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Biomimetic two-dimensional nanozymes: synthesis, hybridization, functional tailoring, and biosensor applications.

Bin Liu, Yan Wang, Yun Chen, Lei Guo, Gang Wei,

Biological enzymes play important roles in mediating the biological reactions in vitro and in vivo due to their high catalytic activity, strong bioactivity, and high specificity; however, they have also some disadvantages such as high cost, low environmental stability, weak reusability, and difficult production. To overcome these shortcomings, functional nanomaterials ... Read more >>

J Mater Chem B (Journal of materials chemistry. B)
[2020, 8(44):10065-10086]

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Recent advances in the fabrication, functionalization, and bioapplications of peptide hydrogels.

Yan Wang, Wensi Zhang, Coucong Gong, Bin Liu, Yiduo Li, Luchen Wang, Zhiqiang Su, Gang Wei,

Self-assembled peptide-based nanomaterials have exhibited wide application potential in the fields of materials science, nanodevices, biomedicine, tissue engineering, biosensors, energy storage, environmental science, and others. Due to their porous structure, strong mechanical stability, high biocompatibility, and easy functionalization, three-dimensional self-assembled peptide hydrogels revealed promising potential in bio-related applications. To present ... Read more >>

Soft Matter (Soft matter)
[2020, 16(44):10029-10045]

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Silver nanoparticles coated by green graphene quantum dots for accelerating the healing of MRSA-infected wounds.

Xianghua Zhong, Chunyi Tong, Tiansheng Liu, Li Li, Xu Liu, Yuejun Yang, Rushi Liu, Bin Liu,

Bacterial infection, especially multidrug-resistant bacteria-induced infection, threatens human health seriously, which has posed great challenges for clinical therapy. The overuse of conventional antibiotics has given rise to bacterial resistance that severely restricts the clinical treatment options of conventional antibiotics. The development of highly effective antibacterial materials and therapeutic strategies to ... Read more >>

Biomater Sci (Biomaterials science)
[2020, 8(23):6670-6682]

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PEGylated WS2 nanodrug system with erythrocyte membrane coating for chemo/photothermal therapy of cervical cancer.

Ying Long, Xianjin Wu, Zhen Li, Jialong Fan, Xing Hu, Bin Liu,

The side effects of chemical drugs and multi-drug resistance are serious obstacles hindering efficient tumor therapy. Therefore, recently, the combination of chemo/photothermal therapy (CT/PT) has been adopted to address these issues using a low drug dosage. However, the development of multi-functional drug delivery systems with improved immune escape capability and ... Read more >>

Biomater Sci (Biomaterials science)
[2020, 8(18):5088-5105]

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Ganoderic acid A from Ganoderma lucidum ameliorates lipid metabolism and alters gut microbiota composition in hyperlipidemic mice fed a high-fat diet.

Wei-Ling Guo, Jian-Bin Guo, Bin-Yu Liu, Jin-Qiang Lu, Min Chen, Bin Liu, Wei-Dong Bai, Ping-Fan Rao, Li Ni, Xu-Cong Lv,

Ganoderic acid A (GA) is one of the most abundant triterpenoids in Ganoderma lucidum, and has been proved to possess a wide range of beneficial health effects. The aim of the current study is to investigate the amelioration effects and mechanism of GA on improving hyperlipidemia in mice fed a ... Read more >>

Food Funct (Food & function)
[2020, 11(8):6818-6833]

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Gold nanoparticle-engineered electrochemical aptamer biosensor for ultrasensitive detection of thrombin.

Ying Chen, Junyi Xiang, Bin Liu, Zhengbo Chen, Xia Zuo,

In order to obtain a lower detection limit in electrochemical detection, the choice of signal amplification strategy is of great importance. In this work, we describe an electrochemical sandwich aptasensor based on a signal amplification system involving two thrombin (TB) aptamers (TBA1 and TBA2), gold nanoparticles (AuNPs) as aptamer carriers, ... Read more >>

Anal Methods (Analytical methods : advancing methods and applications)
[2020, 12(29):3729-3733]

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A [email protected] heterostructure for sodium-ion storage with enhanced kinetics.

Yemao Lin, Xiaodong Guo, Mingjun Hu, Bin Liu, Yucheng Dong, Xin Wang, Neng Li, Hong-En Wang,

Layered metal sulphides are promising anode materials for sodium-ion batteries (SIBs) and capacitors owing to their distinctive crystal structures and large interlayer spacings, which are suitable for Na+ insertion/extraction. However, low electronic conductivity, sluggish ion transfer and large volume variation of metal sulphides during sodiation/desodiation processes have hindered their practical ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(27):14689-14698]

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Colorimetric discriminatory array for detection and discrimination of antioxidants based on HAuCl4/3,3',5,5'-tetramethylbenzidine.

