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Hydrocarbon staple constructing highly efficient α-helix cell-penetrating peptides for intracellular cargo delivery.

Shu Li, Xingjiao Zhang, Chen Guo, Yali Peng, Xiaojing Liu, Bo Wang, Ran Zhuang, Min Chang, Rui Wang,

The effects of all-hydrocarbon cross-linking on the cell-penetrating properties of Tat were systematically investigated. These stapled cell-penetrating peptides were designed to exhibit a cationic secondary amphipathic profile. We found that the hydrophobicity and helical conformation of these hydrocarbon staple peptides correlate well with their cellular uptake efficiency. Our results also ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2020, 56(100):15655-15658]

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Investigation of enhanced oxidation stability of microencapsulated enzymatically produced tuna oil concentrates using complex coacervation.

Qiuyu Xia, Taiwo O Akanbi, Bo Wang, Rui Li, Shucheng Liu, Colin J Barrow,

Tuna oil was selectively hydrolysed using Thermomyces lanuginosus lipase for 6 h to prepare omega-3 acylglycerol concentrate with the DHA content significantly increased from 24.9% in tuna oil to 36.3% in the acylglycerol concentrate. The acylglycerol concentrate was subsequently encapsulated into the "multi-core" microcapsules using gelatin-sodium hexametaphosphate complex coacervates as ... Read more >>

Food Funct (Food & function)
[2020, 11(12):10748-10757]

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Carbon dots with positive surface charge from tartaric acid and m-aminophenol for selective killing of Gram-positive bacteria.

Huibo Wang, Fang Lu, Chongqing Ma, Yurong Ma, Mengling Zhang, Bo Wang, Yue Zhang, Yang Liu, Hui Huang, Zhenhui Kang,

Gram-positive bacteria are one of the most common pathogens causing severe and acute infection, and hospital infection caused by Gram-positive bacteria have increased significantly. Also, as antibiotics have been widely used, abusing of antibiotics is becoming an increasingly serious problem which is followed by dangerous drug resistance. Here, we developed ... Read more >>

J Mater Chem B (Journal of materials chemistry. B)
[2021, 9(1):125-130]

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Ultrafast carrier relaxation dynamics of photoexcited GaAs and GaAs/AlGaAs nanowire array.

Bowen Zhang, Zhaogang Nie, Bo Wang, Dengkui Wang, Jilong Tang, Xiaohua Wang, Jiahua Zhang, Guichuan Xing, Wenchun Zhang, Zhipeng Wei,

Femtosecond optical pump-probe spectroscopy is employed to elucidate the ultrafast carrier nonradiative relaxation dynamics of bare GaAs and a core-shell GaAs/AlGaAs semiconductor nanowire array. Different from the single nanowire conventionally used for the study of ultrafast dynamics, a simple spin coating and peeling off method was performed to prepare transparent ... Read more >>

Phys Chem Chem Phys (Physical chemistry chemical physics : PCCP)
[2020, 22(44):25819-25826]

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The rapid production of multiple transition metal carbides via microwave combustion under ambient conditions.

Huiyu Jiang, Junfeng Li, Zhiheng Xiao, Bo Wang, Mingzhao Fan, Siqi Xu, Jun Wan,

Transition metal carbides (TMCs) have attracted great interest owing to their potential applications for energy storage and electrocatalysis. But the synthesis of high-quality TMCs usually needs high energy consumption, long reaction times, or dangerous chemical reagents, limiting their practical application. Here, a microwave combustion method is developed to rapidly (∼2 ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(30):16245-16252]

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Bulk COFs and COF nanosheets for electrochemical energy storage and conversion.

Jie Li, Xuechun Jing, Qingqing Li, Siwu Li, Xing Gao, Xiao Feng, Bo Wang,

Covalent organic frameworks (COFs) as an emerging class of crystalline porous materials have received much attention due to their tunable porosity, modifiable skeletons, and atomically precise structures. Besides, COFs can provide multiple high-rate charge carrier transport (electron, hole, and ion) pathways, including conjugated skeletons, overlapped π electron clouds among the ... Read more >>

Chem Soc Rev (Chemical Society reviews)
[2020, 49(11):3565-3604]

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High-efficiency perovskite nanocrystal light-emitting diodes via decorating NiOx on the nanocrystal surface.

