Full Text Journal Articles by
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New insights into atypical Alzheimer's disease in the era of biomarkers.

Jonathan Graff-Radford, Keir X X Yong, Liana G Apostolova, Femke H Bouwman, Maria Carrillo, Bradford C Dickerson, Gil D Rabinovici, Jonathan M Schott, David T Jones, Melissa E Murray,

Most patients with Alzheimer's disease present with amnestic problems; however, a substantial proportion, over-represented in young-onset cases, have atypical phenotypes including predominant visual, language, executive, behavioural, or motor dysfunction. In the past, these individuals often received a late diagnosis; however, availability of CSF and PET biomarkers of Alzheimer's disease pathologies ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2021, 20(3):222-234]

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Regional prefrontal cortical atrophy predicts specific cognitive-behavioral symptoms in ALS-FTD.

Elena Ratti, Kimiko Domoto-Reilly, Christina Caso, Alyssa Murphy, Michael Brickhouse, Daisy Hochberg, Nikos Makris, Merit E Cudkowicz, Bradford C Dickerson,

Amyotrophic Lateral Sclerosis-Frontotemporal Dementia (ALS-FTD) may present typical behavioral variant FTD symptoms. This study aims to determine whether profile and severity of cognitive-behavioral symptoms in ALS/ALS-FTD are predicted by regional cortical atrophy. The hypothesis is that executive dysfunction can be predicted by dorsolateral prefrontal cortical (dlPFC) atrophy, apathy by dorsomedial ... Read more >>

Brain Imaging Behav (Brain imaging and behavior)
[2021, :]

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18F-AV-1451 positron emission tomography in neuropathological substrates of corticobasal syndrome.

Anna E Goodheart, Joseph J Locascio, Wesley R Samore, Jessica A Collins, Michael Brickhouse, Aaron Schultz, Alexandra Touroutoglou, Keith A Johnson, Matthew P Frosch, John H Growdon, Bradford C Dickerson, Stephen N Gomperts,

Multiple neuropathological processes can manifest in life as a corticobasal syndrome. We sought to relate retention of the tau-PET tracer 18F-AV-1451 and structural magnetic resonance measures of regional atrophy to clinical features in clinically diagnosed and neuropathologically confirmed cases of corticobasal syndrome and to determine whether these vary with the ... Read more >>

Brain (Brain : a journal of neurology)
[2021, 144(1):266-277]

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Advances in neuroimaging to support translational medicine in dementia.

Thomas Edmund Cope, Rimona Sharon Weil, Emrah Düzel, Bradford C Dickerson, James Benedict Rowe,

Advances in neuroimaging are ideally placed to facilitate the translation from progress made in cellular genetics and molecular biology of neurodegeneration into improved diagnosis, prevention and treatment of dementia. New positron emission tomography (PET) ligands allow one to quantify neuropathology, inflammation and metabolism in vivo safely and reliably, to examine ... Read more >>

J Neurol Neurosurg Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2021, 92(3):263-270]

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An MRI-based strategy for differentiation of frontotemporal dementia and Alzheimer's disease.

Qun Yu, Yingren Mai, Yuting Ruan, Yishan Luo, Lei Zhao, Wenli Fang, Zhiyu Cao, Yi Li, Wang Liao, Songhua Xiao, Vincent C T Mok, Lin Shi, Jun Liu, , ,

<h4>Background</h4>The differential diagnosis of frontotemporal dementia (FTD) and Alzheimer's disease (AD) is difficult due to the overlaps of clinical symptoms. Structural magnetic resonance imaging (sMRI) presents distinct brain atrophy and potentially helps in their differentiation. In this study, we aim at deriving a novel integrated index by leveraging the volumetric ... Read more >>

Alzheimers Res Ther (Alzheimer's research & therapy)
[2021, 13(1):23]

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Breakdowns in Informativeness of Naturalistic Speech Production in Primary Progressive Aphasia.

Jeanne Gallée, Claire Cordella, Evelina Fedorenko, Daisy Hochberg, Alexandra Touroutoglou, Megan Quimby, Bradford C Dickerson,

"Functional communication" refers to an individual's ability to communicate effectively in his or her everyday environment, and thus is a paramount skill to monitor and target therapeutically in people with aphasia. However, traditional controlled-paradigm assessments commonly used in both research and clinical settings often fail to adequately capture this ability. ... Read more >>

Brain Sci (Brain sciences)
[2021, 11(2):]

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Neuroimaging in Frontotemporal Lobar Degeneration: Research and Clinical Utility.

