Full Text Journal Articles by
Author Bradley A Warady

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Low Serum Bicarbonate and CKD Progression in Children.

Denver D Brown, Jennifer Roem, Derek K Ng, Kimberly J Reidy, Juhi Kumar, Matthew K Abramowitz, Robert H Mak, Susan L Furth, George J Schwartz, Bradley A Warady, Frederick J Kaskel, Michal L Melamed,

BACKGROUND AND OBJECTIVES:Studies of adults have demonstrated an association between metabolic acidosis, as measured by low serum bicarbonate levels, and CKD progression. We evaluated this relationship in children using data from the Chronic Kidney Disease in Children study. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS:The relationship between serum bicarbonate and a composite ... Read more >>

Clin J Am Soc Nephrol (Clinical journal of the American Society of Nephrology : CJASN)
[2020, :]

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Targeting optimal PD management in children: what have we learned from the IPPN registry?

Dagmara Borzych-Dużałka, Franz Schaefer, Bradley A Warady,

National and international registries have great potential for providing data that describe disease burden, treatments, and outcomes especially in rare diseases. In the setting of pediatric end-stage renal disease (ESRD), the available data are limited to highly developed countries, whereas the lack of data from emerging economies blurs the global ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2020, :]

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Hypothyroidism Due to Iodine Overload in Children Receiving Peritoneal Dialysis: A Report of 4 Cases.

Sai Sudha Mannemuddhu, Heather A Morgans, Naile Tufan Pekkucuksen, Bradley A Warady, Lawrence R Shoemaker,

Children who receive peritoneal dialysis (PD) are at increased risk for thyroid dysfunction. A rarely appreciated cause is iodine overload. We report 4 children who developed iodine overload and secondary hypothyroidism. All had kidney failure treated by PD. Each previously had normal thyroid function screening test results. At the time ... Read more >>

Am. J. Kidney Dis. (American journal of kidney diseases : the official journal of the National Kidney Foundation)
[2020, :]

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Adiposity, Sex, and Cardiovascular Disease Risk in Children With CKD: A Longitudinal Study of Youth Enrolled in the Chronic Kidney Disease in Children (CKiD) Study.

Tammy M Brady, Jennifer Roem, Christopher Cox, Michael F Schneider, Amy C Wilson, Susan L Furth, Bradley A Warady, Mark Mitsnefes,

RATIONALE & OBJECTIVE:Traditional and nontraditional cardiovascular disease risk factors are highly prevalent in children with chronic kidney disease (CKD). We examined the longitudinal association of adiposity with cardiac damage among children with CKD and explored whether this association was modified by sex. STUDY DESIGN:Prospective cohort study. SETTING & PARTICIPANTS:Children with ... Read more >>

Am. J. Kidney Dis. (American journal of kidney diseases : the official journal of the National Kidney Foundation)
[2020, :]

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Cinacalcet studies in pediatric subjects with secondary hyperparathyroidism receiving dialysis.

Bradley A Warady, Eric Ng, Laura Bloss, May Mo, Franz Schaefer, Justine Bacchetta,

BACKGROUND:Secondary hyperparathyroidism (sHPT), a complication of chronic kidney disease (CKD) characterized by persistently elevated parathyroid hormone (PTH), alterations in calcium-phosphorus homeostasis, and vitamin D metabolism, affects 50% of children receiving dialysis. A significant proportion of these children develop CKD-mineral and bone disorder (CKD-MBD), associated with an increased risk of fractures ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2020, :]

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Timing of patient-reported renal replacement therapy planning discussions by disease severity among children and young adults with chronic kidney disease.

Derek K Ng, Yunwen Xu, Julien Hogan, Jeffrey M Saland, Larry A Greenbaum, Susan L Furth, Bradley A Warady, Craig S Wong,

BACKGROUND:Preparing children with chronic kidney disease (CKD) for renal replacement therapy (RRT) begins with a discussion about transplant and dialysis, but its typical timing in the course of CKD management is unclear. We aimed to describe participant-reported RRT planning discussions by CKD stage, clinical and sociodemographic characteristics, in the Chronic ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2020, :]

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A longitudinal analysis of the effect of anemia on health-related quality of life in children with mild-to-moderate chronic kidney disease.

