Full Text Journal Articles by
Author Borut Jug

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Short-Term Water- and Land-Based Exercise Training Comparably Improve Exercise Capacity and Vascular Function in Patients After a Recent Coronary Event: A Pilot Randomized Controlled Trial.

Danijela Vasić, Marko Novaković, Mojca Božič Mijovski, Breda Barbič Žagar, Borut Jug,

Background:We hypothesized that a 2-week twice daily aquatic endurance plus calisthenics exercise training program: (i) increases aerobic exercise capacity (peak oxygen uptake/ V˙ O2peak), (ii) improves endothelium-dependent flow-mediated vasodilation (FMD), and (iii) reduces circulating markers of low-grade inflammation and hemostasis, as compared to land-based endurance plus calisthenics exercise training or ... Read more >>

Front Physiol (Frontiers in Physiology)
[2019, 10:903]

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Blood Flow Restriction Resistance Exercise Improves Muscle Strength and Hemodynamics, but Not Vascular Function in Coronary Artery Disease Patients: A Pilot Randomized Controlled Trial.

Tim Kambič, Marko Novaković, Katja Tomažin, Vojko Strojnik, Borut Jug,

Resistance training may be associated with unfavorable cardiovascular responses (such as hemodynamic alterations, anginal symptoms or ventricular arrhythmias). In healthy adults, blood flow-restricted (BFR) resistance training improves muscle strength and hypertrophy improvements at lower loads with minimal systemic cardiovascular adverse responses. The aim of this study was to assess the ... Read more >>

Front Physiol (Frontiers in physiology)
[2019, 10:656]

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Effect of diastolic dysfunction on intraventricular velocity behavior in early diastole by flow mapping.

Bostjan Berlot, Jose Luis Moya Mur, Borut Jug, Daniel Rodríguez Muñoz, Alicia Megias, Eduardo Casas Rojo, Covadonga Fernández-Golfín, Jose Luis Zamorano,

Intraventricular velocity distribution reflects left ventricular (LV) diastolic function and can be measured non-invasively by flow mapping technologies. We designed our study to compare intraventricular velocities and gradients, obtained by vector flow mapping (VFM) technology during early diastole in consecutive patients diagnosed with mild and advanced diastolic dysfunction at echocardiography ... Read more >>

Int J Cardiovasc Imaging (The international journal of cardiovascular imaging)
[2019, 35(9):1627-1636]

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Endocan Is an Independent Predictor of Heart Failure-Related Mortality and Hospitalizations in Patients with Chronic Stable Heart Failure.

Gorazd Kosir, Borut Jug, Marko Novakovic, Mojca Bozic Mijovski, Jus Ksela,

Background:Heart failure (HF) is characterized by unfavorable prognosis. Disease trajectory of HF, however, may vary, and risk assessment of patients remains elusive. In our study, we sought to determine the prognostic impact of endocan-a novel biomarker of endothelial dysfunction and low-grade inflammation-in patients with heart failure. Methods:In outpatients with chronic ... Read more >>

Dis. Markers (Disease markers)
[2019, 2019:9134096]

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Moderate-pain versus pain-free exercise, walking capacity, and cardiovascular health in patients with peripheral artery disease.

Marko Novaković, Barbara Krevel, Uroš Rajkovič, Tjaša Vižintin Cuderman, Katja Janša Trontelj, Zlatko Fras, Borut Jug,

OBJECTIVE:Supervised exercise training (walking) is recommended in patients with intermittent claudication, both as a means to improve symptoms (walking distance and quality of life [QoL]) and as a means to improve general cardiovascular health (including vascular function and heart rate variability [HRV]). Our aim was to compare two types of ... Read more >>

J. Vasc. Surg. (Journal of vascular surgery)
[2019, :]

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Exercise training in adults with repaired tetralogy of Fallot: A randomized controlled pilot study of continuous versus interval training.

