Full Text Journal Articles by
Author Brian J Anderson

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Harnessing remifentanil adverse effects.

Luis Ignacio Cortínez, Brian J Anderson,

Paediatr Anaesth (Paediatric anaesthesia)
[2021, 31(5):513-514]

Cited: 0 times

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Deep learning to detect acute respiratory distress syndrome on chest radiographs: a retrospective study with external validation.

Michael W Sjoding, Daniel Taylor, Jonathan Motyka, Elizabeth Lee, Ivan Co, Dru Claar, Jakob I McSparron, Sardar Ansari, Meeta Prasad Kerlin, John P Reilly, Michael G S Shashaty, Brian J Anderson, Tiffanie K Jones, Harrison M Drebin, Caroline A G Ittner, Nuala J Meyer, Theodore J Iwashyna, Kevin R Ward, Christopher E Gillies,

<h4>Background</h4>Acute respiratory distress syndrome (ARDS) is a common, but under-recognised, critical illness syndrome associated with high mortality. An important factor in its under-recognition is the variability in chest radiograph interpretation for ARDS. We sought to train a deep convolutional neural network (CNN) to detect ARDS findings on chest radiographs.<h4>Methods</h4>CNNs were ... Read more >>

Lancet Digit Health (The Lancet. Digital health)
[2021, :]

Cited: 0 times

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Prediction of levobupivacaine concentrations in neonates and infants following neuraxial rescue blocks.

Geoff Frawley, Luis Ignacio Cortinez, Brian J Anderson,

<h4>Aim</h4>Pharmacokinetic simulation was used to characterize levobupivacaine disposition after regional anesthetic rescue for failed spinal anesthesia in neonates and infants.<h4>Methods</h4>Population pharmacokinetics of levobupivacaine were estimated after spinal blockade in a cohort of neonates and infants (n = 25, postnatal age 5-18 weeks, gestation 21-41 weeks, weight 2.4-6 kg). Total levobupivacaine concentrations were assayed 3-4 times ... Read more >>

Paediatr Anaesth (Paediatric anaesthesia)
[2021, :]

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Incidence of post-induction hypoxemia in children and the effect of induction gas composition.

David Cumin, Paul A Baker, Brian J Anderson,

<h4>Background</h4>Pediatric preoxygenation and inhalation induction of anesthesia can include a mixture of gases. In children, the clinical impact on oxygenation while using other gases with oxygen during an inhalation induction is unknown.<h4>Aim</h4>We aimed to determine the impact of oxygen, nitrous oxide, and air concentrations added to the volatile agent by ... Read more >>

Paediatr Anaesth (Paediatric anaesthesia)
[2021, :]

Cited: 0 times

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Intranasal Fentanyl for Intervention-Associated Breakthrough Pain After Cardiac Surgery.

Antti Valtola, Maisa Laakso, Henriikka Hakomäki, Brian J Anderson, Hannu Kokki, Veli-Pekka Ranta, Valtteri Rinne, Merja Kokki,

<h4>Background</h4>Cardiac bypass surgery patients have early postoperative interventions that elicit breakthrough pain. We evaluated the use of intranasal fentanyl for breakthrough pain management in these patients.<h4>Methods</h4>Multimodal analgesia (paracetamol 1 g three times a day, oxycodone 2-3 mg boluses with a patient-controlled intravenous pump) was used in 16 patients (age 49-70 ... Read more >>

Clin Pharmacokinet (Clinical pharmacokinetics)
[2021, :]

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Characteristics, Outcomes, and Trends of Patients With COVID-19-Related Critical Illness at a Learning Health System in the United States.

