Full Text Journal Articles by
Author Birger Trollfors

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Changes in incidence and etiology of early-onset neonatal infections 1997-2017 - a retrospective cohort study in western Sweden.

Margrét Johansson Gudjónsdóttir, Anders Elfvin, Elisabet Hentz, Ingegerd Adlerberth, Ingemar Tessin, Birger Trollfors,

BACKGROUND:The objective of the study was to evaluate data on early-onset neonatal invasive infections in western Sweden for the period 1997-2017. To identify changes in incidence, etiology and mortality and compare to previous studies from the same area starting from 1975. METHODS:Observational epidemiological, retrospective study on infants 0-6 days of age ... Read more >>

BMC Pediatr (BMC pediatrics)
[2019, 19(1):490]

Cited: 0 times

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Response to: Patch test reactivity to aluminium chambers.

Annica Inerot, Elisabet Bergfors, Birger Trollfors,

Contact Derm. (Contact dermatitis)
[2020, 82(2):135]

Cited: 0 times

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Cost-effectiveness of childhood pneumococcal vaccination program in Ethiopia: results from a quasi-experimental evaluation.

Tayue Tateke Kebede, Mikael Svensson, Adamu Addissie, Birger Trollfors, Rune Andersson,

BACKGROUND:Ethiopia was among the 15 countries that, together accounted for 64% of the world's severe episodes of pneumonia among children below the age of 5 in 2011. To reduce this burden, the 10-valent pneumococcal conjugate vaccine (PCV 10) was introduced into the general childhood national immunization program in Ethiopia in ... Read more >>

BMC Public Health (BMC public health)
[2019, 19(1):1078]

Cited: 0 times

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Patch testing children with aluminium chloride hexahydrate in petrolatum: A review and a recommendation.

Elisabet Bergfors, Annica Inerot, Lars Falk, Ulla Nyström, Birger Trollfors,

BACKGROUND:According to studies on adults, patch testing with aluminium chloride hexahydrate 2% pet. is insufficient to detect aluminium allergy, and a 10% preparation is recommended. Other studies suggest that a 2% preparation is sufficient for testing children. OBJECTIVES:To review three previously published Swedish studies on patch testing children with aluminium ... Read more >>

Contact Derm. (Contact dermatitis)
[2019, 81(2):81-88]

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Age appropriateness of vaccination with recommended childhood vaccines in Sri Lanka.

Hanna Lindqvist, Galmangoda Najith Duminda Guruge, Birger Trollfors,

Vaccination status is conventionally measured by up-to-date coverage. This method does not take in to account whether the vaccines were received at the correct age and interval which is essential for optimal disease protection. Sri Lanka - a lower middle-income country in the Indian Ocean, has previously presented with high ... Read more >>

Vaccine X (Vaccine: X)
[2019, 2:100016]

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Pathogen Clearance and New Respiratory Tract Infections Among Febrile Children in Zanzibar Investigated With Multitargeting Real-Time Polymerase Chain Reaction on Paired Nasopharyngeal Swab Samples.

Kristina Elfving, Deler Shakely, Maria Andersson, Kimberly Baltzell, Mwinyi I Msellem, Anders Björkman, Andreas Mårtensson, Max Petzold, Birger Trollfors, Magnus Lindh,

BACKGROUND:New molecular methods have revealed frequent and often polymicrobial respiratory infections in children in low-income settings. It is not known whether presence of multiple pathogens is due to prolonged infections or to frequent exposure. The aim of this study was to analyze short-term pathogen clearance from nasopharynx and the rate ... Read more >>

Pediatr. Infect. Dis. J. (The Pediatric infectious disease journal)
[2018, 37(7):643-648]

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Comparison of reactivity to a metallic disc and 2% aluminium salt in 366 children, and reproducibility over time for 241 young adults with childhood vaccine-related aluminium contact allergy.

Anette Gente Lidholm, Annica Inerot, Martin Gillstedt, Elisabet Bergfors, Birger Trollfors,

BACKGROUND:An aluminium hydroxide-adsorbed pertussis toxoid vaccine was studied in 76 000 children in the 1990s in Gothenburg, Sweden. Long-lasting itchy subcutaneous nodules at the vaccination site were seen in 745 participants. Of 495 children with itchy nodules who were patch tested for aluminium allergy, 377 were positive. In 2007-2008, 241 of ... Read more >>

Contact Derm. (Contact dermatitis)
[2018, 79(1):26-30]

Cited: 1 time

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Replik till Läkemedelsverket: - Risken för tandbiverkningar av doxycyklin är negligerbar.

