Full Text Journal Articles by
Author Birgitte Fagerlund

Advertisement

Find full text journal articles






Effectiveness of cognitive remediation in the ultra-high risk state for psychosis.

Louise B Glenthøj, Lise S Mariegaard, Birgitte Fagerlund, Jens R M Jepsen, Tina D Kristensen, Christina Wenneberg, Kristine Krakauer, Alice Medalia, David L Roberts, Carsten Hjorthøj, Merete Nordentoft,

(World psychiatry : official journal of the World Psychiatric Association (WPA))
[2020, 19(3):401-402]

Cited: 0 times

View full text PDF listing >>



A machine-learning framework for robust and reliable prediction of short- and long-term treatment response in initially antipsychotic-naïve schizophrenia patients based on multimodal neuropsychiatric data.

Karen S Ambrosen, Martin W Skjerbæk, Jonathan Foldager, Martin C Axelsen, Nikolaj Bak, Lars Arvastson, Søren R Christensen, Louise B Johansen, Jayachandra M Raghava, Bob Oranje, Egill Rostrup, Mette Ø Nielsen, Merete Osler, Birgitte Fagerlund, Christos Pantelis, Bruce J Kinon, Birte Y Glenthøj, Lars K Hansen, Bjørn H Ebdrup,

The reproducibility of machine-learning analyses in computational psychiatry is a growing concern. In a multimodal neuropsychiatric dataset of antipsychotic-naïve, first-episode schizophrenia patients, we discuss a workflow aimed at reducing bias and overfitting by invoking simulated data in the design process and analysis in two independent machine-learning approaches, one based on ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2020, 10(1):276]

Cited: 0 times

View full text PDF listing >>



Advertisement

Discovering correlates of age-related decline in a healthy late-midlife male birth cohort.

Kiyana Zarnani, Stephen M Smith, Fidel Alfaro-Almagro, Birgitte Fagerlund, Martin Lauritzen, Egill Rostrup, Thomas E Nichols,

Studies exploring age-related brain and cognitive change have identified substantial heterogeneity among individuals, but the underlying reasons for the differential trajectories remain largely unknown. We investigated cross-sectional and longitudinal associations between brain-imaging phenotypes (IDPs) and cognitive ability, and how these relations may be modified by common risk and protective factors. ... Read more >>

Aging (Albany NY) (Aging)
[2020, 12(17):16709-16743]

Cited: 0 times

View full text PDF listing >>



No Effects of Cognitive Remediation on Cerebral White Matter in Individuals at Ultra-High Risk for Psychosis-A Randomized Clinical Trial.

Tina D Kristensen, Bjørn H Ebdrup, Carsten Hjorthøj, René C W Mandl, Jayachandra M Raghava, Jens Richardt M Jepsen, Birgitte Fagerlund, Louise B Glenthøj, Christina Wenneberg, Kristine Krakauer, Christos Pantelis, Birte Y Glenthøj, Merete Nordentoft,

Background:Individuals at ultra-high risk for psychosis (UHR) present with subtle alterations in cerebral white matter (WM), which appear to be associated with clinical and functional outcome. The effect of cognitive remediation on WM organization in UHR individuals has not been investigated previously. Methods:In a randomized, clinical trial, UHR individuals aged ... Read more >>

Front Psychiatry (Frontiers in psychiatry)
[2020, 11:873]

Cited: 0 times

View full text PDF listing >>



Associations Between Cognitive Function and Levels of Glutamatergic Metabolites and Gamma-Aminobutyric Acid in Antipsychotic-Naïve Patients With Schizophrenia or Psychosis.