Joann Carlson, Arlene C Gerson, Matthew B Matheson, Sharon Manne, Bradley A Warady, Stephen R Hooper, Marc Lande, Lyndsay A Harshman, Rebecca J Johnson, Shlomo Shinnar, Amy J Kogon, Susan Furth,

BACKGROUND:To evaluate impact of anemia on health-related quality of life (HRQOL) over time in a large pediatric cohort with mild-to-moderate chronic kidney disease (CKD). METHODS:Participants were enrolled in the Chronic Kidney Disease in Children Study (CKiD), a multicenter, longitudinal cohort. HRQOL was measured using the Pediatric Quality of Life Inventory ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2020, :]

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Delayed menarche in girls with chronic kidney disease and the association with short stature.

Hannah S Kim, Derek K Ng, Matthew B Matheson, Meredith A Atkinson, Bradley A Warady, Susan L Furth, Rebecca L Ruebner,

BACKGROUND:Children with chronic kidney disease (CKD) have delays in normal growth and pubertal development. We describe factors associated with delayed menarche and the association of delayed menarche with short stature in girls with CKD. METHODS:Two hundred eighty-seven girls with CKD onset prior to menarche within the Chronic Kidney Disease in ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2020, :]

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Bicarbonate, blood pressure, and executive function in pediatric CKD-is there a link?

Lyndsay A Harshman, Amy J Kogon, Matthew B Matheson, Rebecca J Johnson, Shlomo Shinnar, Arlene C Gerson, Bradley A Warady, Susan L Furth, Stephen R Hooper, Marc B Lande,

BACKGROUND:In adult chronic kidney disease (CKD), metabolic acidosis is associated with diminished cognition, notably executive function (EF). Data from the Chronic Kidney Disease in Children (CKiD) study demonstrate a risk for impairment of EF, a finding associated with heightened blood pressure variability (BPV). We sought to determine whether low serum ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2020, 35(7):1323-1330]

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Consensus recommendations for the care of children receiving chronic dialysis in association with the COVID-19 epidemic.

Qian Shen, Mo Wang, Ruochen Che, Qiu Li, Jianhua Zhou, Fang Wang, Ying Shen, Jie Ding, Songming Huang, Hui-Kim Yap, Bradley A Warady, Hong Xu, Aihua Zhang, ,

Coronavirus disease 2019 (COVID-19) has rapidly spread not only in China but throughout the world. Children with kidney failure (chronic kidney disease (CKD) stage 5) are at significant risk for COVID-19. In turn, a set of recommendations for the prevention and control of the severe acute respiratory syndrome coronavirus 2 ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2020, 35(7):1351-1357]

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Consensus guidelines for management of hyperammonaemia in paediatric patients receiving continuous kidney replacement therapy.

Rupesh Raina, Jirair K Bedoyan, Uta Lichter-Konecki, Philippe Jouvet, Stefano Picca, Nicholas Ah Mew, Marcel C Machado, Ronith Chakraborty, Meghana Vemuganti, Manpreet K Grewal, Timothy Bunchman, Sidharth Kumar Sethi, Vinod Krishnappa, Mignon McCulloch, Khalid Alhasan, Arvind Bagga, Rajit K Basu, Franz Schaefer, Guido Filler, Bradley A Warady,

Hyperammonaemia in children can lead to grave consequences in the form of cerebral oedema, severe neurological impairment and even death. In infants and children, common causes of hyperammonaemia include urea cycle disorders or organic acidaemias. Few studies have assessed the role of extracorporeal therapies in the management of hyperammonaemia in ... Read more >>

Nat Rev Nephrol (Nature reviews. Nephrology)
[2020, :]

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Prognostic Value of Ambulatory Blood Pressure Load in Pediatric CKD.

Jason Lee, Charles E McCulloch, Joseph T Flynn, Joshua Samuels, Bradley A Warady, Susan L Furth, Divya Seth, Barbara A Grimes, Mark M Mitsnefes, Elaine Ku,

BACKGROUND AND OBJECTIVES:Elevated BP load is part of the criteria for ambulatory hypertension in pediatric but not adult guidelines. Our objectives were to determine the prevalence of isolated BP load elevation and associated risk with adverse outcomes in children with CKD, and to ascertain whether BP load offers risk discrimination ... Read more >>

Clin J Am Soc Nephrol (Clinical journal of the American Society of Nephrology : CJASN)
[2020, 15(4):493-500]

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A longitudinal examination of parent-reported emotional-behavioral functioning of children with mild to moderate chronic kidney disease.

