of GAL influencing normal or pathological bone metabolism. GAL expression, however, is upregulated in central and peripheral nerves following axotomy and is known to influence neural regeneration. Thus, severance ... Read more >>

Bone (Bone)
[2003, 33(5):788-797]

Cited: 14 times

View full text PDF listing >>





Advertisement


Disclaimer

0.8519 s