Kirsten Borup Bojesen, Brian Villumsen Broberg, Birgitte Fagerlund, Kasper Jessen, Marie Bjerregaard Thomas, Anne Sigvard, Karen Tangmose, Mette Ødegaard Nielsen, Gitte Saltoft Andersen, Henrik Bo Wiberg Larsson, Richard A E Edden, Egill Rostrup, Birte Yding Glenthøj,

BACKGROUND:Abnormal glutamate and GABA (gamma-aminobutyric acid) levels have been found in the early phase of schizophrenia and may underlie cognitive deficits. However, the association between cognitive function and levels of glutamatergic metabolites and GABA has not been investigated in a large group of antipsychotic-naïve patients. METHODS:In total, 56 antipsychotic-naïve patients ... Read more >>

Biol Psychiatry (Biological psychiatry)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Cognitive remediation plus standard treatment versus standard treatment alone for individuals at ultra-high risk of developing psychosis: Results of the FOCUS randomised clinical trial.

Louise B Glenthøj, Lise S Mariegaard, Birgitte Fagerlund, Jens R M Jepsen, Tina D Kristensen, Christina Wenneberg, Kristine Krakauer, Alice Medalia, David L Roberts, Carsten Hjorthøj, Merete Nordentoft,

BACKGROUND:Individuals at ultra-high risk (UHR) for psychosis have significant cognitive deficits that can impede functional recovery. Applying cognitive remediation (CR) before the onset of frank psychosis may improve the cognitive and functional prognosis of UHR individuals, however, little is known about the feasibility and efficacy of CR for this population. ... Read more >>

Schizophr Res (Schizophrenia research)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Heritability of specific cognitive functions and associations with schizophrenia spectrum disorders using CANTAB: a nation-wide twin study.

Cecilie K Lemvigh, Rachel M Brouwer, Christos Pantelis, Maria H Jensen, Rikke W Hilker, Christian S Legind, Simon J Anhøj, Trevor W Robbins, Barbara J Sahakian, Birte Y Glenthøj, Birgitte Fagerlund,

BACKGROUND:Many cognitive functions are under strong genetic control and twin studies have demonstrated genetic overlap between some aspects of cognition and schizophrenia. How the genetic relationship between specific cognitive functions and schizophrenia is influenced by IQ is currently unknown. METHODS:We applied selected tests from the Cambridge Neuropsychological Test Automated Battery ... Read more >>

Psychol Med (Psychological medicine)
[2020, :1-14]

Cited: 0 times

View full text PDF listing >>



T60. GENETIC INFLUENCES ON MEMORY FUNCTIONS AND RELATED BRAIN STRUCTURES AND ASSOCIATIONS WITH SCHIZOPHRENIA SPECTRUM DISORDERS: A NATION-WIDE TWIN STUDY.

Cecilie Lemvigh, Rachel Brouwer, Louise Baruel Johansen, Rikke Hilker, Christos Pantelis, Birte Glenthoj, Birgitte Fagerlund,

AbstractBackgroundImpaired memory is among the most profound cognitive deficits observed in patients with schizophrenia. Evidence from twin studies suggests that memory is mainly influenced by genetics. Moreover, a few twin studies have demonstrated genetic overlap between specific memory functions and schizophrenia. Memory deficits in schizophrenia seem to involve abnormalities in ... Read more >>

(Schizophrenia bulletin)
[2020, 46(Suppl 1):S254-S254]

Cited: 0 times

View full text PDF listing >>



Multimodal assessment of white matter microstructure in antipsychotic-naïve schizophrenia patients and confounding effects of recreational drug use.

Jayachandra M Raghava, René C W Mandl, Mette Ø Nielsen, Birgitte Fagerlund, Birte Y Glenthøj, Egill Rostrup, Bjørn H Ebdrup,

Cerebral white matter (WM) aberrations in schizophrenia have been linked to multiple neurobiological substrates but the underlying mechanisms remain unknown. Moreover, antipsychotic treatment and substance use constitute potential confounders. Multimodal studies using diffusion tensor imaging (DTI) and magnetization transfer imaging (MTI) may provide deeper insight into the whole brain WM ... Read more >>

Brain Imaging Behav (Brain imaging and behavior)
[2020, :]

Cited: 0 times

View full text PDF listing >>



O6.3. ASSOCIATIONS BETWEEN COGNITIVE FUNCTION AND CORTICAL LEVELS OF GLUTAMATE AND GABA IN ANTIPSYCHOTIC-NAïVE PATIENTS WITH SCHIZOPHRENIA OR PSYCHOSIS.

