Full Text Journal Articles by
Author Brandon J Manley

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Correlating Immune Cell Infiltration Patterns with Recurrent Somatic Mutations in Advanced Clear Cell Renal Cell Carcinoma.

Nicholas H Chakiryan, Ali Hajiran, Youngchul Kim, Ahmet M Aydin, Logan Zemp, Esther Katende, Jonathan Nguyen, Wenyi Fan, Chia-Ho Cheng, Neale Lopez-Blanco, Jad Chahoud, Philippe E Spiess, Michelle Fournier, Jasreman Dhillon, Liang Wang, Carlos Moran-Segura, James Mulé, Dongliang Du, Sean J Yoder, Anders Berglund, Jamie K Teer, Brandon J Manley,

<h4>Background</h4>Clear cell renal cell carcinoma (ccRCC) tumors have low frequencies of genetic alterations compared with other malignancies, but very high levels of immune cell infiltration and favorable response rates to immunotherapy. Currently, the interplay between specific ccRCC somatic mutations and immune infiltration pattern is unclear.<h4>Objective</h4>To analyze the associations between common ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Preoperative immunonutrition and carbohydrate loading associated with improved bowel function after radical cystectomy.

Sephalie Y Patel, Nathaniel Trona, Brandon Alford, Jose M Laborde, Youngchul Kim, Roger Li, Brandon J Manley, Scott M Gilbert, Wade J Sexton, Philippe E Spiess, Michael A Poch,

<h4>Background</h4>Preoperative malnourishment has been consistently associated with poor outcomes after radical cystectomy and other major abdominal surgeries. Most enhanced recovery after surgery (ERAS) studies have examined preoperative nutrition and its relationship to outcomes after gastrointestinal surgery. Although numerous studies have demonstrated the benefits of using an ERAS protocol, this study ... Read more >>

Nutr Clin Pract (Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition)
[2021, :]

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Prevalence of Preoperative Iron Deficiency Anemia: A Case Series Among Patients Undergoing Radical Cystectomy.

Sephalie Y Patel, Timothy E Kubal, Roger Li, Brandon J Manley, Scott M Gilbert, Wade J Sexton, Philippe E Spiess, David Boulware, Michael A Poch,

Anemia occurs in a significant group of patients with bladder cancer before radical cystectomy. Iron deficiency is a readily identifiable cause of anemia, which can be treated before surgery. The proportion of patients with bladder cancer with iron deficiency anemia is unknown. Laboratory and clinical outcomes were collected on 47 ... Read more >>

A A Pract (A&A practice)
[2021, 15(5):e01477]

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Pathologic Downstaging and Survival Outcomes Associated with Neoadjuvant Chemotherapy for Variant Histology Muscle Invasive Bladder Cancer.

Nicholas H Chakiryan, Da David Jiang, Kyle A Gillis, Elizabeth Green, Ali Hajiran, Lee Hugar, Logan Zemp, Jingsong Zhang, Rohit Jain, Jad Chahoud, Michael Poch, Brandon J Manley, Roger Li, Wade Sexton, Scott M Gilbert,

<h4>Purpose</h4>Patients with muscle invasive bladder cancer (MIBC) of variant histology have a poor prognosis. It is unclear if neoadjuvant chemotherapy prior to radical cystectomy is associated with pathologic downstaging or improved overall survival (OS) for patients with variant histology. Our objective was to assess for associations between receipt of neoadjuvant ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001855]

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Real-World Survival Outcomes Associated With First-Line Immunotherapy, Targeted Therapy, and Combination Therapy for Metastatic Clear Cell Renal Cell Carcinoma.

Nicholas H Chakiryan, Da David Jiang, Kyle A Gillis, Elizabeth Green, Ali Hajiran, Lee Hugar, Logan Zemp, Jingsong Zhang, Rohit K Jain, Jad Chahoud, Philippe E Spiess, Wade Sexton, Scott M Gilbert, Brandon J Manley,

<h4>Importance</h4>Clinical trials have shown an overall survival (OS) benefit associated with first-line immunotherapy (IT) and combination targeted therapy (TT) and IT regimens compared with TT among patients with metastatic clear cell renal cell carcinoma (RCC). Generalizability of these findings in a real-world cohort outside of a clinical trial setting is ... Read more >>

JAMA Netw Open (JAMA network open)
[2021, 4(5):e2111329]

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Spatial clustering of CD68+ tumor associated macrophages with tumor cells is associated with worse overall survival in metastatic clear cell renal cell carcinoma.

