Full Text Journal Articles by
Author Brian J Anderson

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A Universal Pharmacokinetic Model for Dexmedetomidine in Children and Adults.

James D Morse, L Ignacio Cortinez, Brian J Anderson,

A universal pharmacokinetic model was developed from pooled paediatric and adult data (40.6 postmenstrual weeks, 70.8 years, 3.1-152 kg). A three-compartment pharmacokinetic model with first-order elimination was superior to a two-compartment model to describe these pooled dexmedetomidine data. Population parameter estimates (population parameter variability%) were clearance (CL) 0.9 L/min/70 kg ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(11):]

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Benchmarking Critical Care Well-Being: Before and After the Coronavirus Disease 2019 Pandemic.

Sofia Gomez, Brian J Anderson, Hyunmin Yu, Jacob Gutsche, Juliane Jablonski, Niels Martin, Meeta Prasad Kerlin, Mark E Mikkelsen,

Objectives:Examine well-being, measured as burnout and professional fulfillment, across critical care healthcare professionals, ICUs, and hospitals within a health system; examine the impact of the coronavirus disease 2019 pandemic. Design:To complement a longitudinal survey administered to medical critical care physicians at the end of an ICU rotation, which began in ... Read more >>

Crit Care Explor (Critical care explorations)
[2020, 2(10):e0233]

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Society of Critical Care Medicine's International Consensus Conference on Prediction and Identification of Long-Term Impairments After Critical Illness.

Mark E Mikkelsen, Mary Still, Brian J Anderson, O Joseph Bienvenu, Martin B Brodsky, Nathan Brummel, Brad Butcher, Alison S Clay, Hali Felt, Lauren E Ferrante, Kimberley J Haines, Michael O Harhay, Aluko A Hope, Ramona O Hopkins, Megan Hosey, Catherine Terri L Hough, James C Jackson, Annie Johnson, Babar Khan, Nazir I Lone, Pamela MacTavish, Joanne McPeake, Ashley Montgomery-Yates, Dale M Needham, Giora Netzer, Christa Schorr, Becky Skidmore, Joanna L Stollings, Reba Umberger, Adair Andrews, Theodore J Iwashyna, Carla M Sevin,

BACKGROUND:After critical illness, new or worsening impairments in physical, cognitive, and/or mental health function are common among patients who have survived. Who should be screened for long-term impairments, what tools to use, and when remain unclear. OBJECTIVES:Provide pragmatic recommendations to clinicians caring for adult survivors of critical illness related to ... Read more >>

Crit Care Med (Critical care medicine)
[2020, 48(11):1670-1679]

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Delivering transformative action in paediatric pain: a Lancet Child & Adolescent Health Commission.

Christopher Eccleston, Emma Fisher, Richard F Howard, Rebeccah Slater, Paula Forgeron, Tonya M Palermo, Kathryn A Birnie, Brian J Anderson, Christine T Chambers, Geert Crombez, Gustaf Ljungman, Isabel Jordan, Zachary Jordan, Caitriona Roberts, Neil Schechter, Christine B Sieberg, Dick Tibboel, Suellen M Walker, Dominic Wilkinson, Chantal Wood,

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, :]

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Prediction Models for Physical, Cognitive, and Mental Health Impairments After Critical Illness: A Systematic Review and Critical Appraisal.

Kimberley J Haines, Elizabeth Hibbert, Joanne McPeake, Brian J Anderson, Oscar Joseph Bienvenu, Adair Andrews, Nathan E Brummel, Lauren E Ferrante, Ramona O Hopkins, Catherine L Hough, James Jackson, Mark E Mikkelsen, Nina Leggett, Ashley Montgomery-Yates, Dale M Needham, Carla M Sevin, Becky Skidmore, Mary Still, Maarten van Smeden, Gary S Collins, Michael O Harhay,

OBJECTIVES:Improved ability to predict impairments after critical illness could guide clinical decision-making, inform trial enrollment, and facilitate comprehensive patient recovery. A systematic review of the literature was conducted to investigate whether physical, cognitive, and mental health impairments could be predicted in adult survivors of critical illness. DATA SOURCES:A systematic search ... Read more >>

Crit Care Med (Critical care medicine)
[2020, :]

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The ABO Histo-Blood Group, endothelial activation, and acute respiratory distress syndrome risk in critical illness.