Kirsten Bojesen, Brian V Broberg, Birgitte Fagerlund, Kasper Jessen, Marie B Jensen, Anne Sigvard, Karen Tangmose, Mette ødegård nielsen, Gitte Saltoft Andersen, Henrik Bo Wiberg Larsson, Richard Edden, Egill Rostrup, Birte Glenthoj,

AbstractBackgroundDysfunctional glutamatergic and gamma-aminobutyric acid (GABA)ergic neurotransmission may be part of the schizophrenia pathophysiology and underlie cognitive deficits. Abnormal levels of glutamate and GABA have been found in patients with first-episode psychosis or schizophrenia, and studies of mainly medicated patients have reported correlations between cortical glutamate and GABA levels and ... Read more >>

Schizophr Bull (Schizophrenia bulletin)
[2020, 46(Suppl 1):S14-S14]

Cited: 0 times

View full text PDF listing >>



T46. THE EFFECT OF COMPREHENSIVE COGNITIVE REMEDIATION IN INDIVIDUALS AT ULTRA-HIGH RISK FOR PSYCHOSIS: A SINGLE-BLIND, RANDOMISED, CLINICAL TRIAL (FOCUS).

Louise Birkedal Glenthoej, Mariegaard Lise, Birgitte Fagerlund, Jens Richardt Jepsen, Tina Dam Kristensen, Christina Wenneberg, Kristine Krakauer, Alice Medalia, David Roberts, Carsten Hjorthøj, Merete Nordentoft,

AbstractBackgroundIndividuals at ultra-high risk (UHR) for psychosis display significant cognitive deficits that constitute a barrier to functional recovery. Applying cognitive remediation (CR) before the onset of manifest psychosis may improve cognition and the clinical and functional prognosis of UHR individuals.MethodsThis randomised, clinical trial randomly assigned 146 UHR individuals aged 18–40 ... Read more >>

(Schizophrenia bulletin)
[2020, 46(Suppl 1):S249-S249]

Cited: 0 times

View full text PDF listing >>



S12. A MACHINE LEARNING FRAMEWORK FOR ROBUST AND RELIABLE PREDICTION OF SHORT- AND LONG-TERM CLINICAL RESPONSE IN INITIALLY ANTIPSYCHOTIC-NAïVE SCHIZOPHRENIA PATIENTS BASED ON MULTIMODAL NEUROPSYCHIATRIC DATA.

Karen S Ambrosen, Martin W Skjerbæk, Jonathan Foldager, Martin C Axelsen, Nikolaj Bak, Lars Arvastson, Søren R Christensen, Louise B Johansen, Jayachandra M Raghava, Bob Oranje, Egill Rostrup, Mette Ø Nielsen, Merete Osler, Birgitte Fagerlund, Christos Pantelis, Bruce J Kinon, Birte Y Glenthøj, Lars K Hansen, Bjørn H Ebdrup,

AbstractBackgroundThe treatment response of patients with schizophrenia is heterogeneous, and markers of clinical response are missing. Studies using machine learning approaches have provided encouraging results regarding prediction of outcomes, but replicability has been challenging. In the present study, we present a novel methodological framework for applying machine learning to clinical ... Read more >>

Schizophr Bull (Schizophrenia bulletin)
[2020, 46(Suppl 1):S34-S35]

Cited: 0 times

View full text PDF listing >>



Identification of a Serotonin 2A Receptor Subtype of Schizophrenia Spectrum Disorders With Pimavanserin: The Sub-Sero Proof-of-Concept Trial Protocol.