Nicholas H Chakiryan, Gregory J Kimmel, Youngchul Kim, Ali Hajiran, Ahmet M Aydin, Logan Zemp, Esther Katende, Jonathan Nguyen, Neale Lopez-Blanco, Jad Chahoud, Philippe E Spiess, Michelle Fournier, Jasreman Dhillon, Liang Wang, Carlos Moran-Segura, Asmaa El-Kenawi, James Mulé, Philipp M Altrock, Brandon J Manley,

Immune infiltration is typically quantified using cellular density, not accounting for cellular clustering. Tumor-associated macrophages (TAM) activate oncogenic signaling through paracrine interactions with tumor cells, which may be better reflected by local cellular clustering than global density metrics. Using multiplex immunohistochemistry and digital pathologic analysis we quantified cellular density and ... Read more >>

PLoS One (PloS one)
[2021, 16(4):e0245415]

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Retroperitoneal Lymph Node Dissection Versus Surveillance for Adult Early Stage Pure Testicular Teratoma: A Nationwide Analysis.

Ali Hajiran, Mounsif Azizi, Ahmet M Aydin, Nicholas H Chakiryan, Charles C Peyton, David C Boulware, Brandon J Manley, Scott M Gilbert, Wade J Sexton,

<h4>Purpose</h4>Following radical orchiectomy, surveillance and primary retroperitoneal lymph node dissection (RPLND) are acceptable options for the management of early stage pure testicular teratoma in adult patients; however, there is no uniform consensus. The aim of this study was to investigate survival outcomes of adults with early stage pure testicular teratoma ... Read more >>

Ann Surg Oncol (Annals of surgical oncology)
[2021, 28(7):3648-3655]

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Identification of sarcomatoid differentiation in renal cell carcinoma by machine learning on multiparametric MRI.

Asim Mazin, Samuel H Hawkins, Olya Stringfield, Jasreman Dhillon, Brandon J Manley, Daniel K Jeong, Natarajan Raghunand,

Sarcomatoid differentiation in RCC (sRCC) is associated with a poor prognosis, necessitating more aggressive management than RCC without sarcomatoid components (nsRCC). Since suspected renal cell carcinoma (RCC) tumors are not routinely biopsied for histologic evaluation, there is a clinical need for a non-invasive method to detect sarcomatoid differentiation pre-operatively. We ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):3785]

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Reply By Authors.

Ali Hajiran, Mounsif Azizi, Ahmet M Aydin, Logan Zemp, Charles C Peyton, Jasreman Dhillon, Samantha Nealon, Richard R Reich, Biwei Cao, Roger Li, Brandon J Manley, Wade J Sexton, Scott M Gilbert,

J Urol (The Journal of urology)
[2021, 205(1):108]

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Pathological and Survival Outcomes Associated with Variant Histology Bladder Cancers Managed by Cystectomy with or without Neoadjuvant Chemotherapy.

Ali Hajiran, Mounsif Azizi, Ahmet M Aydin, Logan Zemp, Charles C Peyton, Jasreman Dhillon, Samantha Nealon, Richard R Reich, Biwei Cao, Roger Li, Brandon J Manley, Wade J Sexton, Scott M Gilbert,

<h4>Purpose</h4>Although neoadjuvant chemotherapy is associated with a survival advantage in pure urothelial, muscle invasive bladder cancer, the role of neoadjuvant chemotherapy is less clear in variant histology or urothelial carcinoma with divergent differentiation. We compared chemotherapy response and survival outcomes of patients with nonpure urothelial carcinoma histology who were managed ... Read more >>

J Urol (The Journal of urology)
[2021, 205(1):100-108]

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Focal bipolar radiofrequency ablation for localized prostate cancer: Safety and feasibility.