John P Reilly, Nuala J Meyer, Michael Gs Shashaty, Brian J Anderson, Caroline Ittner, Thomas G Dunn, Brian Lim, Caitlin Forker, Michael P Bonk, Ethan D Kotloff, Rui Feng, Edward Cantu, Nilam S Mangalmurti, Carolyn S Calfee, Michael A Matthay, Carmen Mikacenic, Keith R Walley, James A Russell, David C Christiani, Mark M Wurfel, Paul N Lanken, Muredach P Reilly, Jason D Christie,

BACKGROUND:The ABO histo-blood group is defined by carbohydrate modifications and is associated with risk for multiple diseases including Acute Respiratory Distress Syndrome (ARDS). We hypothesized that genetically determined blood subtype A1 is associated with increased risk of ARDS and markers of microvascular dysfunction and coagulation. METHODS:We conducted analyses in three ... Read more >>

J Clin Invest (The Journal of clinical investigation)
[2020, :]

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Dexmedetomidine Sedation in Mechanically Ventilated Critically Ill Children: A Pilot Randomized Controlled Trial.

Simon J Erickson, Johnny Millar, Brian J Anderson, Marino S Festa, Lahn Straney, Yahya Shehabi, Debbie A Long, ,

OBJECTIVES:To assess the feasibility, safety, and efficacy of a sedation protocol using dexmedetomidine as the primary sedative in mechanically ventilated critically ill children. DESIGN:Open-label, pilot, prospective, multicenter, randomized, controlled trial. The primary outcome was the proportion of sedation scores in the target sedation range in the first 48 hours. Safety ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2020, 21(9):e731-e739]

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The time course of pain after tonsillectomy.

Lena Tan, Peter Carachi, Brian J Anderson,

Paediatr Anaesth (Paediatric anaesthesia)
[2020, :]

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Bioavailability of oxycodone by mouth in coronary artery bypass surgery patients - a randomized trial.

Antti Valtola, James D Morse, Pawel Florkiewicz, Heidi Hautajärvi, Pasi Lahtinen, Tadeusz Musialowicz, Brian J Anderson, Veli-Pekka Ranta, Hannu Kokki,

Objective:Pain after coronary artery by-pass (CAB) surgery is severe. Analgesic administration by mouth is unreliable until after gastrointestinal function has recovered. We evaluated the bioavailability of oxycodone co-administered with naloxone by mouth in patients after CAB surgery using either a conventional extracorporeal circulation (CECC) or off-pump surgery (OPCAB). Methods:Twenty-four patients, ... Read more >>

J Drug Assess (Journal of drug assessment)
[2020, 9(1):117-128]

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Postoperative admission to paediatric intensive care after tonsillectomy.

Eric Levi, Andrés Alvo, Brian J Anderson, Murali Mahadevan,

Objectives:To review interventions required by children admitted for intensive care management following tonsillectomy or adenotonsillectomy either as elective or unplanned admission in a tertiary children's hospital. Methods:A retrospective chart review over a 10-year period between April 2007 and March 2017 was performed. Charts were interrogated for treatments that were administered ... Read more >>

SAGE Open Med (SAGE open medicine)
[2020, 8:2050312120922027]

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Pharmacokinetics of an intravenous bolus dose of clonidine in children undergoing surgery.

Bettina N Nielsen, Brian J Anderson, Lars Falcon, Steen W Henneberg, Torsten Lauritsen, Erik Lomstein, Mogens Ydemann, Arash Afshari,

BACKGROUND:Clonidine is used off-label in children but only limited pediatric pharmacokinetic data are available for intravenously administered clonidine. OBJECTIVES:To determine pharmacokinetic parameter estimates of clonidine in healthy children undergoing surgery and to investigate age-related differences. Furthermore, to investigate possible pharmacokinetic differences of clonidine between this group of children and a ... Read more >>

Paediatr Anaesth (Paediatric anaesthesia)
[2020, 30(5):607-613]

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Pharmacokinetic and Pharmacodynamic Analysis of Alfaxalone Administered as a Bolus Intravenous Injection of Phaxan in a Phase 1 Randomized Trial.

Colin S Goodchild, Juliet M Serrao, John W Sear, Brian J Anderson,

BACKGROUND:Previous formulations of alfaxalone have shown it to be a fast-acting intravenous anesthetic with high therapeutic index. Alfaxalone has been reformulated for human use as Phaxan, an aqueous solution of 10 mg/mL of alfaxalone and 13% betadex. This study assessed the pharmacokinetic (PK) and pharmacodynamic (PD) characteristics of alfaxalone given ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2020, 130(3):704-714]

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Pharmacokinetic and pharmacodynamic considerations of general anesthesia in pediatric subjects.

