Full Text Journal Articles by
Author Birgit Ertl Wagner

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Association of outcomes in acute flaccid myelitis with identification of enterovirus at presentation: a Canadian, nationwide, longitudinal study.

Carmen Yea, Ari Bitnun, Helen M Branson, Beyza Ciftci-Kavaklioglu, Mubeen F Rafay, Olivier Fortin, Paola Moresoli, Guillaume Sébire, Myriam Srour, Hélène Decaluwe, Louis Marois, Félixe Pelletier, Michelle Barton, Maryam Nabavi Nouri, Jason Brophy, Sunita Venkateswaran, Daniela Pohl, Kathryn Selby, Kevin Jones, Joan Robinson, Aleksandra Mineyko, Christoph Licht, Birgit Ertl-Wagner, E Ann Yeh,

BACKGROUND:Acute flaccid myelitis (AFM) is characterised by rapid onset of limb weakness with spinal cord grey-matter abnormalities on MRI scan. We aimed to assess whether detection of enterovirus in respiratory or other specimens can help predict prognosis in children with AFM. METHODS:In this nationwide, longitudinal study, we evaluated the significance ... Read more >>

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, 4(11):828-836]

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Animal tissue-based quantitative comparison of dual-energy CT to SPR conversion methods using high-resolution gel dosimetry.

Katharina Beatrice Niepel, Michael Stanislawski, Matthias Wuerl, Fabian Doerringer, Marco Pinto, Olaf Dietrich, Birgit Ertl-Wagner, Arthur Lalonde, Hugo Bouchard, Evangelos Pappas, Indra Yohannes, Martin Hillbrand, Guillaume Landry, Katia Parodi,

Dual-energy computed tomography (DECT) has been shown to allow for more accurate ion therapy treatment planning by improving the estimation of tissue stopping power ratio (SPR) relative to water, among other tissue properties. In this study, we measured and compared the accuracy of SPR values derived using both dual- and ... Read more >>

Phys Med Biol (Physics in medicine and biology)
[2020, :]

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Resting-state fMRI detects alterations in whole brain connectivity related to tumor biology in glioma patients.

Veit M Stoecklein, Sophia Stoecklein, Franziska Galiè, Jianxun Ren, Michael Schmutzer, Marcus Unterrainer, Nathalie L Albert, Friedrich-W Kreth, Niklas Thon, Thomas Liebig, Birgit Ertl-Wagner, Joerg-C Tonn, Hesheng Liu,

BACKGROUND:Systemic infiltration of the brain by tumor cells is a hallmark of glioma pathogenesis which may cause disturbances in functional connectivity. We hypothesized that aggressive high-grade tumors cause more damage to functional connectivity than low-grade tumors. METHODS:We designed an imaging tool based on resting-state functional (f)MRI to individually quantify abnormality ... Read more >>

Neuro Oncol (Neuro-oncology)
[2020, 22(9):1388-1398]

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Treatment of cervix carcinoma FIGO IIIb with Photofrin II as a radiosensitizer: a case report.

Pamela Schaffer, Ron Batash, Birgit Ertl-Wagner, Alfons Hofstetter, Noam Asna, Moshe Schaffer,

Cervical cancer is the fourth-most common type of cancer and cause of death in women. Human papilloma virus (HPV) infection is responsible for over 90% of cervical cancers. The recommended treatment is multidisciplinary, consisting of a combination of surgery, chemotherapy, and radiation therapy. The standard treatment in advanced stages, such ... Read more >>

Photochem Photobiol Sci (Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology)
[2019, 18(5):1275-1279]

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Small vessel disease more than Alzheimer's disease determines diffusion MRI alterations in memory clinic patients.

Sofia Finsterwalder, Naomi Vlegels, Benno Gesierich, Miguel Á Araque Caballero, Nick A Weaver, Nicolai Franzmeier, Marios K Georgakis, Marek J Konieczny, Huiberdina L Koek, , Celeste M Karch, Neill R Graff-Radford, Stephen Salloway, Hwamee Oh, Ricardo F Allegri, Jasmeer P Chhatwal, , Frank Jessen, Emrah Düzel, Laura Dobisch, Coraline Metzger, Oliver Peters, Enise I Incesoy, Josef Priller, Eike J Spruth, Anja Schneider, Klaus Fließbach, Katharina Buerger, Daniel Janowitz, Stefan J Teipel, Ingo Kilimann, Christoph Laske, Martina Buchmann, Michael T Heneka, Frederic Brosseron, Annika Spottke, Nina Roy, Birgit Ertl-Wagner, Klaus Scheffler, , , Sang Won Seo, Yeshin Kim, Duk L Na, Hee Jin Kim, Hyemin Jang, Michael Ewers, Johannes Levin, Reinhold Schmidt, Ofer Pasternak, Martin Dichgans, Geert Jan Biessels, Marco Duering,

