Full Text Journal Articles by
Author Brian Dewar

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Rationalisations for women-only randomised controlled trials in conditions that affect both sexes: a scoping review protocol.

Ainsley Matthewson, Olena Bereznyakova, Brian Dewar, Alexandra Davis, Mark Fedyk, Vignan Yogendrakumar, Dean A Fergusson, Sophia Gocan, Dar Dowlatshahi, Robert Fahed, Michel Shamy,

<h4>Introduction</h4>Women have historically been under-represented in randomised controlled trials (RCTs), including many landmark RCTs that established standards of care. In light of this fact, some modern researchers are calling for replication of earlier landmark trials with women only. This approach is ethically concerning, in that it would require some enrolled ... Read more >>

BMJ Open (BMJ open)
[2021, 11(2):e043370]

Cited: 0 times

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Advanced consent for acute stroke trials.

Michel Shamy, Brian Dewar, Naomi Niznick, Stuart Nicholls, Dar Dowlatshahi,

Lancet Neurol (The Lancet. Neurology)
[2021, 20(3):170]

Cited: 0 times

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Advanced consent for participation in acute care randomised control trials: protocol for a scoping review.

Naomi Niznick, Ronda Lun, Brian Dewar, Dar Dowlatshahi, Michel Shamy,

<h4>Introduction</h4>Informed consent is essential to clinical research, though obtaining informed consent for participation in research for emergency conditions is challenging. Adapted consent methods include consent from a substitute-decision maker, deferral of consent and waiver of consent. A novel approach is to use advanced consent, where a potential participant provides consent ... Read more >>

BMJ Open (BMJ open)
[2020, 10(10):e039172]

Cited: 0 times

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Physician preparedness for resource allocation decisions under pandemic conditions: A cross-sectional survey of Canadian physicians, April 2020.

Brian Dewar, Joanna E Anderson, Edmund S H Kwok, Tim Ramsay, Dar Dowlatshahi, Robert Fahed, Claire Dyason, Michel Shamy,

<h4>Background</h4>Under the pandemic conditions created by the novel coronavirus of 2019 (COVID-19), physicians have faced difficult choices allocating scarce resources, including but not limited to critical care beds and ventilators. Past experiences with severe acute respiratory syndrome (SARS) and current reports suggest that making these decisions carries a heavy emotional ... Read more >>

PLoS One (PloS one)
[2020, 15(10):e0238842]

Cited: 1 time

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Prevalence of non-contrast CT abnormalities in adults with reversible cerebral vasoconstriction syndrome: protocol for a systematic review and meta-analysis.

Ryan Daniel Gotesman, Naomi Niznick, Brian Dewar, Dean A Fergusson, Risa Shorr, Michel Shamy, Dar Dowlatshahi,

<h4>Introduction</h4>Reversible cerebral vasoconstriction syndrome (RCVS) is characterised by severe, recurrent thunderclap headaches (TCHs) and vasoconstriction of cerebral arteries that resolve within 3 months. Abnormalities on non-contrast CT (NCCT) such as ischaemic strokes, intracerebral haemorrhage and subarachnoid haemorrhages are frequently observed on brain imaging of patients with RCVS though their prevalence ... Read more >>

BMJ Open (BMJ open)
[2020, 10(9):e041776]

Cited: 0 times

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Recurrence of cervical artery dissection: protocol for a systematic review.

Elizabeth Lounsbury, Brian Dewar, Alexandra Davis, Dean A Fergusson, Dar Dowlatshahi, Michel Shamy,

<h4>Introduction</h4>Cervical artery dissection, including carotid and vertebral artery dissection, is an important cause of stroke in the young. Risk of developing cervical artery dissection has been associated with physical activity in various forms and has been presumed to be related to minor trauma and mechanical stretching of the cervical arteries. ... Read more >>

BMJ Open (BMJ open)
[2020, 10(9):e037124]

Cited: 0 times

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Natural history of recovery after intracerebral haemorrhage: a scoping review protocol.

