Full Text Journal Articles by
Author Birte Kretschmer

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Unique human immune signature of Ebola virus disease in Guinea.

Paula Ruibal, Lisa Oestereich, Anja Lüdtke, Beate Becker-Ziaja, David M Wozniak, Romy Kerber, Miša Korva, Mar Cabeza-Cabrerizo, Joseph A Bore, Fara Raymond Koundouno, Sophie Duraffour, Romy Weller, Anja Thorenz, Eleonora Cimini, Domenico Viola, Chiara Agrati, Johanna Repits, Babak Afrough, Lauren A Cowley, Didier Ngabo, Julia Hinzmann, Marc Mertens, Inês Vitoriano, Christopher H Logue, Jan Peter Boettcher, Elisa Pallasch, Andreas Sachse, Amadou Bah, Katja Nitzsche, Eeva Kuisma, Janine Michel, Tobias Holm, Elsa-Gayle Zekeng, Isabel García-Dorival, Roman Wölfel, Kilian Stoecker, Erna Fleischmann, Thomas Strecker, Antonino Di Caro, Tatjana Avšič-Županc, Andreas Kurth, Silvia Meschi, Stephane Mély, Edmund Newman, Anne Bocquin, Zoltan Kis, Anne Kelterbaum, Peter Molkenthin, Fabrizio Carletti, Jasmine Portmann, Svenja Wolff, Concetta Castilletti, Gordian Schudt, Alexandra Fizet, Lisa J Ottowell, Eva Herker, Thomas Jacobs, Birte Kretschmer, Ettore Severi, Nobila Ouedraogo, Mar Lago, Anabel Negredo, Leticia Franco, Pedro Anda, Stefan Schmiedel, Benno Kreuels, Dominic Wichmann, Marylyn M Addo, Ansgar W Lohse, Hilde De Clerck, Carolina Nanclares, Sylvie Jonckheere, Michel Van Herp, Armand Sprecher, Gao Xiaojiang, Mary Carrington, Osvaldo Miranda, Carlos M Castro, Martin Gabriel, Patrick Drury, Pierre Formenty, Boubacar Diallo, Lamine Koivogui, N'Faly Magassouba, Miles W Carroll, Stephan Günther, César Muñoz-Fontela,

Despite the magnitude of the Ebola virus disease (EVD) outbreak in West Africa, there is still a fundamental lack of knowledge about the pathophysiology of EVD. In particular, very little is known about human immune responses to Ebola virus. Here we evaluate the physiology of the human T cell immune ... Read more >>

Nature (Nature)
[2016, 533(7601):100-104]

Cited: 48 times

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Temporal and spatial analysis of the 2014-2015 Ebola virus outbreak in West Africa.

Miles W Carroll, David A Matthews, Julian A Hiscox, Michael J Elmore, Georgios Pollakis, Andrew Rambaut, Roger Hewson, Isabel García-Dorival, Joseph Akoi Bore, Raymond Koundouno, Saïd Abdellati, Babak Afrough, John Aiyepada, Patience Akhilomen, Danny Asogun, Barry Atkinson, Marlis Badusche, Amadou Bah, Simon Bate, Jan Baumann, Dirk Becker, Beate Becker-Ziaja, Anne Bocquin, Benny Borremans, Andrew Bosworth, Jan Peter Boettcher, Angela Cannas, Fabrizio Carletti, Concetta Castilletti, Simon Clark, Francesca Colavita, Sandra Diederich, Adomeh Donatus, Sophie Duraffour, Deborah Ehichioya, Heinz Ellerbrok, Maria Dolores Fernandez-Garcia, Alexandra Fizet, Erna Fleischmann, Sophie Gryseels, Antje Hermelink, Julia Hinzmann, Ute Hopf-Guevara, Yemisi Ighodalo, Lisa Jameson, Anne Kelterbaum, Zoltan Kis, Stefan Kloth, Claudia Kohl, Miša Korva, Annette Kraus, Eeva Kuisma, Andreas Kurth, Britta Liedigk, Christopher H Logue, Anja Lüdtke, Piet Maes, James McCowen, Stéphane Mély, Marc Mertens, Silvia Meschi, Benjamin Meyer, Janine Michel, Peter Molkenthin, César Muñoz-Fontela, Doreen Muth, Edmund N C Newman, Didier Ngabo, Lisa Oestereich, Jennifer Okosun, Thomas Olokor, Racheal Omiunu, Emmanuel Omomoh, Elisa Pallasch, Bernadett Pályi, Jasmine Portmann, Thomas Pottage, Catherine Pratt, Simone Priesnitz, Serena Quartu, Julie Rappe, Johanna Repits, Martin Richter, Martin Rudolf, Andreas Sachse, Kristina Maria Schmidt, Gordian Schudt, Thomas Strecker, Ruth Thom, Stephen Thomas, Ekaete Tobin, Howard Tolley, Jochen Trautner, Tine Vermoesen, Inês Vitoriano, Matthias Wagner, Svenja Wolff, Constanze Yue, Maria Rosaria Capobianchi, Birte Kretschmer, Yper Hall, John G Kenny, Natasha Y Rickett, Gytis Dudas, Cordelia E M Coltart, Romy Kerber, Damien Steer, Callum Wright, Francis Senyah, Sakoba Keita, Patrick Drury, Boubacar Diallo, Hilde de Clerck, Michel Van Herp, Armand Sprecher, Alexis Traore, Mandiou Diakite, Mandy Kader Konde, Lamine Koivogui, N'Faly Magassouba, Tatjana Avšič-Županc, Andreas Nitsche, Marc Strasser, Giuseppe Ippolito, Stephan Becker, Kilian Stoecker, Martin Gabriel, Hervé Raoul, Antonino Di Caro, Roman Wölfel, Pierre Formenty, Stephan Günther,