Marko Novaković, Katja Prokšelj, Uroš Rajkovič, Tjaša Vižintin Cuderman, Katja Janša Trontelj, Zlatko Fras, Borut Jug,

INTRODUCTION:Adults with repaired tetralogy of Fallot (ToF) have impaired exercise capacity, vascular and cardiac autonomic function, and quality of life (QoL). Specific effects of high-intensity interval or moderate continuous exercise training on these parameters in adults with repaired ToF remain unknown. METHODS AND RESULTS:Thirty adults with repaired ToF were randomized ... Read more >>

Int. J. Cardiol. (International journal of cardiology)
[2018, 255:37-44]

Cited: 1 time

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Heat shock protein 27 acts as a predictor of prognosis in chronic heart failure patients.

Denise Traxler, Mitja Lainscak, Elisabeth Simader, Hendrik Jan Ankersmit, Borut Jug,

Heat shock proteins (HSPs) represent intracellular mechanisms of stress response. Clinical implications of their (systemic) expression in patients with chronic heart failure (HF) remain inconclusive.In outpatients with chronic stable HF plasma HSP27 levels were measured using ELISA. Patients were followed for a minimum of one year, and a multivariate Cox ... Read more >>

Clin. Chim. Acta (Clinica chimica acta; international journal of clinical chemistry)
[2017, 473:127-132]

Cited: 2 times

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Heart-Rate Reduction With Adjusted-Dose Ivabradine in Patients Undergoing Coronary Computed Tomographic Angiography: A Randomized Trial.

Blaž Kacijan, Zala Novak, Borut Jug, Maja Dolenc Novak, Matjaž Vrtovec, Barbara Gužič Salobir,

Our prospective, randomized, open-label study assessed the efficacy of a heart rate-lowering, adjusted-dose protocol with ivabradine prior to coronary computed tomographic angiography (CCTA).Patients undergoing CCTA were randomized to 7 days of adjusted-dose ivabradine or standard care (ie, no additional medication). Heart rate and β-blocker and antianxiety medication use on the ... Read more >>

J Comput Assist Tomogr (Journal of computer assisted tomography)
[2017, 41(3):360-363]

Cited: 1 time

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Cardiovascular autonomic dysfunction and carotid stiffness in adults with repaired tetralogy of Fallot.

Marko Novaković, Katja Prokšelj, Vito Starc, Borut Jug,

Adults after surgical repair of tetralogy of Fallot (ToF) may have impaired vascular and cardiac autonomic function. Thus, we wanted to assess interrelations between heart rate variability (HRV) and heart rate recovery (HRR), as parameters of cardiac autonomic function, and arterial stiffness, as a parameter of vascular function, in adults ... Read more >>

Clin. Auton. Res. (Clinical autonomic research : official journal of the Clinical Autonomic Research Society)
[2017, 27(3):185-192]

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Cardiac monitoring in patients on trastuzumab: correlation of ultrasound and radionuclide ventriculography.

Erika Matos, Borut Jug, Barbara Vidergar Kralj, Branko Zakotnik,

Guidance on cardiac surveillance during adjuvant trastuzumab therapy remains elusive. The recommended methods are two-dimensional echocardiography (2D-ECHO) and electrocardiography gated equilibrium radionuclide ventriculography (RNV). We assessed the correlation and possible specific merits of these two methods.In a prospective cohort study in patients undergoing post-anthracycline adjuvant trastuzumab therapy, clinical assessment, 2D-ECHO ... Read more >>

Minerva Cardioangiol (Minerva cardioangiologica)
[2017, 65(3):288-298]

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Functional compared to anatomical imaging in the initial evaluation of patients with suspected coronary artery disease: An international, multi-center, randomized controlled trial (IAEA-SPECT/CTA study).

