Full Text Journal Articles by
Author Bo Jacobsson

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FIGO good practice recommendations on the use of prenatal corticosteroids to improve outcomes and minimize harm in babies born preterm.

Jane Norman, Andrew Shennan, Bo Jacobsson, Sarah J Stock, ,

For women with a singleton or a multiple pregnancy in situations where active neonatal care is appropriate, and for whom preterm birth is anticipated between 24 and 34 weeks of gestation, one course of prenatal corticosteroids should ideally be offered 18 to 72 h before preterm birth is expected to improve outcomes ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, 155(1):26-30]

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FIGO good practice recommendations on the importance of registry data for monitoring rates and health systems performance in prevention and management of preterm birth.

J Frederik Frøen, Ana Bianchi, Ann-Beth Moller, Bo Jacobsson, ,

FIGO calls for strengthening of health information systems for reproductive, maternal, newborn, and child health services, co-designed with users, to ensure the timely accessibility of actionable high-quality data for all stakeholders engaged in preventing and managing preterm birth consequences. FIGO calls for strengthening of investments and capacity for implementing digital ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, 155(1):5-7]

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FIGO good practice recommendations on reduction of preterm birth in pregnancies conceived by assisted reproductive technologies.

Ben W Mol, Bo Jacobsson, William A Grobman, Kelle Moley, ,

FIGO (the International Federation of Gynecology and Obstetrics) supports assisted reproductive technologies (ART) to achieve pregnancy and supports their availability in all nations. However, the increased frequency of preterm birth must be taken into account. Therefore, before in vitro fertilization (IVF) is started, other approaches, including expectant management, should be ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, 155(1):13-15]

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FIGO good practice recommendations for reducing preterm birth and improving child outcomes.

Bo Jacobsson, Joe Leigh Simpson, ,

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, 155(1):1-4]

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FIGO good practice recommendations on cervical cerclage for prevention of preterm birth.

Andrew Shennan, Lisa Story, Bo Jacobsson, William A Grobman, ,

Cervical cerclage is an intervention which when given to the right women can prevent preterm birth and second-trimester fetal losses. A history-indicated cerclage should be offered to women who have had three or more preterm deliveries and/or mid-trimester losses. An ultrasound-indicated cerclage should be offered to women with a cervical ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, 155(1):19-22]

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FIGO good practice recommendations on delayed umbilical cord clamping.

Ana Bianchi, Bo Jacobsson, Ben W Mol, ,

Delayed cord clamping in the first minute in preterm infants born before 34 weeks of gestation improves neonatal hematologic measures and may reduce mortality without increasing any other morbidity. In term-born babies, it also seems to improve both the short- and long-term outcomes and shows favorable scores in fine motor and ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, 155(1):34-36]

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FIGO good practice recommendations on modifiable causes of iatrogenic preterm birth.

Catalina M Valencia, Ben W Mol, Bo Jacobsson, ,

Iatrogenic preterm birth is a planned delivery that occurs before 37 weeks of gestation due to maternal and/or fetal causes. However, in some cases, such deliveries also occur with no apparent medical indication. The increasing numbers of iatrogenic preterm deliveries worldwide have led researchers to identify modifiable causes that allow the ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, 155(1):8-12]

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FIGO good practice recommendations on progestogens for prevention of preterm delivery.

Andrew Shennan, Natalie Suff, Joe Leigh Simpson, Bo Jacobsson, Ben W Mol, William A Grobman, ,

Women at high risk of preterm birth (either a previous spontaneous preterm birth and/or sonographic short cervix) with a singleton gestation should be offered daily vaginal progesterone or weekly 17-OHPC treatment to prevent preterm birth. Benefit is most significant in those with prior history of preterm birth and a short ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, 155(1):16-18]

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FIGO good practice recommendations on the use of pessary for reducing the frequency and improving outcomes of preterm birth.

William A Grobman, Jane Norman, Bo Jacobsson, ,

A pessary is a device made of synthetic material that is placed in the vagina and has been used for prevention of preterm birth. It has been suggested that a potential mechanism of the pessary is alteration of the cervico-uterine angle to a more posterior position, which reduces cervical compression ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, 155(1):23-25]

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Vaginal dysbiosis in pregnancy associates with risk of emergency cesarean section: a prospective cohort study.