INTRODUCTION:Microstructural alterations as assessed by diffusion tensor imaging (DTI) are key findings in both Alzheimer's disease (AD) and small vessel disease (SVD). We determined the contribution of each of these conditions to diffusion alterations. METHODS:We studied six samples (N = 365 participants) covering the spectrum of AD and SVD, including ... Read more >>

Alzheimers Dement (Alzheimer's & dementia : the journal of the Alzheimer's Association)
[2020, 16(11):1504-1514]

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Immune signatures of prodromal multiple sclerosis in monozygotic twins.

Lisa Ann Gerdes, Claudia Janoschka, Maria Eveslage, Bianca Mannig, Timo Wirth, Andreas Schulte-Mecklenbeck, Sarah Lauks, Laura Glau, Catharina C Gross, Eva Tolosa, Andrea Flierl-Hecht, Birgit Ertl-Wagner, Frederik Barkhof, Sven G Meuth, Tania Kümpfel, Heinz Wiendl, Reinhard Hohlfeld, Luisa Klotz,

The tremendous heterogeneity of the human population presents a major obstacle in understanding how autoimmune diseases like multiple sclerosis (MS) contribute to variations in human peripheral immune signatures. To minimize heterogeneity, we made use of a unique cohort of 43 monozygotic twin pairs clinically discordant for MS and searched for ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2020, 117(35):21546-21556]

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Consensus on technical procedures in radiology to include in simulation-based training for residents: a European-wide needs assessment.

Leizl Joy Nayahangan, Elisabeth Albrecht-Beste, Lars Konge, Boris Brkljačić, Carlo Catalano, Birgit Ertl-Wagner, Katrine Riklund, Michael Bachmann Nielsen,

OBJECTIVES:To identify and prioritize technical procedures for simulation-based training that should be part of the education of residents in radiology. METHODS:This European-wide needs assessment study used a modified Delphi technique to gather consensus from different key education stakeholders in the field. The first round was a brainstorming phase to identify ... Read more >>

Eur Radiol (European radiology)
[2020, :]

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Effects of bifrontal transcranial direct current stimulation on brain glutamate levels and resting state connectivity: multimodal MRI data for the cathodal stimulation site.

Eva Mezger, Boris-Stephan Rauchmann, Andre R Brunoni, Lucia Bulubas, Axel Thielscher, Jana Werle, Matin Mortazavi, Temmuz Karali, Sophia Stöcklein, Birgit Ertl-Wagner, Stephan Goerigk, Frank Padberg, Daniel Keeser,

Transcranial direct current stimulation (tDCS) over prefrontal cortex (PFC) regions is currently proposed as therapeutic intervention for major depression and other psychiatric disorders. The in-depth mechanistic understanding of this bipolar and non-focal stimulation technique is still incomplete. In a pilot study, we investigated the effects of bifrontal stimulation on brain ... Read more >>

Eur Arch Psychiatry Clin Neurosci (European archives of psychiatry and clinical neuroscience)
[2020, :]

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Preparedness for the COVID-19 pandemic in a tertiary pediatric radiology department.

Birgit B Ertl-Wagner, Wayne Lee, David E Manson, Joao G Amaral, Zoran Bojic, Michelle S Cote, Joanne M Fernandes, Darlene Murray, Amer Shammas, Natalie Therrien-Miller, Manohar M Shroff,

Pediatr Radiol (Pediatric radiology)
[2020, 50(8):1059-1068]

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Effect of aerobic exercise on cortical thickness in patients with schizophrenia-A dataset.

Shun Takahashi, Daniel Keeser, Boris-Stephan Rauchmann, Thomas Schneider-Axmann, Katriona Keller-Varady, Isabel Maurus, Peter Dechent, Thomas Wobrock, Alkomiet Hasan, Andrea Schmitt, Birgit Ertl-Wagner, Berend Malchow, Peter Falkai,

This is a data article from the original publication "Effect of aerobic exercise combined with cognitive remediation on cortical thickness and prediction of social adaptation in patients with schizophrenia" [1]. Twenty-one patients with schizophrenia and 23 healthy controls underwent aerobic exercise. Another 21 patients with schizophrenia played table soccer instead. ... Read more >>

Data Brief (Data in brief)
[2020, 30:105517]

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Machine-learning based exploration of determinants of gray matter volume in the KORA-MRI study.