Weilin Zheng, Qun Wan, Qinggang Zhang, Mingming Liu, Congyang Zhang, Bo Wang, Long Kong, Liang Li,

Nickel oxides exhibit a great potential as hole transport layers for the fabrication of efficient perovskite light-emitting diodes (LEDs) due to their high carrier mobility and good energy band matching with perovskite nanocrystals. In this work, nickel oxides were directly decorated on the CsPbBr3 nanocrystal surface through adsorption and a ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(16):8711-8719]

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Atorvastatin combined with low-dose dexamethasone for vascular endothelial cell dysfunction induced by chronic subdural hematoma.

Yue-Shan Fan, Bo Wang, Dong Wang, Xin Xu, Chuang Gao, Ying Li, Shu Zhang, Gui-Li Yang, Xiao Liu, Rong-Cai Jiang, Jian-Ning Zhang,

Atorvastatin has been shown to be a safe and effective non-surgical treatment option for patients with chronic subdural hematoma. However, treatment with atorvastatin is not effective in some patients, who must undergo further surgical treatment. Dexamethasone has anti-inflammatory and immunomodulatory effects, and low dosages are safe and effective for the ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(3):523-530]

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Synthesis of imides via palladium-catalyzed three-component coupling of aryl halides, isocyanides and carboxylic acids.

Bo Wang, Dan He, Beige Ren, Tuanli Yao,

A palladium-catalyzed three-component synthesis of acyclic imides from feedstock aryl halides, carboxylic acids and isocyanides through the intermediacy of isoimides has been developed. The key to the success of this approach was controlled isocyanide slow addition and organic/aqueous biphasic conditions. This transition-metal-catalyzed approach features readily available starting materials, atom- and ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2020, 56(6):900-903]

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Bioinspired hierarchical cross-linked graphene-silicon nanofilms via synergistic interfacial interactions as integrated negative electrodes for high-performance lithium storage.

Bo Wang, Xiaoyu Wu, Jinhui Zhang, Xiaoyu Zhang, Songmei Li,

Inspired by the intrinsic relationship between sophisticated interfacial architecture and the outstanding mechanical performance of natural nacre, a flexible, large-area and robust bioinspired reduced graphene oxide-silicon-carboxymethyl cellulose-polyacrylic acid (rGO-Si-CMC-PAA) nanocomposite film with a hierarchically laminated structure was prepared via a vacuum-assisted filtration self-assembly process and a thermal condensation reaction. The ... Read more >>

Phys Chem Chem Phys (Physical chemistry chemical physics : PCCP)
[2020, 22(4):2105-2114]

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Clinical Characteristics of 204 Children With Human Adenovirus Type 7 Pneumonia Identified by Whole Genome Sequencing in Liuzhou, China.

Xiaoli Huang, Yongsong Yi, Xiaogang Chen, Bo Wang, Yiqin Long, Jichang Chen, Chokechai Rongkavilit,

<h4>Background</h4>Clinical knowledge of human adenovirus type 7 (HAdV-7) pneumonia in children remains limited. Moreover, predictors for disease severity are largely unknown.<h4>Methods</h4>This is a retrospective study of children hospitalized at Liuzhou Maternal and Child Health Hospital, China, with HAdV-7 pneumonia in 2018-2019. Demographics, clinical characteristics, laboratory results, and imaging data were ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(2):91-95]

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Prevalence and characteristics of hepatitis B and D virus infections among HIV-positive individuals in Southwestern Nigeria.

Oluyinka Oladele Opaleye, Olusola Anuoluwapo Akanbi, Folakemi Abiodun Osundare, Bo Wang, Olufisayo Adesina, Adeolu Sunday Oluremi, Sola Thomas Sunday, Abiodun Akeem Akindele, Patrycja Klink, C Thomas Bock,

<h4>Background</h4>Coinfections of HIV-positive individuals with Hepatitis B and D virus (HBV and HDV) are common and can be associated with rapid liver damage. Several antiretroviral drugs for HIV exhibit anti-HBV effect; however, the selection of HBV drug resistance mutations (DRMs) in individuals under HIV antiretroviral therapy (ART) has been reported ... Read more >>

Virol J (Virology journal)
[2021, 18(1):20]

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Low expression of miR-142-3p promotes intervertebral disk degeneration.

Jianmin Xue, Baoyang Hu, Wenhua Xing, Feng Li, Zhi Huang, Wenkai Zheng, Bo Wang, Yong Zhu, Xuejun Yang,

<h4>Background</h4>Intervertebral disk degeneration (IDD) is a degenerative disease characterized by cytoplasm loss and extracellular matrix degradation. Numerous evidence reported that miRNAs participated in IDD development. Nevertheless, the function of miR-142-3p in IDD development remains unknown. This study mainly explored the potential role and function of miR-142-3p in IDD development.<h4>Methods</h4>One percent ... Read more >>

J Orthop Surg Res (Journal of orthopaedic surgery and research)
[2021, 16(1):55]

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Ionic Current Extraction in an Electrostatic-Fluid-Based Tripolar System for Ethanol Sensing.

