Full Text Journal Articles by
Author Bradley A Warady

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Longitudinal outcomes of body mass index in overweight and obese children with chronic kidney disease.

Nancy M Rodig, Jennifer Roem, Michael F Schneider, Patricia W Seo-Mayer, Kimberly J Reidy, Frederick J Kaskel, Amy J Kogon, Susan L Furth, Bradley A Warady,

<h4>Background</h4>Longitudinal changes in body mass index (BMI) among overweight and obese children with chronic kidney disease (CKD) are not well characterized. We studied longitudinal trajectories and correlates of these trajectories, as results may identify opportunities to optimize health outcomes.<h4>Methods</h4>Longitudinal changes in age-sex-specific BMI z-scores over 1851 person-years of follow-up were ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2021, :]

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Variability in Culture-Negative Peritonitis Rates in Pediatric Peritoneal Dialysis Programs in the United States.

T Keefe Davis, Kristina A Bryant, Jonathan Rodean, Troy Richardson, Rangaraj Selvarangan, Xuan Qin, Alicia Neu, Bradley A Warady,

<h4>Background and objectives</h4>International guidelines suggest a target culture-negative peritonitis rate of <15% among patients receiving long-term peritoneal dialysis. Through a pediatric multicenter dialysis collaborative, we identified variable rates of culture-negative peritonitis among participating centers. We sought to evaluate whether specific practices are associated with the variability in culture-negative rates between ... Read more >>

Clin J Am Soc Nephrol (Clinical journal of the American Society of Nephrology : CJASN)
[2021, :]

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Social Determinants of Cardiovascular Health in African American Children With CKD: An Analysis of the Chronic Kidney Disease in Children (CKiD) Study.

Kristen Sgambat, Jennifer Roem, Tammy M Brady, Joseph T Flynn, Mark Mitsnefes, Joshua A Samuels, Bradley A Warady, Susan L Furth, Asha Moudgil,

<h4>Rationale & objective</h4>To identify differences in socioeconomic factors (SES) and subclinical CVD markers by race among CKiD participants and determine whether differences in CVD markers persist after adjusting for SES.<h4>Study design</h4>Analysis of 3103 visits with repeated measures from 628 children (497 Caucasian; 131 African American) enrolled in the CKiD study.<h4>Setting ... Read more >>

Am J Kidney Dis (American journal of kidney diseases : the official journal of the National Kidney Foundation)
[2021, :]

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"Save the Vein" Initiative in Children With CKD: A Quality Improvement Study.

Nisha S Singh, JoLynn Grimes, Gina K Gregg, Amy E Nau, Douglas C Rivard, Moriah Fields, Nicholas Flaucher, Ashley K Sherman, Maria U Williams, Kaylene J Wiley, Kristen Kerwin, Bradley A Warady,

<h4>Rationale and objective</h4>An arteriovenous fistula (AVF) in the non-dominant arm is the preferred access for hemodialysis (HD) patients. Prior peripheral intravenous (PIV) line placement can lead to vascular injury and limit options for AVF placement, a particular problem for children with the potential need for HD over a lifetime. We ... Read more >>

Am J Kidney Dis (American journal of kidney diseases : the official journal of the National Kidney Foundation)
[2021, :]

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Assessment of nutritional status in children with kidney diseases-clinical practice recommendations from the Pediatric Renal Nutrition Taskforce.

Christina L Nelms, Vanessa Shaw, Larry A Greenbaum, Caroline Anderson, An Desloovere, Dieter Haffner, Michiel J S Oosterveld, Fabio Paglialonga, Nonnie Polderman, Leila Qizalbash, Lesley Rees, José Renken-Terhaerdt, Jetta Tuokkola, Johan Vande Walle, Rukshana Shroff, Bradley A Warady,

In children with kidney diseases, an assessment of the child's growth and nutritional status is important to guide the dietary prescription. No single metric can comprehensively describe the nutrition status; therefore, a series of indices and tools are required for evaluation. The Pediatric Renal Nutrition Taskforce (PRNT) is an international ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2020, :]

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Age- and sex-dependent clinical equations to estimate glomerular filtration rates in children and young adults with chronic kidney disease.

Christopher B Pierce, Alvaro Muñoz, Derek K Ng, Bradley A Warady, Susan L Furth, George J Schwartz,

Using data (2655 observations from 928 participants) from the Chronic Kidney Disease in Children Study, we developed and internally validated new glomerular filtration rate estimating equations for clinical use in children and young adults: two forms of k × [height (ht) serum creatinine (sCr)] and two forms of k × ... Read more >>

Kidney Int (Kidney international)
[2020, :]

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Achieved clinic blood pressure level and chronic kidney disease progression in children: a report from the Chronic Kidney Disease in Children cohort.