Ganesan Karthikeyan, Barbara Guzic Salobir, Borut Jug, Niveditha Devasenapathy, Erick Alexanderson, Joao Vitola, Otakar Kraft, Elgin Ozkan, Saket Sharma, Gaurav Purohit, Maja Dolenc Novak, Aloha Meave, Sergio Trevethan, Rodrigo Cerci, Sandra Zier, Lucia Gotthardtová, Tomáš Jonszta, Timucin Altin, Cigdem Soydal, Chetan Patel, Gurpreet Gulati, Diana Paez, Maurizio Dondi, Ravi Kashyap,

OBJECTIVE:To test the hypothesis that, in the initial evaluation of patients with suspected coronary artery disease (CAD), stress myocardial perfusion imaging (MPI) would result in less downstream testing than coronary computed tomographic angiography (CCTA). METHODS:In this international, randomized trial, mildly symptomatic patients with an intermediate likelihood of having CAD, and ... Read more >>

J Nucl Cardiol (Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology)
[2017, 24(2):507-517]

Cited: 9 times

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Clinical impact of exercise in patients with peripheral arterial disease.

Marko Novakovic, Borut Jug, Helena Lenasi,

Increasing prevalence, high morbidity and mortality, and decreased health-related quality of life are hallmarks of peripheral arterial disease. About one-third of peripheral arterial disease patients have intermittent claudication with deleterious effects on everyday activities, such as walking. Exercise training improves peripheral arterial disease symptoms and is recommended as first line ... Read more >>

Vascular (Vascular)
[2017, 25(4):412-422]

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A Prospective Cohort Study on Cardiotoxicity of Adjuvant Trastuzumab Therapy in Breast Cancer Patients.

Erika Matos, Borut Jug, Rok Blagus, Branko Zakotnik,

Cardiotoxicity is an important side effect of trastuzumab therapy and cardiac surveillance is recommended.The aim of our study was to prospectively assess baseline patients' characteristics, level of N-terminal pro-brain natriuretic peptide (NT-proBNP) and echocardiographic parameters as possible predictors of trastuzumab-related cardiac dysfunction.In a prospective cohort study, clinical, echocardiographic and neurohumoral ... Read more >>

Arq. Bras. Cardiol. (Arquivos brasileiros de cardiologia)
[2016, 107(1):40-47]

Cited: 3 times

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Orosomucoid is an independent predictor of prognosis in chronic heart failure.

Petra Kaplan, Bojan Vrtovec, Borut Jug,

Heart failure is associated with low-grade inflammation. In the present study we sought to assess the prognostic impact of orosomucoid, a marker of inflammation, in outpatients with heart failure.In outpatients with chronic heart failure (no change in clinical status and/or therapy >3 months prior to inclusion), baseline levels of orosomucoid were determined. ... Read more >>

Wien. Klin. Wochenschr. (Wiener klinische Wochenschrift)
[2016, 128(23-24):870-874]

Cited: 2 times

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2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts): Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR).

, Massimo F Piepoli, Arno W Hoes, Stefan Agewall, Christian Albus, Carlos Brotons, Alberico L Catapano, Marie-Therese Cooney, Ugo Corrà, Bernard Cosyns, Christi Deaton, Ian Graham, Michael Stephen Hall, F D Richard Hobbs, Maja-Lisa Løchen, Herbert Löllgen, Pedro Marques-Vidal, Joep Perk, Eva Prescott, Josep Redon, Dimitrios J Richter, Naveed Sattar, Yvo Smulders, Monica Tiberi, H Bart van der Worp, Ineke van Dis, W M Monique Verschuren, , , Guy De Backer, Marco Roffi, Victor Aboyans, Norbert Bachl, Héctor Bueno, Scipione Carerj, Leslie Cho, John Cox, Johan De Sutter, Günther Egidi, Miles Fisher, Donna Fitzsimons, Oscar H Franco, Maxime Guenoun, Catriona Jennings, Borut Jug, Paulus Kirchhof, Kornelia Kotseva, Gregory Y H Lip, François Mach, Giuseppe Mancia, Franz Martin Bermudo, Alessandro Mezzani, Alexander Niessner, Piotr Ponikowski, Bernhard Rauch, Lars Rydén, Adrienne Stauder, Guillaume Turc, Olov Wiklund, Stephan Windecker, Jose Luis Zamorano,

Eur J Prev Cardiol (European journal of preventive cardiology)
[2016, 23(11):NP1-NP96]

Cited: 219 times

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Diagnostic accuracy of 64 slice multidetector coronary computed tomographic angiography in left ventricular systolic dysfunction.