Bo Wang, Yan-Fang Wang, Zi Wang, Zhong-Yu Hou,

We report a microfluidics-based tripolar system to extract the ionic current from the gas discharge process for gas sensing, which is structurally and fluidically compatible with the gas chromatography (GC) systems. The tripolar system was fabricated based on the microelectromechanical systems technology and tested as a gas detector with the ... Read more >>

ACS Sens (ACS sensors)
[2021, :]

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Principal Component Analysis Applications in COVID-19 Genome Sequence Studies

Bo Wang, Lin Jiang,

RNA genomes from coronavirus have a length as long as 32 kilobases, and the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that caused the outbreak of coronavirus disease 2019 (COVID-19) pandemic has long sequences which made the analysis difficult. Over 20,000 sequences have been submitted to GISAID, and the number ... Read more >>

(Cognitive Computation)
[2021, :1-12]

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Antitumor effects of targeted killing of tumor-associated macrophages under photothermal conditions.

Bo Wang, Ying Huang,

Immunotherapy of tumors has become a research hotspot. Tumor-associated macrophages (TAMs) are the most abundant interstitial cells in a tumor's microenvironment. As the concentration of the prepared nanoparticles increased, so their cytotoxicity of intensified. Under photothermal conditions, mAb-CD163/Au inhibited tumor invasion by killing M2 macrophages in vitro. After exposure to ... Read more >>

Lasers Med Sci (Lasers in medical science)
[2021, :]

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The relationship between different types of caries and periodontal disease severity in middle-aged and elderly people: findings from the 4th National Oral Health Survey of China

Lixia Yu, Xing WANG, Xi Ping FENG, Bao Jun TAI, De Yu HU, Bo WANG, Chun Xiao WANG, Shu Guo ZHENG, Xue Nan LIU, Wen Sheng RONG, Wei Jian WANG, Yan SI, Huan Cai Lin,

<h4>Background: </h4> The relationship between dental caries and periodontal disease is still controversial. The objective of this study is to explore the relationship between different types of caries and periodontal disease severity in middle-aged and elderly people in China. <h4>Methods: </h4> The study population consisted of 4,387 middle-aged and 3,225 ... Read more >>

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Surgical outcomes and prognostic factors of parasagittal meningioma: a single-center experience 165 consecutive cases.

Bo Wang, Gui-Jun Zhang, Zhen Wu, Jun-Ting Zhang, Pi-Nan Liu,

<h4>Purpose</h4>This study aimed to estimate the prognostic factors, long-term outcomes, and surgical strategies for parasagittal meningioma (PSM) and provide a better understanding of surgical experience.<h4>Materials and methods</h4>Patients (<i>n</i> = 1438) who underwent surgery for meningioma between January 2012 and January 2013 were enrolled in a database. We then identified 165 patients with ... Read more >>

Br J Neurosurg (British journal of neurosurgery)
[2021, :1-7]

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Design and efficacy of a monovalent bispecific PD-1/CTLA-4 antibody that enhances CTLA-4 blockade on PD-1+ activated T cells.

Simon J Dovedi, Matthew J Elder, Chunning Yang, Suzanne I Sitnikova, Lorraine Irving, Anna Hansen, James Hair, Des C Jones, Sumati Hasani, Bo Wang, Seock-Ah Im, Ben Tran, Deepa S Subramaniam, Shelby D Gainer, Kapil Vashisht, Arthur Lewis, Xiaofang Jin, Stacy Kentner, Kathy Mulgrew, Yaya Wang, Michael G Overstreet, James Dodgson, Yanli Wu, Asis Palazón, Michelle Morrow, Godfrey J Rainey, Gareth J Browne, Frances Neal, Thomas V Murray, Aleksandra D Toloczko, William Dall'Acqua, Ikbel Achour, Daniel J Freeman, Robert W Wilkinson, Yariv Mazor,

The clinical benefit of PD-1 blockade can be improved by combination with CTLA-4 inhibition but is commensurate with significant irAEs sub-optimally limiting the doses of anti-CTLA-4 mAb that can be used. MEDI5752 is a monovalent bispecific antibody designed to suppress the PD-1 pathway and provide modulated CTLA-4 inhibition favouring enhanced ... Read more >>

