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Author Bowen Li

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Design of 2D materials - MSi2CxN4-x (M = Cr, Mo, and W; x = 1 and 2) - with tunable electronic and magnetic properties.

Bowen Li, Jiazhong Geng, Haoqiang Ai, Youchao Kong, Haoyun Bai, Kin Ho Lo, Kar Wei Ng, Yoshiyuki Kawazoe, Hui Pan,

Two-dimensional (2D) materials have attracted increasing interest in the past decades due to their unique physical and chemical properties for diverse applications. In this work, we present a first-principles design on a novel 2D family, MSi<sub>2</sub>C<sub>x</sub>N<sub>4-x</sub> (M = Cr, Mo, and W; x = 1 and 2), based on density-functional ... Read more >>

Nanoscale (Nanoscale)
[2021, 13(17):8038-8048]

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Metal-organic frameworks containing xanthene dyes for photocatalytic applications.

Yanhong Liu, Bowen Li, Han-Shu Li, Pengyan Wu, Jian Wang,

Metal-organic frameworks (MOFs) have recently emerged as a new type of prospective photocatalytic material due to their characteristics such as tunable structures, pore modification, crystalline nature with eliminated structural defects, unique semiconductor properties, etc. However, most of these systems also suffer from low activity, high cost, and low visible light ... Read more >>

Dalton Trans (Dalton transactions (Cambridge, England : 2003))
[2020, 49(48):17520-17526]

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Clinical relevance of neutrophil-to-lymphocyte ratio and mean platelet volume in pediatric Henoch-Schonlein Purpura: a meta-analysis.

Bowen Li, Qian Ren, Jizu Ling, Zhongbin Tao, Xuemei Yang, Yuning Li,

The association of neutrophil-to-lymphocyte ratio (NLR) and mean platelet volume (MPV) with the severe gastrointestinal (GI) involvement in pediatric Henoch-Schonlein Purpura (HSP) has been reported in many studies. However, the conclusions from the previous studies were controversial. Therefore, for the first time, we performed a meta-analysis to systematically evaluate the ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):286-295]

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Circular RNA UBE2Q2 promotes malignant progression of gastric cancer by regulating signal transducer and activator of transcription 3-mediated autophagy and glycolysis.

Jing Yang, Xing Zhang, Jiacheng Cao, Penghui Xu, Zetian Chen, Sen Wang, Bowen Li, Lu Zhang, Li Xie, Lang Fang, Zekuan Xu,

Gastric cancer remains the third leading cause of cancer-related mortality worldwide. Emerging evidence has shown that circular RNAs (circRNAs) play a critical regulatory role in the occurrence and development of various cancers through sponging miRNAs or acting as RNA-binding protein (RBP) sponges. We found that circUBE2Q2 was significantly upregulated in ... Read more >>

Cell Death Dis (Cell death & disease)
[2021, 12(10):910]

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Investigating the growth of an engineered strain of Cyanobacteria with an Agent-Based Model and a Recurrent Neural Network

Jonathan Sakkos, Joe Weaver, Connor Robertson, Bowen Li, Denis Taniguchi, Ketan Maheshwari, Daniel Ducat, Paolo Zuliani, Andrew Stephen McGough, Tom Curtis, Miguel Fuentes-Cabrera,

A computational framework combining Agent-Based Models (ABMs) and Deep Learning techniques was developed to help design microbial communities that convert light and CO 2 into useful bioproducts. An ABM that accounts for CO 2 , light, sucrose export rate and cell-to-cell mechanical interactions was used to investigate the growth of ... Read more >>

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The F-box E3 ubiquitin ligase AtSDR is involved in salt and drought stress responses in Arabidopsis.

Bowen Li, Shuai Gao, Zhimin Yang, Jianbo Song,

F-box protein genes have been shown to play vital roles in plant development and stress respones. In Arabidopsis, there are more than 600 F-box proteins, and most of their functions are unclear. The present study shows that the F-box (SKP1-Cullin/CDC53-F-box) gene At5g15710 (Salt and Drought Responsiveness, SDR) is involved in ... Read more >>

Gene (Gene)
[2021, :146011]

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Characteristics of Cu(II)-modified aerobic granular sludge biocarbon in removal of doxycycline hydroxide.