Franziska Galiè, Susanne Rospleszcz, Daniel Keeser, Ebba Beller, Ben Illigens, Roberto Lorbeer, Sergio Grosu, Sonja Selder, Sigrid Auweter, Christopher L Schlett, Wolfgang Rathmann, Lars Schwettmann, Karl-Heinz Ladwig, Jakob Linseisen, Annette Peters, Fabian Bamberg, Birgit Ertl-Wagner, Sophia Stoecklein,

To identify the most important factors that impact brain volume, while accounting for potential collinearity, we used a data-driven machine-learning approach. Gray Matter Volume (GMV) was derived from magnetic resonance imaging (3T, FLAIR) and adjusted for intracranial volume (ICV). 93 potential determinants of GMV from the categories sociodemographics, anthropometric measurements, ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):8363]

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Investigation of potential adverse central nervous system effects after long term oral administration of gadolinium in mice.

Dominik Nörenberg, Felix Schmidt, Karin Schinke, Thomas Frenzel, Hubertus Pietsch, Armin Giese, Birgit Ertl-Wagner, Johannes Levin,

OBJECTIVES:To examine potential gadolinium (Gd) accumulation in the brain of healthy mice after long-term oral administration of Gd-containing food pellets and to investigate whether Gd leads to adverse central nervous system (CNS) effects, specifically focussing on locomotor impairment in Gd exposed compared to control animals. MATERIALS AND METHODS:The local Animal ... Read more >>

PLoS One (PloS one)
[2020, 15(4):e0231495]

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Vestibular Disorders.

Michael Strupp, Julia Dlugaiczyk, Birgit Bettina Ertl-Wagner, Dan Rujescu, Martin Westhofen, Marianne Dieterich,

BACKGROUND:Recent research findings have improved the understanding of the diagnosis, pathophysiology, genetics, etiology, and treatment of peripheral, central, and functional vestibular vertigo syndromes. METHOD:A literature search, with special attention to the current classification, treatment trials, Cochrane analyses, and other meta-analyses. RESULTS:There are internationally accepted diagnostic criteria for benign positional paroxysmal ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2020, 117(17):300-310]

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Implications of the putamen in pain and motor deficits in complex regional pain syndrome.

Monica Azqueta-Gavaldon, Andrew M Youssef, Claudia Storz, Jordan Lemme, Heike Schulte-Göcking, Lino Becerra, Shahnaz C Azad, Anselm Reiners, Birgit Ertl-Wagner, David Borsook, Jaymin Upadhyay, Eduard Kraft,

Complex regional pain syndrome (CRPS) develops after-limb injury, with persistent pain and deficits in movement frequently co-occurring. The striatum is critical for mediating multiple mechanisms that are often aberrant in CRPS, which includes sensory and pain processing, motor function, and goal-directed behaviors associated with movement. Yet, much remains unknown with ... Read more >>

Pain (Pain)
[2020, 161(3):595-608]

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Abnormal Regional and Global Connectivity Measures in Subjective Cognitive Decline Depending on Cerebral Amyloid Status

Shumei Li, Marcel Daamen, Lukas Scheef, Florian Gaertner, Ralph Buchert, Martina Buchmann, Katharina Buerger, Cihan Catak, Laura Dobisch, Alexander Drzezga, Birgit Ertl-Wagner, Markus Essler, Klaus Fliessbach, John Dylan Haynes, Enise Irem Incesoy, Ingo Kilimann, Bernd Krause, Catharina Lange, Christoph Laske, Josef Priller, Alfredo Ramirez, Matthias Reimold, Axel Rominger, Nina Roy, Klaus Scheffler, Angelika Schmitt, Anja Schneider, Annika Spottke, Eike Jakob Spruth, Stefan Teipel, Maike Tscheuschler, Michael Wagner, Steffen Wolfsgruber, Emrah Düzel, Frank Jessen, Oliver Peters, Henning Boecker,

Abstract Background : While cerebral beta-amyloid accumulation was found in many studies to alter precuneus-based functional connectivity (FC) in mild cognitive impairment and demented Alzheimer’s disease (AD) patients, its impact is less well understood in subjective cognitive decline (SCD), which in the presence of underlying AD pathologic change corresponds to ... Read more >>

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Analyzing the co-localization of substantia nigra hyper-echogenicities and iron accumulation in Parkinson's disease: A multi-modal atlas study with transcranial ultrasound and MRI.