Cancer Discov (Cancer discovery)
[2021, :]

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The CAFs Related Gene CALD1 Is a Prognostic Biomarker and Correlated With Immune Infiltration in Bladder Cancer

YiHeng Du, Xiang Jiang, Bo Wang, Jin Cao, Yi Wang, Jiang Yu, XiZhi Wang, HaiTao Liu,

<h4>Background: </h4> Stromal components of the tumor microenvironment contribute to bladder cancer progression, and Cancer-Associated Fibroblasts (CAFs) were reported to play an important role. Accumulating pieces of evidence indicate that CAFs participate in the crosstalk with tumor cells and have a complex interaction network with immune components. Further study of ... Read more >>

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Magnetic anchoring and guidance-assisted endoscopic irreversible electroporation for gastric mucosal ablation: a preclinical study in canine model.

Qingshan Li, Xuyao Gao, Yuchi Zhang, Xuan Han, Zhuoqun Li, Yu Zhang, Yue Wang, Lihong Liang, Dake Chu, Zheng Wu, Bo Wang, Rongqian Wu, Yi Lv, Fenggang Ren,

<h4>Background</h4>The aim of this study was to evaluate the feasibility, safety, and efficacy of magnetic anchoring and guidance-assisted endoscopic irreversible electroporation (MAG-IRE) for gastric mucosal ablation.<h4>Methods</h4>A catheter-based, donut-like, and MAG-assisted electrode was developed. MAG-IRE for gastric mucosal ablation was performed in eight beagle canines. The parameters of one set of ... Read more >>

Surg Endosc (Surgical endoscopy)
[2021, :]

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Deep Differentiable Random Forests for Age Estimation.

Wei Shen, Yilu Guo, Yan Wang, Kai Zhao, Bo Wang, Alan Yuille,

Age estimation from facial images is typically cast as a label distribution learning or regression problem, since aging is a gradual progress. Its main challenge is the facial feature space w.r.t. ages is inhomogeneous, due to the large variation in facial appearance across different persons of the same age and ... Read more >>

IEEE Trans Pattern Anal Mach Intell (IEEE transactions on pattern analysis and machine intelligence)
[2021, 43(2):404-419]

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Long-term Improvement on Photoaging After ALA Photodynamic Therapy for Actinic Keratosis: A Retrospective Study.

Linglin Zhang, Zijun Zhao, Peiru Wang, Guolong Zhang, Bo Wang, Lei Shi, Xiaojing Liu, Zhongxia Zhou, Xiuli Wang,

<h4>Background</h4>5-aminolevulinic acid photodynamic therapy (ALA-PDT) is not only the first-line treatment for actinic keratosis (AK), but also demonstrated to improve photoaging during AK field treatment. However, its long-term improvement effect on photoaging remains elusive.<h4>Objective</h4>To evaluate the long-term improvement effect of ALA-PDT on photoaging.<h4>Methods</h4>The data of 10 patients with AK who ... Read more >>

Photodiagnosis Photodyn Ther (Photodiagnosis and photodynamic therapy)
[2021, :102181]

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Upconversion luminescence and temperature sensing characteristics of Yb3+/Tm3+:KLa(MoO4)2 phosphors.

Yuhong Zhang, Bo Wang, Yunhe Liu, Guangyao Bai, Zuoling Fu, Hang Liu,

Yb3+/Tm3+ codoped KLa(MoO4)2 phosphors are synthesized by a hydrothermal method. Under 980 nm excitation, the upconversion (UC) emission spectra of the phosphors are observed. The temperature sensing characteristic based on the fluorescence intensity ratio is studied. The maximum sensitivity reaches 2.93% K-1 at 453 K. The sensitivity value of non-thermally ... Read more >>

Dalton Trans (Dalton transactions (Cambridge, England : 2003))
[2021, :]

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Prognostic factors affecting the short-term efficacy of non-surgical treatment of chronic periodontitis: a multilevel modelling analysis

Hui-Jie Liu, Bo Wang, Ao-Chen Wang, Dan-Hong Zhang, Cui Mao, Qiu-Hong Li,

<h4>Background: </h4> This current study is aimed to analyze the prognostic factors affecting the short-term efficacy of non-surgical treatment of patients in periodontitis from stage Ⅱ to stage Ⅳ by the multilevel modelling analysis. Materials and Methods: A total of 58 patients with chronic periodontitis were included in this study. ... Read more >>

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