Rebecca J Johnson, Arlene C Gerson, Lyndsay A Harshman, Matthew B Matheson, Shlomo Shinnar, Marc B Lande, Amy Kogon, Debbie S Gipson, Bradley A Warady, Susan L Furth, Stephen R Hooper,

BACKGROUND:Children with mild to moderate chronic kidney disease (CKD) are at increased risk for deficits in neurocognition. Less is known about how CKD affects emotional-behavioral functioning in this population. METHODS:Parent ratings of emotional-behavioral functioning at baseline and over time were examined for 845 children with mild to moderate CKD using ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2020, 35(7):1287-1295]

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Correction to: Mode of initial renal replacement therapy and transplant outcomes in the chronic kidney disease in children (CKiD) study.

Meredith A Atkinson, Jennifer L Roem, Anuradha Gajjar, Bradley A Warady, Susan L Furth, Alvaro Muñoz,

The original version of this article unfortunately contained a mistake. ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2020, 35(6):1141-1142]

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Increased history of ischemic stroke and decreased neurocognitive performance in children with chronic kidney disease.

Juan C Kupferman, Matthew B Matheson, Marc B Lande, Joseph T Flynn, Susan Furth, Bradley A Warady, Stephen R Hooper,

BACKGROUND:This study aimed to determine stroke incidence and assess the association between stroke and neurocognitive functioning in children with chronic kidney disease (CKD). METHODS:Data was derived from the Chronic Kidney Disease in Children (CKiD) cohort study. Stroke incidence was calculated after confirming self-reports of stroke occurrence by chart review. Each ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2020, 35(7):1315-1321]

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Acute kidney injury in paediatric patients with sickle cell disease is associated with increased morbidity and resource utilization.

Meghan McCormick, Troy Richardson, Bradley A Warady, Enrico M Novelli, Ramasubramanian Kalpatthi,

Renal disease is a common complication experienced by patients with sickle cell disease (SCD), though the epidemiology of acute kidney injury (AKI) in paediatric patients and its impact on long-term renal outcomes is unclear. We utilized the Pediatric Health Information System (PHIS) to identify inpatient encounters of paediatric patients with ... Read more >>

Br. J. Haematol. (British journal of haematology)
[2020, 189(3):559-565]

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The CKiD study: overview and summary of findings related to kidney disease progression.

Meredith A Atkinson, Derek K Ng, Bradley A Warady, Susan L Furth, Joseph T Flynn,

The Chronic Kidney Disease in Children (CKiD) cohort study is a North American (USA and Canada) multicenter, prospective study of children with chronic kidney disease (CKD). The original aims of the study were (1) to identify novel risk factors for CKD progression; (2) to measure the impact of kidney function ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2020, :]

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Plasma Soluble Urokinase Plasminogen Activator Receptor (suPAR) and CKD Progression in Children.

Darcy K Weidemann, Alison G Abraham, Jennifer L Roem, Susan L Furth, Bradley A Warady,

RATIONALE & OBJECTIVE:Soluble urokinase plasminogen activator receptor (suPAR) is a novel biomarker associated with incident chronic kidney disease (CKD) and has been identified as an independent risk factor for CKD progression in children, although these findings remain preliminary, limited to a single point in time, and unreplicated in pediatric cohorts. ... Read more >>

Am. J. Kidney Dis. (American journal of kidney diseases : the official journal of the National Kidney Foundation)
[2020, :]

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Model-based approach for methoxy polyethylene glycol-epoetin beta drug development in paediatric patients with anaemia of chronic kidney disease.

Pascal Chanu, Franz Schaefer, Bradley A Warady, Claus Peter Schmitt, Bruno Reigner, Gabriel Schnetzler, Sylvie Meyer Reigner, Mark Eisner, Arlette Weichert, Nicolas Frey,

AIMS:Methoxy polyethylene glycol-epoetin beta (continuous erythropoietin receptor activator, C.E.R.A.) is used for the treatment of anaemia in adults with chronic kidney disease (CKD). Patients treated with shorter-acting erythropoiesis-stimulating agents up to three times weekly can be switched to once-monthly C.E.R.A.. Doses can be adjusted on a monthly basis based on ... Read more >>

Br J Clin Pharmacol (British journal of clinical pharmacology)
[2020, 86(4):801-811]

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Prescribing peritoneal dialysis for high-quality care in children.