Danny Lee, Dong Li, Borut Jug, Jenny Papazian, Matthew Budoff,

Detecting coronary artery disease (CAD) is pivotal in etiologic assessment and management of left ventricular (LV) systolic dysfunction. Only a limited number of studies have specifically addressed the accuracy of coronary computed tomographic angiography (CCTA) in detection/exclusion of CAD in patients with LV systolic dysfunction.We included patients who were referred ... Read more >>

Int J Cardiol Heart Vasc (International Journal of Cardiology. Heart & Vasculature)
[2015, 8:42-46]

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General public awareness of heart failure: results of questionnaire survey during Heart Failure Awareness Day 2011.

Mitja Lainscak, Mitja Letonja, Dragan Kovacic, Lea Majc Hodoscek, Apolon Marolt, Cvetka Melihen Bartolic, Marija Mulej, Meta Penko, Janez Poles, Tinkara Ravnikar, Mojca Savnik Iskra, Cirila Slemenik Pusnik, Borut Jug,

INTRODUCTION: General public views about heart failure (HF) alone and in comparison with other chronic conditions are largely unknown; thus we conducted this survey to evaluate general public awareness about HF and HF disease burden relative to common chronic disease. MATERIAL AND METHODS: This was a cross-sectional survey during European ... Read more >>

Arch Med Sci (Archives of medical science : AMS)
[2014, 10(2):355-360]

Cited: 7 times

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Cardiovascular risk assessment in HIV-infected male patients: a comparison of Framingham, SCORE, PROCAM and DAD risk equations.

Mateja Pirš, Borut Jug, Barbara Eržen, Mišo Šabović, Primož Karner, Mario Poljak, Janez Tomažič,

INTRODUCTION: Traditional cardiovascular (CVD) risk assessment algorithms such as the Framingham Risk Score (FRS), Systematic Coronary Risk Evaluation (SCORE) and Prospective Cardiovascular Munster (PROCAM) were developed for general populations, their usefulness in HIV-infected population has not been confirmed. DAD algorithm was developed specifically for HIV-infected patients. The aim of our ... Read more >>

Acta Dermatovenerol Alp Pannonica Adriat (Acta dermatovenerologica Alpina, Pannonica, et Adriatica)
[2014, 23(3):43-47]

Cited: 11 times

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Early atherosclerosis in HIV-infected patients below the age of 55 years: Slovenian national study.

Mateja Pirs, Barbara Eržen, Mišo Sabović, Primož Karner, Ludvik Vidmar, Mario Poljak, Borut Jug, Mojca Mikac, Janez Tomažič,

Increased life expectancy of human immunodeficiency virus (HIV)-infected patients appears to be coupled with increased incidence of cardiovascular disease (CVD).The aim of our study was to determine the presence of early atherosclerosis among Slovenian HIV-infected patients below the age of 55 years.A total of 86 HIV-infected male patients below the ... Read more >>

Wien. Klin. Wochenschr. (Wiener klinische Wochenschrift)
[2014, 126(9-10):263-269]

Cited: 0 times

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Relationship between markers of endothelial dysfunction and inflammation and subclinical atherosclerosis in HIV-infected male patients below 55 years of age.

Mateja Pirš, Borut Jug, Barbara Eržen, Mišo Šabović, Primož Karner, Mario Poljak, Janez Tomažič,

INTRODUCTION: Antiretroviral therapy in HIV-infected patients appears to be associated with increased incidence of cardiovascular disease (CVD).The aim of our study was to investigate the differences in markers of inflammation, endothelial dysfunction and prothrombotic state between treated and untreated HIV-infected patients with or without subclinical atherosclerosis. METHODS: Eighty-six Slovenian HIV-infected ... Read more >>

Acta Dermatovenerol Alp Pannonica Adriat (Acta dermatovenerologica Alpina, Pannonica, et Adriatica)
[2014, 23(3):49-52]

Cited: 3 times

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The effect of short-term cardiac rehabilitation after acute myocardial infarction on high-sensitivity C-reactive protein.