Xia Zhao, Hao Wang, Guozhen Zhang, Weina Pei, Yumin Xu, Bowen Li,

In this study, the biocarbon derived from aerobic granular sludge with different nutritive proportions was modified by Cu(NO<sub>3</sub>)<sub>2</sub>•3H<sub>2</sub>O (Cu-BC) to improve its adsorption capacity of doxycycline hydrochloride (DOX). The surface area, pores, functional groups, and element composition of biocarbon were characterized by scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) surface area, ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2021, :]

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Expression, regulation, and function of exosome-derived miRNAs in cancer progression and therapy.

Bowen Li, Yu Cao, Mingjun Sun, Hui Feng,

Exosomes are a novel class of intercellular signal modulators that contain a wide range of molecules and deliver information between cells and tissues. MicroRNAs (miRNAs), a type of regulatory non-coding RNA, are often incorporated into exosomes as signaling molecules. In this review, we discuss the expression of exosomal miRNAs from ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(10):e21916]

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Endovascular Thrombectomy preceded by intravenous Alteplase versus endovascular Thrombectomy alone in Han Chinese patients treated for acute ischemic stroke with large vessel occlusion: a single-center retrospective analysis.

Ruodong Han, Bowen Li, Yajie Yue, Guozhu Wu, Xiuxia Yan,

<h4>Background</h4>The American Heart Association/ American Stroke Association and the Chinese Stroke Association guidelines are recommending intravenous alteplase intervention before endovascular thrombectomy if patients are eligible to do so but the benefits of endovascular thrombectomy are different in Chinese patients with stroke than those of the white patients. The objective of ... Read more >>

BMC Neurol (BMC neurology)
[2021, 21(1):375]

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Dietary serine supplementation: Friend or foe?

Jingwen Jiang, Bowen Li, Weifeng He, Canhua Huang,

Serine lies at a critical node in biological processes involved in supplying intermediates for redox homeostasis, nucleotide, or lipid biosynthesis and one-carbon metabolism-coupled methyl donor production. Recently, dietary serine supplementation has been reported to modulate cellular serine levels and ameliorate neurological abnormalities induced by serine deficiency. Moreover, growing evidence showed ... Read more >>

Curr Opin Pharmacol (Current opinion in pharmacology)
[2021, 61:12-20]

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Polyketide Starter and Extender Units Serve as Regulatory Ligands to Coordinate the Biosynthesis of Antibiotics in Actinomycetes.

Panpan Wu, Ketao Chen, Bowen Li, Yanni Zhang, Hang Wu, Yuhong Chen, Shaohua Ren, Sabir Khan, Lixin Zhang, Buchang Zhang,

Polyketides are one of the largest categories of secondary metabolites, and their biosynthesis is initiated by polyketide synthases (PKSs) using coenzyme A esters of short fatty acids (acyl-CoAs) as starter and extender units. In this study, we discover a universal regulatory mechanism in which the starter and extender units, beyond ... Read more >>

mBio (mBio)
[2021, :e0229821]

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miR-151a-3p-rich small extracellular vesicles derived from gastric cancer accelerate liver metastasis via initiating a hepatic stemness-enhancing niche.

Bowen Li, Yiwen Xia, Jialun Lv, Weizhi Wang, Zhe Xuan, Cen Chen, Tianlu Jiang, Lang Fang, Linjun Wang, Zheng Li, Zhongyuan He, Qingya Li, Li Xie, Shengkui Qiu, Lu Zhang, Diancai Zhang, Hao Xu, Zekuan Xu,

Liver metastasis (LM) severely affects gastric cancer (GC) patients' prognosis. Small extracellular vesicles (sEVs) play key roles in intercellular communication. Specific sEV-miRNAs from several types of cancer were found to induce a premetastatic niche in target organs before tumor cell arrive. However, whether the primary GC affects hepatic microenvironment or ... Read more >>

Oncogene (Oncogene)
[2021, :]

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Discovery and Characterization of Differentially Expressed Soybean MiRNAs and Their Targets During Soybean Mosaic Virus Infection Unveils Novel Insight Into Soybean-SMV Interaction

Bowen Li, Adhimoolam Karthikeyan, Liqun Wang, Jinlong Yin, Tongtong Jin, Hui Liu, Kai Li, Junyi Gai, Haijian Zhi,

<h4>Background: </h4> Soybean mosaic virus (SMV) is the most devastating pathogen of soybean. MicroRNAs (miRNAs) are a class of non-coding RNAs (21-24 nucleotides) and play important roles in regulating defense responses against pathogens. However, miRNA's response to SMV in soybean is not as well documented. <h4>Result: </h4> In this study, ... Read more >>

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Uncovering and Engineering a Mini-Regulatory Network of the TetR-Family Regulator SACE_0303 for Yield Improvement of Erythromycin in Saccharopolyspora erythraea.