Bradley A Warady, Franz Schaefer, Arvind Bagga, Francisco Cano, Mignon McCulloch, Hui-Kim Yap, Rukshana Shroff,

BACKGROUND:Peritoneal dialysis (PD) remains the most widely used modality for chronic dialysis in children, particularly in younger children and in lower and middle income countries (LMICs). We present guidelines for dialysis initiation, modality selection, small solute clearance, and fluid removal in children on PD. A review of the literature and ... Read more >>

Perit Dial Int (Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis)
[2020, 40(3):333-340]

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Grip strength in children with chronic kidney disease.

Julien Hogan, Michael F Schneider, Rima Pai, Michelle R Denburg, Amy Kogon, Ellen R Brooks, Frederick J Kaskel, Kimberly J Reidy, Jeffrey M Saland, Bradley A Warady, Susan L Furth, Rachel E Patzer, Larry A Greenbaum,

BACKGROUND:The relationship between muscle strength and chronic kidney disease (CKD) in children is unknown. This study aims to quantify the association between grip strength (GS) and kidney function and to explore factors associated with grip strength in children and adolescents with CKD. METHODS:We included 411 children (699 GS assessments) of ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2020, 35(5):891-899]

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Aortic dilatation in children with mild to moderate chronic kidney disease.

Peace C Madueme, Derek K Ng, Luke Guju, Lauren Longshore, Vicky Moore, Lynn Jefferies, Bradley A Warady, Susan Furth, Mark Mitsnefes,

BACKGROUND:Children with mild to moderate chronic kidney disease are at an increased risk for cardiovascular sequelae, the leading cause of death in children with end-stage renal disease. We aimed to establish the prevalence of aortic dilatation, a newly recognized cardiovascular sequelae of renal disease, within a cohort of pediatric patients ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2020, 35(6):1023-1031]

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Maintenance Peritoneal Dialysis in Children With Autosomal Recessive Polycystic Kidney Disease: A Comparative Cohort Study of the International Pediatric Peritoneal Dialysis Network Registry.

Abdelaziz Akarkach, Kathrin Burgmaier, Anja Sander, Nakysa Hooman, Lale Sever, Francisco Cano, Pedro Zambrano, Ilmay Bilge, Joseph T Flynn, Onder Yavascan, Patricia G Vallés, Reyner Loza Munarriz, Hiren P Patel, Erkin Serdaroglu, Vera H Koch, Angela Del Carmen Suarez, Monica Galanti, Claudia Gonzalez Celedon, Anabella Rébori, Jameela A Kari, Cynthia J Wong, Ewa Elenberg, Luisa F Rojas, Bradley A Warady, Max C Liebau, Franz Schaefer, ,

Am. J. Kidney Dis. (American journal of kidney diseases : the official journal of the National Kidney Foundation)
[2020, 75(3):460-464]

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Incidence of Initial Renal Replacement Therapy Over the Course of Kidney Disease in Children.

Derek K Ng, Matthew B Matheson, Bradley A Warady, Susan R Mendley, Susan L Furth, Alvaro Muñoz,

The Chronic Kidney Disease in Children Study, a prospective cohort study with data collected from 2003 to 2018, provided the first opportunity to characterize the incidence of renal replacement therapy (RRT) initiation over the life course of pediatric kidney diseases. In the current analysis, parametric generalized gamma models were fitted ... Read more >>

Am. J. Epidemiol. (American journal of epidemiology)
[2019, 188(12):2156-2164]

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Mode of initial renal replacement therapy and transplant outcomes in the chronic kidney disease in children (CKiD) study.

Meredith A Atkinson, Jennifer L Roem, Anuradha Gajjar, Bradley A Warady, Susan L Furth, Alvaro Muñoz,

BACKGROUND:Kidney transplant is the renal replacement therapy (RRT) of choice for children with end stage kidney disease (ESKD). Only 21.3% of children who initiate RRT receive a preemptive kidney transplant (PKT). We characterized the transition to RRT in children in the CKiD cohort including the prevalence of dialysis as first ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2020, 35(6):1015-1021]

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