Thor Haahr, Tine Dalsgaard Clausen, Jonathan Thorsen, Morten A Rasmussen, Martin S Mortensen, Jenni Lehtimäki, Shiraz A Shah, Mathis H Hjelmsø, Klaus Bønnelykke, Bo L Chawes, Gisle Vestergaard, Bo Jacobsson, Per-Göran Larsson, Susanne Brix, Søren J Sørensen, Hans Bisgaard, Jakob Stokholm,

<h4>Objectives</h4>We aimed to investigate changes in vaginal microbiota during pregnancy, and the association between vaginal dysbiosis and reproductive outcomes.<h4>Methods</h4>A total of 730 (week 24) and 666 (week 36) vaginal samples from 738 unselected pregnant women were studied by microscopy (Nugent score) and characterized by 16S rRNA gene sequencing. A novel ... Read more >>

Clin Microbiol Infect (Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases)
[2021, :]

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Thyroid hormones in relation to toxic metal exposure in pregnancy, and potential interactions with iodine and selenium.

Klara Gustin, Malin Barman, Helena Skröder, Bo Jacobsson, Anna Sandin, Ann-Sofie Sandberg, Agnes E Wold, Marie Vahter, Maria Kippler,

<h4>Background</h4>Several endocrine-disrupting metals may affect thyroid function, but the few available studies of exposure during pregnancy and thyroid hormones are inconclusive.<h4>Objective</h4>To explore if environmental exposure to cadmium (Cd), lead (Pb), and methylmercury (MeHg) impacts thyroid function in pregnancy, and interacts with iodine and selenium status.<h4>Methods</h4>Women in a Swedish birth cohort ... Read more >>

Environ Int (Environment international)
[2021, 157:106869]

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Maternal seafood intake during pregnancy, prenatal mercury exposure and child body mass index trajectories up to 8 years.

Eleni Papadopoulou, Jérémie Botton, Ida Henriette Caspersen, Jan Alexander, Merete Eggesbø, Margaretha Haugen, Nina Iszatt, Bo Jacobsson, Helle Katrine Knutsen, Helle Margrete Meltzer, Verena Sengpiel, Nikos Stratakis, Kristine Vejrup, Anne Lise Brantsæter,

<h4>Background</h4>Maternal seafood intake during pregnancy and prenatal mercury exposure may influence children's growth trajectories.<h4>Methods</h4>This study, based on the Norwegian Mother, Father and Child Cohort Study (MoBa), includes 51 952 mother-child pairs recruited in pregnancy during 2002-08 and a subsample (n = 2277) with maternal mercury concentrations in whole blood. Individual growth trajectories were ... Read more >>

Int J Epidemiol (International journal of epidemiology)
[2021, 50(4):1134-1146]

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Integrative genetic, genomic and transcriptomic analysis of heat shock protein and nuclear hormone receptor gene associations with spontaneous preterm birth.

Johanna M Huusko, Heli Tiensuu, Antti M Haapalainen, Anu Pasanen, Pinja Tissarinen, Minna K Karjalainen, Ge Zhang, Kaare Christensen, Kelli K Ryckman, Bo Jacobsson, Jeffrey C Murray, Stephen F Kingsmore, Mikko Hallman, Louis J Muglia, Mika Rämet,

Heat shock proteins are involved in the response to stress including activation of the immune response. Elevated circulating heat shock proteins are associated with spontaneous preterm birth (SPTB). Intracellular heat shock proteins act as multifunctional molecular chaperones that regulate activity of nuclear hormone receptors. Since SPTB has a significant genetic ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):17115]

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Effect of second-trimester sonographic cervical length on the risk of spontaneous preterm delivery in different risk groups: A prospective observational multicenter study.