Daniel Bremell, Birger Trollfors,

Lakartidningen (Lakartidningen)
[2017, 114:]

Cited: 0 times

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Rapid Clearance and Frequent Reinfection With Enteric Pathogens Among Children With Acute Diarrhea in Zanzibar.

Maria Eva Andersson, Kristina Elfving, Deler Shakely, Staffan Nilsson, Mwinyi Msellem, Birger Trollfors, Andreas Mårtensson, Anders Björkman, Magnus Lindh,

Acute infectious gastroenteritis is an important cause of illness and death among children in low-income countries. In addition to rotavirus vaccination, actions to improve nutrition status, sanitation, and water quality are important to reduce enteric infections, which are frequent also among asymptomatic children. The aim of this study was to ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2017, 65(8):1371-1377]

Cited: 2 times

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Neuroborreliosis in Swedish Children: A Population-based Study on Incidence and Clinical Characteristics.

Liv Södermark, Vignir Sigurdsson, Wilhelmina Näs, Pernilla Wall, Birger Trollfors,

Borrelia burgdorferi is a common cause of bacterial meningitis, but there are very few studies on incidence in Europe. The aim of this study was to report the incidence and symptoms of neuroborreliosis in Swedish children.Medical records of children (< 15 years) treated for neuroborreliosis 2002-2014 were studied retrospectively. The ... Read more >>

Pediatr. Infect. Dis. J. (The Pediatric infectious disease journal)
[2017, 36(11):1052-1056]

Cited: 2 times

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[Doxycycline can be given to children without risk of staining of teeth].

Daniel Bremell, Birger Trollfors,

Doxycycline can be given to children without risk of staining of teeth In Sweden, several hundred children are treated for Lyme neuroborreliosis annually, the majority of which are treated with intravenous ceftriaxone. Older tetracycline class antibiotics can cause permanent staining of the teeth. For doxycycline this has never been shown. ... Read more >>

Lakartidningen (Lakartidningen)
[2017, 114:]

Cited: 0 times

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Relation between BCG vaccine scar and an interferon-gamma release assay in immigrant children with "positive" tuberculin skin test (≥10 mm).

Margret Johansson Gudjónsdóttir, Karsten Kötz, Ruth Stangebye Nielsen, Philip Wilmar, Sofia Olausson, Daniel Wallmyr, Birger Trollfors,

Immigrants from countries with high incidence of tuberculosis (TB) are usually offered screening when they arrive to low incidence countries. The tuberculin skin test (TST) is often used. The interferon gamma release assays (IGRAs) are more specific and not affected by BCG vaccination. The aims of this study were 1. ... Read more >>

BMC Infect. Dis. (BMC infectious diseases)
[2016, 16(1):540]

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Epidemiology of invasive pneumococcal infections: manifestations, incidence and case fatality rate correlated to age, gender and risk factors.

Erik Backhaus, Stefan Berg, Rune Andersson, Gunilla Ockborn, Petter Malmström, Mats Dahl, Salmir Nasic, Birger Trollfors,

Incidence, manifestations and case-fatality rate (CFR) of invasive pneumococcal disease (IPD) vary with age and comorbidities. New vaccines, changing age distribution, prolonged survival among immunocompromised patients and improved sepsis management have created a need for an update of basic facts to inform vaccine recommendations.Age, gender and comorbidities were related to ... Read more >>

BMC Infect. Dis. (BMC infectious diseases)
[2016, 16:367]

Cited: 17 times

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Acute Uncomplicated Febrile Illness in Children Aged 2-59 months in Zanzibar - Aetiologies, Antibiotic Treatment and Outcome.

Kristina Elfving, Deler Shakely, Maria Andersson, Kimberly Baltzell, Abdullah S Ali, Marc Bachelard, Kerstin I Falk, Annika Ljung, Mwinyi I Msellem, Rahila S Omar, Philippe Parola, Weiping Xu, Max Petzold, Birger Trollfors, Anders Björkman, Magnus Lindh, Andreas Mårtensson,

BACKGROUND:Despite the fact that a large proportion of children with fever in Africa present at primary health care facilities, few studies have been designed to specifically study the causes of uncomplicated childhood febrile illness at this level of care, especially in areas like Zanzibar that has recently undergone a dramatic ... Read more >>

PLoS ONE (PloS one)
[2016, 11(1):e0146054]

Cited: 20 times

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Serotypes of group B streptococci in western Sweden and comparison with serotypes in two previous studies starting from 1988.

