Full Text Journal Articles by
Author Birke Bartosch

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Effect of endothelial cell heterogeneity on nanoparticle uptake.

Aldy Aliyandi, Simon Satchell, Ronald E Unger, Birke Bartosch, Romain Parent, Inge S Zuhorn, Anna Salvati,

Endothelial cells exhibit distinct properties in morphology and functions in different organs that can be exploited for nanomedicine targeting. In this work, endothelial cells from different organs, i.e. brain, lung, liver, and kidney, were exposed to plain, carboxylated, and amino-modified silica. As expected, different protein coronas were formed on the ... Read more >>

Int J Pharm (International journal of pharmaceutics)
[2020, 587:119699]

Cited: 0 times

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NLRP3 controls ATM activation in response to DNA damage

Mélanie Bodnar-Wachtel, Anne-Laure Huber, Julie Gorry, Sabine Hacot, Laetitia Gerossier, Baptiste Guey, Nadège Goutagny, Birke Bartosch, Elise Ballot, François Ghiringhelli, Bénédicte Py, Yohann Coute, Annabelle Ballesta, Sylvie Lantuejoul, Janet Hall, Virginie Petrilli,

ABSTRACT The DNA damage response (DDR) is essential to preserve genomic integrity and acts as a barrier to cancer. The ATM pathway orchestrates the cellular response to DNA double strand breaks (DSBs), and its attenuation is frequent during tumorigenesis. Here, we show that NLRP3, a Pattern Recognition Receptor known for ... Read more >>

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Cluster of differentiation 44 promotes osteosarcoma progression in mice lacking the tumor suppressor Merlin.

Junzhi Ma, Janina Klemm, Monserrat Gerardo-Ramírez, Lucien Frappart, Darko Castven, Diana Becker, Ansgar Zoch, Romain Parent, Birke Bartosch, Kerstin Minnich, Marco Giovannini, Sven Danckwardt, Nils Hartmann, Helen Morrison, Peter Herrlich, Jens U Marquardt, Monika Hartmann,

Merlin is a versatile tumor suppressor protein encoded by the NF2 gene. Several lines of evidence suggest that Merlin exerts its tumor suppressor activity, at least in part, by forming an inhibitory complex with cluster of differentiation 44 (CD44). Consistently, numerous NF2 mutations in cancer patients are predicted to perturb ... Read more >>

Int. J. Cancer (International journal of cancer)
[2020, :]

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Hypoxia sensing by hepatic stellate cells leads to VEGF-dependent angiogenesis and may contribute to accelerated liver regeneration.

Konstantin Dirscherl, Martin Schläpfer, Birgit Roth Z'graggen, Roland H Wenger, Christa Booy, Renata Flury-Frei, Rita Fatzer, Costica Aloman, Birke Bartosch, Romain Parent, Vartan Kurtcuoglu, Diane de Zélicourt, Donat R Spahn, Beatrice Beck Schimmer, Erik Schadde,

Portal vein ligation (PVL) induces liver growth prior to resection. Associating liver partition and portal vein ligation (PVL plus transection=ALPPS) or the addition of the prolyl-hydroxylase inhibitor dimethyloxalylglycine (DMOG) to PVL both accelerate growth via stabilization of HIF-α subunits. This study aims at clarifying the crosstalk of hepatocytes (HC), hepatic ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):4392]

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Corrigendum to "Toll-like receptor 3 downregulation is an escape mechanism from apoptosis during hepatocarcinogenesis" [J Hepatol 71 (2019) 763-772].

Marc Bonnin, Nadim Fares, Barbara Testoni, Yann Estornes, Kathrin Weber, Béatrice Vanbervliet, Lydie Lefrançois, Amandine Garcia, Alain Kfoury, Floriane Pez, Isabelle Coste, Pierre Saintigny, Alain Viari, Kévin Lang, Baptiste Guey, Virginie Petrilli, Valérie Hervieu, Brigitte Bancel, Birke Bartosch, David Durantel, Toufic Renno, Philippe Merle, Serge Lebecque,

J. Hepatol. (Journal of hepatology)
[2020, 72(3):594]

Cited: 0 times

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Metabolic Hallmarks of Hepatic Stellate Cells in Liver Fibrosis.

