Full Text Journal Articles by
Author Blase N Polite

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Ensuring Equity and Justice in the Care and Outcomes of Patients With Cancer.

Blase N Polite, Abbe R Gluck, Otis W Brawley,

JAMA (JAMA)
[2019, :]

Cited: 0 times

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State of Cancer Care in America: Reflections on an Inaugural Year.

Blase N Polite, Jerome E Seid, Morganna Freeman, Laura A Levit, M Kelsey Kirkwood, Caroline Schenkel, Suanna S Bruinooge, Richard L Schilsky,

J Oncol Pract (Journal of oncology practice)
[2019, 15(4):163-165]

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Investigation of a multimedia, computer-based approach to improve knowledge, attitudes, self-efficacy, and receptivity to cancer clinical trials among newly diagnosed patients with diverse health literacy skills.

Blase N Polite, Toni M Cipriano-Steffens, Chuanhong Liao, Edward L Miller, Nicole L Arndt, Elizabeth A Hahn,

BACKGROUND:Enrollment in therapeutic cancer trials remains low, and is especially challenging for patients with low health literacy. The authors tested an interactive technology designed for patients with diverse health literacy skills with the aim of improving patient receptiveness, willingness, knowledge, self-efficacy, and positive attitudes regarding clinical trials. METHODS:Patients presenting for ... Read more >>

Cancer (Cancer)
[2019, 125(12):2066-2075]

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A UGT1A1 genotype-guided dosing study of modified FOLFIRINOX in previously untreated patients with advanced gastrointestinal malignancies.

Manish R Sharma, Smita S Joshi, Theodore G Karrison, Kenisha Allen, Grace Suh, Robert Marsh, Mark F Kozloff, Blase N Polite, Daniel V T Catenacci, Hedy L Kindler,

BACKGROUND:FOLFIRINOX (5-fluorouracil [5-FU], leucovorin, irinotecan, oxaliplatin) is an effective but toxic therapy for pancreatic cancer. UGT1A1 (UDP glucuronosyltransferase 1A1) eliminates the active metabolite of irinotecan. Polymorphisms reduce UGT1A1 activity, leading to toxicity. The primary objective was to determine the dose-limiting toxicity (DLT) rate in cycle 1 of modified FOLFIRINOX (mFOLFIRINOX) ... Read more >>

Cancer (Cancer)
[2019, 125(10):1629-1636]

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Cost-effectiveness of Maintenance Capecitabine and Bevacizumab for Metastatic Colorectal Cancer.

Scott K Sherman, Joel J Lange, Fadi S Dahdaleh, Rahul Rajeev, T Clark Gamblin, Blase N Polite, Kiran K Turaga,

Importance:Unregulated drug prices increase cancer therapy costs. After induction chemotherapy, patients with metastatic colon cancer can receive maintenance capecitabine and bevacizumab therapy based on improved progression-free survival, but whether this treatment's cost justifies its benefits has not been evaluated in the United States. Objective:This study sought to determine the influence ... Read more >>

JAMA Oncol (JAMA oncology)
[2018, :]

Cited: 0 times

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Engaging Patients in Value-Based Cancer Care: A Missed Opportunity.

S Yousuf Zafar, Blase N Polite, Mark McClellan,

JAMA Oncol (JAMA oncology)
[2018, 4(11):1479-1480]

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Obstruction predicts worse long-term outcomes in stage III colon cancer: A secondary analysis of the N0147 trial.

Fadi S Dahdaleh, Scott K Sherman, Elizabeth C Poli, Janani Vigneswaran, Blase N Polite, Manish R Sharma, Daniel V Catenacci, Steven B Maron, Kiran K Turaga,

BACKGROUND:Patients with colon cancer often present with obstruction. Large series have reported obstruction among the high-risk features, yet prospective data on its specific prognostic influence are lacking. We hypothesized that obstruction is an independent risk factor for poor prognosis in patients with stage III colon cancer. METHODS:N0147 was a trial ... Read more >>

Surgery (Surgery)
[2018, 164(6):1223-1229]

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Consolidation mFOLFOX6 Chemotherapy After Chemoradiotherapy Improves Survival in Patients With Locally Advanced Rectal Cancer: Final Results of a Multicenter Phase II Trial.