Joseph T Flynn, Megan K Carroll, Derek K Ng, Susan L Furth, Bradley A Warady,

<h4>Background</h4>Control of hypertension delays progression of pediatric chronic kidney disease (CKD), yet few data are available regarding what clinic blood pressure (BP) levels may slow progression.<h4>Methods</h4>Longitudinal BP data from children in the Chronic Kidney Disease in Children cohort study who had hypertension or an auscultatory BP ≥ 90th percentile were ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2020, :]

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Streptococcus salivarius peritonitis in an infant receiving chronic peritoneal dialysis.

Edgar Barajas-Colon, Bradley A Warady,

Peritonitis is the most common infectious complication of chronic peritoneal dialysis in children and the most common reason for hospitalization. Although the most common organisms responsible for peritonitis are gram-positive bacteria, peritonitis has not previously been reported secondary to <i>Streptococcus salivarius</i>, one of the 26 species in the <i>Streptococcus viridians</i> ... Read more >>

Perit Dial Int (Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis)
[2020, :896860820964285]

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Serially assessed bisphenol A and phthalate exposure and association with kidney function in children with chronic kidney disease in the US and Canada: A longitudinal cohort study.

Melanie H Jacobson, Yinxiang Wu, Mengling Liu, Teresa M Attina, Mrudula Naidu, Rajendiran Karthikraj, Kurunthachalam Kannan, Bradley A Warady, Susan Furth, Suzanne Vento, Howard Trachtman, Leonardo Trasande,

<h4>Background</h4>Exposure to environmental chemicals may be a modifiable risk factor for progression of chronic kidney disease (CKD). The purpose of this study was to examine the impact of serially assessed exposure to bisphenol A (BPA) and phthalates on measures of kidney function, tubular injury, and oxidative stress over time in ... Read more >>

PLoS Med (PLoS medicine)
[2020, 17(10):e1003384]

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Correction to: Aortic dilatation in children with mild to moderate chronic kidney disease.

Peace C Madueme, Derek K Ng, Luke Guju, Lauren Longshore, Vicky Moore, Lynn Jefferies, Bradley A Warady, Susan Furth, Mark Mitsnefes,

The original version of this article unfortunately contained a mistake. ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2020, 35(10):2017]

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Telehealth for Home Dialysis in COVID-19 and Beyond: A Perspective From the American Society of Nephrology COVID-19 Home Dialysis Subcommittee.

Susie Q Lew, Eric L Wallace, Vesh Srivatana, Bradley A Warady, Suzanne Watnick, Jayson Hood, David L White, Vikram Aggarwal, Caroline Wilkie, Mihran V Naljayan, Mary Gellens, Jeffrey Perl, Martin J Schreiber,

The coronavirus disease 2019 (COVID-19) pandemic, technological advancements, regulatory waivers, and user acceptance have converged to boost telehealth activities. Due to the state of emergency, regulatory waivers in the United States have made it possible for providers to deliver and bill for services across state lines for new and established ... Read more >>

Am J Kidney Dis (American journal of kidney diseases : the official journal of the National Kidney Foundation)
[2021, 77(1):142-148]

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Pediatric kidney transplantation in China: an analysis from the IPNA Global Kidney Replacement Therapy Registry.

Qian Shen, Xiaoyan Fang, Xinyue Man, Yihui Zhai, Longshan Liu, Changxi Wang, Wenjun Shang, Guiwen Feng, Lei Zhang, Li Zeng, Youhua Zhu, Jing Chen, Jia Rao, Bradley A Warady, Franz Schaefer, Hong Xu,

<h4>Background</h4>The International Pediatric Nephrology Association (IPNA) Global Kidney Replacement Therapy (KRT) Registry was established to evaluate the incidence and outcomes of kidney replacement therapy (dialysis and transplantation) provided to children worldwide. Analysis of registry data for separate regions is feasible.<h4>Methods</h4>Three centers located in Shanghai, Guangzhou, and Zhengzhou, which have the ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2020, :]

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Estimation of Albumin-Creatinine Ratio From Protein-Creatinine Ratio in Urine of Children and Adolescents With CKD.

Michael F Schneider, Alvaro Muñoz, Elaine Ku, Bradley A Warady, Susan L Furth, George J Schwartz,

Am J Kidney Dis (American journal of kidney diseases : the official journal of the National Kidney Foundation)
[2020, :]

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Alport Syndrome Classification and Management.