Sheena I Dev, Bradford C Dickerson, Alexandra Touroutoglou,

Frontotemporal lobar dementia (FTLD) is a clinically and pathologically complex disease. Advances in neuroimaging techniques have provided a specialized set of tools to investigate underlying pathophysiology and identify clinical biomarkers that aid in diagnosis, prognostication, monitoring, and identification of appropriate endpoints in clinical trials. In this chapter, we review data ... Read more >>

Adv Exp Med Biol (Advances in experimental medicine and biology)
[2021, 1281:93-112]

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Brain volumetric deficits in MAPT mutation carriers: a multisite study.

Stephanie A Chu, Taru M Flagan, Adam M Staffaroni, Lize C Jiskoot, Jersey Deng, Salvatore Spina, Liwen Zhang, Virginia E Sturm, Jennifer S Yokoyama, William W Seeley, Janne M Papma, Dan H Geschwind, Howard J Rosen, Bradley F Boeve, Adam L Boxer, Hilary W Heuer, Leah K Forsberg, Danielle E Brushaber, Murray Grossman, Giovanni Coppola, Bradford C Dickerson, Yvette M Bordelon, Kelley Faber, Howard H Feldman, Julie A Fields, Jamie C Fong, Tatiana Foroud, Ralitza H Gavrilova, Nupur Ghoshal, Neill R Graff-Radford, Ging-Yuek Robin Hsiung, Edward D Huey, David J Irwin, Kejal Kantarci, Daniel I Kaufer, Anna M Karydas, David S Knopman, John Kornak, Joel H Kramer, Walter A Kukull, Maria I Lapid, Irene Litvan, Ian R A Mackenzie, Mario F Mendez, Bruce L Miller, Chiadi U Onyike, Alexander Y Pantelyat, Rosa Rademakers, Eliana Marisa Ramos, Erik D Roberson, Maria Carmela Tartaglia, Nadine A Tatton, Arthur W Toga, Ashley Vetor, Sandra Weintraub, Bonnie Wong, Zbigniew K Wszolek, , John C Van Swieten, Suzee E Lee,

<h4>Objective</h4>MAPT mutations typically cause behavioral variant frontotemporal dementia with or without parkinsonism. Previous studies have shown that symptomatic MAPT mutation carriers have frontotemporal atrophy, yet studies have shown mixed results as to whether presymptomatic carriers have low gray matter volumes. To elucidate whether presymptomatic carriers have lower structural brain volumes ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2021, 8(1):95-110]

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Altered functional connectivity of cortical networks in semantic variant Primary Progressive Aphasia.

Haroon Popal, Megan Quimby, Daisy Hochberg, Bradford C Dickerson, Jessica A Collins,

As their illness progresses, patients with the semantic variant of Primary Progressive Aphasia (svPPA) frequently exhibit peculiar behaviors indicative of altered visual attention or an increased interest in artistic endeavors. In the present study, we examined changes within and between large-scale functional brain networks that may explain this altered visual ... Read more >>

Neuroimage Clin (NeuroImage. Clinical)
[2020, 28:102494]

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In It Together: A Qualitative Meta-Synthesis of Common and Unique Psychosocial Stressors and Adaptive Coping Strategies of Persons With Young-Onset Dementia and Their Caregivers.

Sarah Bannon, Mira Reichman, Paula Popok, Juliana Wagner, Melissa Gates, Simrit Uppal, Lisa LeFeber, Bonnie Wong, Bradford C Dickerson, Ana Maria Vranceanu,

<h4>Background and objectives</h4>The common and unique psychosocial stressors and adaptive coping strategies of people with young-onset dementia (PWDs) and their caregivers (CGs) are poorly understood. This meta-synthesis used the stress and coping framework to integrate and organize qualitative data on the common and unique psychosocial stressors and adaptive coping strategies ... Read more >>

Gerontologist (The Gerontologist)
[2020, :]

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Low Frontal Alpha Power Is Associated With the Propensity for Burst Suppression: An Electroencephalogram Phenotype for a "Vulnerable Brain".