Bin Liu, Ying Chen, Mingqian Zhang, Zhengbo Chen, Xia Zuo,

Here, we report a simple but effective nose/tongue-mimic sensor array based on HAuCl4/3,3',5,5'-tetramethylbenzidine (TMB) for colorimetric discrimination and determination of antioxidants. Two concentrations of HAuCl4 were employed as receptor units to construct the colorimetric sensor array. The sensing strategy is based on the fact that HAuCl4 with different concentrations (0.08 ... Read more >>

Analyst (The Analyst)
[2020, 145(15):5221-5225]

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[email protected] mesenchymal stem cells as an "oxygen-laden guided-missile" for the enhanced photodynamic therapy on lung cancer.

Wen Cao, Bin Liu, Fangfang Xia, Meng Duan, Yuping Hong, Jiaqi Niu, Lirui Wang, Yanlei Liu, Can Li, Daxiang Cui,

The critical issue in nanoscale medicine delivery systems is the targeted efficiency to guarantee the maximum accumulation of nanodrugs in tumors to exert better therapeutic action. In this study, we adopted an active and potent strategy based on mesenchymal stem cells (MSCs) certified with excellent tumor-tropism ability to load and ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(5):3090-3102]

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Enhancing magnetic hardness by sonication assisted synthesis of heterometallic carbonato spin-glass Na[Ni(H2O)4Ru2(CO3)4]·3H2O.

Jing-Yu Li, Yu-Chen Tian, Li-Na Feng, Zi-Qin Zhou, Lin-Lin Wang, Jian-Hui Yang, Bin Liu,

Control of magnetic performances of molecular magnets is essential but few efforts have been documented. A green and efficient sonication assisted synthesis of a new heterometallic diruthenium(ii,iii) carbonate, Na[Ni(H2O)4Ru2(CO3)4]·3H2O (1), was carried out by self-assembling in aqueous solution. Compound 1 exhibits spin-glass behavior below ∼5.0 K, and a systematic investigation ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2020, 56(9):1369-1372]

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The construction of enzymolyzed α-lactalbumin based micellar nanoassemblies for encapsulating various kinds of hydrophobic bioactive compounds.

Yulin Hu, Cheng Bao, Dan Li, Lingxin You, Yizheng Du, Bin Liu, Xin Li, Fazheng Ren, Yuan Li,

Protein-based nanoassemblies can encapsulate hydrophobic compounds into their hydrophobic region and effectively improve their aqueous solubility and stability. However, hydrolyzed food protein based micellar nanoassemblies and their interaction with different hydrophobic compounds are less understood. Here, 20 nm α-lactalbumin (α-lac) micellar nanoassemblies were constructed via self-assembly of partially hydrolyzed α-lac ... Read more >>

Food Funct (Food & function)
[2019, 10(12):8263-8272]

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A modular approach for cytosolic protein delivery: metal ion-induced self-assembly of gold nanoclusters as a general platform.

Lirui Wang, Chunlei Zhang, Tianliang Li, Meng Duan, Fangfang Xia, Xinhong Li, Cunfeng Song, Shaojun Pan, Bin Liu, Daxiang Cui,

We developed a versatile and modular method for cytosolic protein delivery through metal ion-induced co-assembly of gold nanoclusters and proteins into supramolecular assemblies. The versatility and high efficiency of this strategy to assemble and deliver various proteins into living cells were demonstrated. Importantly, the activity of proteins was maintained during ... Read more >>

Nanoscale (Nanoscale)
[2019, 11(46):22237-22242]

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Early Diagnosed Gestational Diabetes Mellitus Is Associated With Adverse Pregnancy Outcomes: A Prospective Cohort Study.

Bin Liu, Jian Cai, Yun Xu, Yuhang Long, Langhui Deng, Suiwen Lin, Jinxin Zhang, Jianbo Yang, Lieqiang Zhong, Yanmin Luo, Yi Zhou, Ying Zhang, Zhuyu Li, Hanqing Chen, Zilian Wang,

CONTEXT:The significance of an early diagnosis of gestational diabetes mellitus (GDM) with oral glucose tolerance test (OGTT) has not been determined. OBJECTIVE:The objective of this work is to investigate GDM diagnosed by early and standard OGTTs and determine adverse maternal and neonatal outcomes associated with early GDM diagnosis. RESEARCH DESIGN ... Read more >>

J Clin Endocrinol Metab (The Journal of clinical endocrinology and metabolism)
[2020, 105(12):]

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The effect of fluid shear stress on fibroblasts and stem cells on plane and groove topographies.