Ahmet Murat Aydin, Kenneth Gage, Jasreman Dhillon, Salim K Cheriyan, Michael A Poch, Brandon J Manley, Roger Li, Wade J Sexton, Philippe E Spiess, Scott M Gilbert, Julio M Pow-Sang,

<h4>Objectives</h4>To evaluate the safety and feasibility of focal bipolar radiofrequency ablation in men with localized prostate cancer.<h4>Methods</h4>A review of 10 patients treated with a novel bipolar radiofrequency ablation probe integrated in a coil design (Encage; Trod Medical, Bradenton, FL, USA) between 2011 and 2017 in two prospective pilot trials. All ... Read more >>

Int J Urol (International journal of urology : official journal of the Japanese Urological Association)
[2020, 27(10):882-889]

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Positive Ki-67 and PD-L1 expression in post-neoadjuvant chemotherapy muscle-invasive bladder cancer is associated with shorter overall survival: a retrospective study.

Selene Rubino, Youngchul Kim, Junmin Zhou, Jasreman Dhilon, Roger Li, Philippe Spiess, Michael Poch, Brandon J Manley, Julio Pow-Sang, Scott Gilbert, Wade Sexton, Jingsong Zhang,

<h4>Purpose</h4>There is an unmet need to develop prognostic biomarkers in post-neoadjuvant chemotherapy (NAC) muscle-invasive bladder cancer (MIBC) patients. We examine whether Ki-67 and PD-L1 expression can be used to guide adjuvant therapy.<h4>Methods</h4>Tissue microarrays were constructed from 130 post-NAC radical cystectomy samples. Up to 5 cores per sample were included. Expressions ... Read more >>

World J Urol (World journal of urology)
[2021, 39(5):1539-1547]

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Aberrant Epidermal Growth Factor Receptor RNA Splice Products Are Among the Most Frequent Somatic Alterations in Clear Cell Renal Cell Carcinoma and Are Associated with a Poor Response to Immunotherapy.

Saif Zaman, Ali Hajiran, George A Coba, Timothy Robinson, Thushara W Madanayake, Daniel T Segarra, Boris I Chobrutskiy, Theresa A Boyle, Jun-Min Zhou, Youngchul Kim, James J Mulé, Jamie K Teer, Brandon J Manley,

<h4>Background</h4>Accumulating evidence suggests that alternative RNA splicing has an important role in cancer development and progression by driving the expression of a diverse array of RNA and protein isoforms from a handful of genes. However, our understanding of the clinical significance of cancer-specific RNA splicing in renal cell carcinoma (RCC) ... Read more >>

Eur Urol Focus (European urology focus)
[2021, 7(2):373-380]

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Chromophobe Renal Cell Carcinoma: Results From a Large Single-Institution Series.

Jozefina Casuscelli, Maria F Becerra, Kenneth Seier, Brandon J Manley, Nicole Benfante, Almedina Redzematovic, Christian G Stief, James J Hsieh, Satish K Tickoo, Victor E Reuter, Jonathan A Coleman, Paul Russo, Irina Ostrovnaya, A Ari Hakimi,

<h4>Background</h4>The purpose of the study was to evaluate clinical features and prognostic factors in a large single institutional cohort of chromophobe renal cell carcinoma (ChRCC) patients for identification of tumors with the highest metastatic potential.<h4>Patients and methods</h4>Clinicopathological parameters of all patients with ChRCC diagnosed and surgically treated at Memorial Sloan ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2019, 17(5):373-379.e4]

Cited: 3 times

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Harnessing the Genomic Landscape of the Small Renal Mass to Guide Clinical Management.

Andrew W Silagy, Alejandro Sanchez, Brandon J Manley, Karim Bensalah, Axel Bex, Jose A Karam, Börje Ljungberg, Brian Shuch, A Ari Hakimi,

<h4>Context</h4>Small renal masses (SRMs; tumors <4 cm) encompass a diagnostic and therapeutic challenge. Genomic profiling has the potential to improve risk stratification and personalize treatment selection.<h4>Objective</h4>Herein, we review the evidence regarding the utility, challenges, and potential implications of genomic profiling in the management of SRMs.<h4>Evidence acquisition</h4>Pertinent publications available on PubMed database ... Read more >>

Eur Urol Focus (European urology focus)
[2019, 5(6):949-957]

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Green tea extract for prevention of prostate cancer progression in patients on active surveillance.

