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Rotation-restricted thermally activated delayed fluorescence compounds for efficient solution-processed OLEDs with EQEs of up to 24.3% and small roll-off.

Kuofei Li, Yunhui Zhu, Bing Yao, Yuannan Chen, Hao Deng, Qisheng Zhang, Hongmei Zhan, Zhiyuan Xie, Yanxiang Cheng,

Two triphenylamine or 4,4'-di(tert-butyl)triphenylamine groups are introduced at the 1,8-positions of 3,6-di(tert-butyl)-9-(4-(4,6-diphenyl-1,3,5-triazin-2-yl)phenyl)carbazole to yield two emitters containing a cofacial donor-acceptor-donor chromophore, which exhibit strong TADF characteristics dominated by through-space charge-transfer. The solution-processed OLEDs achieve maximum external quantum efficiencies of up to 17.4% and 24.3% with small efficiency roll-off rates. ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2020, 56(44):5957-5960]

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Overexpression of microRNA-129-5p in glioblastoma inhibits cell proliferation, migration, and colony-forming ability by targeting ZFP36L1.

Xu Guo, Haozhe Piao, Ye Zhang, Peixin Sun, Bing Yao,

Glioblastoma multiforme (GBM) is a highly invasive cancer with a high recurrence rate. The prognosis of GBM patients remains poor, even after standard surgical resection combined with chemoradiotherapy. Thus, there is an urgent need for new therapeutic targets in GBM. In recent years, microRNAs have received considerable attention due to ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, 20(4):459-470]

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Omega-3 polyunsaturated fatty acids alleviate hydrogen sulfide-induced blood-testis barrier disruption in the testes of adult mice.

Shuxian Wang, Qiwei Chen, Yu Zhang, Feng Zheng, Tongmin Xue, Xie Ge, Rujun Ma, Xiaoyan Li, Ronghua Wu, Kuan Liang, Zhang Qian, Yifeng Ge, Jinzhao Ma, Bing Yao,

Hydrogen sulfide (H2S), a gaseous intracellular signal transducer, participates in multiple physiological and pathological conditions, including reproductive conditions, and disrupts spermatogenesis. The blood-testis barrier (BTB) plays a vital role in spermatogenesis. However, the effect of H2S on the BTB and the underlying mechanism remain unclear. Herein, we examined the effect ... Read more >>

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2020, :]

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PD-L1 lncRNA splice promotes lung adenocarcinoma progression via enhancing c-Myc activity

Shuang Qu, Zichen Jiao, Geng Lu, Bing Yao, Ting Wang, Weiwei Rong, Jiahan Xu, Ting Fan, Xinlei Sun, Rong Yang, Jun Wang, Yongzhong Yao, Guifang Xu, Xin Yan, Tao Wang, Hongwei Liang, Ke Zen,

ABSTRACT Although blockade of programmed death-ligand 1 (PD-L1) to enhance T cell immune responses shows great promise in tumor immunotherapy, the efficacy of such immune-checkpoint inhibition strategy is limited for patients with solid tumors. The mechanism underlying the limited efficacy of PD-L1 inhibitors remains unclear. Here, we show that human ... Read more >>

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A novel N6-methyladenosine (m6A)-dependent fate decision for the lncRNA THOR.

Hongmei Liu, Yuxin Xu, Bing Yao, Tingting Sui, Liangxue Lai, Zhanjun Li,

Previous studies have revealed the critical roles of the N6-methyladenosine (m6A) modification of long non-coding RNAs (lncRNAs) in cancers, but the relationship between the oncogenic role of the lncRNA THOR (a representative of cancer/testis lncRNAs) and m6A modification remains unclear. Here, we show that the internal m6A modification of the ... Read more >>

Cell Death Dis (Cell death & disease)
[2020, 11(8):613]

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Oxidized-LDL inhibits testosterone biosynthesis by affecting mitochondrial function and the p38 MAPK/COX-2 signaling pathway in Leydig cells.

Jun Jing, Ning Ding, Dandan Wang, Xie Ge, Jinzhao Ma, Rujun Ma, Xuan Huang, Kadiliya Jueraitetibaike, Kuan Liang, Shuxian Wang, Siyuan Cao, Allan Zijian Zhao, Bing Yao,

Abnormal lipid/lipoprotein metabolism induced by obesity may affect spermatogenesis by inhibiting testosterone synthesis in Leydig cells. It is crucial to determine which components of lipoproteins inhibit testosterone synthesis. Circulating oxidized low-density lipoprotein (oxLDL), the oxidized form of LDL, has been reported to be an independent risk factor for decreased serum ... Read more >>

Cell Death Dis (Cell death & disease)
[2020, 11(8):626]

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Exposure to per- and polyfluoroalkyl substances (PFASs) in serum versus semen and their association with male reproductive hormones.