Sara Massicotte, Ronda Lun, Vignan Yogendrakumar, Brian Dewar, Alexandra Davies, Dean A Fergusson, Michel Shamy, Dar Dowlatshahi,

<h4>Introduction</h4>Clinical trials for intracerebral haemorrhage typically measure outcomes in the same way and at the same time points as trials for ischaemic stroke. However, there is growing evidence that the trajectory of recovery following intracerebral haemorrhage may differ significantly from that following ischaemic stroke. A better understanding of current approaches ... Read more >>

BMJ Open (BMJ open)
[2020, 10(8):e039460]

Cited: 0 times

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Different meanings of equipoise and the four quadrants of uncertainty.

Michel Shamy, Brian Dewar, Mark Fedyk,

J Clin Epidemiol (Journal of clinical epidemiology)
[2020, 127:248-249]

Cited: 0 times

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Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial.

Michael D Hill, Mayank Goyal, Bijoy K Menon, Raul G Nogueira, Ryan A McTaggart, Andrew M Demchuk, Alexandre Y Poppe, Brian H Buck, Thalia S Field, Dar Dowlatshahi, Brian A van Adel, Richard H Swartz, Ruchir A Shah, Eric Sauvageau, Charlotte Zerna, Johanna M Ospel, Manish Joshi, Mohammed A Almekhlafi, Karla J Ryckborst, Mark W Lowerison, Kathy Heard, David Garman, Diogo Haussen, Shawna M Cutting, Shelagh B Coutts, Daniel Roy, Jeremy L Rempel, Axel Cr Rohr, Daniela Iancu, Demetrios J Sahlas, Amy Y X Yu, Thomas G Devlin, Ricardo A Hanel, Volker Puetz, Frank L Silver, Bruce C V Campbell, René Chapot, Jeanne Teitelbaum, Jennifer L Mandzia, Timothy J Kleinig, David Turkel-Parrella, Donald Heck, Michael E Kelly, Aditya Bharatha, Oh Young Bang, Ashutosh Jadhav, Rishi Gupta, Donald F Frei, Jason W Tarpley, Cameron G McDougall, Staffan Holmin, Joung-Ho Rha, Ajit S Puri, Marie-Christine Camden, Götz Thomalla, Hana Choe, Stephen J Phillips, Joseph L Schindler, John Thornton, Simon Nagel, Ji Hoe Heo, Sung-Il Sohn, Marios-Nikos Psychogios, Ronald F Budzik, Sidney Starkman, Coleman O Martin, Paul A Burns, Seán Murphy, George A Lopez, Joey English, Michael Tymianski, ,

BACKGROUND:Nerinetide, an eicosapeptide that interferes with post-synaptic density protein 95, is a neuroprotectant that is effective in preclinical stroke models of ischaemia-reperfusion. In this trial, we assessed the efficacy and safety of nerinetide in human ischaemia-reperfusion that occurs with rapid endovascular thrombectomy in patients who had an acute ischaemic stroke. ... Read more >>

Lancet (Lancet (London, England))
[2020, 395(10227):878-887]

Cited: 30 times

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Spotlight on Consent:  Lessons from the SPOTLIGHT Trial for Acute Intracerebral Hemorrhage

Tess Fitzpatrick, Michel Shamy, Brian Dewar, Julie Spence, Andrew Demchuk, Michael Hill, Matthew Flaherty, David Gladstone,

<h4>Background: </h4> SPOTLIGHT was a Canadian multicentre, placebo-controlled, randomized trial of emergency treatment with recombinant Factor VIIa for patients with acute intracerebral hemorrhage that enrolled a subset of eligible patients via deferral of consent. We investigated attitudes towards deferral of consent among participants and their legally-authorized representatives (LARs). Methods All ... Read more >>

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Overcoming Neurophobia With the Help of Peruvian Talking Bears.

Brian Dewar, Gregory S Day, Michel C F Shamy,

JAMA Neurol (JAMA neurology)
[2020, 77(3):291-292]

Cited: 0 times

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Lyn regulates creatine uptake in an imatinib-resistant CML cell line.