Bradley A Warady, Rajiv Agarwal, Sripal Bangalore, Arlene Chapman, Adeera Levin, Peter Stenvinkel, Robert D Toto, Glenn M Chertow,

Alport syndrome affects up to 60,000 people in the United States. The proposed reclassification of thin basement membrane nephropathy and some cases of focal segmental glomerulosclerosis as Alport syndrome could substantially increase the affected population. The reclassification scheme categorizes Alport syndrome as 3 distinct diseases of type IV collagen α3/4/5 ... Read more >>

Kidney Med (Kidney medicine)
[2020, 2(5):639-649]

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Optimizing Peritoneal Dialysis-Associated Peritonitis Prevention in the United States: From Standardized Peritoneal Dialysis-Associated Peritonitis Reporting and Beyond.

Jeffrey Perl, Douglas S Fuller, Neil Boudville, Alan S Kliger, Douglas E Schaubel, Isaac Teitelbaum, Bradley A Warady, Alicia M Neu, Priti R Patel, Beth Piraino, Martin Schreiber, Ronald L Pisoni,

Peritoneal dialysis (PD)-associated peritonitis is the leading cause of permanent transition to hemodialysis among patients receiving PD. Peritonitis is associated with higher mortality risk and added treatment costs and limits more widespread PD utilization. Optimizing the prevention of peritonitis in the United States will first require standardization of peritonitis definitions, ... Read more >>

Clin J Am Soc Nephrol (Clinical journal of the American Society of Nephrology : CJASN)
[2020, 16(1):154-161]

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Developing Consensus-Based Outcome Domains for Trials in Children and Adolescents With CKD: An International Delphi Survey.

Charlotte Logeman, Chandana Guha, Martin Howell, Camilla S Hanson, Jonathan C Craig, Susan Samuel, Michael Zappitelli, Mina Matsuda-Abedini, Allison Dart, Susan Furth, Allison Eddy, Jaap Groothoff, Hui-Kim Yap, Detlef Bockenhauer, Aditi Sinha, Stephen I Alexander, Stuart L Goldstein, Debbie S Gipson, Mini Michael, Amanda Walker, Joshua Kausman, Segolene Gaillard, Justine Bacchetta, Michelle N Rheault, Bradley A Warady, Alicia Neu, Martin Christian, Steven McTaggart, Isaac Liu, Sharon Teo, Benedicte Sautenet, Talia Gutman, Simon Carter, Armando Teixeira-Pinto, Allison Tong,

<h4>Rationale & objective</h4>The inconsistency in outcomes reported and lack of patient-reported outcomes across trials in children with chronic kidney disease (CKD) limits shared decision making. As part of the Standardized Outcomes in Nephrology (SONG)-Kids initiative, we aimed to generate a consensus-based prioritized list of critically important outcomes to be reported ... Read more >>

Am J Kidney Dis (American journal of kidney diseases : the official journal of the National Kidney Foundation)
[2020, 76(4):533-545]

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Phase 1, single-dose study to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of etelcalcetide in pediatric patients with secondary hyperparathyroidism receiving hemodialysis.

Winnie Sohn, Isidro B Salusky, Claus Peter Schmitt, Christina Taylan, Johan Vande Walle, Jude Ngang, Lucy Yan, Mark Kroenke, Bradley A Warady,

<h4>Background</h4>Data on the safety, efficacy of etelcalcetide in children with secondary hyperparathyroidism (sHPT) are limited.<h4>Methods</h4>This phase 1 study (NCT02833857) evaluated the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) of single-dose etelcalcetide (0.035 mg/kg intravenously) in pediatric hemodialysis patients (two cohorts; 1: 12-< 18 years; 2: 2-< 12 years). Treatment-emergent adverse events ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2021, 36(1):133-142]

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Characterizing the frequency of modifiable histological changes observed on surveillance biopsies in pediatric kidney allograft recipients.

James D Odum, Alexander Kats, Judith Sebestyen VanSickle, Vimal Chadha, Brenda Brewer, Vincent S Staggs, Bradley A Warady,

<h4>Background</h4>Rejection is responsible for just under 50% of graft loss in the pediatric kidney transplant population. Early identification and treatment of allograft injury, specifically modifiable pathologies such as subclinical rejection (SCR), calcineurin inhibitor toxicity, and BK virus nephropathy, may improve allograft survival. Protocol surveillance biopsy (SB) currently offers the earliest ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2020, 35(11):2173-2182]

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The Improving Renal Outcomes Collaborative: Blood Pressure Measurement in Transplant Recipients.

