Full Text Journal Articles by
Author Brian Choi

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Peroxisome compartmentalization of a toxic enzyme improves alkaloid production.

Parbir S Grewal, Jennifer A Samson, Jordan J Baker, Brian Choi, John E Dueber,

Eukaryotic cells compartmentalize metabolic pathways in organelles to achieve optimal reaction conditions and avoid crosstalk with cytosolic factors. We found that cytosolic expression of norcoclaurine synthase (NCS), the enzyme that catalyzes the first committed reaction in benzylisoquinoline alkaloid biosynthesis, is toxic in Saccharomyces cerevisiae and, consequently, restricts (S)-reticuline production. We ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2020, :]

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A yeast platform for high-level synthesis of tetrahydroisoquinoline alkaloids.

Michael E Pyne, Kaspar Kevvai, Parbir S Grewal, Lauren Narcross, Brian Choi, Leanne Bourgeois, John E Dueber, Vincent J J Martin,

The tetrahydroisoquinoline (THIQ) moiety is a privileged substructure of many bioactive natural products and semi-synthetic analogs. Plants manufacture more than 3,000 THIQ alkaloids, including the opioids morphine and codeine. While microbial species have been engineered to synthesize a few compounds from the benzylisoquinoline alkaloid (BIA) family of THIQs, low product ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):3337]

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Repurposing the yeast peroxisome to compartmentalize a toxic enzyme enables improved (S)-reticuline production

Parbir Grewal, Jennifer Samson, Jordan Baker, Brian Choi, John Dueber,

Abstract Eukaryotic cells compartmentalize metabolic pathways in organelles to achieve optimal reaction conditions and avoid crosstalk with other factors in the cytosol. Increasingly, engineers are researching ways in which synthetic compartmentalization could be used to address challenges in metabolic engineering. Here, we identified that norcoclaurine synthase (NCS), the enzyme which ... Read more >>

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A yeast platform for high-level synthesis of natural and unnatural tetrahydroisoquinoline alkaloids

Michael Pyne, Kaspar Kevvai, Parbir Grewal, Lauren Narcross, Brian Choi, Leanne Bourgeois, John Dueber, Vincent Martin,

ABSTRACT The tetrahydroisoquinoline (THIQ) moiety is a privileged substructure of many bioactive natural products and semi-synthetic analogues. The plant kingdom manufactures more than 3,000 THIQ alkaloids, including the opioids morphine and codeine. While microbial species have been engineered to synthesize a few compounds from the benzylisoquinoline alkaloid (BIA) family of ... Read more >>

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Analysis of American College of Cardiology/American Heart Association Guideline Author Self-Disclosure Compared With Open Payments Industry Disclosure.

Ramzi Dudum, Aparna Sajja, Richard L Amdur, Brian G Choi,

Circ Cardiovasc Qual Outcomes (Circulation. Cardiovascular quality and outcomes)
[2019, 12(12):e005613]

Cited: 0 times

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Stabilization of primary cilia reduces abortive cell cycle re-entry to protect injured adult CNS neurons from apoptosis.

Brian K A Choi, Philippe M D'Onofrio, Alireza P Shabanzadeh, Paulo D Koeberle,

Abortive cell cycle (ACC) re-entry of apoptotic neurons is a recently characterized phenomenon that occurs after central nervous system (CNS) injury or over the course of CNS disease. Consequently, inhibiting cell cycle progression is neuroprotective in numerous CNS pathology models. Primary cilia are ubiquitous, centriole-based cellular organelles that prevent cell ... Read more >>

PLoS ONE (PloS one)
[2019, 14(8):e0220056]

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Image-Based Mobile System for Dietary Management in an American Cardiology Population: Pilot Randomized Controlled Trial to Assess the Efficacy of Dietary Coaching Delivered via a Smartphone App Versus Traditional Counseling.

Brian G Choi, Tania Dhawan, Kelli Metzger, Lorraine Marshall, Awdah Akbar, Tushina Jain, Heather A Young, Richard J Katz,

BACKGROUND:Randomized controlled trials conducted in Mediterranean countries have shown that the Mediterranean diet lowers adverse cardiovascular events. In the American population, diet remains the biggest uncontrolled risk factor for cardiovascular disease. OBJECTIVE:This study aimed to test the hypothesis that asynchronous dietary counseling supplied through a custom smartphone app results in ... Read more >>

JMIR Mhealth Uhealth (JMIR mHealth and uHealth)
[2019, 7(4):e10755]

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MMP Inhibition Preserves Integrin Ligation and FAK Activation to Induce Survival and Regeneration in RGCs Following Optic Nerve Damage.