West Africa is currently witnessing the most extensive Ebola virus (EBOV) outbreak so far recorded. Until now, there have been 27,013 reported cases and 11,134 deaths. The origin of the virus is thought to have been a zoonotic transmission from a bat to a two-year-old boy in December 2013 (ref. ... Read more >>

Nature (Nature)
[2015, 524(7563):97-101]

Cited: 126 times

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Anti-CD83 promotes IgG1 isotype switch in marginal zone B cells in response to TI-2 antigen.

Birte Kretschmer, Jan Weber, Andreas Hutloff, Bernhard Fleischer, Minka Breloer, Anke Osterloh,

CD83 is a transmembrane glycoprotein that is rapidly up-regulated on activated B cells. Although CD83 itself is incapable to transduce intracellular signaling, it acts as a negative regulator of B cell function. We have recently described that a single application of anti-CD83 antibody results in dramatically enhanced production of antigen-specific ... Read more >>

Immunobiology (Immunobiology)
[2015, 220(8):964-975]

Cited: 2 times

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Infection with Mansonella perstans Nematodes in Buruli Ulcer Patients, Ghana.

Richard O Phillips, Michael Frimpong, Fred S Sarfo, Birte Kretschmer, Marcus Beissner, Alexander Debrah, Yaw Ampem-Amoako, Kabiru M Abass, William Thompson, Mabel Sarpong Duah, Justice Abotsi, Ohene Adjei, Bernhard Fleischer, Gisela Bretzel, Mark Wansbrough-Jones, Marc Jacobsen,

During August 2010-December 2012, we conducted a study of patients in Ghana who had Buruli ulcer, caused by Mycobacterium ulcerans, and found that 23% were co-infected with Mansonella perstans nematodes; 13% of controls also had M. perstans infection. M. perstans co-infection should be considered in the diagnosis and treatment of ... Read more >>

Emerging Infect. Dis. (Emerging infectious diseases)
[2014, 20(6):1000-1003]

Cited: 6 times

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Activated T cells induce rapid CD83 expression on B cells by engagement of CD40.

Birte Kretschmer, Svenja Kühl, Bernhard Fleischer, Minka Breloer,

The conserved transmembrane glycoprotein CD83 was originally described as highly specific marker for mature dendritic cells in the peripheral circulation. Besides its regulatory role in thymic T cell maturation and peripheral T cell activation, recent studies suggest, that CD83 is also involved in the regulation of B cell maturation, homeostasis ... Read more >>

Immunol. Lett. (Immunology letters)
[2011, 136(2):221-227]

Cited: 14 times

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Engagement of CD83 on B cells modulates B cell function in vivo.

Birte Kretschmer, Katja Lüthje, Stefanie Schneider, Bernhard Fleischer, Minka Breloer,

The transmembrane glycoprotein CD83 is an important regulator of both thymic T cell maturation and peripheral T cell response. Recent studies suggested that CD83 is also involved in the regulation of B cell maturation, activation, and homeostasis. In this study, we show that in vivo overexpression of CD83 dose dependently ... Read more >>

J. Immunol. (Journal of immunology (Baltimore, Md. : 1950))
[2009, 182(5):2827-2834]

Cited: 16 times

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CD83 on murine APC does not function as a costimulatory receptor for T cells.

Birte Kretschmer, Katja Lüthje, Svenja Ehrlich, Anke Osterloh, Melanie Piedavent, Bernhard Fleischer, Minka Breloer,

The transmembrane glycoprotein CD83 is rapidly upregulated on murine and human DC upon maturation and therefore a costimulatory function for T cell activation has been suggested. Studies employing human APC indeed showed that CD83 expression was positively correlated to the stimulatory capacity of the APC. Murine APC that were CD83 ... Read more >>

Immunol. Lett. (Immunology letters)
[2008, 120(1-2):87-95]

Cited: 10 times

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CD83 regulates splenic B cell maturation and peripheral B cell homeostasis.

Katja Lüthje, Birte Kretschmer, Bernhard Fleischer, Minka Breloer,

The central function of murine CD83 that is expressed on thymic epithelial cells is to induce the progression of double-positive thymocytes to single CD4-positive T cells. Several lines of evidence suggest an additional role for CD83 in the regulation of peripheral T and B cell responses. Here we show that ... Read more >>

Int. Immunol. (International immunology)
[2008, 20(8):949-960]

Cited: 12 times

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CD83 is a regulator of murine B cell function in vivo.

Minka Breloer, Birte Kretschmer, Katja Lüthje, Svenja Ehrlich, Uwe Ritter, Thomas Bickert, Christiane Steeg, Simon Fillatreau, Kai Hoehlig, Vassiliki Lampropoulou, Bernhard Fleischer,

The transmembrane glycoprotein CD83 has been described as a specific maturation marker for dendritic cells and several lines of evidence suggest that CD83 regulates thymic T cell maturation as well as peripheral T cell activation. Here we show for the first time that CD83 is involved also in the regulation ... Read more >>

Eur. J. Immunol. (European journal of immunology)
[2007, 37(3):634-648]

Cited: 29 times

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