Ying Liu, Sabir Khan, Panpan Wu, Bowen Li, Lanlan Liu, Jingshu Ni, Hongxia Zhang, Ketao Chen, Hang Wu, Buchang Zhang,

Erythromycins produced by <i>Saccharopolyspora erythraea</i> have broad-spectrum antibacterial activities. Recently, several TetR-family transcriptional regulators (TFRs) were identified to control erythromycin production by multiplex control modes; however, their regulatory network remains poorly understood. In this study, we report a novel TFR, SACE_0303, positively correlated with erythromycin production in <i>Sac. erythraea</i>. It ... Read more >>

Front Bioeng Biotechnol (Frontiers in bioengineering and biotechnology)
[2021, 9:692901]

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Nanoarmour-shielded single-cell factory for bacteriotherapy of Parkinson's disease.

Xin Zhou, Qinglu Guo, Mingming Guo, Bowen Li, Wenchang Peng, Deping Wang, Dong Ming, Bin Zheng,

Cell-based therapy for Parkinson's disease (PD) is a novel and promising approach in recent years. However, exogenous cells are easy to be captured and destroyed by the harsh environment in vivo, so their application prospects have been severely limited. Here, a facile yet versatile approach for decorating individual living cells ... Read more >>

J Control Release (Journal of controlled release : official journal of the Controlled Release Society)
[2021, 338:742-753]

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Delivery of a system xc- inhibitor by a redox-responsive levodopa prodrug nanoassembly for combination ferrotherapy.

Huhu Xin, Yong Huang, Honglin Tang, Yuan Chen, Hongguang Xia, Fu Zhang, Bowen Li, Yuan Ping,

A comprehensive understanding of ferroptosis signaling pathways significantly contributes to the advances in cancer ferrotherapy. Herein, we constructed a self-assembled prodrug nanosystem targeting system x<sub>c</sub><sup>-</sup>, a key regulator for ferroptosis, to amplify the therapeutic efficacy of cancer ferrotherapy. The prodrug nanosystem is assembled between sulfasalazine (SSZ, a ferroptosis resistance inhibitor) ... Read more >>

J Mater Chem B (Journal of materials chemistry. B)
[2021, 9(35):7172-7181]

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Assessment of the water-energy-food nexus under spatial and social complexities: A case study of Guangdong-Hong Kong-Macao.

Pan Zhang, Ya Zhou, Yulei Xie, Yongyang Wang, Bowen Li, Bo Li, Qunpo Jia, Zhifeng Yang, Yanpeng Cai,

Water, energy, and food resources are indispensable and irreplaceable resources for the survival and development of human society. This study systematically assessed the three resources system in Guangdong, Hong Kong, and Macao based on constructed direct and nexus-oriented, multi-regional input-output, and ecological network analysis models. Various network analysis (e.g., control, ... Read more >>

J Environ Manage (Journal of environmental management)
[2021, 299:113664]

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Developmental Angiogenesis Requires the Mitochondrial Phenylalanyl-tRNA Synthetase.

Bowen Li, Kun Chen, Fangfang Liu, Juan Zhang, Xihui Chen, Tangdong Chen, Qi Chen, Yan Yao, Weihong Hu, Li Wang, Yuanming Wu,

<b>Background:</b> Mitochondrial aminoacyl-tRNA synthetases (mtARSs) catalyze the binding of specific amino acids to their cognate tRNAs and play an essential role in the synthesis of proteins encoded by mitochondrial DNA. Defects in mtARSs have been linked to human diseases, but their tissue-specific pathophysiology remains elusive. Here we examined the role ... Read more >>

Front Cardiovasc Med (Frontiers in cardiovascular medicine)
[2021, 8:724846]

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Efficacy and Safety of Abiraterone Acetate and Enzalutamide for the Treatment of Metastatic Castration-Resistant Prostate Cancer: A Systematic Review and Meta-Analysis.