Qianqian Cui, Yitao Pan, Jinghua Wang, Hongxiu Liu, Bing Yao, Jiayin Dai,

Given that per- and polyfluoroalkyl substances (PFASs) exhibit different distribution in the serum and semen of adult men, improving our understanding of the predictors of PFAS concentrations in paired serum and semen samples from an individual is essential. Here, we investigated and compared the effects of emerging and legacy PFAS ... Read more >>

Environ Pollut (Environmental pollution (Barking, Essex : 1987))
[2020, 266(Pt 2):115330]

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Circulating sex hormone levels in relation to male sperm quality.

Wei Zhao, Jun Jing, Yong Shao, Rong Zeng, Cencen Wang, Bing Yao, Dong Hang,

BACKGROUND:Although sex hormones play critical roles in spermatogenesis and sperm maturation, it remains inconclusive whether circulating sex hormones can serve as non-invasive biomarkers to improve the assessment of sperm quality. METHODS:We systematically evaluated the association of various sex hormones in serum with sperm quality among 338 men in subfertile couples. ... Read more >>

BMC Urol (BMC urology)
[2020, 20(1):101]

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Nitratireductor alexandrii sp. nov., from phycosphere microbiota of toxic marine dinoflagellate Alexandrium tamarense.

Zhiwei Jiang, Yuhan Duan, Xi Yang, Bing Yao, Teer Zeng, Xiaoyan Wang, Qi Feng, Min Qi, Qiao Yang, Xiaoling Zhang,

A taxonomic study was carried out on a novel algae-associated bacterial strain Z3-1T, which was isolated from phycosphere microbiota of toxic marine dinoflagellate Alexandrium tamarense 880. Cells of strain Z3-1T were Gram-stain-negative, rod-shaped and strictly aerobic and were motile by means of flagella. Strain Z3-1T grew at 25-42 °C, pH ... Read more >>

Int. J. Syst. Evol. Microbiol. (International journal of systematic and evolutionary microbiology)
[2020, 70(7):4390-4397]

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Identification and validation of glycolysis-related signatures for prognosis in patients with breast cancer

Ming Zhang, Mengying Xing, Yunfei Ma, Bing Yao, Xiang Chen, Changyan Ma,

Abstract Background : Emerging evidence has demonstrated roles of glycolysis in the tumorigenesis and progression of human tumors. However, their underlying clinical implications have not been well elucidated in breast cancer. In present study, we aimed to generate a risk-score from glycolysis-related signatures to predict prognosis of patients with breast ... Read more >>

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Absence of 2019 novel coronavirus in semen and testes of COVID-19 patients†.

Ci Song, Yan Wang, Weiqin Li, Bicheng Hu, Guohua Chen, Ping Xia, Wei Wang, Chaojun Li, Feiyang Diao, Zhibin Hu, Xiaoyu Yang, Bing Yao, Yun Liu,

Biol. Reprod. (Biology of reproduction)
[2020, 103(1):4-6]

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Circulating sex hormone levels in relation to male sperm quality

Wei Zhao, Jun Jing, Yong Shao, Rong Zeng, Cencen Wang, Dong Hang, Bing Yao,

Abstract Background Although sex hormones play critical roles in spermatogenesis and sperm maturation, it remains inconclusive whether circulating sex hormones can serve as non-invasive biomarkers to improve the assessment of sperm quality. Methods We systematically evaluated the association of various sex hormones in serum with sperm quality among 338 men ... Read more >>

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Mitochondria-related miR-574 reduces sperm ATP by targeting ND5 in aging males.

Jinzhao Ma, Qiwei Chen, Shuxian Wang, Rujun Ma, Jun Jing, Yang Yang, Yuming Feng, Zhichuan Zou, Yu Zhang, Xie Ge, Tongmin Xue, Kuan Liang, Siyuan Cao, Dandan Wang, Li Chen, Bing Yao,

Couples are delaying childbearing in recent decades. While women experience a notable decrease in oocyte production in their late thirties, the effect of advanced paternal age on reproduction is incompletely understood. Herein, we observed that numerous miRNAs, including miR-574, increased in the sperm of aging males, as indicated by high-throughput ... Read more >>

Aging (Albany NY) (Aging)
[2020, 12(9):8321-8338]

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Reply to the comment.