Yu Raymond Shao, Pegah Kahali, Timothy T Houle, Hao Deng, Christopher Colvin, Bradford C Dickerson, Emery N Brown, Patrick L Purdon,

<h4>Background</h4>A number of recent studies have reported an association between intraoperative burst suppression and postoperative delirium. These studies suggest that anesthesia-induced burst suppression may be an indicator of underlying brain vulnerability. A prominent feature of electroencephalogram (EEG) under propofol and sevoflurane anesthesia is the frontal alpha oscillation. This frontal alpha ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2020, 131(5):1529-1539]

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Machine Learning to Develop and Internally Validate a Predictive Model for Post-operative Delirium in a Prospective, Observational Clinical Cohort Study of Older Surgical Patients.

Annie M Racine, Douglas Tommet, Madeline L D'Aquila, Tamara G Fong, Yun Gou, Patricia A Tabloski, Eran D Metzger, Tammy T Hshieh, Eva M Schmitt, Sarinnapha M Vasunilashorn, Lisa Kunze, Kamen Vlassakov, Ayesha Abdeen, Jeffrey Lange, Brandon Earp, Bradford C Dickerson, Edward R Marcantonio, Jon Steingrimsson, Thomas G Travison, Sharon K Inouye, Richard N Jones, ,

<h4>Background</h4>Our objective was to assess the performance of machine learning methods to predict post-operative delirium using a prospective clinical cohort.<h4>Methods</h4>We analyzed data from an observational cohort study of 560 older adults (≥ 70 years) without dementia undergoing major elective non-cardiac surgery. Post-operative delirium was determined by the Confusion Assessment Method supplemented by ... Read more >>

J Gen Intern Med (Journal of general internal medicine)
[2021, 36(2):265-273]

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Diffusion tensor-MRI detects exercise-induced neuroplasticity in the hippocampal microstructure in mice.

Mohammad R Islam, Renhao Luo, Sophia Valaris, Erin B Haley, Hajime Takase, Yinching Iris Chen, Bradford C Dickerson, Karin Schon, Ken Arai, Christopher T Nguyen, Christiane D Wrann,

<h4>Background</h4>Despite considerable research on exercise-induced neuroplasticity in the brain, a major ongoing challenge in translating findings from animal studies to humans is that clinical and preclinical settings employ very different techniques.<h4>Objective</h4>Here we aim to bridge this divide by using diffusion tensor imaging MRI (DTI), an advanced imaging technique commonly applied ... Read more >>

Brain Plast (Brain plasticity (Amsterdam, Netherlands))
[2020, 5(2):147-159]

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The Role of Inflammation after Surgery for Elders (RISE) study: Examination of [11C]PBR28 binding and exploration of its link to post-operative delirium.

Yuta Katsumi, Annie M Racine, Angel Torrado-Carvajal, Marco L Loggia, Jacob M Hooker, Douglas N Greve, Baileigh G Hightower, Ciprian Catana, Michele Cavallari, Steven E Arnold, Tamara G Fong, Sarinnapha M Vasunilashorn, Edward R Marcantonio, Eva M Schmitt, Guoquan Xu, Towia A Libermann, Lisa Feldman Barrett, Sharon K Inouye, Bradford C Dickerson, Alexandra Touroutoglou, Jessica A Collins, ,

Major surgery is associated with a systemic inflammatory cascade that is thought, in some cases, to contribute to transient and/or sustained cognitive decline, possibly through neuroinflammatory mechanisms. However, the relationship between surgery, peripheral and central nervous system inflammation, and post-operative cognitive outcomes remains unclear in humans, primarily owing to limitations ... Read more >>

Neuroimage Clin (NeuroImage. Clinical)
[2020, 27:102346]

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Longitudinal structural and metabolic changes in frontotemporal dementia.

Alexandre Bejanin, Gautam Tammewar, Gabe Marx, Yann Cobigo, Leonardo Iaccarino, John Kornak, Adam M Staffaroni, Bradford C Dickerson, Bradley F Boeve, David S Knopman, Marilu Gorno-Tempini, Bruce L Miller, William J Jagust, Adam L Boxer, Howard J Rosen, Gil D Rabinovici,

<h4>Objective</h4>To compare the sensitivity of structural MRI and <sup>18</sup>F-fludeoxyglucose PET (<sup>18</sup>FDG-PET) to detect longitudinal changes in frontotemporal dementia (FTD).<h4>Methods</h4>Thirty patients with behavioral variant FTD (bvFTD), 7 with nonfluent/agrammatic variant primary progressive aphasia (nfvPPA), 16 with semantic variant primary progressive aphasia (svPPA), and 43 cognitively normal controls underwent 2-4 MRI and ... Read more >>

Neurology (Neurology)
[2020, 95(2):e140-e154]

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Diagnostic value of plasma phosphorylated tau181 in Alzheimer's disease and frontotemporal lobar degeneration.