George L Anesi, Juliane Jablonski, Michael O Harhay, Joshua H Atkins, Jasmeet Bajaj, Cameron Baston, Patrick J Brennan, Christina L Candeloro, Lauren M Catalano, Maurizio F Cereda, John M Chandler, Jason D Christie, Tara Collins, Katherine R Courtright, Barry D Fuchs, Emily Gordon, John C Greenwood, Steven Gudowski, Asaf Hanish, C William Hanson Iii, Monica Heuer, Paul Kinniry, Zev Noah Kornfield, Gregory B Kruse, Meghan Lane-Fall, Niels D Martin, Mark E Mikkelsen, Dan Negoianu, Jose L Pascual, Maulik B Patel, Steven C Pugliese, Zaffer A Qasim, John P Reilly, John Salmon, William D Schweickert, Michael J Scott, Michael G S Shashaty, Corinna P Sicoutris, John K Wang, Wei Wang, Arshad A Wani, Brian J Anderson, Jacob T Gutsche,

<h4>Background</h4>The coronavirus disease 2019 (COVID-19) pandemic continues to surge in the United States and globally.<h4>Objective</h4>To describe the epidemiology of COVID-19-related critical illness, including trends in outcomes and care delivery.<h4>Design</h4>Single-health system, multihospital retrospective cohort study.<h4>Setting</h4>5 hospitals within the University of Pennsylvania Health System.<h4>Patients</h4>Adults with COVID-19-related critical illness who were admitted to ... Read more >>

Ann Intern Med (Annals of internal medicine)
[2021, :]

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Dose estimation for bivalirudin during pediatric cardiopulmonary bypass.

Philip Wolstencroft, Philip Arnold, Brian J Anderson,

<h4>Aim</h4>A typical adult-based bivalirudin regimen during cardiopulmonary bypass uses a loading dose of 1 mg kg<sup>-1</sup> and a circuit prime (volume L × 13 mg) with a subsequent intravenous infusion 2.5 mg h<sup>-1</sup>  kg<sup>-1</sup> . Dose in children remains unknown. We wished to determine a practical bivalirudin dosing schedule for children undergoing surgery with cardiopulmonary bypass.<h4>Methods</h4>Published pharmacokinetic ... Read more >>

Paediatr Anaesth (Paediatric anaesthesia)
[2021, :]

Cited: 0 times

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The ABO histo-blood group, endothelial activation, and acute respiratory distress syndrome risk in critical illness.

John P Reilly, Nuala J Meyer, Michael Gs Shashaty, Brian J Anderson, Caroline Ittner, Thomas G Dunn, Brian Lim, Caitlin Forker, Michael P Bonk, Ethan Kotloff, Rui Feng, Edward Cantu, Nilam S Mangalmurti, Carolyn S Calfee, Michael A Matthay, Carmen Mikacenic, Keith R Walley, James Russell, David C Christiani, Mark M Wurfel, Paul N Lanken, Muredach P Reilly, Jason D Christie,

BACKGROUNDThe ABO histo-blood group is defined by carbohydrate modifications and is associated with risk for multiple diseases, including acute respiratory distress syndrome (ARDS). We hypothesized that genetically determined blood subtype A1 is associated with increased risk of ARDS and markers of microvascular dysfunction and coagulation.METHODSWe conducted analyses in 3 cohorts ... Read more >>

J Clin Invest (The Journal of clinical investigation)
[2021, 131(1):]

Cited: 2 times

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Prediction Models for Physical, Cognitive, and Mental Health Impairments After Critical Illness: A Systematic Review and Critical Appraisal.

Kimberley J Haines, Elizabeth Hibbert, Joanne McPeake, Brian J Anderson, Oscar Joseph Bienvenu, Adair Andrews, Nathan E Brummel, Lauren E Ferrante, Ramona O Hopkins, Catherine L Hough, James Jackson, Mark E Mikkelsen, Nina Leggett, Ashley Montgomery-Yates, Dale M Needham, Carla M Sevin, Becky Skidmore, Mary Still, Maarten van Smeden, Gary S Collins, Michael O Harhay,

<h4>Objectives</h4>Improved ability to predict impairments after critical illness could guide clinical decision-making, inform trial enrollment, and facilitate comprehensive patient recovery. A systematic review of the literature was conducted to investigate whether physical, cognitive, and mental health impairments could be predicted in adult survivors of critical illness.<h4>Data sources</h4>A systematic search of ... Read more >>

Crit Care Med (Critical care medicine)
[2020, 48(12):1871-1880]

Cited: 1 time

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A Universal Pharmacokinetic Model for Dexmedetomidine in Children and Adults.