Seyed-Ahmad Ahmadi, Kai Bötzel, Johannes Levin, Juliana Maiostre, Tassilo Klein, Wolfgang Wein, Verena Rozanski, Olaf Dietrich, Birgit Ertl-Wagner, Nassir Navab, Annika Plate,

BACKGROUND:Transcranial B-mode sonography (TCS) can detect hyperechogenic speckles in the area of the substantia nigra (SN) in Parkinson's disease (PD). These speckles correlate with iron accumulation in the SN tissue, but an exact volumetric localization in and around the SN is still unknown. Areas of increased iron content in brain ... Read more >>

Neuroimage Clin (NeuroImage. Clinical)
[2020, 26:102185]

Cited: 2 times

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The transcriptional coactivator and histone acetyltransferase CBP regulates neural precursor cell development and migration.

Melanie Schoof, Michael Launspach, Dörthe Holdhof, Lynhda Nguyen, Verena Engel, Severin Filser, Finn Peters, Jana Immenschuh, Malte Hellwig, Judith Niesen, Volker Mall, Birgit Ertl-Wagner, Christian Hagel, Michael Spohn, Beat Lutz, Jan Sedlacik, Daniela Indenbirken, Daniel J Merk, Ulrich Schüller,

CREB (cyclic AMP response element binding protein) binding protein (CBP, CREBBP) is a ubiquitously expressed transcription coactivator with intrinsic histone acetyltransferase (KAT) activity. Germline mutations within the CBP gene are known to cause Rubinstein-Taybi syndrome (RSTS), a developmental disorder characterized by intellectual disability, specific facial features and physical anomalies. Here, ... Read more >>

Acta Neuropathol Commun (Acta neuropathologica communications)
[2019, 7(1):199]

Cited: 1 time

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Variable functional connectivity architecture of the preterm human brain: Impact of developmental cortical expansion and maturation.

Sophia Stoecklein, Anne Hilgendorff, Meiling Li, Kai Förster, Andreas W Flemmer, Franziska Galiè, Stephan Wunderlich, Danhong Wang, Sophie Stein, Harald Ehrhardt, Olaf Dietrich, Qihong Zou, Shuqin Zhou, Birgit Ertl-Wagner, Hesheng Liu,

Functional connectivity (FC) is known to be individually unique and to reflect cognitive variability. Although FC can serve as a valuable correlate and potential predictor of (patho-) physiological nervous function in high-risk constellations, such as preterm birth, templates for individualized FC analysis are lacking, and knowledge about the capacity of ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2020, 117(2):1201-1206]

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Assessing Radiology Research on Artificial Intelligence: A Brief Guide for Authors, Reviewers, and Readers-From the Radiology Editorial Board.

David A Bluemke, Linda Moy, Miriam A Bredella, Birgit B Ertl-Wagner, Kathryn J Fowler, Vicky J Goh, Elkan F Halpern, Christopher P Hess, Mark L Schiebler, Clifford R Weiss,

Radiology (Radiology)
[2020, 294(3):487-489]

Cited: 5 times

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Effect of aerobic exercise combined with cognitive remediation on cortical thickness and prediction of social adaptation in patients with schizophrenia.

Shun Takahashi, Daniel Keeser, Boris-Stephan Rauchmann, Thomas Schneider-Axmann, Katriona Keller-Varady, Isabel Maurus, Peter Dechent, Thomas Wobrock, Alkomiet Hasan, Andrea Schmitt, Birgit Ertl-Wagner, Berend Malchow, Peter Falkai,

Aerobic exercise is a promising intervention for patients with schizophrenia, but structural neuroplastic effects on brain regions relevant to the pathophysiology of the disease remain unclear. This study aimed to elucidate longitudinal changes in cortical thickness after aerobic exercise intervention in schizophrenia patients and the relationship of these changes to ... Read more >>

Schizophr Res (Schizophrenia research)
[2020, 216:397-407]

Cited: 1 time

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Early adaptive immune activation detected in monozygotic twins with prodromal multiple sclerosis.