Denis O Okumu, Lucas J Aponte-Collazo, Brian J Dewar, Nathan J Cox, Michael P East, Katherine Tech, Ian M McDonald, Andrey P Tikunov, Ekhson Holmuhamedov, Jeffrey M Macdonald, Lee M Graves,

BACKGROUND:Imatinib mesylate (imatinib) is the first-line treatment for newly diagnosed chronic myeloid leukemia (CML) due to its remarkable hematologic and cytogenetic responses. We previously demonstrated that the imatinib-resistant CML cells (Myl-R) contained elevated Lyn activity and intracellular creatine pools compared to imatinib-sensitive Myl cells. METHODS:Stable isotope metabolic labeling, media creatine ... Read more >>

Biochim Biophys Acta Gen Subj (Biochimica et biophysica acta. General subjects)
[2020, 1864(4):129507]

Cited: 0 times

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Benefit of carotid revascularisation for women with symptomatic carotid stenosis: protocol for a systematic review.

Olena Bereznyakova, Brian Dewar, Dar Dowlatshahi, Virginia Howard, Candyce Hamel, Sophia Gocan, Mark Fedyk, Michel Shamy,

INTRODUCTION:Carotid intervention in the form of endarterectomy or stenting is the current standard of care for the majority of patients with symptomatic high-grade carotid stenosis. However, some randomised controlled trials (RCT) have demonstrated that women benefited significantly less from intervention than men. It is unclear if this is a true ... Read more >>

BMJ Open (BMJ open)
[2019, 9(11):e032140]

Cited: 0 times

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Protocol for a systematic scoping review of reasons given to justify the performance of randomised controlled trials.

Brian Dewar, Mark Fedyk, Lucas Jurkovic, Stephanie Chevrier, Rosendo Rodriguez, Simon C Kitto, Raphael Saginur, Michel Shamy,

<h4>Introduction</h4>Randomised controlled trials (RCTs) are widely viewed to generate the most reliable medical knowledge. However, RCTs are not always scientifically necessary and therefore not always ethical. Unfortunately, it is not clear when an RCT is not necessary or how this should be established. This study seeks to systematically catalogue justifications ... Read more >>

BMJ Open (BMJ open)
[2019, 9(7):e027575]

Cited: 1 time

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Response by Dewar and Shamy to Letter Regarding Article "Deferral of Consent in Acute Stroke Trials: Lessons From the ESCAPE Trial".

Brian Dewar, Michel C F Shamy,

Stroke (Stroke)
[2019, 50(8):e236]

Cited: 0 times

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Deferral of Consent in Acute Stroke Trials.

Michel C F Shamy, Brian Dewar, Stephanie Chevrier, Chu-Qi Wang, Stacey Page, Mayank Goyal, Andrew M Demchuk, Michael D Hill,

Background and Purpose- The ESCAPE trial (The Endovascular Treatment for Small Core and Anterior Circulation Proximal Occlusion With Emphasis on Minimizing CT to Recanalization Times) was a multicentre, randomized controlled trial of endovascular thrombectomy versus standard care for patients with acute ischemic stroke that allowed patients to be enrolled with ... Read more >>

Stroke (Stroke)
[2019, 50(4):1017-1020]

Cited: 4 times

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Need for Randomized Trials to Support Procedural Interventions.

Brian Dewar, Michel Shamy,

JAMA (JAMA)
[2019, 321(19):1938]

Cited: 0 times

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tPA for Acute Ischemic Stroke and Its Controversies: A Review.

Brian Dewar, Michel Shamy,

<h4>Background and purpose</h4>Although neurologists consider intravenous tissue plasminogen activator (tPA) to be standard of care in the treatment of patients with acute ischemic stroke, its use remains contentious within the broader medical community, and particularly among emergency physicians. Why might this be? We provide a historical context to this ongoing ... Read more >>

Neurohospitalist (The Neurohospitalist)
[2020, 10(1):5-10]

Cited: 0 times

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Biological, Legal, and Moral Definitions of Brain Death.

Brian Dewar, Mark Fedyk, Michel C F Shamy,

JAMA (JAMA)
[2018, 320(14):1494]

Cited: 0 times

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Loss of the nutrient sensor TAS1R3 leads to reduced bone resorption.

Michael S Eaton, Nicholas Weinstein, Jordan B Newby, Maggie M Plattes, Hanna E Foster, Jon W Arthur, Taylor D Ward, Stephen R Shively, Ryann Shor, Justin Nathan, Hannah M Davis, Lilian I Plotkin, Eric M Wauson, Brian J Dewar, Aaron Broege, Jonathan W Lowery,

The taste receptor type 1 (TAS1R) family of heterotrimeric G protein-coupled receptors participates in monitoring energy and nutrient status. TAS1R member 3 (TAS1R3) is a bi-functional protein that recognizes amino acids such as L-glycine and L-glutamate or sweet molecules such as sucrose and fructose when dimerized with TAS1R member 1 ... Read more >>

J Physiol Biochem (Journal of physiology and biochemistry)
[2018, 74(1):3-8]

Cited: 3 times

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Can anonymous posters on medical forums be reidentified?