Michael R Marco, Lihong Zhou, Sujata Patil, Jorge E Marcet, Madhulika G Varma, Samuel Oommen, Peter A Cataldo, Steven R Hunt, Anjali Kumar, Daniel O Herzig, Alessandro Fichera, Blase N Polite, Neil H Hyman, Charles A Ternent, Michael J Stamos, Alessio Pigazzi, David Dietz, Yuliya Yakunina, Raphael Pelossof, Julio Garcia-Aguilar, ,

Adding modified FOLFOX6 (folinic acid, fluorouracil, and oxaliplatin) after chemoradiotherapy and lengthening the chemoradiotherapy-to-surgery interval is associated with an increase in the proportion of rectal cancer patients with a pathological complete response.The purpose of this study was to analyze disease-free and overall survival.This was a nonrandomized phase II trial.The study ... Read more >>

Dis. Colon Rectum (Diseases of the colon and rectum)
[2018, 61(10):1146-1155]

Cited: 2 times

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A pharmacodynamic study of sirolimus and metformin in patients with advanced solid tumors.

Amikar Sehdev, Theodore Karrison, Yuanyuan Zha, Linda Janisch, Michelle Turcich, Ezra E W Cohen, Michael Maitland, Blase N Polite, Thomas F Gajewski, Ravi Salgia, Navin Pinto, Marc B Bissonnette, Gini F Fleming, Mark J Ratain, Manish R Sharma,

BACKGROUND:Sirolimus is a mammalian target of rapamycin (mTOR) inhibitor. Metformin may potentiate mTOR inhibition by sirolimus while mitigating its adverse effects. We conducted a pilot study to test this hypothesis. METHODS:Patients with advanced solid tumor were treated with sirolimus for 7 days followed by randomization to either sirolimus with metformin ... Read more >>

Cancer Chemother. Pharmacol. (Cancer chemotherapy and pharmacology)
[2018, 82(2):309-317]

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A New Look at the State of Cancer Care in America.

Blase N Polite, Jerome E Seid, Laura A Levit, M Kelsey Kirkwood, Caroline Schenkel, Suanna S Bruinooge, Stephen S Grubbs, Deborah Y Kamin, Richard L Schilsky,

J Oncol Pract (Journal of oncology practice)
[2018, 14(7):397-399]

Cited: 0 times

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The State of Oncology Practice in America, 2018: Results of the ASCO Practice Census Survey.

M Kelsey Kirkwood, Amy Hanley, Suanna S Bruinooge, Elizabeth Garrett-Mayer, Laura A Levit, Caroline Schenkel, Jerome E Seid, Blase N Polite, Richard L Schilsky,

PURPOSE:To describe the US hematology and medical oncology practice landscape and to report findings of the sixth annual ASCO Oncology Practice Census survey. PARTICIPANTS AND METHODS:ASCO used Medicare Physician Compare data to characterize oncology practices in the United States. Practice size, number of care sites, and geographic distribution were determined. ... Read more >>

J Oncol Pract (Journal of oncology practice)
[2018, 14(7):e412-e420]

Cited: 5 times

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Analyzing the clinical actionability of germline pharmacogenomic findings in oncology.

Rebecca Wellmann, Brittany A Borden, Keith Danahey, Rita Nanda, Blase N Polite, Walter M Stadler, Mark J Ratain, Peter H O'Donnell,

BACKGROUND:Germline and tumor pharmacogenomics impact drug responses, but germline markers less commonly guide oncology prescribing. The authors hypothesized that a critical number of clinically actionable germline pharmacogenomic associations exist, representing clinical implementation opportunities. METHODS:In total, 125 oncology drugs were analyzed for positive germline pharmacogenomic associations in journals with impact factors ... Read more >>

Cancer (Cancer)
[2018, 124(14):3052-3065]

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Impact on Oncology Practices of Including Drug Costs in Bundled Payments.