Xing Lei, Bin Liu, Hao Wu, Xiao Wu, Xiu-Li Wang, Yue Song, Shuai-Shuai Zhang, Jun-Qin Li, Long Bi, Guo-Xian Pei,

In this study, we aimed to study the effect of fluid shear stress on fibroblasts and BMSCs on plane and groove topographies. The results showed that 0.6-Hz stress had the greatest influence on the alignment, polarity, migration and adhesion of fibroblasts on plane by increasing the expression of reoriented actin ... Read more >>

Cell Adh Migr (Cell adhesion & migration)
[2020, 14(1):12-23]

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Precise Puncture Combined With Simplified Percutaneous Vertebroplasty to Treat Osteoporotic Vertebral Compression Fractures: A Comparative Analysis With Conventional Percutaneous Vertebroplasty

Ju-tao Pang, Hong Chen, Bin Liu, Xin-hu Zhang,

Abstract ObjectiveThis study aimed to investigate the feasibility and clinical efficacy of precise puncture combined with simplified percutaneous vertebroplasty (PVP) for treating osteoporotic vertebral compression fractures (OVCF).MethodsA total of 82 patients with single-segment osteoporotic vertebral compression fractures (OVCF) were treated with PVP from Dec. 2016 to Nov. 2018. Among the ... Read more >>

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A Domino Fusion of an Organic ligand Depended on Metal-Induced and Oxygen Insertion, Unraveled by Crystallography, Mass Spectrometry and DFT Calculation.

Minghua Zeng, Jin-Ming Chen, Liang Peng, Fu-Fang Zhou, Bin Liu, Cheng Hou, Jia-Wei Li, Zhou Huang, Mohamedally Kurmoo,

Here, we report the reaction, CH 3 CN at 120 °C, of (1-methyl-1H-benzo[d]imidazol-2-yl)methanamine ( L1 ) with Co(H 2 O) 6 Cl 2 leading to the 2,3,5,6-tetrakis(1-methyl-1H-benzo[d]imidazol-2-yl)pyrazine ( 3 ), isolated as a dimeric cluster {[Co II 2 ( 3 )Cl 4 ]∙2CH 3 CN} ( 2 ). When O ... Read more >>

Chemistry (Chemistry (Weinheim an der Bergstrasse, Germany))
[2020, :]

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Emergence of low-symmetry foldamers from single monomers.

Charalampos G Pappas, Pradeep K Mandal, Bin Liu, Brice Kauffmann, Xiaoming Miao, Dávid Komáromy, Waldemar Hoffmann, Christian Manz, Rayoon Chang, Kai Liu, Kevin Pagel, Ivan Huc, Sijbren Otto,

Self-assembly is a powerful method to obtain large discrete functional molecular architectures. When using a single building block, self-assembly generally yields symmetrical objects in which all the subunits relate similarly to their neighbours. Here we report the discovery of a family of self-constructing cyclic macromolecules with stable folded conformations of ... Read more >>

Nat Chem (Nature chemistry)
[2020, 12(12):1180-1186]

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Maximum chest CT score is associated with progression to severe illness in patients with COVID-19: A retrospective study from Wuhan, China

Jianwei Xiao, Xiang Li, Yuanliang Xie, Zengfa Huang, Yi Ding, Shengchao Zhao, Pei Yang, Dan Du, Bin Liu, xiang wang,

Abstract Background: The Coronavirus Disease 2019 (COVID-19) pandemic is a world-wide health crisis. Limited information is available regarding which patients will experience more severe disease symptoms. We evaluated hospitalized patients who were initially diagnosed with moderate COVID-19 for clinical parameters and radiological feature that showed an association with progression to ... Read more >>

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Repeated subarachnoid administrations of allogeneic human umbilical cord mesenchymal stem cells for spinal cord injury: a phase 1/2 pilot study.

Yang Yang, Mao Pang, Cong Du, Zhong-Yu Liu, Zi-Hao Chen, Nan-Xiang Wang, Liang-Ming Zhang, Yu-Yong Chen, Jian Mo, Jian-Wen Dong, Pei-Gen Xie, Qi-You Wang, Bin Liu, Li-Min Rong,

BACKGROUND AIMS:Stem cell transplantation is a potential treatment for intractable spinal cord injury (SCI), and allogeneic human umbilical cord mesenchymal stem cells (hUC-MSCs) are a promising candidate because of the advantages of immune privilege, paracrine effect, immunomodulatory function, convenient collection procedure and little ethical concern, and there is an urgent ... Read more >>

Cytotherapy (Cytotherapy)
[2020, :]

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Explore prognostic biomarker of bladder cancer based on competing endogenous network.