James D Morse, L Ignacio Cortinez, Brian J Anderson,

A universal pharmacokinetic model was developed from pooled paediatric and adult data (40.6 postmenstrual weeks, 70.8 years, 3.1-152 kg). A three-compartment pharmacokinetic model with first-order elimination was superior to a two-compartment model to describe these pooled dexmedetomidine data. Population parameter estimates (population parameter variability%) were clearance (CL) 0.9 L/min/70 kg ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(11):]

Cited: 0 times

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Benchmarking Critical Care Well-Being: Before and After the Coronavirus Disease 2019 Pandemic.

Sofia Gomez, Brian J Anderson, Hyunmin Yu, Jacob Gutsche, Juliane Jablonski, Niels Martin, Meeta Prasad Kerlin, Mark E Mikkelsen,

<h4>Objectives</h4>Examine well-being, measured as burnout and professional fulfillment, across critical care healthcare professionals, ICUs, and hospitals within a health system; examine the impact of the coronavirus disease 2019 pandemic.<h4>Design</h4>To complement a longitudinal survey administered to medical critical care physicians at the end of an ICU rotation, which began in May ... Read more >>

Crit Care Explor (Critical care explorations)
[2020, 2(10):e0233]

Cited: 2 times

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Delivering transformative action in paediatric pain: a Lancet Child & Adolescent Health Commission.

Christopher Eccleston, Emma Fisher, Richard F Howard, Rebeccah Slater, Paula Forgeron, Tonya M Palermo, Kathryn A Birnie, Brian J Anderson, Christine T Chambers, Geert Crombez, Gustaf Ljungman, Isabel Jordan, Zachary Jordan, Caitriona Roberts, Neil Schechter, Christine B Sieberg, Dick Tibboel, Suellen M Walker, Dominic Wilkinson, Chantal Wood,

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2021, 5(1):47-87]

Cited: 3 times

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Society of Critical Care Medicine's International Consensus Conference on Prediction and Identification of Long-Term Impairments After Critical Illness.

Mark E Mikkelsen, Mary Still, Brian J Anderson, O Joseph Bienvenu, Martin B Brodsky, Nathan Brummel, Brad Butcher, Alison S Clay, Hali Felt, Lauren E Ferrante, Kimberley J Haines, Michael O Harhay, Aluko A Hope, Ramona O Hopkins, Megan Hosey, Catherine Terri L Hough, James C Jackson, Annie Johnson, Babar Khan, Nazir I Lone, Pamela MacTavish, Joanne McPeake, Ashley Montgomery-Yates, Dale M Needham, Giora Netzer, Christa Schorr, Becky Skidmore, Joanna L Stollings, Reba Umberger, Adair Andrews, Theodore J Iwashyna, Carla M Sevin,

<h4>Background</h4>After critical illness, new or worsening impairments in physical, cognitive, and/or mental health function are common among patients who have survived. Who should be screened for long-term impairments, what tools to use, and when remain unclear.<h4>Objectives</h4>Provide pragmatic recommendations to clinicians caring for adult survivors of critical illness related to screening ... Read more >>

Crit Care Med (Critical care medicine)
[2020, 48(11):1670-1679]

Cited: 8 times

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Dexmedetomidine Sedation in Mechanically Ventilated Critically Ill Children: A Pilot Randomized Controlled Trial.

Simon J Erickson, Johnny Millar, Brian J Anderson, Marino S Festa, Lahn Straney, Yahya Shehabi, Debbie A Long, ,

<h4>Objectives</h4>To assess the feasibility, safety, and efficacy of a sedation protocol using dexmedetomidine as the primary sedative in mechanically ventilated critically ill children.<h4>Design</h4>Open-label, pilot, prospective, multicenter, randomized, controlled trial. The primary outcome was the proportion of sedation scores in the target sedation range in the first 48 hours. Safety outcomes ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2020, 21(9):e731-e739]

Cited: 0 times

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The time course of pain after tonsillectomy.

Lena Tan, Peter Carachi, Brian J Anderson,

Paediatr Anaesth (Paediatric anaesthesia)
[2020, 30(9):1051-1053]

Cited: 0 times

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Bioavailability of oxycodone by mouth in coronary artery bypass surgery patients - a randomized trial.