Jeffery C Ward, Laura A Levit, Ray D Page, John E Hennessy, John V Cox, Deborah Y Kamin, Suanna S Bruinooge, Ya-Chen Tina Shih, Blase N Polite,

INTRODUCTION:This analysis evaluates the impact of bundling drug costs into a hypothetic bundled payment. METHODS:An economic model was created for patient vignettes from: advanced-stage III colon cancer and metastatic non-small-cell lung cancer. First quarter 2016 Medicare reimbursement rates were used to calculate the average fee-for-service (FFS) reimbursement for these vignettes. ... Read more >>

J Oncol Pract (Journal of oncology practice)
[2018, 14(5):e259-e268]

Cited: 2 times

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A Rules-Based Algorithm to Prioritize Poor Prognosis Cancer Patients in Need of Advance Care Planning.

Christine M Bestvina, Kristen E Wroblewski, Bobby Daly, Brittany Beach, Selina Chow, Andrew Hantel, Monica Malec, Michael T Huber, Blase N Polite,

Accurate understanding of the prognosis of an advanced cancer patient can lead to decreased aggressive care at the end of life and earlier hospice enrollment.Our goal was to determine the association between high-risk clinical events identified by a simple, rules-based algorithm and decreased overall survival, to target poor prognosis cancer ... Read more >>

J Palliat Med (Journal of palliative medicine)
[2018, 21(6):846-849]

Cited: 1 time

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Association of externalizing religious and spiritual beliefs on stage of colon cancer diagnosis among black and white multicenter urban patient populations.

Blase N Polite, Toni M Cipriano-Steffens, Fay J Hlubocky, Pascal Jean-Pierre, Ying Cheng, Katherine C Brewer, Garth H Rauscher, George A Fitchett,

This study explores whether externalizing religious and spiritual beliefs is associated with advanced-stage colon cancer at initial oncology presentation and whether this association is stronger for blacks than for whites.Patients who had newly diagnosed, invasive colon cancer were recruited at 9 sites in the Chicago metropolitan area. Eligible patients were ... Read more >>

Cancer (Cancer)
[2018, 124(12):2578-2587]

Cited: 0 times

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The Road From Theory to Reality: Illuminating the Complexity of Prospective Cancer Bundles.

Blase N Polite,

J Oncol Pract (Journal of oncology practice)
[2018, 14(2):59-61]

Cited: 0 times

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Blase Polite on How Disparities Research Must Move Into an Era of Action.

Blase N Polite,

Oncology (Williston Park, N.Y.) (Oncology (Williston Park, N.Y.))
[2017, 31(10):709-10, 717]

Cited: 0 times

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Examining racial disparities in colon cancer clinical delay in the Colon Cancer Patterns of Care in Chicago study.

Lindsey A Jones, Carol Estwing Ferrans, Blase N Polite, Katherine C Brewer, Ajay V Maker, Heather A Pauls, Garth H Rauscher,

PURPOSE:We explored a potential racial disparity in clinical delay among non-Hispanic (nH) Black and White colon cancer patients and examined factors that might account for the observed disparity. METHODS:Patients aged 30-79 years with a newly diagnosed colon cancer from 2010 to 2014 (n = 386) were recruited from a diverse sample of ... Read more >>

Ann Epidemiol (Annals of epidemiology)
[2017, 27(11):731-738.e1]

Cited: 0 times

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Charting the Future of Cancer Health Disparities Research: A Position Statement From the American Association for Cancer Research, the American Cancer Society, the American Society of Clinical Oncology, and the National Cancer Institute.

Blase N Polite, Lucile L Adams-Campbell, Otis W Brawley, Nina Bickell, John M Carethers, Christopher R Flowers, Margaret Foti, Scarlett Lin Gomez, Jennifer J Griggs, Christopher S Lathan, Christopher I Li, J Leonard Lichtenfeld, Worta McCaskill-Stevens, Electra D Paskett,

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2017, 35(26):3075-3082]

Cited: 9 times

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Charting the future of cancer health disparities research: A position statement from the American Association for Cancer Research, the American Cancer Society, the American Society of Clinical Oncology, and the National Cancer Institute.