Olga B Baltzersen, Herbert Y Meltzer, Vibe G Frokjaer, Jayachandra M Raghava, Lone Baandrup, Birgitte Fagerlund, Henrik B W Larsson, H Christian Fibiger, Birte Y Glenthøj, Gitte M Knudsen, Bjørn H Ebdrup,

Background:All current approved antipsychotic drugs against schizophrenia spectrum disorders share affinity for the dopamine receptor (D2R). However, up to one-third of these patients respond insufficiently, and in some cases, side-effects outweigh symptom reduction. Previous data have suggested that a subgroup of antipsychotic-naïve patients will respond to serotonin 2A receptor (2AR) ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:591]

Cited: 0 times

View full text PDF listing >>



T18. EFFECTS OF COGNITIVE REMEDIATION ON WHITE MATTER IN INDIVIDUALS AT ULTRA-HIGH RISK FOR PSYCHOSIS – A RANDOMIZED, CONTROLLED CLINICAL TRIAL.

Tina Kristensen, Bjørn H Ebdrup, Carsten Hjorthøj, Rene C W Mandl, Jayachandra Mitta Raghava, Jens Richardt Møllegaard Jepsen, Birgitte Fagerlund, Louise B Glenthøj, Christina Wenneberg, Kristine Krakauer, Christos Pantelis, Birte Y Glenthøj, Merete Nordentoft,

AbstractBackgroundIndividuals at ultra-high risk for psychosis (UHR) present with subtle white matter alterations, which have been associated with clinical and functional outcome. The effect of cognitive remediation on white matter (WM) in UHR-individuals has not been investigated.MethodsIn a randomized, clinical intervention-trial (FOCUS), UHR-individuals aged 18–40 years were assigned to treatment ... Read more >>

(Schizophrenia bulletin)
[2020, 46(Suppl 1):S237-S238]

Cited: 0 times

View full text PDF listing >>



Associations between facial affect recognition and neurocognition in subjects at ultra-high risk for psychosis: A case-control study.

Lasse Randers, Jens Richardt M Jepsen, Birgitte Fagerlund, Dorte Nordholm, Kristine Krakauer, Carsten Hjorthøj, Birte Glenthøj, Merete Nordentoft,

The nature of facial affect recognition (FAR) deficits in subjects at ultra-high risk (UHR) for psychosis remains unclear. In schizophrenia, associations between FAR impairment and poor neurocognition have been demonstrated meta-analytically, but this potential link is understudied in the UHR population. Our study investigated a cross-sectional sample of UHR subjects ... Read more >>

Psychiatry Res (Psychiatry research)
[2020, 290:112969]

Cited: 0 times

View full text PDF listing >>



Differential effects of age at illness onset on verbal memory functions in antipsychotic-naïve schizophrenia patients aged 12-43 years.

Birgitte Fagerlund, Christos Pantelis, Jens Richardt Møllegaard Jepsen, Jayachandra Mitta Raghava, Egill Rostrup, Marie Bjerregaard Thomas, Mette Ødegaard Nielsen, Kirsten Bojesen, Karsten Gjessing Jensen, Marie Stentebjerg-Decara, Dea Gowers Klauber, Ditte Rudå, Bjørn H Ebdrup, Kasper Jessen, Anne Sigvard, Karen Tangmose, Pia Jeppesen, Christoph U Correll, Anders Fink-Jensen, Anne Katrine Pagsberg, Birte Yding Glenthøj,

BACKGROUND:The typical onset of schizophrenia coincides with the maturational peak in cognition; however, for a significant proportion of patients the onset is before age 18 and after age 30 years. While cognitive deficits are considered core features of schizophrenia, few studies have directly examined the impact of age of illness ... Read more >>

Psychol Med (Psychological medicine)
[2020, :1-11]

Cited: 0 times

View full text PDF listing >>



Measuring movements in adolescents with psychosis using the Microsoft Kinect sensor: a pilot study exploring a new tool for assessing aspects of antipsychotic-induced parkinsonism.