Elisabeth H Thijssen, Renaud La Joie, Amy Wolf, Amelia Strom, Ping Wang, Leonardo Iaccarino, Viktoriya Bourakova, Yann Cobigo, Hilary Heuer, Salvatore Spina, Lawren VandeVrede, Xiyun Chai, Nicholas K Proctor, David C Airey, Sergey Shcherbinin, Cynthia Duggan Evans, John R Sims, Henrik Zetterberg, Kaj Blennow, Anna M Karydas, Charlotte E Teunissen, Joel H Kramer, Lea T Grinberg, William W Seeley, Howie Rosen, Bradley F Boeve, Bruce L Miller, Gil D Rabinovici, Jeffrey L Dage, Julio C Rojas, Adam L Boxer, ,

With the potential development of new disease-modifying Alzheimer's disease (AD) therapies, simple, widely available screening tests are needed to identify which individuals, who are experiencing symptoms of cognitive or behavioral decline, should be further evaluated for initiation of treatment. A blood-based test for AD would be a less invasive and ... Read more >>

Nat Med (Nature medicine)
[2020, 26(3):387-397]

Cited: 40 times

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Word retrieval across the biomarker-confirmed Alzheimer's disease syndromic spectrum.

Deepti Putcha, Bradford C Dickerson, Michael Brickhouse, Keith A Johnson, Reisa A Sperling, Kathryn V Papp,

Alzheimer's disease (AD) is now conceptualized as a biological entity defined by amyloid and tau deposition and neurodegeneration, with heterogeneous clinical presentations. With the aid of in vivo biomarkers, clinicians are better poised to examine clinical syndromic variability arising from a common pathology. Word retrieval deficits, measured using verbal fluency ... Read more >>

Neuropsychologia (Neuropsychologia)
[2020, 140:107391]

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Topography of cortical thinning in the Lewy body diseases.

Rong Ye, Alexandra Touroutoglou, Michael Brickhouse, Samantha Katz, John H Growdon, Keith A Johnson, Bradford C Dickerson, Stephen N Gomperts,

<h4>Objective</h4>Regional cortical thinning in dementia with Lewy bodies (DLB) and Parkinson disease dementia (PDD) may underlie some aspect of their clinical impairments; cortical atrophy likely reflects extensive Lewy body pathology with alpha-synuclein deposits, as well as associated Alzheimer's disease co-pathologies, when present. Here we investigated the topographic distribution of cortical ... Read more >>

Neuroimage Clin (NeuroImage. Clinical)
[2020, 26:102196]

Cited: 2 times

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New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures.

Adam L Boxer, Michael Gold, Howard Feldman, Bradley F Boeve, Susan L-J Dickinson, Howard Fillit, Carole Ho, Robert Paul, Rodney Pearlman, Margaret Sutherland, Ajay Verma, Stephen P Arneric, Brian M Alexander, Bradford C Dickerson, Earl Ray Dorsey, Murray Grossman, Edward D Huey, Michael C Irizarry, William J Marks, Mario Masellis, Frances McFarland, Debra Niehoff, Chiadi U Onyike, Sabrina Paganoni, Michael A Panzara, Kenneth Rockwood, Jonathan D Rohrer, Howard Rosen, Robert N Schuck, Holly D Soares, Nadine Tatton,

<h4>Introduction</h4>Frontotemporal lobar degeneration (FTLD) is the most common form of dementia for those under 60 years of age. Increasing numbers of therapeutics targeting FTLD syndromes are being developed.<h4>Methods</h4>In March 2018, the Association for Frontotemporal Degeneration convened the Frontotemporal Degeneration Study Group meeting in Washington, DC, to discuss advances in the clinical ... Read more >>

Alzheimers Dement (Alzheimer's & dementia : the journal of the Alzheimer's Association)
[2020, 16(1):131-143]

Cited: 5 times

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Stronger Functional Connectivity in the Default Mode and Salience Networks Is Associated With Youthful Memory in Superaging.