Ning Ding, Fang Hong Li, Bing Yao, Yun Ping Mu, Allan Z Zhao,

Gut (Gut)
[2020, :]

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PRMT5-dependent transcriptional repression of c-Myc target genes promotes gastric cancer progression.

Ming Liu, Bing Yao, Tao Gui, Chan Guo, Xiaobin Wu, Jiahuang Li, Lingling Ma, Yexuan Deng, Peipei Xu, Ying Wang, Dongjun Yang, Qixiang Li, Xiangwei Zeng, Xinyu Li, Ruifeng Hu, Jingru Ge, Zenong Yu, Yugen Chen, Bing Chen, Junyi Ju, Quan Zhao,

The proto-oncogene c-Myc regulates multiple biological processes mainly through selectively activating gene expression. However, the mechanisms underlying c-Myc-mediated gene repression in the context of cancer remain less clear. This study aimed to clarify the role of PRMT5 in the transcriptional repression of c-Myc target genes in gastric cancer. Methods: Immunohistochemistry ... Read more >>

Theranostics (Theranostics)
[2020, 10(10):4437-4452]

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CRISPR/Cas9-mediated Disruption of Fibroblast Growth Factor 5 in Rabbits Results in a Systemic Long Hair Phenotype by Prolonging Anagen.

Yuxin Xu, Hongmei Liu, Huilin Pan, Xinyue Wang, Yuxin Zhang, Bing Yao, Nannan Li, Liangxue Lai, Zhanjun Li,

Hair growth and morphology are generally regulated by the hair cycle in mammals. Fibroblast Growth Factor 5 (FGF5), which is a hair cycle regulator, has a role in regulating the hair cycle during the transition from the anagen phase to the catagen phase, and a hereditary long hair phenotype has ... Read more >>

Genes (Basel) (Genes)
[2020, 11(3):]

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The minimal promoter (P1) of Xist is non-essential for X chromosome inactivation.

Bing Yao, Mingming Liang, Hongmei Liu, Tingting Sui, Yuning Song, Yuxin Zhang, Jichao Deng, Yuxin Xu, Liangxue Lai, Zhanjun Li,

The previous report shows the minimal promoter (P1) contributes to the Xist RNA activation in cells, while the role of the Xist P1 has not yet been investigated in animal individuals. Here, female Xist P1 knockout rabbits (Xist P1-/-) were generated for the studies. The results showed that there is ... Read more >>

RNA Biol (RNA biology)
[2020, 17(5):623-629]

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Ochratoxin A in human blood plasma samples from apparently healthy volunteers in Nanjing, China.

Kai Fan, Xi Cheng, Wenbo Guo, Xing Liu, Zhiqi Zhang, Qi Yao, Dongxie Nie, Bing Yao, Zheng Han,

This study was conducted to investigate the exposure to ochratoxin A (OTA) of populations living in Nanjing, China. Plasma samples were collected from 147 healthy adults (age 18-63 years) and analyzed for OTA by a reliable and sensitive ultra-high-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method (limit of detection 0.04 ng/mL). After ... Read more >>

Mycotoxin Res (Mycotoxin research)
[2020, 36(3):269-276]

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Brain microRNAs associated with late-life depressive symptoms are also associated with cognitive trajectory and dementia.

Thomas S Wingo, Jingjing Yang, Wen Fan, Se Min Canon, Ekaterina Sergeevna Gerasimov, Adriana Lori, Benjamin Logsdon, Bing Yao, Nicholas T Seyfried, James J Lah, Allan I Levey, Patricia A Boyle, Julia A Schneider, Philip L De Jager, David A Bennett, Aliza P Wingo,

Late-life depression is associated with an increased risk for dementia but we have limited knowledge of the molecular mechanisms underlying this association. Here we investigated whether brain microRNAs, important posttranscriptional regulators of gene expression, contribute to this association. Late-life depressive symptoms were assessed annually in 300 participants of the Religious ... Read more >>

NPJ Genom Med (NPJ genomic medicine)
[2020, 5:6]

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Impairment of spermatogenesis and sperm motility by the high-fat diet-induced dysbiosis of gut microbes.