Olga Khomich, Alexander V Ivanov, Birke Bartosch,

Liver fibrosis is a regenerative process that occurs after injury. It is characterized by the deposition of connective tissue by specialized fibroblasts and concomitant proliferative responses. Chronic damage that stimulates fibrogenic processes in the long-term may result in the deposition of excess matrix tissue and impairment of liver functions. End-stage ... Read more >>

Cells (Cells)
[2019, 9(1):]

Cited: 3 times

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Regulation of Mitochondria-Associated Membranes (MAMs) by NO/sGC/PKG Participates in the Control of Hepatic Insulin Response.

Arthur Bassot, Marie-Agnès Chauvin, Nadia Bendridi, Jingwei Ji-Cao, Guillaume Vial, Léa Monnier, Birke Bartosch, Anaïs Alves, Cécile Cottet-Rousselle, Yves Gouriou, Jennifer Rieusset, Béatrice Morio,

Under physiological conditions, nitric oxide (NO) produced by the endothelial NO synthase (eNOS) upregulates hepatic insulin sensitivity. Recently, contact sites between the endoplasmic reticulum and mitochondria named mitochondria-associated membranes (MAMs) emerged as a crucial hub for insulin signaling in the liver. As mitochondria are targets of NO, we explored whether ... Read more >>

Cells (Cells)
[2019, 8(11):]

Cited: 1 time

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Two phase kinetics of the inflammatory response from hepatocyte-peripheral blood mononuclear cell interactions.

Audrey Beringer, Jennifer Molle, Birke Bartosch, Pierre Miossec,

Active liver diseases are characterized by an infiltration of inflammatory immune cells, which interact locally with hepatocytes. Co-cultures between non- and -activated human peripheral blood mononuclear cells (PBMCs) and human hepatoma HepaRG cells were used to determine the role of these cell interactions in the inflammatory response. At the early ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):8378]

Cited: 1 time

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CD81 large extracellular loop-containing fusion proteins with a dominant negative effect on HCV cell spread and replication.

Boyan Grigorov, Jennifer Molle, Eric Rubinstein, Fabien Zoulim, Birke Bartosch,

The roles of CD81 in the hepatitis C virus (HCV) life cycle are multiple but remain ill characterized. CD81 is known to interact with the HCV glycoproteins as an attachment factor. It also has an important role in the post-attachment entry process. Its interaction with claudin-1, for example, is vital ... Read more >>

J. Gen. Virol. (The Journal of general virology)
[2017, 98(7):1646-1657]

Cited: 1 time

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Oxidative Stress in Infection and Consequent Disease.

Alexander V Ivanov, Birke Bartosch, Maria G Isaguliants,

Oxid Med Cell Longev (Oxidative Medicine and Cellular Longevity)
[2017, 2017:3496043]

Cited: 12 times

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Hepatitis C virus infection triggers a tumor-like glutamine metabolism.

Pierre L Lévy, Sarah Duponchel, Hannah Eischeid, Jennifer Molle, Maud Michelet, Gaëlle Diserens, Martina Vermathen, Peter Vermathen, Jean-Francois Dufour, Hans-Peter Dienes, Hans-Michael Steffen, Margarete Odenthal, Fabien Zoulim, Birke Bartosch,

Chronic infection with hepatitis C virus (HCV) is one of the main causes of hepatocellular carcinoma. However, the molecular mechanisms linking the infection to cancer development remain poorly understood. Here we used HCV-infected cells and liver biopsies to study how HCV modulates the glutaminolysis pathway, which is known to play ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2017, 65(3):789-803]

Cited: 11 times

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Hepatitis C virus alters metabolism of biogenic polyamines by affecting expression of key enzymes of their metabolism.

Olga A Smirnova, Tuomo A Keinanen, Olga N Ivanova, Mervi T Hyvonen, Alex R Khomutov, Sergey N Kochetkov, Birke Bartosch, Alexander V Ivanov,

Chronic infection with hepatitis C virus (HCV) induces liver fibrosis and cancer. In particular metabolic alterations and associated oxidative stress induced by the virus play a key role in disease progression. Albeit the pivotal role of biogenic polyamines spermine and spermidine in the regulation of liver metabolism and function and ... Read more >>

Biochem. Biophys. Res. Commun. (Biochemical and biophysical research communications)
[2017, 483(2):904-909]

Cited: 13 times

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Hepatitis C virus infection propagates through interactions between Syndecan-1 and CD81 and impacts the hepatocyte glycocalyx.