Michael E Seifert, Devesh S Dahale, Margret Kamel, Pamela D Winterberg, Gina-Marie Barletta, Craig W Belsha, Abanti Chaudhuri, Joseph T Flynn, Rouba Garro, Roshan P George, Jens W Goebel, David B Kershaw, Debora Matossian, Jason Misurac, Corina Nailescu, Christina R Nguyen, Meghan Pearl, Ari Pollack, Cozumel S Pruette, Pamela Singer, Judith S VanSickle, Priya Verghese, Bradley A Warady, Andrew Warmin, Patricia L Weng, Larysa Wickman, Amy C Wilson, David K Hooper, ,

<h4>Background and objectives</h4>Hypertension is highly prevalent in pediatric kidney transplant recipients and contributes to cardiovascular death and graft loss. Improper blood pressure (BP) measurement limits the ability to control hypertension in this population. Here, we report multicenter efforts from the Improving Renal Outcomes Collaborative (IROC) to standardize and improve appropriate ... Read more >>

Pediatrics (Pediatrics)
[2020, 146(1):]

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Correction to: Mode of initial renal replacement therapy and transplant outcomes in the chronic kidney disease in children (CKiD) study.

Meredith A Atkinson, Jennifer L Roem, Anuradha Gajjar, Bradley A Warady, Susan L Furth, Alvaro Muñoz,

The original version of this article unfortunately contained a mistake. ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2020, 35(6):1141-1142]

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Low Serum Bicarbonate and CKD Progression in Children.

Denver D Brown, Jennifer Roem, Derek K Ng, Kimberly J Reidy, Juhi Kumar, Matthew K Abramowitz, Robert H Mak, Susan L Furth, George J Schwartz, Bradley A Warady, Frederick J Kaskel, Michal L Melamed,

<h4>Background and objectives</h4>Studies of adults have demonstrated an association between metabolic acidosis, as measured by low serum bicarbonate levels, and CKD progression. We evaluated this relationship in children using data from the Chronic Kidney Disease in Children study.<h4>Design, setting, participants, & measurements</h4>The relationship between serum bicarbonate and a composite end ... Read more >>

Clin J Am Soc Nephrol (Clinical journal of the American Society of Nephrology : CJASN)
[2020, 15(6):755-765]

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Targeting optimal PD management in children: what have we learned from the IPPN registry?

Dagmara Borzych-Dużałka, Franz Schaefer, Bradley A Warady,

National and international registries have great potential for providing data that describe disease burden, treatments, and outcomes especially in rare diseases. In the setting of pediatric end-stage renal disease (ESRD), the available data are limited to highly developed countries, whereas the lack of data from emerging economies blurs the global ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2020, :]

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Association Between Chronic Kidney Disease-Mineral Bone Disease (CKD-MBD) and Cognition in Children: Chronic Kidney Disease in Children (CKiD) Study.

Jennifer S Yokoyama, Mina Matsuda-Abedini, Michelle R Denburg, Juhi Kumar, Bradley A Warady, Susan L Furth, Stephen R Hooper, Anthony A Portale, Farzana Perwad,

Rationale & Objective:Chronic kidney disease (CKD) in children is associated with cognitive dysfunction that affects school performance and quality of life. The relationship between CKD-mineral and bone disorder and cognitive function in children is unknown. Study Design:Observational study. Participants:702 children enrolled in the Chronic Kidney Disease in Children (CKiD) Study. ... Read more >>

Kidney Med (Kidney medicine)
[2020, 2(4):398-406]

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Hypothyroidism Due to Iodine Overload in Children Receiving Peritoneal Dialysis: A Report of 4 Cases.

Sai Sudha Mannemuddhu, Heather A Morgans, Naile Tufan Pekkucuksen, Bradley A Warady, Lawrence R Shoemaker,

Children who receive peritoneal dialysis (PD) are at increased risk for thyroid dysfunction. A rarely appreciated cause is iodine overload. We report 4 children who developed iodine overload and secondary hypothyroidism. All had kidney failure treated by PD. Each previously had normal thyroid function screening test results. At the time ... Read more >>

Am J Kidney Dis (American journal of kidney diseases : the official journal of the National Kidney Foundation)
[2020, 76(6):889-892]

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Adiposity, Sex, and Cardiovascular Disease Risk in Children With CKD: A Longitudinal Study of Youth Enrolled in the Chronic Kidney Disease in Children (CKiD) Study.

Tammy M Brady, Jennifer Roem, Christopher Cox, Michael F Schneider, Amy C Wilson, Susan L Furth, Bradley A Warady, Mark Mitsnefes,

RATIONALE & OBJECTIVE:Traditional and nontraditional cardiovascular disease risk factors are highly prevalent in children with chronic kidney disease (CKD). We examined the longitudinal association of adiposity with cardiac damage among children with CKD and explored whether this association was modified by sex. STUDY DESIGN:Prospective cohort study. SETTING & PARTICIPANTS:Children with ... Read more >>

Am J Kidney Dis (American journal of kidney diseases : the official journal of the National Kidney Foundation)
[2020, 76(2):166-173]

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