Ning Ding, Xin Zhang, Xue Di Zhang, Jun Jing, Shan Shan Liu, Yun Ping Mu, Li Li Peng, Yun Jing Yan, Geng Miao Xiao, Xin Yun Bi, Hao Chen, Fang Hong Li, Bing Yao, Allan Z Zhao,

OBJECTIVE:High-fat diet (HFD)-induced metabolic disorders can lead to impaired sperm production. We aim to investigate if HFD-induced gut microbiota dysbiosis can functionally influence spermatogenesis and sperm motility. DESIGN:Faecal microbes derived from the HFD-fed or normal diet (ND)-fed male mice were transplanted to the mice maintained on ND. The gut microbes, ... Read more >>

Gut (Gut)
[2020, 69(9):1608-1619]

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Sequential interval micro-droplet loading in closed hemi-straw carrier system: A convenient and efficient method for ultra-rapid cryopreservation in extreme oligozoospermia.

Wu-Jian Huang, Duo Zhang, Zhi-Wei Hong, Zhi-Biao Chen, Li-Hong Dong, Yan Zhang, Guo-Yong Chen, Yun Liu, Bing Yao,

Cryopreservation of human spermatozoa with low concentration while maintaining adequate post-thawing motility remains a major challenge for male fertility preservation. A convenient and efficient ultra-rapid freezing method for small amounts of human spermatozoa in a closed Hemi-Straw carrier system (CHS) was developed. Spermatozoa from 60 healthy men were involved in ... Read more >>

Cryobiology (Cryobiology)
[2020, 93:75-83]

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Transforming growth factor-β1-regulated Fas/FasL pathway activation suppresses nucleus pulposus cell apoptosis in an inflammatory environment.

Jingjing Xie, Bo Li, Bing Yao, Pingchao Zhang, Lixin Wang, Hua Lu, Xuan Song,

BACKGROUND:During disc degeneration, inflammatory cytokine tumor necrosis factor (TNF)-α is correlated with nucleus pulposus (NP) cell apoptosis. Transforming growth factor (TGF)-β1 has the potential to regenerate degenerative disc. OBJECTIVE:To investigate the protective role of TGF-β1 against TNF-α-mediated NP cell apoptosis and the underlying mechanism. METHODS:Rat NP cells were treated with ... Read more >>

Biosci Rep (Bioscience reports)
[2020, 40(2):]

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Profiles of Emerging and Legacy Per-/Polyfluoroalkyl Substances in Matched Serum and Semen Samples: New Implications for Human Semen Quality.

Yitao Pan, Qianqian Cui, Jinghua Wang, Nan Sheng, Jun Jing, Bing Yao, Jiayin Dai,

BACKGROUND:Epidemiological evidence remains equivocal on the associations between environmentally relevant levels of per-/polyfluoroalkyl substances (PFASs) and human semen quality. OBJECTIVES:We aimed to test whether the potential effects on semen quality could be better observed when seminal PFAS levels were used as an exposure marker compared with serum PFAS levels. METHODS:Matched ... Read more >>

Environ. Health Perspect. (Environmental health perspectives)
[2019, 127(12):127005]

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circMeta: a unified computational framework for genomic feature annotation and differential expression analysis of circular RNAs.

Li Chen, Feng Wang, Emily C Bruggeman, Chao Li, Bing Yao,

MOTIVATION:Circular RNAs (circRNAs), a class of non-coding RNAs generated from non-canonical back-splicing events, have emerged to play key roles in many biological processes. Though numerous tools have been developed to detect circRNAs from rRNA-depleted RNA-seq data based on back-splicing junction-spanning reads, computational tools to identify critical genomic features regulating circRNA ... Read more >>

Bioinformatics (Bioinformatics (Oxford, England))
[2020, 36(2):539-545]

Cited: 3 times

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[Correlation between follicular fluid sRAGE level and ovarian responsiveness in non-PCOS patients undergoing controlled ovarian hyperstimulation].

Meiling Li, Yong Shao, Haiyan Fu, Cheng Zhou, Bing Yao, Yong Tan,

OBJECTIVE:To investigate the correlation between soluble receptor for advanced glycation end products (sRAGE) level in the follicular fluid and ovarian responsiveness in non-PCOS patients undergoing controlled ovarian hyperstimulation. METHODS:Ninety non-PCOS patients underwent IVF/ICSI using a short-acting long protocol for ovarian stimulation with a GnRH agonist. For each patient, the level ... Read more >>

Nan Fang Yi Ke Da Xue Xue Bao (Nan fang yi ke da xue xue bao = Journal of Southern Medical University)
[2019, 39(12):1482-1486]

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