Ditte Rudå, Gudmundur Einarsson, Jannik Boll Matthiassen, Christoph U Correll, Karsten Gjessing Jensen, Dea Gowers Klauber, Clara Josefine Richard, Anne Sofie Schott Andersen, Sabrina Krøigaard, Jens Richardt Møllegaard Jepsen, Birgitte Fagerlund, Kristian Winge, Line K H Clemmesen, Anne Katrine Pagsberg, Rasmus R Paulsen, Anders Fink-Jensen,

BACKGROUND:The assessment of motor disturbances in antipsychotic-treated adolescent patients is often limited to the use of observer-based rating scales with interobserver variability. The objectives of this pilot study were to measure movement patterns associated with antipsychotic-induced parkinsonism in young patients with psychosis and initiating/treated with antipsychotics, using a computer application ... Read more >>

Child Adolesc Ment Health (Child and adolescent mental health)
[2020, 25(2):79-94]

Cited: 0 times

View full text PDF listing >>



No Effects of Cognitive Remediation on Cerebral White Matter in Individuals at Ultra-High Risk for Psychosis—A Randomized Clinical Trial

Tina D. Kristensen, Bjørn H. Ebdrup, Carsten Hjorthøj, René C. W. Mandl, Jayachandra M. Raghava, Jens Richardt M. Jepsen, Birgitte Fagerlund, Louise B. Glenthøj, Christina Wenneberg, Kristine Krakauer, Christos Pantelis, Birte Y. Glenthøj, Merete Nordentoft,

Background Individuals at ultra-high risk for psychosis (UHR) present with subtle alterations in cerebral white matter (WM), which appear to be associated with clinical and functional outcome. The effect of cognitive remediation on WM organization in UHR individuals has not been investigated previously. Methods In a randomized, clinical trial, UHR ... Read more >>

Front Psychiatry (Frontiers in psychiatry)
[2020, 11:]

Cited: 0 times

View full text PDF listing >>



Cerebral Glutamate and Gamma-Aminobutyric Acid Levels in Individuals at Ultra-high Risk for Psychosis and the Association With Clinical Symptoms and Cognition.

Christina Wenneberg, Merete Nordentoft, Egill Rostrup, Louise Birkedal Glenthøj, Kirsten Borup Bojesen, Birgitte Fagerlund, Carsten Hjorthøj, Kristine Krakauer, Tina Dam Kristensen, Camilla Schwartz, Richard A E Edden, Brian Villumsen Broberg, Birte Yding Glenthøj,

BACKGROUND:Studies examining glutamate or gamma-aminobutyric acid (GABA) in ultra-high risk for psychosis (UHR) and the association with pathophysiology and cognition have shown conflicting results. We aimed to determine whether perturbed glutamate and GABA levels in the anterior cingulate cortex and glutamate levels in the left thalamus were present in UHR ... Read more >>

Biol Psychiatry Cogn Neurosci Neuroimaging (Biological psychiatry. Cognitive neuroscience and neuroimaging)
[2020, 5(6):569-579]

Cited: 0 times

View full text PDF listing >>



Diagnostic stability and long-term symptomatic and functional outcomes in first-episode antipsychotic-naïve patients with schizophrenia.

Lea R Klærke, Lone Baandrup, Birgitte Fagerlund, Bjørn H Ebdrup, Christos Pantelis, Birte Y Glenthøj, Mette Ø Nielsen,

OBJECTIVE:In a prospective cohort design, we investigated: i) diagnostic stability of initially antipsychotic-naïve schizophrenia patients, ii) symptom severity including symptomatic remission, and iii) functional remission including full recovery. METHODS:We included 143 antipsychotic-naïve patients with first-episode schizophrenia or schizoaffective disorder. After 4-18 years, we clinically re-evaluated diagnosis, symptom severity and functioning ... Read more >>

Eur. Psychiatry (European psychiatry : the journal of the Association of European Psychiatrists)
[2019, 62:130-137]

Cited: 0 times

View full text PDF listing >>



Auditory sensory gating in young adolescents with early-onset psychosis: a comparison with attention deficit/hyperactivity disorder.