Nagi B Kumar, Shohreh I Dickinson, Michael J Schell, Brandon J Manley, Michael A Poch, Julio Pow-Sang,

Background:Active surveillance (AS) has evolved as a management strategy for men with low grade prostate cancer (PCa). However, these patients report anxiety, doubts about the possible progression of the disease as well as higher decisional conflict regarding selection of active surveillance, and have been reported to ultimately opt for treatment ... Read more >>

Oncotarget (Oncotarget)
[2018, 9(102):37798-37806]

Cited: 2 times

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Cystic Renal Cell Carcinoma: A Report on Outcomes of Surgery and Active Surveillance in Patients Retrospectively Identified on Pretreatment Imaging.

Mahyar Kashan, Mazyar Ghanaat, Andreas M Hötker, Cihan Duzgol, Alejandro Sanchez, Renzo G DiNatale, Kyle A Blum, Maria F Becerra, Brandon J Manley, Jozefina Casuscelli, Michael Chiok, Jonathan A Coleman, Paul Russo, Satish K Tickoo, Oguz Akin, A Ari Hakimi,

PURPOSE:We evaluated the outcomes of surgical intervention and active surveillance in patients diagnosed with cystic renal cell carcinoma at our hypothesized radiological cutoff of greater than 50% cystic. MATERIALS AND METHODS:We identified all 430 patients with a pathologically confirmed cystic renal mass that fit our criteria from 2000 to 2015. ... Read more >>

J Urol (The Journal of urology)
[2018, 200(2):275-282]

Cited: 4 times

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Characterizing recurrent and lethal small renal masses in clear cell renal cell carcinoma using recurrent somatic mutations.

Brandon J Manley, Ed Reznik, Mazyar Ghanaat, Mahyar Kashan, Maria F Becerra, Jozefina Casuscelli, Daniel Tennenbaum, Almedina Redzematovic, Maria I Carlo, Yusuke Sato, Maria Arcila, Martin H Voss, Darren R Feldman, Robert J Motzer, Paul Russo, Jonathan Coleman, James J Hsieh, Ari A Hakimi,

<h4>Introduction</h4>Small renal masses (SRMs) with evidence of clear cell renal cell carcinoma (ccRCC) are understudied. Current algorithms for the management of SRMs include surgical resection, ablation, and active surveillance. We sought to identify genomic biomarkers that could potentially refine the management of ccRCC in SRMs, especially in patients being evaluated ... Read more >>

Urol Oncol (Urologic oncology)
[2019, 37(1):12-17]

Cited: 12 times

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Characterization and Impact of TERT Promoter Region Mutations on Clinical Outcome in Renal Cell Carcinoma.

Jozefina Casuscelli, Maria F Becerra, Brandon J Manley, Emily C Zabor, Ed Reznik, Almedina Redzematovic, Maria E Arcila, Daniel M Tennenbaum, Mazyar Ghanaat, Mahyar Kashan, Christian G Stief, Maria Carlo, Martin H Voss, Darren R Feldman, Robert J Motzer, Yingbei Chen, Victor E Reuter, Jonathan A Coleman, Paul Russo, James J Hsieh, Abraham Ari Hakimi,

BACKGROUND:Mutations in the promoter region of the TERT gene have been detected in a variety of cancers. These mutations can potentially lead to unlimited cell divisions and result in poor clinical prognosis. OBJECTIVE:To determine the role and relevance of TERT promoter region mutations in both clear cell (ccRCC) and non-clear ... Read more >>

Eur Urol Focus (European urology focus)
[2019, 5(4):642-649]

Cited: 10 times

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Validation of preoperative variables and stratification of patients to help predict benefit of cytoreductive nephrectomy in the targeted therapy ERA.

Brandon J Manley, Eric H Kim, Joel M Vetter, Aaron M Potretzke, Seth A Strope,

<h4>Objectives</h4>To further elucidate which patients with metastatic renal cell carcinoma (mRCC) may benefit from cytoreductive nephrectomy (CN) before targeted therapy (TT), and to assess the overall survival of patients undergoing CN and TT versus TT alone.<h4>Materials and methods</h4>We identified 88 patients who underwent CN at our institution prior to planned ... Read more >>

Int Braz J Urol (International braz j urol : official journal of the Brazilian Society of Urology)
[2017, 43(3):432-439]

Cited: 1 time

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Genomic alterations as predictors of survival among patients within a combined cohort with clear cell renal cell carcinoma undergoing cytoreductive nephrectomy.