Brian J Anderson, James D Morse, Jacqueline A Hannam, L Ignacio Cortinez,

Introduction: The target concentration strategy uses PKPD information for dose determination. Models have also quantified exposure-response relationships, improved understanding of developmental pharmacokinetics, rationalized dose prescription, provided insight into the importance of covariate information, explained drug interactions and driven decision-making and learning during drug development.Areas covered: The prime PKPD consideration is ... Read more >>

Expert Opin Drug Metab Toxicol (Expert opinion on drug metabolism & toxicology)
[2020, 16(4):279-295]

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Plasma sRAGE Acts as a Genetically Regulated Causal Intermediate in Sepsis-associated Acute Respiratory Distress Syndrome.

Tiffanie K Jones, Rui Feng, V Eric Kerchberger, John P Reilly, Brian J Anderson, Michael G S Shashaty, Fan Wang, Thomas G Dunn, Thomas R Riley, Jason Abbott, Caroline A G Ittner, David C Christiani, Carmen Mikacenic, Mark M Wurfel, Lorraine B Ware, Carolyn S Calfee, Michael A Matthay, Jason D Christie, Nuala J Meyer,

Rationale: Acute respiratory distress syndrome (ARDS) lacks known causal biomarkers. Plasma concentrations of sRAGE (soluble receptor for advanced glycation end products) strongly associate with ARDS risk. However, whether plasma sRAGE contributes causally to ARDS remains unknown.Objectives: Evaluate plasma sRAGE as a causal intermediate in ARDS by Mendelian randomization (MR), a ... Read more >>

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2020, 201(1):47-56]

Cited: 4 times

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Plasma sTNFR1 and IL8 for prognostic enrichment in sepsis trials: a prospective cohort study.

Brian J Anderson, Carolyn S Calfee, Kathleen D Liu, John P Reilly, Kirsten N Kangelaris, Michael G S Shashaty, Aili L Lazaar, Andrew I Bayliffe, Robert J Gallop, Todd A Miano, Thomas G Dunn, Erik Johansson, Jason Abbott, Alejandra Jauregui, Thomas Deiss, Kathryn Vessel, Annika Belzer, Hanjing Zhuo, Michael A Matthay, Nuala J Meyer, Jason D Christie,

BACKGROUND:Enrichment strategies improve therapeutic targeting and trial efficiency, but enrichment factors for sepsis trials are lacking. We determined whether concentrations of soluble tumor necrosis factor receptor-1 (sTNFR1), interleukin-8 (IL8), and angiopoietin-2 (Ang2) could identify sepsis patients at higher mortality risk and serve as prognostic enrichment factors. METHODS:In a multicenter prospective ... Read more >>

Crit Care (Critical care (London, England))
[2019, 23(1):400]

Cited: 2 times

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Clinical Impact of an Electronic Dashboard and Alert System for Sedation Minimization and Ventilator Liberation: A Before-After Study.

Brian J Anderson, David Do, Corey Chivers, Katherine Choi, Yevgeniy Gitelman, Shivan J Mehta, Venkat Panchandam, Steve Gudowski, Margie Pierce, Maurizio Cereda, Jason D Christie, William D Schweickert, Andrea Gabrielli, Ann Huffenberger, Mike Draugelis, Barry D Fuchs,

Sedation minimization and ventilator liberation protocols improve outcomes but are challenging to implement. We sought to demonstrate proof-of-concept and impact of an electronic application promoting sedation minimization and ventilator liberation. Design:Multi-ICU proof-of-concept study and a single ICU before-after study. Setting:University hospital ICUs. Patients:Adult patients receiving mechanical ventilation. Interventions:An automated application ... Read more >>

Crit Care Explor (Critical care explorations)
[2019, 1(10):e0057]

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Plasma Mitochondrial DNA Levels Are Associated With ARDS in Trauma and Sepsis Patients.

Hilary E Faust, John P Reilly, Brian J Anderson, Caroline A G Ittner, Caitlyn M Forker, Peggy Zhang, Benjamin A Weaver, Daniel N Holena, Paul N Lanken, Jason D Christie, Nuala J Meyer, Nilam S Mangalmurti, Michael G S Shashaty,

BACKGROUND:Critically ill patients who develop ARDS have substantial associated morbidity and mortality. Circulating mitochondrial DNA (mtDNA) released during critical illness causes endothelial dysfunction and lung injury in experimental models. This study hypothesized that elevated plasma mtDNA is associated with ARDS in critically ill patients with trauma and sepsis. METHODS:Plasma mtDNA ... Read more >>

Chest (Chest)
[2020, 157(1):67-76]

Cited: 3 times

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Burnout, and Fulfillment, in the Profession of Critical Care Medicine.