Faping Li, Hui Guo, Bin Liu, Nian Liu, Zhixiang Xu, Yishu Wang, Honglan Zhou,

Bladder cancer (BC) is the most common tumor of the urinary tract. Increasing evidence showed that long non-coding RNA (lncRNA) is a critical regulator in cancer development and progression. However, the functions of lncRNAs in the development of BC remain mostly undefined. In this study, based on RNA sequence profiles ... Read more >>

Biosci Rep (Bioscience reports)
[2020, :]

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Effect of anthocyanin-absorbed whey protein microgels on physicochemical and textural properties of reduced-fat Cheddar cheese.

Pengcheng Wen, Yanli Zhu, Jie Luo, Pengjie Wang, Bin Liu, Yizheng Du, Yaoyao Jiao, Yulin Hu, Chong Chen, Fazheng Ren, Calderón-Urrea Alejandro, Yuan Li,

Reduced-fat foods have become more popular due to their health benefits; however, reducing the fat content of food affects the sensory experience. Therefore, it is necessary to improve the sensory acceptance of reduced-fat foods to that of full-fat equivalents. The aim of this study was to evaluate the effect of ... Read more >>

J Dairy Sci (Journal of dairy science)
[2020, :]

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Genome-Wide Gene Expression Profiles Analysis Reveal Novel Insights into Drought Stress in Foxtail Millet (Setaria italica L.).

Ling Qin, Erying Chen, Feifei Li, Xiao Yu, Zhenyu Liu, Yanbing Yang, Runfeng Wang, Huawen Zhang, Hailian Wang, Bin Liu, Yan'an Guan, Ying Ruan,

Foxtail millet (Setaria italica (L.) P. Beauv) is an important food and forage crop because of its health benefits and adaptation to drought stress; however, reports of transcriptomic analysis of genes responding to re-watering after drought stress in foxtail millet are rare. The present study evaluated physiological parameters, such as ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(22):]

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ILF3 Mediated BMP2 and STAT1 Transcription Is Responsible for Hyperlipidemia-Induced Arteriosclerotic Calcification

Fei Xie, Zhao-yang Wang, Bin Liu, Wen Qiao, Na Li, Jie Cheng, Ya-min Hou, Xin-ying Dong, Yuguo Chen, Ming-xiang Zhang,

Abstract Calcification is common in atherosclerotic plaque and can induce vulnerability, which further leads to myocardial infarction, plaque rupture and stroke. The mechanisms of atherosclerotic calcification are poorly characterized. Interleukin enhancer binding factor 3 (ILF3) has been identified as a novel factor affecting dyslipidemia and stroke subtypes. However, the precise ... Read more >>

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Proteogenomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes and Identifies Therapeutic Targets.

Renata Ferrarotto, Yoshitsugu Mitani, Daniel J McGrail, Kaiyi Li, Tatiana V Karpinets, Diana Bell, Steven J Frank, Xingzhi Song, Michael E Kupferman, Bin Liu, J Jack Lee, Bonnie S Glisson, Jianhua Zhang, Jon C Aster, Shiaw-Yih Lin, P Andrew Futreal, John V Heymach, Adel K El-Naggar,

PURPOSE:Salivary gland adenoid cystic carcinoma (ACC) has heterogeneous clinical behavior. Currently, all patients are treated uniformly, and no standard of care systemic therapy exists for metastatic ACC. We conducted an integrated proteogenomic analyses of ACC tumors to identify dysregulated pathways and propose a classification with therapeutic implications. EXPERIMENTAL DESIGN:RNA/DNA sequencing ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2020, :]

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Application of a microbial consortium improves the growth of Camellia sinensis and influences the indigenous rhizosphere bacterial communities.

Jing Shang, Bin Liu,

AIMS:To investigate the role of a microbial consortium in influencing of Camellia sinensis growth and rhizosphere bacteria microbial community structure. METHODS AND RESULTS:Based on glasshouse trials, the microbial consortium TCM was selected for a field trial. TCM significantly increased bud density (67.53%), leaf area (31.15%) and hundred-bud weight (22.5%) compared ... Read more >>

J Appl Microbiol (Journal of applied microbiology)
[2020, :]

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