Margrét Johansson Gudjónsdóttir, Elisabet Hentz, Stefan Berg, Erik Backhaus, Anders Elfvin, Samir Kawash, Birger Trollfors,

Group B Streptococci (GBS) are the most common neonatal pathogens and infect immunocompromised and elderly individuals. The species has 10 different serotypes. Serotypes have been studied in the south-west area of Sweden in 1988-1997 and 1998-2001. The aim of this study was to study serotypes in the same area from ... Read more >>

BMC Infect. Dis. (BMC infectious diseases)
[2015, 15:507]

Cited: 4 times

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Incidence, risk factors and hospital burden in children under five years of age hospitalised with respiratory syncytial virus infections.

Charlotta Svensson, Karin Berg, Nele Sigurs, Birger Trollfors,

Respiratory syncytial virus (RSV) infections are among the most common lower respiratory tract infections in infants, but few studies have determined the age-specific incidence of hospitalisation in defined populations. This study gathered Swedish data on RSV in Gothenburg and its 10 surrounding municipalities from 2004 to 2011.Information was obtained from ... Read more >>

Acta Paediatr. (Acta paediatrica (Oslo, Norway : 1992))
[2015, 104(9):922-926]

Cited: 9 times

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Clinical manifestations of invasive pneumococcal disease by vaccine and non-vaccine types.

Sarah Browall, Erik Backhaus, Pontus Naucler, Ilias Galanis, Karin Sjöström, Diana Karlsson, Stefan Berg, Joachim Luthander, Margareta Eriksson, Carl Spindler, Mikael Ejdebäck, Birger Trollfors, Jessica Darenberg, Mats Kalin, Ake Örtqvist, Rune Andersson, Birgitta Henriques-Normark,

Pneumococcal conjugated vaccines (PCVs) have shown protection against invasive pneumococcal disease by vaccine serotypes, but an increase in non-vaccine serotype disease has been observed. Type-specific effects on clinical manifestation need to be explored. Clinical data from 2096 adults and 192 children with invasive pneumococcal disease were correlated to pneumococcal molecular ... Read more >>

Eur. Respir. J. (The European respiratory journal)
[2014, 44(6):1646-1657]

Cited: 14 times

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How common are long-lasting, intensely itching vaccination granulomas and contact allergy to aluminium induced by currently used pediatric vaccines? A prospective cohort study.

Elisabet Bergfors, Göran Hermansson, Ulla Nyström Kronander, Lars Falk, Lars Valter, Birger Trollfors,

The frequency of long-lasting, intensely itching subcutaneous nodules at the injection site for aluminium (Al)-adsorbed vaccines (vaccination granulomas) was investigated in a prospective cohort study comprising 4,758 children who received either a diphtheria-tetanus-pertussis-polio-Haemophilus influenzae type b vaccine (Infanrix®, Pentavac®) alone or concomitant with a pneumococcal conjugate (Prevenar). Both vaccines were ... Read more >>

Eur. J. Pediatr. (European journal of pediatrics)
[2014, 173(10):1297-1307]

Cited: 12 times

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Toward a new vaccine for pertussis.

John B Robbins, Rachel Schneerson, Joanna Kubler-Kielb, Jerry M Keith, Birger Trollfors, Evgeny Vinogradov, Joseph Shiloach,

To overcome the limitations of the current pertussis vaccines, those of limited duration of action and failure to induce direct killing of Bordetella pertussis, a synthetic scheme was devised for preparing a conjugate vaccine composed of the Bordetella bronchiseptica core oligosaccharide with one terminal trisaccharide to aminooxylated BSA via their ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2014, 111(9):3213-3216]

Cited: 14 times

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Burden of severe rotavirus disease leading to hospitalization assessed in a prospective cohort study in Sweden.