Mark E Mikkelsen, Brian J Anderson, Lisa Bellini, William D Schweickert, Barry D Fuchs, Meeta Prasad Kerlin,

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2019, 200(7):931-933]

Cited: 1 time

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Dosing clonidine for sedation in intensive care.

Peter Larsson, Brian J Anderson, Susan M Goobie,

Paediatr Anaesth (Paediatric anaesthesia)
[2019, 29(10):983-984]

Cited: 0 times

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A target concentration strategy to determine ibuprofen dosing in children.

Brian J Anderson, Jacqueline A Hannam,

BACKGROUND:Ibuprofen is widely used for ductus arteriosus closure in premature neonates and for analgesia in children and adults. There are no maturation descriptors of clearance. This lack of maturation understanding limits dosing recommendations from premature neonates to adulthood. METHODS:Published clearance estimates from different aged patients determined after administration from time-concentration ... Read more >>

Paediatr Anaesth (Paediatric anaesthesia)
[2019, 29(11):1107-1113]

Cited: 1 time

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A manual propofol infusion regimen for neonates and infants.

James Morse, Jacqueline A Hannam, Luis Ignacio Cortinez, Karel Allegaert, Brian J Anderson,

AIMS:Manual propofol infusion regimens for neonates and infants have been determined from clinical observations in children under the age of 3 years undergoing anesthesia. We assessed the performance of these regimens using reported age-specific pharmacokinetic parameters for propofol. Where performance was poor, we propose alternative dosing regimens. METHODS:Simulations using a reported ... Read more >>

Paediatr Anaesth (Paediatric anaesthesia)
[2019, 29(9):907-914]

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In Response to Hemodynamic and Pharmacokinetic Analysis of Oxymetazoline Use During Nasal Surgery in Children.

Richard S Cartabuke, Brian J Anderson, Charles Elmaraghy, Dmitry Tumin, Joseph D Tobias,

Laryngoscope (The Laryngoscope)
[2019, 129(10):E348]

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Pharmacokinetic-pharmacodynamic population modelling in paediatric anaesthesia and its clinical translation.

James D Morse, Jacqueline Hannam, Brian J Anderson,

PURPOSE OF REVIEW:Pharmacokinetic-pharmacodynamic (PKPD) population modelling has advanced adult anaesthesia. Current literature was reviewed to discern use of this analytic technique for benefit in the perioperative management of children. RECENT FINDINGS:Variability in drug response, selection of a dose that achieves a desired target concentration and optimizing sampling protocols for further ... Read more >>

Curr Opin Anaesthesiol (Current opinion in anaesthesiology)
[2019, 32(3):353-362]

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Practicalities of Total Intravenous Anesthesia and Target-controlled Infusion in Children.

Brian J Anderson, Oliver Bagshaw,

Propofol administered in conjunction with an opioid such as remifentanil is used to provide total intravenous anesthesia for children. Drugs can be given as infusion controlled manually by the physician or as automated target-controlled infusion that targets plasma or effect site. Smart pumps programmed with pharmacokinetic parameter estimates administer drugs ... Read more >>

Anesthesiology (Anesthesiology)
[2019, 131(1):164-185]

Cited: 1 time

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Plasma receptor interacting protein kinase-3 levels are associated with acute respiratory distress syndrome in sepsis and trauma: a cohort study.

Michael G S Shashaty, John P Reilly, Hilary E Faust, Caitlin M Forker, Caroline A G Ittner, Peggy X Zhang, Meghan J Hotz, David Fitzgerald, Wei Yang, Brian J Anderson, Daniel N Holena, Paul N Lanken, Jason D Christie, Nuala J Meyer, Nilam S Mangalmurti,

BACKGROUND:Necroptosis, a form of programmed cell death mediated by receptor interacting serine/threonine-protein kinase-3 (RIPK3), is implicated in murine models of acute respiratory distress syndrome (ARDS). We hypothesized that plasma RIPK3 concentrations in sepsis and trauma would be associated with ARDS development and that plasma RIPK3 would reflect changes in lung ... Read more >>

Crit Care (Critical care (London, England))
[2019, 23(1):235]

Cited: 2 times

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