Philippe M D'Onofrio, Alireza P Shabanzadeh, Brian K Choi, Mathias Bähr, Paulo D Koeberle,

Purpose:Integrin adherence to the extracellular matrix (ECM) is essential for retinal ganglion cell (RGC) survival: damage causes production and release of ECM degrading matrix metalloproteinases (MMPs) that disrupt integrin ligation, leading to RGC death. The interplay of MMPs, integrins, and focal adhesion kinase (FAK) was studied in RGCs after optic ... Read more >>

Invest. Ophthalmol. Vis. Sci. (Investigative ophthalmology & visual science)
[2019, 60(2):634-649]

Cited: 1 time

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Statistical optimization of preparing marine macroalgae derived activated carbon/iron oxide magnetic composites for sequestering acetylsalicylic acid from aqueous media using response surface methodologys.

Kyung-Won Jung, Brian Hyun Choi, Kyung Guen Song, Jae-Woo Choi,

This study focuses on the optimization of synthetic conditions for preparing marine macroalgae-derived activated carbon/iron oxide magnetic composites (AC/Fe-MC) and its feasibility for the removal of acetylsalicylic acid from aqueous media. Response surface methodology coupled with a 3k Box-Behnken design was applied to determine the optimal conditions (independent variables: impregnation ... Read more >>

Chemosphere (Chemosphere)
[2019, 215:432-443]

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Trends in Authorship Demographics for Manuscripts Published in The American Journal of Cardiology.

Nigel Amankwah, Mindy Park, Alex Gu, Brian G Choi,

The demographics of authors in manuscript publications have been investigated in many specialties but not yet cardiology. We explored the authorship trends in The American Journal of Cardiology, a fundamental journal in this field, to uncover the historical demographic patterns in the field. Manuscripts published in 1958 (the first year ... Read more >>

Am. J. Cardiol. (The American journal of cardiology)
[2018, 122(7):1255-1259]

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Evolutionary engineering improves tolerance for medium-chain alcohols in Saccharomyces cerevisiae.

Stephanie A Davis López, Douglas Andrew Griffith, Brian Choi, Jamie H D Cate, Danielle Tullman-Ercek,

Background:Yeast-based chemical production is an environmentally friendly alternative to petroleum-based production or processes that involve harsh chemicals. However, many potential alcohol biofuels, such as n-butanol, isobutanol and n-hexanol, are toxic to production organisms, lowering the efficiency and cost-effectiveness of these processes. We set out to improve the tolerance of Saccharomyces ... Read more >>

(Biotechnology for biofuels)
[2018, 11:90]

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Escherichia coli cultures maintain stable subpopulation structure during long-term evolution.

Megan G Behringer, Brian I Choi, Samuel F Miller, Thomas G Doak, Jonathan A Karty, Wanfeng Guo, Michael Lynch,

How genetic variation is generated and maintained remains a central question in evolutionary biology. When presented with a complex environment, microbes can take advantage of genetic variation to exploit new niches. Here we present a massively parallel experiment where WT and repair-deficient (∆mutL) Escherichia coli populations have evolved over 3 ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2018, 115(20):E4642-E4650]

Cited: 5 times

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Security of Text Messaging in Clinical Care.

Brian G Choi, Scott K Intner,

JAMA (JAMA)
[2017, 318(14):1395]

Cited: 2 times

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Exosomes Mediate Mobilization of Autocrine Wnt10b to Promote Axonal Regeneration in the Injured CNS.

Nardos G Tassew, Jason Charish, Alireza P Shabanzadeh, Valbona Luga, Hidekiyo Harada, Nahal Farhani, Philippe D'Onofrio, Brian Choi, Ahmad Ellabban, Philip E B Nickerson, Valerie A Wallace, Paulo D Koeberle, Jeffrey L Wrana, Philippe P Monnier,

Developing strategies that promote axonal regeneration within the injured CNS is a major therapeutic challenge, as axonal outgrowth is potently inhibited by myelin and the glial scar. Although regeneration can be achieved using the genetic deletion of PTEN, a negative regulator of the mTOR pathway, this requires inactivation prior to ... Read more >>

Cell Rep (Cell reports)
[2017, 20(1):99-111]

Cited: 19 times

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Extreme Endurance Exercise and Progressive Coronary Artery Disease.

Jeffrey Lin, James R DeLuca, Michael T Lu, Stefan G Ruehm, Ramzi Dudum, Brian Choi, Daniel E Lieberman, Udo Hoffman, Aaron L Baggish,

J. Am. Coll. Cardiol. (Journal of the American College of Cardiology)
[2017, 70(2):293-295]

Cited: 5 times

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Breast arterial calcification association with coronary artery calcium scoring and implications for cardiovascular risk assessment in women.

Angela J Ryan, Andrew D Choi, Brian G Choi, Jannet F Lewis,

Breast arterial calcification (BAC) is a type of medial artery calcification that can be seen incidentally on mammography. Studies have suggested association of BAC with cardiovascular risk factors, coronary artery disease (CAD), and cardiovascular morbidity and mortality. Recently published studies have also suggested a modest correlation of BAC with coronary ... Read more >>

Clin Cardiol (Clinical cardiology)
[2017, 40(9):648-653]

Cited: 3 times

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Facile synthesis of magnetic biochar/Fe3O4 nanocomposites using electro-magnetization technique and its application on the removal of acid orange 7 from aqueous media.