Malin Rinder, Anh Nhi Tran, Rutger Bennet, Maria Brytting, Tobias Cassel, Margareta Eriksson, Deborah Frithiof, Leif Gothefors, Jann Storsaeter, Birger Trollfors, Sindri Valdimarsson, Martin Wennerström, Kari Johansen,

BACKGROUND: The aim of this prospective cohort study was to estimate the burden of severe disease caused by rotavirus-induced gastroenteritis in Swedish children aged < 5 y. METHODS: Rotavirus-positive children admitted to hospitals serving 3 geographical regions with 155,838 children aged < 5 y, were offered inclusion in this 1-year ... Read more >>

Scand. J. Infect. Dis. (Scandinavian journal of infectious diseases)
[2014, 46(4):294-302]

Cited: 12 times

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Real-time PCR threshold cycle cutoffs help to identify agents causing acute childhood diarrhea in Zanzibar.

Kristina Elfving, Maria Andersson, Mwinyi I Msellem, Christina Welinder-Olsson, Max Petzold, Anders Björkman, Birger Trollfors, Andreas Mårtensson, Magnus Lindh,

Molecular assays might improve the identification of causes of acute diarrheal disease but might lead to more frequent detection of asymptomatic infections. In the present study, real-time PCR targeting 14 pathogens was applied to rectal swabs from 330 children aged 2 to 59 months in Zanzibar, including 165 patients with ... Read more >>

J. Clin. Microbiol. (Journal of clinical microbiology)
[2014, 52(3):916-923]

Cited: 23 times

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A phase I clinical study of a live attenuated Bordetella pertussis vaccine--BPZE1; a single centre, double-blind, placebo-controlled, dose-escalating study of BPZE1 given intranasally to healthy adult male volunteers.

Rigmor Thorstensson, Birger Trollfors, Nabil Al-Tawil, Maja Jahnmatz, Jakob Bergström, Margaretha Ljungman, Anna Törner, Lena Wehlin, Annie Van Broekhoven, Fons Bosman, Anne-Sophie Debrie, Nathalie Mielcarek, Camille Locht,

Acellular pertussis vaccines do not control pertussis. A new approach to offer protection to infants is necessary. BPZE1, a genetically modified Bordetella pertussis strain, was developed as a live attenuated nasal pertussis vaccine by genetically eliminating or detoxifying 3 toxins.We performed a double-blind, placebo-controlled, dose-escalating study of BPZE1 given intranasally ... Read more >>

PLoS ONE (PloS one)
[2014, 9(1):e83449]

Cited: 46 times

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Experience with monocomponent acellular pertussis combination vaccines for infants, children, adolescents and adults--a review of safety, immunogenicity, efficacy and effectiveness studies and 15 years of field experience.

Birgit Thierry-Carstensen, Tine Dalby, Michael A Stevner, John B Robbins, Rachel Schneerson, Birger Trollfors,

Combination vaccines containing a monocomponent acellular pertussis (aP) vaccine, manufactured at Statens Serum Institut (SSI), Denmark, have successfully controlled Bordetella pertussis infections in Denmark since 1997. The efficacy of this aP vaccine was 71% in a double-blind, randomised and controlled clinical trial. Its safety and immunogenicity have been demonstrated in ... Read more >>

Vaccine (Vaccine)
[2013, 31(45):5178-5191]

Cited: 31 times

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Unexpected loss of contact allergy to aluminium induced by vaccine.

Anette Gente Lidholm, Elisabet Bergfors, Annica Inerot, Ulla Blomgren, Martin Gillstedt, Birger Trollfors,

BACKGROUND: In studies in Gothenburg, Sweden, in the 1990s of an aluminium hydroxide-adsorbed pertussis toxoid vaccine, 745 of ~76 000 vaccinated children developed long-lasting itchy subcutaneous nodules at the vaccination site. Of 495 children with itchy nodules patch tested for aluminium allergy, 376 (76%) were positive. OBJECTIVES: To study the ... Read more >>

Contact Derm. (Contact dermatitis)
[2013, 68(5):286-292]

Cited: 13 times

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Two cases of hemolytic uremic syndrome caused by Streptococcus pneumoniae serotype 3, one being a vaccine failure.

Daniel Novak, Anna Lundgren, Susanne Westphal, Sindri Valdimarsson, Martin L Olsson, Birger Trollfors,

We report two cases of Streptococcus pneumoniae-associated hemolytic uremic syndrome (SP-HUS) caused by serotype 3. One case occurred in an unvaccinated boy and 1 in a girl vaccinated with the 13-valent pneumococcal conjugate vaccine. SP-HUS must be considered in children, and conjugate vaccines may be less effective against serotype 3 ... Read more >>

Scand. J. Infect. Dis. (Scandinavian journal of infectious diseases)
[2013, 45(5):411-414]

Cited: 2 times

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