Polona Mlakar, Barbara Salobir, Nusret Cobo, Borut Jug, Marjeta Terčelj, Mišo Sabovič,

BACKGROUND: High-sensitivity C-reactive protein (hsCRP) is an important biomarker of risk for coronary heart disease morbidity and mortality. We investigated the influence of short-term cardiac rehabilitation (CR) after acute myocardial infarction (AMI) on values of hsCRP and classical risk factors, including metabolic syndrome. METHODS: hsCRP and classical risk factors were ... Read more >>

Metab Syndr Relat Disord (Metabolic syndrome and related disorders)
[2014, 12(2):149-155]

Cited: 0 times

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Coronary calcifications and plaque characteristics in patients with end-stage renal disease: a computed tomographic study.

Borut Jug, Jigar Kadakia, Mohit Gupta, Jenny Papazian, Arya Derakhshani, Sheri Koplik, Ronald P Karlsberg, Matthew J Budoff,

BACKGROUND: We examined the association between coronary artery calcifications, atherosclerotic burden, and plaque morphology in end-stage renal disease (ESRD) and non-ESRD patients undergoing 64-slice multidetector coronary computed tomographic angiography. METHODS: The prevalence, extent, and severity of coronary atherosclerosis, calcium burden, and plaque morphology were determined in ESRD patients (n=48), and ... Read more >>

Coron. Artery Dis. (Coronary artery disease)
[2013, 24(6):501-508]

Cited: 9 times

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Extended-release niacin/laropiprant improves endothelial function in patients after myocardial infarction.

Urska Bregar, Borut Jug, Irena Keber, Matija Cevc, Miran Sebestjen,

Raising high-density lipoprotein cholesterol (HDL-C) is an important strategy for reducing residual cardiovascular risk. In the present study, we sought to assess the effect of extended-release niacin/laropiprant on endothelial function in patients after a myocardial infarction with target low-density lipoprotein cholesterol (LDL-C). In this double-blind, placebo-controlled trial, 63 men (35-60 ... Read more >>

Heart Vessels (Heart and vessels)
[2014, 29(3):313-319]

Cited: 5 times

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Diagnostic performance of computed tomographic coronary angiography in patients with end-stage renal disease.

Borut Jug, Jenny Papazian, Mohit Gupta, Harpreet Bhatia, Arya Derakhshani, Sheri Koplik, Ronald P Karlsberg, Matthew J Budoff,

BACKGROUND: End-stage renal disease (ESRD) is characterized by a very high rate of cardiovascular events that warrants thorough screening for coronary atherosclerosis, especially in patients undergoing a kidney transplant. Therefore, we assessed the diagnostic performance of 64-slice multidetector coronary computed tomographic angiography (CCTA) in patients with ESRD. METHODS: We included ... Read more >>

Coron. Artery Dis. (Coronary artery disease)
[2013, 24(2):135-141]

Cited: 1 time

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Detection and quantification of myocardial perfusion defects by resting single-phase 64-slice cardiac computed tomography angiography compared with SPECT myocardial perfusion imaging.

Mohit Gupta, Jigar Kadakia, Borut Jug, Song Shou Mao, Matthew J Budoff,

OBJECTIVE: Hypoenhanced regions on cardiac computed tomography angiography (CCTA) correlate with myocardial hypoperfusion. We evaluated the ability of resting single-phase 64-slice CCTA to detect the presence of myocardial infarction (MI) compared with nuclear myocardial perfusion imaging (MPI). METHODS: One hundred and forty symptomatic patients (age 66±12 years, 64% men) with ... Read more >>

Coron. Artery Dis. (Coronary artery disease)
[2013, 24(4):290-297]

Cited: 6 times

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