Kyung-Won Jung, Brian Hyun Choi, Tae-Un Jeong, Kyu-Hong Ahn,

This study introduces a new methodology to synthesize magnetic biochar/Fe3O4 nanocomposites (M-BC) from marine macroalgae using a facile electro-magnetization technique. M-BC was prepared by stainless steel electrode-based electrochemical system, followed by pyrolysis. Physical and chemical analyses revealed that the porosity and magnetic properties were simultaneously improved via the electro-magnetization process, ... Read more >>

Bioresour. Technol. (Bioresource technology)
[2016, 220:672-676]

Cited: 6 times

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The Reply.

Hani A Alhamoud, Ramzi Dudum, Heather A Young, Brian G Choi,

Am. J. Med. (The American journal of medicine)
[2016, 129(9):e195-6]

Cited: 0 times

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Fabrication of granular activated carbons derived from spent coffee grounds by entrapment in calcium alginate beads for adsorption of acid orange 7 and methylene blue.

Kyung-Won Jung, Brian Hyun Choi, Min-Jin Hwang, Tae-Un Jeong, Kyu-Hong Ahn,

Biomass-based granular activated carbon was successfully prepared by entrapping activated carbon powder derived from spent coffee grounds into calcium-alginate beads (SCG-GAC) for the removal of acid orange 7 (AO7) and methylene blue (MB) from aqueous media. The dye adsorption process is highly pH-dependent and essentially independent of ionic effects. The ... Read more >>

Bioresour. Technol. (Bioresource technology)
[2016, 219:185-195]

Cited: 6 times

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Impact of Mental Health and Substance Use Disorders on Emergency Department Visit Outcomes for HIV Patients.

Brian Y Choi, Diana M DiNitto, C Nathan Marti, Namkee G Choi,

A disproportionate number of individuals with human immunodeficiency virus (HIV) have mental health and substance-use disorders (MHSUDs), and MHSUDs are significantly associated with their emergency department (ED) visits. With an increasing share of older adults among HIV patients, this study investigated the associations of MHSUDs with ED outcomes of HIV ... Read more >>

West J Emerg Med (The western journal of emergency medicine)
[2016, 17(2):153-164]

Cited: 5 times

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Author Self-disclosure Compared with Pharmaceutical Company Reporting of Physician Payments.

Hani A Alhamoud, Ramzi Dudum, Heather A Young, Brian G Choi,

Industry manufacturers are required by the Sunshine Act to disclose payments to physicians. These data recently became publicly available, but some manufacturers prereleased their data since 2009. We tested the hypotheses that there would be discrepancies between manufacturers' and physicians' disclosures.The financial disclosures by authors of all 39 American College ... Read more >>

Am. J. Med. (The American journal of medicine)
[2016, 129(1):59-63]

Cited: 7 times

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Bioimaging and subclinical cardiovascular disease in low- and middle-income countries.

Rajesh Vedanthan, Brian G Choi, Usman Baber, Jagat Narula, Valentin Fuster,

Cardiovascular disease (CVD) is the leading cause of mortality worldwide and also exerts a significant economic burden, especially in low- and middle-income countries (LMICs). Detection of subclinical CVD, before an individual experiences a major event, may therefore offer the potential to prevent or delay morbidity and mortality, if combined with ... Read more >>

J Cardiovasc Transl Res (Journal of cardiovascular translational research)
[2014, 7(8):701-710]

Cited: 2 times

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Unhinged: A Memoir of Enduring, Surviving, and Overcoming Family Mental Illness.

Varsha Iyer, Brian Choi, Robert G. Bota,

(Mental Illness)
[2014, 6(2):]

Cited: 0 times

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A 63-year-old woman presents with palpitations.

Frances A Tangherlini, Brian G Choi, Allen J Solomon,

Heart (Heart (British Cardiac Society))
[2015, 101(3):184, 229]

Cited: 0 times

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Pulmonary hypertension in hypertensive patients: association with diastolic dysfunction and increased pulmonary vascular resistance.

Monica Mukherjee, Nishaki K Mehta, James J Connolly, Raman S Dusaj, Brian G Choi, Richard J Katz, Jannet F Lewis,

BACKGROUND: Pulmonary hypertension (PH) in patients with systemic hypertension and preserved ejection fraction (PEF) has been described. However, the pathophysiology and consequences are not entirely clear. We sought to distinguish the clinical and anatomic features among hypertensive patients with or without coexistent PH. METHODS: Echocardiograms and records of hypertensive patients ... Read more >>

Echocardiography (Echocardiography (Mount Kisco, N.Y.))
[2014, 31(4):442-448]

Cited: 3 times

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