Eduardo Beltrán, Lisa Ann Gerdes, Julia Hansen, Andrea Flierl-Hecht, Stefan Krebs, Helmut Blum, Birgit Ertl-Wagner, Frederik Barkhof, Tania Kümpfel, Reinhard Hohlfeld, Klaus Dornmair,

Multiple sclerosis (MS) is a disabling disease of the CNS. Inflammatory features of MS include lymphocyte accumulations in the CNS and cerebrospinal fluid (CSF). The preclinical events leading to established MS are still enigmatic. Here we compared gene expression patterns of CSF cells from MS-discordant monozygotic twin pairs. Six "healthy" ... Read more >>

J Clin Invest (The Journal of clinical investigation)
[2019, 129(11):4758-4768]

Cited: 5 times

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Association of smoking and physical inactivity with MRI derived changes in cardiac function and structure in cardiovascular healthy subjects.

Anina Schafnitzel, Roberto Lorbeer, Christian Bayerl, Hannah Patscheider, Sigrid D Auweter, Christa Meisinger, Margit Heier, Birgit Ertl-Wagner, Maximilian Reiser, Annette Peters, Fabian Bamberg, Holger Hetterich,

We aimed to investigate the association of smoking and physical exercise on ventricular function and structure, determined by cardiac magnetic resonance imaging (CMR), in subjects without known cardiovascular diseases. A total of 381 participants (median age 57 years) of the Cooperative Health Research in the Region of Augsburg (KORA) FF4 ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):18616]

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The impact of endurance training and table soccer on brain metabolites in schizophrenia.

Boris-Stephan Rauchmann, Farhad Ghaseminejad, Daniel Keeser, Katriona Keller-Varady, Thomas Schneider-Axmann, Shun Takahashi, Temmuz Karali, Gunther Helms, Peter Dechent, Isabel Maurus, Alkomiet Hasan, Thomas Wobrock, Birgit Ertl-Wagner, Andrea Schmitt, Berend Malchow, Peter Falkai,

Higher glutamate and glutamine (together: Glx) and lower N-acetyl-aspartate (NAA) levels were reported in schizophrenia. Endurance training normalizes NAA in the hippocampus, but its effects on other metabolites in the brain and the relationship of metabolites to clinical symptoms remain unknown. For 12 weeks, 20 schizophrenia inpatients (14 men, 6 women) ... Read more >>

Brain Imaging Behav (Brain imaging and behavior)
[2020, 14(2):515-526]

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Bayesian pharmacokinetic modeling of dynamic contrast-enhanced magnetic resonance imaging: validation and application.

Andreas Mittermeier, Birgit Ertl-Wagner, Jens Ricke, Olaf Dietrich, Michael Ingrisch,

Tracer-kinetic analysis of dynamic contrast-enhanced magnetic resonance imaging data is commonly performed with the well-known Tofts model and nonlinear least squares (NLLS) regression. This approach yields point estimates of model parameters, uncertainty of these estimates can be assessed e.g. by an additional bootstrapping analysis. Here, we present a Bayesian probabilistic ... Read more >>

Phys Med Biol (Physics in medicine and biology)
[2019, 64(18):18NT02]

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Safety and efficacy of epigallocatechin gallate in multiple system atrophy (PROMESA): a randomised, double-blind, placebo-controlled trial.

Johannes Levin, Sylvia Maaß, Madeleine Schuberth, Armin Giese, Wolfgang H Oertel, Werner Poewe, Claudia Trenkwalder, Gregor K Wenning, Ulrich Mansmann, Martin Südmeyer, Karla Eggert, Brit Mollenhauer, Axel Lipp, Matthias Löhle, Joseph Classen, Alexander Münchau, Jan Kassubek, Florin Gandor, Daniela Berg, Silvia Egert-Schwender, Cornelia Eberhardt, Friedemann Paul, Kai Bötzel, Birgit Ertl-Wagner, Hans-Jürgen Huppertz, Ingrid Ricard, Günter U Höglinger, ,

BACKGROUND:Multiple system atrophy is a rare neurodegenerative disease characterised by aggregation of α-synuclein in oligodendrocytes and neurons. The polyphenol epigallocatechin gallate inhibits α-synuclein aggregation and reduces associated toxicity. We aimed to establish if epigallocatechin gallate could safely slow disease progression in patients with multiple system atrophy. METHODS:We did a randomised, ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2019, 18(8):724-735]

Cited: 7 times

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