Tove Wikström, Henrik Hagberg, Bo Jacobsson, Pihla Kuusela, Jan Wesström, Peter Lindgren, Helena Fadl, Ulla-Britt Wennerholm, Lil Valentin,

<h4>Introduction</h4>The aim of the study is to compare the effect of cervical length measured with transvaginal ultrasound in the second trimester on the risk of spontaneous preterm delivery (PTD) between different risk groups of asymptomatic women with a singleton pregnancy.<h4>Material and methods</h4>This is a pre-planned exploratory analysis of the CERVIX ... Read more >>

Acta Obstet Gynecol Scand (Acta obstetricia et gynecologica Scandinavica)
[2021, 100(9):1644-1655]

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Maternal selenium intake and selenium status during pregnancy in relation to preeclampsia and pregnancy-induced hypertension in a large Norwegian Pregnancy Cohort Study.

Ebba Holmquist, Anne Lise Brantsæter, Helle Margrete Meltzer, Bo Jacobsson, Malin Barman, Verena Sengpiel,

<h4>Background</h4>Pregnancy-induced hypertensive disorders (PIHD), including preeclampsia, cause maternal and perinatal morbidity and mortality worldwide. Several studies have linked selenium supplementation and selenium status to the risk of preeclampsia, but there are no published prospective population-based studies examining associations between dietary selenium intake and preeclampsia.<h4>Aim</h4>To examine associations between selenium intake from ... Read more >>

Sci Total Environ (The Science of the total environment)
[2021, 798:149271]

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Birth weight and intra-amniotic inflammatory and infection-related complications in pregnancies with preterm prelabor rupture of membranes: a retrospective cohort study.

Jana Matulova, Marian Kacerovsky, Radka Bolehovska, Jaroslav Stranik, Richard Spacek, Hana Burckova, Bo Jacobsson, Ivana Musilova,

<h4>Objective</h4>To assess the association between the birth weight of newborns and microbial invasion of the amniotic cavity (MIAC) and/or intra-amniotic inflammation in pregnancies with preterm prelabor rupture of membranes.<h4>Methods</h4>A total of 528 pregnancies with preterm prelabor rupture of membranes were included in this retrospective cohort study. Transabdominal amniocentesis to determine ... Read more >>

J Matern Fetal Neonatal Med (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2021, :1-11]

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Intra-amniotic infection and sterile intra-amniotic inflammation in women with preterm labor with intact membranes are associated with a higher rate of Ureaplasma species DNA presence in the cervical fluid.

Marian Kacerovsky, Jaroslav Stranik, Rudolf Kukla, Radka Bolehovska, Pavel Bostik, Jana Matulova, Martin Stepan, Jan Hladky, Bo Jacobsson, Ivana Musilova,

<h4>Objective</h4>To determine the prevalence of <i>Ureaplasma</i> spp. DNA and its load in the cervical fluid in women with preterm labor with intact membranes (PTL) complicated by intra-amniotic infection (the presence of both microbial invasion of the amniotic cavity and intra-amniotic inflammation) or sterile intra-amniotic inflammation (the presence of intra-amniotic inflammation ... Read more >>

J Matern Fetal Neonatal Med (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2021, :1-9]

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Authors' response to: "Re: obstetric anal sphincter injury after episiotomy in vacuum extraction: an epidemiological study using an emulated randomised trial approach: robustness and external validity of different practices": Reply: Episiotomy in vacuum extraction.

Victoria Ankarcrona, Hongwei Zhao, Bo Jacobsson, Sophia Brismar Wendel,

BJOG (BJOG : an international journal of obstetrics and gynaecology)
[2021, :]

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[Clinical translation of genomic medicine].

Danuta Gawel, Eva Bojner Horwitz, Oleg Sysoev, Bo Jacobsson, Jan-Ingvar Jönsson, Erik Melén, Anders Ynnerman, Mikael Benson,

Recent technical developments and early clinical examples support that precision medicine has potential to provide novel diagnostic and therapeutic solutions for patients with complex diseases, who are not responding to existing therapies. Those solutions will require integration of genomic data with routine clinical, imaging, sensor, biobank and registry data. Moreover, ... Read more >>

Lakartidningen (Lakartidningen)
[2021, 118:]

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[Precision medicine in complex diseases].