Jiahe Zhang, Joseph M Andreano, Bradford C Dickerson, Alexandra Touroutoglou, Lisa Feldman Barrett,

"Superagers" are older adults who, despite their advanced age, maintain youthful memory. Previous morphometry studies revealed multiple default mode network (DMN) and salience network (SN) regions whose cortical thickness is greater in superagers and correlates with memory performance. In this study, we examined the intrinsic functional connectivity within DMN and ... Read more >>

Cereb Cortex (Cerebral cortex (New York, N.Y. : 1991))
[2020, 30(1):72-84]

Cited: 5 times

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Clinical and volumetric changes with increasing functional impairment in familial frontotemporal lobar degeneration.

Nicholas T Olney, Elise Ong, Sheng-Yang M Goh, Lynn Bajorek, Reilly Dever, Adam M Staffaroni, Yann Cobigo, Meredith Bock, Kevin Chiang, Peter Ljubenkov, John Kornak, Hilary W Heuer, Ping Wang, Katya Rascovsky, Amelia Wolf, Brian Appleby, Jessica Bove, Yvette Bordelon, Patrick Brannelly, Danielle Brushaber, Christine Caso, Giovanni Coppola, Bradford C Dickerson, Susan Dickinson, Kimiko Domoto-Reilly, Kelly Faber, Jessica Ferrall, Julie Fields, Ann Fishman, Jamie Fong, Tatiana Foroud, Leah K Forsberg, Debra J Gearhart, Behnaz Ghazanfari, Nupur Ghoshal, Jill Goldman, Jonathan Graff-Radford, Neill R Graff-Radford, Ian Grant, Murray Grossman, Dana Haley, Gingyuek Hsiung, Edward D Huey, David J Irwin, David T Jones, Kejal Kantarci, Anna M Karydas, Daniel Kaufer, Diana Kerwin, David S Knopman, Joel H Kramer, Ruth Kraft, Walter Kremers, Walter Kukull, Maria I Lapid, Irene Litvan, Ian R Mackenzie, Miranda Maldonado, Masood Manoochehri, Scott M McGinnis, Emily C McKinley, Mario F Mendez, Bruce L Miller, Chiadi Onyike, Alex Pantelyat, Rodney Pearlman, Len Petrucelli, Madeleine Potter, Rosa Rademakers, Eliana M Ramos, Katherine P Rankin, Erik D Roberson, Emily Rogalski, Pheth Sengdy, Leslie M Shaw, Jeremy Syrjanen, M Carmela Tartaglia, Nadine Tatton, Joanne Taylor, Arthur Toga, John Q Trojanowski, Sandra Weintraub, Bonnie Wong, Zbigniew Wszolek, Adam L Boxer, Brad F Boeve, Howard J Rosen, ,

<h4>Introduction</h4>The Advancing Research and Treatment in Frontotemporal Lobar Degeneration and Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects longitudinal studies were designed to describe the natural history of familial-frontotemporal lobar degeneration due to autosomal dominant mutations.<h4>Methods</h4>We examined cognitive performance, behavioral ratings, and brain volumes from the first time point in 320 ... Read more >>

Alzheimers Dement (Alzheimer's & dementia : the journal of the Alzheimer's Association)
[2020, 16(1):49-59]

Cited: 5 times

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Individualized atrophy scores predict dementia onset in familial frontotemporal lobar degeneration.