Cecilie Koldbæk Lemvigh, Jens Richardt Møllegaard Jepsen, Birgitte Fagerlund, Anne Katrine Pagsberg, Birte Yding Glenthøj, Jacob Rydkjær, Bob Oranje,

Numerous studies have demonstrated impaired sensory gating in schizophrenia and this impairment has been proposed as a candidate biomarker for the disorder. The typical age of onset for schizophrenia is early adulthood, however a sizable group of patients present with psychotic symptoms before the age of 18, commonly referred to ... Read more >>

Neuropsychopharmacology (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology)
[2020, 45(4):649-655]

Cited: 0 times

View full text PDF listing >>



Heritability of Cerebral Blood Flow and the Correlation to Schizophrenia Spectrum Disorders: A Pseudo-continuous Arterial Spin Labeling Twin Study.

Christian S Legind, Brian V Broberg, Rachel Brouwer, René C W Mandl, Bjørn H Ebdrup, Simon J Anhøj, Maria H Jensen, Rikke Hilker, Birgitte Fagerlund, Hilleke E Hulshoff Pol, Birte Y Glenthøj, Egill Rostrup,

Whether aberrant cerebral blood flow (CBF) in schizophrenia is affected by genetic influences, and consequently a potential marker for genetic susceptibility, is unknown. Our aims were to determine the heritability of CBF in thalamic, frontal, and striatal areas, and to ascertain if associations with disease were under genetic influence. Monozygotic ... Read more >>

Schizophr Bull (Schizophrenia bulletin)
[2019, 45(6):1231-1241]

Cited: 0 times

View full text PDF listing >>



Discovering markers of healthy aging: a prospective study in a Danish male birth cohort.

Kiyana Zarnani, Thomas E Nichols, Fidel Alfaro-Almagro, Birgitte Fagerlund, Martin Lauritzen, Egill Rostrup, Stephen M Smith,

There is a pressing need to identify markers of cognitive and neural decline in healthy late-midlife participants. We explored the relationship between cross-sectional structural brain-imaging derived phenotypes (IDPs) and cognitive ability, demographic, health and lifestyle factors (non-IDPs). Participants were recruited from the 1953 Danish Male Birth Cohort (N=193). Applying an ... Read more >>

Aging (Albany NY) (Aging)
[2019, 11(16):5943-5974]

Cited: 0 times

View full text PDF listing >>



Widespread higher fractional anisotropy associates to better cognitive functions in individuals at ultra-high risk for psychosis.

Tina D Kristensen, René C W Mandl, Jayachandra M Raghava, Kasper Jessen, Jens Richardt M Jepsen, Birgitte Fagerlund, Louise B Glenthøj, Christina Wenneberg, Kristine Krakauer, Christos Pantelis, Merete Nordentoft, Birte Y Glenthøj, Bjørn H Ebdrup,

In schizophrenia patients, cognitive functions appear linked to widespread alterations in cerebral white matter microstructure. Here we examine patterns of associations between regional white matter and cognitive functions in individuals at ultra-high risk for psychosis. One hundred and sixteen individuals at ultra-high risk for psychosis and 49 matched healthy controls ... Read more >>

Hum Brain Mapp (Human brain mapping)
[2019, 40(18):5185-5201]

Cited: 2 times

View full text PDF listing >>



Cognitive reserve attenuates age-related cognitive decline in the context of putatively accelerated brain ageing in schizophrenia-spectrum disorders.

Tamsyn E Van Rheenen, Vanessa Cropley, Birgitte Fagerlund, Cassandra Wannan, Jason Bruggemann, Rhoshel K Lenroot, Suresh Sundram, Cynthia Shannon Weickert, Thomas W Weickert, Andrew Zalesky, Chad A Bousman, Christos Pantelis,

BACKGROUND:In schizophrenia, relative stability in the magnitude of cognitive deficits across age and illness duration is inconsistent with the evidence of accelerated deterioration in brain regions known to support these functions. These discrepant brain-cognition outcomes may be explained by variability in cognitive reserve (CR), which in neurological disorders has been ... Read more >>

Psychol Med (Psychological medicine)
[2020, 50(9):1475-1489]

Cited: 0 times

View full text PDF listing >>



Advertisement

Disclaimer
1.1135 s