Blase N Polite, Lucile L Adams-Campbell, Otis W Brawley, Nina Bickell, John M Carethers, Christopher R Flowers, Margaret Foti, Scarlett Lin Gomez, Jennifer J Griggs, Christopher S Lathan, Christopher I Li, J Leonard Lichtenfeld, Worta McCaskill-Stevens, Electra D Paskett,

CA Cancer J Clin (CA: a cancer journal for clinicians)
[2017, 67(5):353-361]

Cited: 1 time

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Charting the Future of Cancer Health Disparities Research: A Position Statement from the American Association for Cancer Research, the American Cancer Society, the American Society of Clinical Oncology, and the National Cancer Institute.

Blase N Polite, Lucile L Adams-Campbell, Otis W Brawley, Nina Bickell, John M Carethers, Christopher R Flowers, Margaret Foti, Scarlett Lin Gomez, Jennifer J Griggs, Christopher S Lathan, Christopher I Li, J Leonard Lichtenfeld, Worta McCaskill-Stevens, Electra D Paskett,

Cancer Res. (Cancer research)
[2017, 77(17):4548-4555]

Cited: 3 times

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Effect of First-Line Chemotherapy Combined With Cetuximab or Bevacizumab on Overall Survival in Patients With KRAS Wild-Type Advanced or Metastatic Colorectal Cancer: A Randomized Clinical Trial.

Alan P Venook, Donna Niedzwiecki, Heinz-Josef Lenz, Federico Innocenti, Briant Fruth, Jeffrey A Meyerhardt, Deborah Schrag, Claire Greene, Bert H O'Neil, James Norman Atkins, Scott Berry, Blase N Polite, Eileen M O'Reilly, Richard M Goldberg, Howard S Hochster, Richard L Schilsky, Monica M Bertagnolli, Anthony B El-Khoueiry, Peter Watson, Al B Benson, Daniel L Mulkerin, Robert J Mayer, Charles Blanke,

Combining biologic monoclonal antibodies with chemotherapeutic cytotoxic drugs provides clinical benefit to patients with advanced or metastatic colorectal cancer, but the optimal choice of the initial biologic therapy in previously untreated patients is unknown.To determine if the addition of cetuximab vs bevacizumab to the combination of leucovorin, fluorouracil, and oxaliplatin ... Read more >>

JAMA (JAMA)
[2017, 317(23):2392-2401]

Cited: 70 times

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Implementation of Advance Care Planning in Oncology: A Review of the Literature.

Christine M Bestvina, Blase N Polite,

Advance care planning (ACP) should be initiated early and be readdressed often for patients with cancer. This directive is expressed in the Institute of Medicine's report, "Dying in America," and is a component of several quality metrics, including ASCO's Quality Oncology Practice Initiative and the Centers for Medicare & Medicaid ... Read more >>

J Oncol Pract (Journal of oncology practice)
[2017, 13(10):657-662]

Cited: 5 times

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Under-representation of peritoneal metastases in published clinical trials of metastatic colorectal cancer.

Jennifer Tseng, Darren S Bryan, Elizabeth Poli, Manish Sharma, Blase N Polite, Kiran K Turaga,

Lancet Oncol. (The Lancet. Oncology)
[2017, 18(6):711-712]

Cited: 2 times

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Exceptional Chemotherapy Response in Metastatic Colorectal Cancer Associated With Hyper-Indel-Hypermutated Cancer Genome and Comutation of POLD1 and MLH1.

Manish R Sharma, James T Auman, Nirali M Patel, Juneko E Grilley-Olson, Xiaobei Zhao, Stergios J Moschos, Joel S Parker, Xiaoying Yin, Michele C Hayward, Blase N Polite, Elena Marangon, Bianca Posocco, Giuseppe Toffoli, D Neil Hayes, Federico Innocenti,

A73-year-old woman with metastatic colon cancer experienced a complete response to chemotherapy with dose-intensified irinotecan that has been durable for 5 years. We sequenced her tumor and germ line DNA and looked for similar patterns in publicly available genomic data from patients with colorectal cancer.Tumor DNA was obtained from a ... Read more >>

JCO Precis Oncol (JCO precision oncology)
[2017, 2017:]

Cited: 0 times

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