Adam M Staffaroni, Yann Cobigo, Sheng-Yang M Goh, John Kornak, Lynn Bajorek, Kevin Chiang, Brian Appleby, Jessica Bove, Yvette Bordelon, Patrick Brannelly, Danielle Brushaber, Christina Caso, Giovanni Coppola, Reilly Dever, Christina Dheel, Bradford C Dickerson, Susan Dickinson, Sophia Dominguez, Kimiko Domoto-Reilly, Kelly Faber, Jessica Ferrall, Julie A Fields, Ann Fishman, Jamie Fong, Tatiana Foroud, Leah K Forsberg, Ralitza Gavrilova, Debra Gearhart, Behnaz Ghazanfari, Nupur Ghoshal, Jill Goldman, Jonathan Graff-Radford, Neill Graff-Radford, Ian Grant, Murray Grossman, Dana Haley, Hilary W Heuer, Ging-Yuek Hsiung, Edward D Huey, David J Irwin, David T Jones, Lynne Jones, Kejal Kantarci, Anna Karydas, Daniel I Kaufer, Diana R Kerwin, David S Knopman, Ruth Kraft, Joel H Kramer, Walter K Kremers, Walter A Kukull, Irene Litvan, Peter A Ljubenkov, Diane Lucente, Codrin Lungu, Ian R Mackenzie, Miranda Maldonado, Masood Manoochehri, Scott M McGinnis, Emily McKinley, Mario F Mendez, Bruce L Miller, Namita Multani, Chiadi Onyike, Jaya Padmanabhan, Alex Pantelyat, Rodney Pearlman, Len Petrucelli, Madeline Potter, Rosa Rademakers, Eliana Marisa Ramos, Katherine P Rankin, Katya Rascovsky, Erik D Roberson, Emily Rogalski, Pheth Sengdy, Leslie M Shaw, Jeremy Syrjanen, M Carmela Tartaglia, Nadine Tatton, Joanne Taylor, Arthur Toga, John Q Trojanowski, Sandra Weintraub, Ping Wang, Bonnie Wong, Zbigniew Wszolek, Adam L Boxer, Brad F Boeve, Howard J Rosen, ,

<h4>Introduction</h4>Some models of therapy for neurodegenerative diseases envision starting treatment before symptoms develop. Demonstrating that such treatments are effective requires accurate knowledge of when symptoms would have started without treatment. Familial frontotemporal lobar degeneration offers a unique opportunity to develop predictors of symptom onset.<h4>Methods</h4>We created dementia risk scores in 268 ... Read more >>

Alzheimers Dement (Alzheimer's & dementia : the journal of the Alzheimer's Association)
[2020, 16(1):37-48]

Cited: 7 times

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Assessment of executive function declines in presymptomatic and mildly symptomatic familial frontotemporal dementia: NIH-EXAMINER as a potential clinical trial endpoint.

Adam M Staffaroni, Lynn Bajorek, Kaitlin B Casaletto, Yann Cobigo, Sheng-Yang M Goh, Amy Wolf, Hilary W Heuer, Fanny M Elahi, Peter A Ljubenkov, Reilly Dever, John Kornak, Brian Appleby, Jessica Bove, Yvette Bordelon, Patrick Brannelly, Danielle Brushaber, Christina Caso, Giovanni Coppola, Christina Dheel, Bradford C Dickerson, Susan Dickinson, Sophia Dominguez, Kimiko Domoto-Reilly, Kelly Faber, Jessica Ferrall, Julie A Fields, Ann Fishman, Jamie Fong, Tatiana Foroud, Leah K Forsberg, Ralitza Gavrilova, Debra Gearhart, Behnaz Ghazanfari, Nupur Ghoshal, Jill Goldman, Jonathan Graff-Radford, Neill Graff-Radford, Ian Grant, Murray Grossman, Dana Haley, Ging-Yuek Hsiung, Edward D Huey, David J Irwin, David T Jones, Lynne Jones, Kejal Kantarci, Anna Karydas, Daniel I Kaufer, Diana R Kerwin, David S Knopman, Ruth Kraft, Walter K Kremers, Walter A Kukull, Irene Litvan, Diane Lucente, Codrin Lungu, Ian R Mackenzie, Miranda Maldonado, Masood Manoochehri, Scott M McGinnis, Emily McKinley, Mario F Mendez, Bruce L Miller, Namita Multani, Chiadi Onyike, Jaya Padmanabhan, Alex Pantelyat, Rodney Pearlman, Len Petrucelli, Madeline Potter, Rosa Rademakers, Eliana Marisa Ramos, Katherine P Rankin, Katya Rascovsky, Erik D Roberson, Emily Rogalski, Pheth Sengdy, Leslie M Shaw, Jeremy Syrjanen, M Carmela Tartaglia, Nadine Tatton, Joanne Taylor, Arthur Toga, John Q Trojanowski, Sandra Weintraub, Ping Wang, Bonnie Wong, Zbigniew Wszolek, Adam L Boxer, Brad F Boeve, Joel H Kramer, Howard J Rosen, ,

<h4>Introduction</h4>Identifying clinical measures that track disease in the earliest stages of frontotemporal lobar degeneration (FTLD) is important for clinical trials. Familial FTLD provides a unique paradigm to study early FTLD. Executive dysfunction is a clinically relevant hallmark of FTLD and may be a marker of disease progression.<h4>Methods</h4>Ninety-three mutation carriers with ... Read more >>

Alzheimers Dement (Alzheimer's & dementia : the journal of the Alzheimer's Association)
[2020, 16(1):11-21]

Cited: 2 times

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Older Patients with Alzheimer's Disease-Related Cortical Atrophy Who Develop Post-Operative Delirium May Be at Increased Risk of Long-Term Cognitive Decline After Surgery.