ZhenHeng Wei, ChuXin Chen, BoWen Li, YongYue Li, Hong Gu,

<h4>Objective</h4>The androgen receptor-targeting drugs abiraterone acetate and enzalutamide have shown positive results as treatments for metastatic castration-resistant prostate cancer (mCRPC). Therefore, a meta-analysis was conducted to compare the efficacy and safety of abiraterone acetate and enzalutamide in patients with mCRPC.<h4>Methods</h4>We retrieved relevant articles from PubMed, Cochrane, and EMBASE published before ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:732599]

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Photoassisted Electron-Ion Synergic Doping Induced Phase Transition of n-VO2/p-GaN Thin-Film Heterojunction.

Bowen Li, Liang Li, Hui Ren, Yuan Lu, Fangfang Peng, Yuliang Chen, Changlong Hu, Guobin Zhang, Chongwen Zou,

As a typical correlated metal oxide, vanadium dioxide (VO<sub>2</sub>) shows specific metal-insulator transition (MIT) properties and demonstrates great potential applications in ultrafast optoelectronic switch, resistive memory, and neuromorphic devices. Effective control of the MIT process is essential for improving the device performance. In the current study, we have first proposed ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2021, 13(36):43562-43572]

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Effect of warming and degradation on phenophases of Kobresia pygmaea and Potentilla multifida on the Tibetan Plateau

Lirong Zhang, Wangwang Lv, Shujuan Cui, Lili Jiang, Bowen Li, Peipei Liu, Qi Wang, Yang Zhou, Huan Hong, A Wang, Caiyun Luo, Zhenhua Zhang, Tsechoe Dorji, Shiping Wang,

Many studies have focused on the responses of phenophases to warming in natural, non-degraded grasslands. However, degraded grasslands widely distribute in the world due to climate change and overgrazing. So far, a comprehensive understanding of how plant phenology responds to warming, degradation and their interactions remains elusive. Here, the relative ... Read more >>

(Agriculture, ecosystems & environment.)
[2021, 300:Not Available]

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Novel epigenetic signature of DNA damage response genes for prognostication and immunophenotype of non-G-CIMP glioblastomas

Bowen Li, Fangfang Liu, Weihong Hu, Rui Li, Amandine Etcheverry, Marc Aubry, Jean Mosser, Xiang Zhang, Yuanming Wu, Anan Yin, Kun Chen, Yalong He,

<h4>Background: </h4> Dysregulation and dysfunction of DNA damage response (DDR) have prognostic and predictive implications for glioblastomas (GBMs) without glioma-CpGs island methylator phenotype (G-CIMP); mathematical modeling based on DNA methylation abnormality in DDR genes may serve as clinically useful biomarkers. Methods Independent cohorts of non-G-CIMP GBMs and IDH wild ... Read more >>

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Composition Optimization, High-temperature Stability and Thermal Cycling Performance of Sc-doped Gd2Zr2O7 Thermal Barrier Coatings: Theoretical and Experimental Studies

Lei Guo, Bowen Li, Yuxian Cheng, Lu Wang,

Sc was doped into Gd 2 Zr 2 O 7 for expanding the potential for thermal barrier coating (TBC) applications. According to first-principles calculation, solid solution mechanism of Sc in Gd 2 Zr 2 O 7 lattice was revealed, i.e., Sc atoms first occupy the lattice interstitial sites followed by ... Read more >>

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QSAR Model Based Gradient Boosting Regression of N-Arylsulfonyl-Indole-2-Carboxamide Derivatives as Inhibitors for Fructose-1,6-Bisphosphatase

Ziyi Zhao, Jialong Yang, Bowen Li, Tingting Sun, Hongzong Si, Tongshang Ni,

As is known to all, diabetes metellius is a global health threaten and it has caused worldwide attention of scientists. To get a better investigation of the drug design of diabetes, we used heuristic method to established the linear model and used Gradient Boosting Regression to establish the nonlinear model ... Read more >>

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Key sunitinib-related biomarkers for renal cell carcinoma.

Yun Peng, Shiqiang Dong, Yuxuan Song, Dingkun Hou, Lili Wang, Bowen Li, Haitao Wang,

<h4>Background</h4>Renal cell carcinoma (RCC) contributed to 403,262 new cases worldwide in 2018, which constitutes 2.2% of global cancer, nevertheless, sunitinib, one of the major targeted therapeutic agent for RCC, often developed invalid due to resistance. Emerging evidences suggested sunitinib can impact tumor environment which has been proven to be a ... Read more >>

Cancer Med (Cancer medicine)
[2021, 10(19):6917-6930]

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