Daniel M Tennenbaum, Brandon J Manley, Emily Zabor, Maria F Becerra, Maria I Carlo, Jozefina Casuscelli, Almedina Redzematovic, Nabeela Khan, Maria E Arcila, Martin H Voss, Darren R Feldman, Robert J Motzer, Nicole E Benfante, Jonathan A Coleman, Paul Russo, James J Hsieh, Abraham Ari Hakimi,

<h4>Purpose</h4>To establish prognostic genomic biomarkers for patients with metastatic clear cell renal cell carcinoma (ccRCC).<h4>Materials and methods</h4>We identified 60 patients who presented with metastatic ccRCC at our institution between 2001 and 2015 and had genomic sequencing on their primary tumor. We pooled these patients with 107 other patients with the ... Read more >>

Urol Oncol (Urologic oncology)
[2017, 35(8):532.e7-532.e13]

Cited: 8 times

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Erratum to: Tumor immune microenvironment characterization in clear cell renal cell carcinoma identifies prognostic and immunotherapeutically relevant messenger RNA signatures.

Yasin Şenbabaoğlu, Ron S Gejman, Andrew G Winer, Ming Liu, Eliezer M Van Allen, Guillermo de Velasco, Diana Miao, Irina Ostrovnaya, Esther Drill, Augustin Luna, Nils Weinhold, William Lee, Brandon J Manley, Danny N Khalil, Samuel D Kaffenberger, Yingbei Chen, Ludmila Danilova, Martin H Voss, Jonathan A Coleman, Paul Russo, Victor E Reuter, Timothy A Chan, Emily H Cheng, David A Scheinberg, Ming O Li, Toni K Choueiri, James J Hsieh, Chris Sander, A Ari Hakimi,

Genome Biol (Genome biology)
[2017, 18(1):46]

Cited: 1 time

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Genomic landscape and evolution of metastatic chromophobe renal cell carcinoma.

Jozefina Casuscelli, Nils Weinhold, Gunes Gundem, Lu Wang, Emily C Zabor, Esther Drill, Patricia I Wang, Gouri J Nanjangud, Almedina Redzematovic, Amrita M Nargund, Brandon J Manley, Maria E Arcila, Nicholas M Donin, John C Cheville, R Houston Thompson, Allan J Pantuck, Paul Russo, Emily H Cheng, William Lee, Satish K Tickoo, Irina Ostrovnaya, Chad J Creighton, Elli Papaemmanuil, Venkatraman E Seshan, A Ari Hakimi, James J Hsieh,

Chromophobe renal cell carcinoma (chRCC) typically shows ~7 chromosome losses (1, 2, 6, 10, 13, 17, and 21) and ~31 exonic somatic mutations, yet carries ~5%-10% metastatic incidence. Since extensive chromosomal losses can generate proteotoxic stress and compromise cellular proliferation, it is intriguing how chRCC, a tumor with extensive chromosome ... Read more >>

JCI Insight (JCI insight)
[2017, 2(12):]

Cited: 23 times

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Overcome tumor heterogeneity-imposed therapeutic barriers through convergent genomic biomarker discovery: A braided cancer river model of kidney cancer.

James J Hsieh, Brandon J Manley, Nabeela Khan, JianJiong Gao, Maria I Carlo, Emily H Cheng,

Tumor heterogeneity, encompassing genetic, epigenetic, and microenvironmental variables, is extremely complex and presents challenges to cancer diagnosis and therapy. Genomic efforts on genetic intratumor heterogeneity (G-ITH) confirm branched evolution, support the trunk-branch cancer model, and present a seemingly insurmountable obstacle to conquering cancers. G-ITH is conspicuous in clear cell renal ... Read more >>

Semin Cell Dev Biol (Seminars in cell & developmental biology)
[2017, 64:98-106]

Cited: 22 times

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Molecular profiling of renal cell carcinoma: building a bridge toward clinical impact.

Brandon J Manley, Abraham Ari Hakimi,

<h4>Purpose of review</h4>The daunting task of identifying key molecular drivers of renal cell carcinoma (RCC) has begun to reveal significant insights into tumor biology. This review provides an update on recent discoveries in this field and their possible clinical implications.<h4>Recent findings</h4>Molecular profiles within the classic RCC histologic subtypes present distinctive ... Read more >>

Curr Opin Urol (Current opinion in urology)
[2016, 26(5):383-387]

Cited: 6 times

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