Victoria Bobicev, Marina Sokolova, Khaled El Emam, Yasser Jafer, Brian Dewar, Elizabeth Jonker, Stan Matwin,

<h4>Background</h4>Participants in medical forums often reveal personal health information about themselves in their online postings. To feel comfortable revealing sensitive personal health information, some participants may hide their identity by posting anonymously. They can do this by using fake identities, nicknames, or pseudonyms that cannot readily be traced back to ... Read more >>

J Med Internet Res (Journal of medical Internet research)
[2013, 15(10):e215]

Cited: 3 times

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Src-mediated phosphorylation of the tyrosine phosphatase PRL-3 is required for PRL-3 promotion of Rho activation, motility and invasion.

James J Fiordalisi, Brian J Dewar, Lee M Graves, James P Madigan, Adrienne D Cox,

The metastasis-associated tyrosine phosphatase PRL-3/PTP4A is upregulated in numerous cancers, but the mechanisms modulating PRL-3 activity other than its expression levels have not been investigated. Here we report evidence for both Src-dependent tyrosine phosphorylation of PRL-3 and Src-mediated regulation of PRL-3 biological activities. We used structural mutants, pharmacological inhibitors and ... Read more >>

PLoS One (PloS one)
[2013, 8(5):e64309]

Cited: 18 times

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Application of multiplexed kinase inhibitor beads to study kinome adaptations in drug-resistant leukemia.

Matthew J Cooper, Nathan J Cox, Eric I Zimmerman, Brian J Dewar, James S Duncan, Martin C Whittle, Thien A Nguyen, Lauren S Jones, Sreerupa Ghose Roy, David M Smalley, Pei Fen Kuan, Kristy L Richards, Richard I Christopherson, Jian Jin, Stephen V Frye, Gary L Johnson, Albert S Baldwin, Lee M Graves,

Protein kinases play key roles in oncogenic signaling and are a major focus in the development of targeted cancer therapies. Imatinib, a BCR-Abl tyrosine kinase inhibitor, is a successful front-line treatment for chronic myelogenous leukemia (CML). However, resistance to imatinib may be acquired by BCR-Abl mutations or hyperactivation of Src ... Read more >>

PLoS One (PloS one)
[2013, 8(6):e66755]

Cited: 32 times

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A sterol-binding protein integrates endosomal lipid metabolism with TOR signaling and nitrogen sensing.

Carl J Mousley, Peihua Yuan, Naseem A Gaur, Kyle D Trettin, Aaron H Nile, Stephen J Deminoff, Brian J Dewar, Max Wolpert, Jeffrey M Macdonald, Paul K Herman, Alan G Hinnebusch, Vytas A Bankaitis,

Kes1, and other oxysterol-binding protein superfamily members, are involved in membrane and lipid trafficking through trans-Golgi network (TGN) and endosomal systems. We demonstrate that Kes1 represents a sterol-regulated antagonist of TGN/endosomal phosphatidylinositol-4-phosphate signaling. This regulation modulates TOR activation by amino acids and dampens gene expression driven by Gcn4, the primary ... Read more >>

Cell (Cell)
[2012, 148(4):702-715]

Cited: 56 times

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A biosensor generated via high-throughput screening quantifies cell edge Src dynamics.

Akash Gulyani, Eric Vitriol, Richard Allen, Jianrong Wu, Dmitriy Gremyachinskiy, Steven Lewis, Brian Dewar, Lee M Graves, Brian K Kay, Brian Kuhlman, Tim Elston, Klaus M Hahn,

Fluorescent biosensors for living cells currently require laborious optimization and a unique design for each target. They are limited by the availability of naturally occurring ligands with appropriate target specificity. Here we describe a biosensor based on an engineered fibronectin monobody scaffold that can be tailored to bind different targets ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2011, 7(7):437-444]

Cited: 39 times

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