Antti Valtola, James D Morse, Pawel Florkiewicz, Heidi Hautajärvi, Pasi Lahtinen, Tadeusz Musialowicz, Brian J Anderson, Veli-Pekka Ranta, Hannu Kokki,

<h4>Objective</h4>Pain after coronary artery by-pass (CAB) surgery is severe. Analgesic administration by mouth is unreliable until after gastrointestinal function has recovered. We evaluated the bioavailability of oxycodone co-administered with naloxone by mouth in patients after CAB surgery using either a conventional extracorporeal circulation (CECC) or off-pump surgery (OPCAB).<h4>Methods</h4>Twenty-four patients, 50-73 years, ... Read more >>

J Drug Assess (Journal of drug assessment)
[2020, 9(1):117-128]

Cited: 1 time

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Postoperative admission to paediatric intensive care after tonsillectomy.

Eric Levi, Andrés Alvo, Brian J Anderson, Murali Mahadevan,

<h4>Objectives</h4>To review interventions required by children admitted for intensive care management following tonsillectomy or adenotonsillectomy either as elective or unplanned admission in a tertiary children's hospital.<h4>Methods</h4>A retrospective chart review over a 10-year period between April 2007 and March 2017 was performed. Charts were interrogated for treatments that were administered in ... Read more >>

SAGE Open Med (SAGE open medicine)
[2020, 8:2050312120922027]

Cited: 0 times

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Pharmacokinetic and Pharmacodynamic Analysis of Alfaxalone Administered as a Bolus Intravenous Injection of Phaxan in a Phase 1 Randomized Trial.

Colin S Goodchild, Juliet M Serrao, John W Sear, Brian J Anderson,

<h4>Background</h4>Previous formulations of alfaxalone have shown it to be a fast-acting intravenous anesthetic with high therapeutic index. Alfaxalone has been reformulated for human use as Phaxan, an aqueous solution of 10 mg/mL of alfaxalone and 13% betadex. This study assessed the pharmacokinetic (PK) and pharmacodynamic (PD) characteristics of alfaxalone given ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2020, 130(3):704-714]

Cited: 0 times

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Pharmacokinetics of an intravenous bolus dose of clonidine in children undergoing surgery.

Bettina N Nielsen, Brian J Anderson, Lars Falcon, Steen W Henneberg, Torsten Lauritsen, Erik Lomstein, Mogens Ydemann, Arash Afshari,

<h4>Background</h4>Clonidine is used off-label in children but only limited pediatric pharmacokinetic data are available for intravenously administered clonidine.<h4>Objectives</h4>To determine pharmacokinetic parameter estimates of clonidine in healthy children undergoing surgery and to investigate age-related differences. Furthermore, to investigate possible pharmacokinetic differences of clonidine between this group of children and a cohort ... Read more >>

Paediatr Anaesth (Paediatric anaesthesia)
[2020, 30(5):607-613]

Cited: 0 times

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Pharmacokinetic and pharmacodynamic considerations of general anesthesia in pediatric subjects.

Brian J Anderson, James D Morse, Jacqueline A Hannam, L Ignacio Cortinez,

<b>Introduction:</b> The target concentration strategy uses PKPD information for dose determination. Models have also quantified exposure-response relationships, improved understanding of developmental pharmacokinetics, rationalized dose prescription, provided insight into the importance of covariate information, explained drug interactions and driven decision-making and learning during drug development.<b>Areas covered:</b> The prime PKPD consideration is ... Read more >>

Expert Opin Drug Metab Toxicol (Expert opinion on drug metabolism & toxicology)
[2020, 16(4):279-295]

Cited: 0 times

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Plasma sRAGE Acts as a Genetically Regulated Causal Intermediate in Sepsis-associated Acute Respiratory Distress Syndrome.