Annie M Racine, Alexandra Touroutoglou, Tatiana Abrantes, Bonnie Wong, Tamara G Fong, Michele Cavallari, Thomas G Travison, Yun Gou, Edward R Marcantonio, David C Alsop, Richard N Jones, Sharon K Inouye, Bradford C Dickerson, ,

<h4>Background</h4>Older surgical patients with Alzheimer's disease (AD) dementia and delirium are at increased risk for accelerated long-term cognitive decline.<h4>Objective</h4>Investigate associations between a probabilistic marker of preclinical AD, delirium, and long-term cognitive decline.<h4>Methods</h4>The Successful Aging after Elective Surgery cohort includes older adults (≥70 years) without dementia who underwent elective surgery. 140 ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2020, 75(1):187-199]

Cited: 0 times

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Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study.

Katrina M Moore, Jennifer Nicholas, Murray Grossman, Corey T McMillan, David J Irwin, Lauren Massimo, Vivianna M Van Deerlin, Jason D Warren, Nick C Fox, Martin N Rossor, Simon Mead, Martina Bocchetta, Bradley F Boeve, David S Knopman, Neill R Graff-Radford, Leah K Forsberg, Rosa Rademakers, Zbigniew K Wszolek, John C van Swieten, Lize C Jiskoot, Lieke H Meeter, Elise Gp Dopper, Janne M Papma, Julie S Snowden, Jennifer Saxon, Matthew Jones, Stuart Pickering-Brown, Isabelle Le Ber, Agnès Camuzat, Alexis Brice, Paola Caroppo, Roberta Ghidoni, Michela Pievani, Luisa Benussi, Giuliano Binetti, Bradford C Dickerson, Diane Lucente, Samantha Krivensky, Caroline Graff, Linn Öijerstedt, Marie Fallström, Håkan Thonberg, Nupur Ghoshal, John C Morris, Barbara Borroni, Alberto Benussi, Alessandro Padovani, Daniela Galimberti, Elio Scarpini, Giorgio G Fumagalli, Ian R Mackenzie, Ging-Yuek R Hsiung, Pheth Sengdy, Adam L Boxer, Howie Rosen, Joanne B Taylor, Matthis Synofzik, Carlo Wilke, Patricia Sulzer, John R Hodges, Glenda Halliday, John Kwok, Raquel Sanchez-Valle, Albert Lladó, Sergi Borrego-Ecija, Isabel Santana, Maria Rosário Almeida, Miguel Tábuas-Pereira, Fermin Moreno, Myriam Barandiaran, Begoña Indakoetxea, Johannes Levin, Adrian Danek, James B Rowe, Thomas E Cope, Markus Otto, Sarah Anderl-Straub, Alexandre de Mendonça, Carolina Maruta, Mario Masellis, Sandra E Black, Philippe Couratier, Geraldine Lautrette, Edward D Huey, Sandro Sorbi, Benedetta Nacmias, Robert Laforce, Marie-Pier L Tremblay, Rik Vandenberghe, Philip Van Damme, Emily J Rogalski, Sandra Weintraub, Alexander Gerhard, Chiadi U Onyike, Simon Ducharme, Sokratis G Papageorgiou, Adeline Su Lyn Ng, Amy Brodtmann, Elizabeth Finger, Rita Guerreiro, Jose Bras, Jonathan D Rohrer, ,

<h4>Background</h4>Frontotemporal dementia is a heterogenous neurodegenerative disorder, with about a third of cases being genetic. Most of this genetic component is accounted for by mutations in GRN, MAPT, and C9orf72. In this study, we aimed to complement previous phenotypic studies by doing an international study of age at symptom onset, ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2020, 19(2):145-156]

Cited: 11 times

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