Boyan Grigorov, Emma Reungoat, Alice Gentil Dit Maurin, Mihayl Varbanov, Julie Blaising, Maud Michelet, Rachel Manuel, Romain Parent, Birke Bartosch, Fabien Zoulim, Florence Ruggiero, Eve-Isabelle Pécheur,

The hepatitis C virus (HCV) infects hepatocytes after binding to heparan sulfate proteoglycans, in particular Syndecan-1, followed by recognition of the tetraspanin CD81 and other receptors. Heparan sulfate proteoglycans are found in a specific microenvironment coating the hepatocyte surface called the glycocalyx and are receptors for extracellular matrix proteins, cytokines, ... Read more >>

Cell. Microbiol. (Cellular microbiology)
[2017, 19(5):]

Cited: 11 times

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Hepatitis C Virus NS5A Protein Triggers Oxidative Stress by Inducing NADPH Oxidases 1 and 4 and Cytochrome P450 2E1.

Olga A Smirnova, Olga N Ivanova, Birke Bartosch, Vladimir T Valuev-Elliston, Furkat Mukhtarov, Sergey N Kochetkov, Alexander V Ivanov,

Replication of hepatitis C virus (HCV) is associated with the induction of oxidative stress, which is thought to play a major role in various liver pathologies associated with chronic hepatitis C. NS5A protein of the virus is one of the two key viral proteins that are known to trigger production ... Read more >>

Oxid Med Cell Longev (Oxidative Medicine and Cellular Longevity)
[2016, 2016:8341937]

Cited: 15 times

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Disruption of calcium transfer from ER to mitochondria links alterations of mitochondria-associated ER membrane integrity to hepatic insulin resistance.

Jennifer Rieusset, Jeremy Fauconnier, Melanie Paillard, Elise Belaidi, Emily Tubbs, Marie-Agnès Chauvin, Annie Durand, Amélie Bravard, Geoffrey Teixeira, Birke Bartosch, Maud Michelet, Pierre Theurey, Guillaume Vial, Marie Demion, Emilie Blond, Fabien Zoulim, Ludovic Gomez, Hubert Vidal, Alain Lacampagne, Michel Ovize,

Mitochondria-associated endoplasmic reticulum membranes (MAMs) are regions of the endoplasmic reticulum (ER) tethered to mitochondria and controlling calcium (Ca(2+)) transfer between both organelles through the complex formed between the voltage-dependent anion channel, glucose-regulated protein 75 and inositol 1,4,5-triphosphate receptor (IP3R). We recently identified cyclophilin D (CYPD) as a new partner ... Read more >>

Diabetologia (Diabetologia)
[2016, 59(3):614-623]

Cited: 21 times

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HCV core protein uses multiple mechanisms to induce oxidative stress in human hepatoma Huh7 cells.

Alexander V Ivanov, Olga A Smirnova, Irina Y Petrushanko, Olga N Ivanova, Inna L Karpenko, Ekaterina Alekseeva, Irina Sominskaya, Alexander A Makarov, Birke Bartosch, Sergey N Kochetkov, Maria G Isaguliants,

Hepatitis C virus (HCV) infection is accompanied by the induction of oxidative stress, mediated by several virus proteins, the most prominent being the nucleocapsid protein (HCV core). Here, using the truncated forms of HCV core, we have delineated several mechanisms by which it induces the oxidative stress. The N-terminal 36 ... Read more >>

Viruses (Viruses)
[2015, 7(6):2745-2770]

Cited: 32 times

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Mitochondria-associated endoplasmic reticulum membrane (MAM) integrity is required for insulin signaling and is implicated in hepatic insulin resistance.

Emily Tubbs, Pierre Theurey, Guillaume Vial, Nadia Bendridi, Amélie Bravard, Marie-Agnès Chauvin, Jingwei Ji-Cao, Fabien Zoulim, Birke Bartosch, Michel Ovize, Hubert Vidal, Jennifer Rieusset,

Mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs) are functional domains between both organelles involved in Ca(2+) exchange, through the voltage-dependent anion channel (VDAC)-1/glucose-regulated protein 75 (Grp75)/inositol 1,4,5-triphosphate receptor (IP3R)-1 complex, and regulating energy metabolism. Whereas mitochondrial dysfunction, ER stress, and altered Ca(2+) homeostasis are associated with altered insulin signaling, the implication ... Read more >>

Diabetes (Diabetes)
[2014, 63(10):3279-3294]

Cited: 89 times

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Piecing together the key players of fibrosis in chronic hepatitis C: what roles do non-hepatic liver resident cell types play?