Tiffanie K Jones, Rui Feng, V Eric Kerchberger, John P Reilly, Brian J Anderson, Michael G S Shashaty, Fan Wang, Thomas G Dunn, Thomas R Riley, Jason Abbott, Caroline A G Ittner, David C Christiani, Carmen Mikacenic, Mark M Wurfel, Lorraine B Ware, Carolyn S Calfee, Michael A Matthay, Jason D Christie, Nuala J Meyer,

<b>Rationale:</b> Acute respiratory distress syndrome (ARDS) lacks known causal biomarkers. Plasma concentrations of sRAGE (soluble receptor for advanced glycation end products) strongly associate with ARDS risk. However, whether plasma sRAGE contributes causally to ARDS remains unknown.<b>Objectives:</b> Evaluate plasma sRAGE as a causal intermediate in ARDS by Mendelian randomization (MR), a ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2020, 201(1):47-56]

Cited: 8 times

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Plasma sTNFR1 and IL8 for prognostic enrichment in sepsis trials: a prospective cohort study.

Brian J Anderson, Carolyn S Calfee, Kathleen D Liu, John P Reilly, Kirsten N Kangelaris, Michael G S Shashaty, Aili L Lazaar, Andrew I Bayliffe, Robert J Gallop, Todd A Miano, Thomas G Dunn, Erik Johansson, Jason Abbott, Alejandra Jauregui, Thomas Deiss, Kathryn Vessel, Annika Belzer, Hanjing Zhuo, Michael A Matthay, Nuala J Meyer, Jason D Christie,

<h4>Background</h4>Enrichment strategies improve therapeutic targeting and trial efficiency, but enrichment factors for sepsis trials are lacking. We determined whether concentrations of soluble tumor necrosis factor receptor-1 (sTNFR1), interleukin-8 (IL8), and angiopoietin-2 (Ang2) could identify sepsis patients at higher mortality risk and serve as prognostic enrichment factors.<h4>Methods</h4>In a multicenter prospective cohort ... Read more >>

Crit Care (Critical care (London, England))
[2019, 23(1):400]

Cited: 2 times

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Clinical Impact of an Electronic Dashboard and Alert System for Sedation Minimization and Ventilator Liberation: A Before-After Study.

Brian J Anderson, David Do, Corey Chivers, Katherine Choi, Yevgeniy Gitelman, Shivan J Mehta, Venkat Panchandam, Steve Gudowski, Margie Pierce, Maurizio Cereda, Jason D Christie, William D Schweickert, Andrea Gabrielli, Ann Huffenberger, Mike Draugelis, Barry D Fuchs,

Sedation minimization and ventilator liberation protocols improve outcomes but are challenging to implement. We sought to demonstrate proof-of-concept and impact of an electronic application promoting sedation minimization and ventilator liberation.<h4>Design</h4>Multi-ICU proof-of-concept study and a single ICU before-after study.<h4>Setting</h4>University hospital ICUs.<h4>Patients</h4>Adult patients receiving mechanical ventilation.<h4>Interventions</h4>An automated application consisting of 1) a ... Read more >>

Crit Care Explor (Critical care explorations)
[2019, 1(10):e0057]

Cited: 1 time

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Plasma Mitochondrial DNA Levels Are Associated With ARDS in Trauma and Sepsis Patients.

Hilary E Faust, John P Reilly, Brian J Anderson, Caroline A G Ittner, Caitlyn M Forker, Peggy Zhang, Benjamin A Weaver, Daniel N Holena, Paul N Lanken, Jason D Christie, Nuala J Meyer, Nilam S Mangalmurti, Michael G S Shashaty,

<h4>Background</h4>Critically ill patients who develop ARDS have substantial associated morbidity and mortality. Circulating mitochondrial DNA (mtDNA) released during critical illness causes endothelial dysfunction and lung injury in experimental models. This study hypothesized that elevated plasma mtDNA is associated with ARDS in critically ill patients with trauma and sepsis.<h4>Methods</h4>Plasma mtDNA concentrations ... Read more >>

Chest (Chest)
[2020, 157(1):67-76]

Cited: 10 times

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Burnout, and Fulfillment, in the Profession of Critical Care Medicine.

Mark E Mikkelsen, Brian J Anderson, Lisa Bellini, William D Schweickert, Barry D Fuchs, Meeta Prasad Kerlin,

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2019, 200(7):931-933]

Cited: 3 times

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