Erik Melén, Bo Jacobsson, Mikael Benson, Marju Orho-Melander, Jonas Halvarson, Christina Jern,

Complex diseases represent a number of common disorders such as allergic conditions, cardiovascular, metabolic and chronic inflammatory diseases. These diseases are caused by a combination of genetic, environmental and lifestyle factors. This complex etiology creates challenges when it comes to diagnostics, follow-up programs and treatment. Although exact disease mechanisms are ... Read more >>

Lakartidningen (Lakartidningen)
[2021, 118:]

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Associations of treated and untreated human papillomavirus infection with preterm delivery and neonatal mortality: A Swedish population-based study.

Johanna Wiik, Staffan Nilsson, Cecilia Kärrberg, Björn Strander, Bo Jacobsson, Verena Sengpiel,

<h4>Background</h4>Treatment of cervical intraepithelial neoplasia (CIN) is associated with an increased risk of preterm delivery (PTD) although the exact pathomechanism is not yet understood. Women with untreated CIN also seem to have an increased risk of PTD. It is unclear whether this is attributable to human papillomavirus (HPV) infection or ... Read more >>

PLoS Med (PLoS medicine)
[2021, 18(5):e1003641]

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A fast wavelet-based functional association analysis replicates several susceptibility loci for birth weight in a Norwegian population.

William R P Denault, Julia Romanowska, Øyvind Helgeland, Bo Jacobsson, Håkon K Gjessing, Astanand Jugessur,

<h4>Background</h4>Birth weight (BW) is one of the most widely studied anthropometric traits in humans because of its role in various adult-onset diseases. The number of loci associated with BW has increased dramatically since the advent of whole-genome screening approaches such as genome-wide association studies (GWASes) and meta-analyses of GWASes (GWAMAs). ... Read more >>

BMC Genomics (BMC genomics)
[2021, 22(1):321]

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Characterization of the genetic architecture of BMI in infancy and early childhood reveals age-specific effects and implicates pathways involved in Mendelian obesity

Øyvind Helgeland, Marc Vaudel, Pol Sole-Navais, Christopher Flatley, Julius Juodakis, Jonas Bacelis, Ingvild Koløen, Gun Peggy Knudsen, Bente Johansson, Per Magnus, Ted Reichborn Kjennerud, Petur Juliusson, Camilla Stoltenberg, Oddgeir Holmen, Ole Andreassen, Bo Jacobsson, Pål Njølstad, Stefan Johansson,

To elucidate the role of common genetic variation on infant and child weight development, we performed genome-wide association studies across 12 time points from birth to eight years in 28,681 children and their parents (27,088 mothers and 26,239 fathers) in the Norwegian Mother, Father and Child Cohort Study (MoBa). We ... Read more >>

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A Rapid Amniotic Fluid Interleukin-6 Assessment for the Identification of Intra-Amniotic Inflammation in Women with Preterm Labor and Intact Membranes.

Teresa Cobo, Victoria Aldecoa, Magdalena Holeckova, Ctirad Andrys, Xavier Filella, Bo Jacobsson, Marian Kacerovsky,

<h4>Objectives</h4>A multivariable predictive model has recently been developed with good accuracy to predict spontaneous preterm delivery within 7 days in women with preterm labor (PTL) and intact membranes. However, this model measures amniotic fluid (AF) interleukin (IL)-6 concentrations using the ELISA method, thereby limiting clinical implementation. The main objectives of ... Read more >>

Fetal Diagn Ther (Fetal diagnosis and therapy)
[2021, 48(5):327-332]

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IgGFc-binding protein in pregnancies complicated by spontaneous preterm delivery: a retrospective cohort study.

Jaroslav Stranik, Marian Kacerovsky, Ondrej Soucek, Martina Kolackova, Ivana Musilova, Lenka Pliskova, Radka Bolehovska, Pavel Bostik, Jana Matulova, Bo Jacobsson, Ctirad Andrys,

To determine the IgGFc-binding protein (FcgammaBP) concentration in amniotic and cervical fluids in preterm prelabor rupture of membranes (PPROM) and preterm labor with intact membranes (PTL) and to assess the diagnostic indices of FcgammaBP to predict intra-amniotic infection (the presence of both microbial invasion of the amniotic cavity and intra-amniotic ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):6107]

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