Birke Bartosch,

Gut (Gut)
[2015, 64(6):862-863]

Cited: 0 times

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An immortalized human liver endothelial sinusoidal cell line for the study of the pathobiology of the liver endothelium.

Romain Parent, David Durantel, Thomas Lahlali, Aurélie Sallé, Marie-Laure Plissonnier, Daniel DaCosta, Gaëtan Lesca, Fabien Zoulim, Marie-Jeanne Marion, Birke Bartosch,

BACKGROUND: The endothelium lines blood and lymph vessels and protects underlying tissues against external agents such as viruses, bacteria and parasites. Yet, microbes and particularly viruses have developed sophisticated ways to bypass the endothelium in order to gain access to inner organs. De novo infection of the liver parenchyma by ... Read more >>

Biochem. Biophys. Res. Commun. (Biochemical and biophysical research communications)
[2014, 450(1):7-12]

Cited: 12 times

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Batch profiling calibration for robust NMR metabonomic data analysis.

Anne Fages, Clément Pontoizeau, Elodie Jobard, Pierre Lévy, Birke Bartosch, Bénédicte Elena-Herrmann,

Metabonomic studies involve the analysis of large numbers of samples to identify significant changes in the metabolic fingerprints of biological systems, possibly with sufficient statistical power for analysis. While procedures related to sample preparation and spectral data acquisition generally include the use of independent sample batches, these might be sources ... Read more >>

Anal Bioanal Chem (Analytical and bioanalytical chemistry)
[2013, 405(27):8819-8827]

Cited: 3 times

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Epstein - Barr virus transforming protein LMP-1 alters B cells gene expression by promoting accumulation of the oncoprotein ΔNp73α.

Rosita Accardi, Ikbal Fathallah, Henri Gruffat, Giuseppe Mariggiò, Florence Le Calvez-Kelm, Catherine Voegele, Birke Bartosch, Hector Hernandez-Vargas, James McKay, Bakary S Sylla, Evelyne Manet, Massimo Tommasino,

Many studies have proved that oncogenic viruses develop redundant mechanisms to alter the functions of the tumor suppressor p53. Here we show that Epstein-Barr virus (EBV), via the oncoprotein LMP-1, induces the expression of ΔNp73α, a strong antagonist of p53. This phenomenon is mediated by the LMP-1 dependent activation of ... Read more >>

PLoS Pathog. (PLoS pathogens)
[2013, 9(3):e1003186]

Cited: 14 times

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Hepatitis B and C viruses and hepatocellular carcinoma.

Birke Bartosch,

Viruses (Viruses)
[2010, 2(8):1504-1509]

Cited: 17 times

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Hepatitis C virus and its complex interplay with hepatic glucose and lipid metabolism.

Birke Bartosch,

J. Hepatol. (Journal of hepatology)
[2009, 50(5):845-847]

Cited: 5 times

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Porcine endogenous retroviruses PERV A and A/C recombinant are insensitive to a range of divergent mammalian TRIM5alpha proteins including human TRIM5alpha.

Andrew Wood, Benjamin L J Webb, Birke Bartosch, Torsten Schaller, Yasuhiro Takeuchi, Greg J Towers,

The potential risk of cross-species transmission of porcine endogenous retroviruses (PERV) to humans has slowed the development of xenotransplantation, using pigs as organ donors. Here, we show that PERVs are insensitive to restriction by divergent TRIM5alpha molecules despite the fact that they strongly restrict a variety of divergent lentiviruses. We ... Read more >>

J. Gen. Virol. (The Journal of general virology)
[2009, 90(Pt 3):702-709]

Cited: 13 times

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Hepatitis C virus-induced hepatocarcinogenesis.

Birke Bartosch, Robert Thimme, Hubert E Blum, Fabien Zoulim,

Although there is strong evidence that hepatitis C virus (HCV) is one of the leading causes of hepatocellular carcinoma (HCC), there is still much to understand regarding the mechanism of HCV-induced transformation. While liver fibrosis resulting from long-lasting chronic inflammation and liver regeneration resulting from immune-mediated cell death are likely ... Read more >>

J. Hepatol. (Journal of hepatology)
[2009, 51(4):810-820]

Cited: 68 times

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