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LH upregulates connexin 43 expression in granulosa cells by activating the Wnt/β-catenin signalling pathway.

Xiaomin Zheng, Hua Jing, Shanqing Gao, Changchun Hei, Xiaofeng Ye, Yinming Liu, Yufang Cai, Bin Kong, Kai Wu, Shiwen Jiang, Chengjun Zhao, Qing Chang,

Connexin (Cx) 43 is the most widely expressed gap junction protein in follicle granulosa cells and plays an important role in follicle development and growth. The aims of this study were to investigate the effects of LH on the expression of Cx43 and key proteins in the downstream Wnt-β/catenin signalling ... Read more >>

Reprod Fertil Dev (Reproduction, fertility, and development)
[2021, :]

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Clinical importance of serum secreted clusterin in predicting invasive breast cancer and treatment responses.

Qing-Feng Chen, Lei Zhang, Qun Su, Ying Zhao, Bin Kong,

Enhanced serum secreted clusterin (sCLU) protein was associated with progression, poor prognosis and chemotherapy sensitivity evaluation in malignant patients. However, the clinical significance of serum sCLU protein levels in patients with invasive breast cancer (IBC) is unknown. In this study, the serum sCLU protein in 2648 patients with IBC was ... Read more >>

Bioengineered (Bioengineered)
[2020, :]

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Long-Term Safety and Efficacy of Percutaneous Left Atrial Appendage Closure with the LAmbre Device.

Guangji Wang, Bin Kong, Yu Liu, He Huang,

<h4>Background</h4>Left atrial appendage closure (LAAC) using the LAmbre device has been associated with prevention of stroke in patients with nonvalvular atrial fibrillation (AF). Here, we interrogated the long-term safety and efficacy of using the LAmbre device in percutaneous LAAC.<h4>Methods</h4>We analyzed 56 records of patients with nonvalvular AF undergoing LAAC procedures ... Read more >>

J Interv Cardiol (Journal of interventional cardiology)
[2020, 2020:6613683]

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Incidence, risk factors, and clinical impact of peridevice leak following left atrial appendage closure with the LAmbre device-Data from a prospective multicenter clinical study.

Guangji Wang, Bin Kong, Tianyou Qin, Yu Liu, Congxin Huang, He Huang,

<h4>Background</h4>In the present study, we sought to explore the incidence, risk factors, and clinical impact of peridevice leaks (PDLs), following LAmbre-assisted left atrial appendage closure (LAAC).<h4>Methods</h4>We performed transesophageal echocardiography (TEE) on patients participating in the LAmbre multicenter study, at Day 1 postimplantation, then at 3 and 12 months to assess PDL, ... Read more >>

J Cardiovasc Electrophysiol (Journal of cardiovascular electrophysiology)
[2020, :]

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Key Player in Cardiac Hypertrophy, Emphasizing the Role of Toll-Like Receptor 4.

Zheng Xiao, Bin Kong, Hongjie Yang, Chang Dai, Jin Fang, Tianyou Qin, He Huang,

Toll-like receptor 4 (TLR4), a key pattern recognition receptor, initiates the innate immune response and leads to chronic and acute inflammation. In the past decades, accumulating evidence has implicated TLR4-mediated inflammatory response in regulation of myocardium hypertrophic remodeling, indicating that regulation of the TLR4 signaling pathway may be an effective ... Read more >>

Front Cardiovasc Med (Frontiers in cardiovascular medicine)
[2020, 7:579036]

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MD1 Depletion Predisposes to Ventricular Arrhythmias in the Setting of Myocardial Infraction.

Hui Fu, Wei Shuai, Bin Kong, Xiaobo Jiang, He Huang,

<h4>Background</h4>Myeloid differentiation protein 1 (MD1) is expressed in the human heart and is a negative regulator of Toll-like receptor 4 (TLR4) signalling. MD1 exerts anti-arrhythmic effects.<h4>Aim</h4>The aim of this study was to determine the role of MD1 in myocardial infarction (MI)-related ventricular arrhythmias (VAs).<h4>Method</h4>Myocardial infarction was induced by surgical ligation ... Read more >>

Heart Lung Circ (Heart, lung & circulation)
[2020, :]

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ASK-1, a new target in treating cardiorenal syndrome (CRS).

Peng Zhong, Mingjie Yuan, Bin Kong, He Huang,

Int J Cardiol (International journal of cardiology)
[2020, 316:208]

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Dual-Core Prebiotic Microcapsule Encapsulating Probiotics for Metabolic Syndrome.

Cheng Zhao, Yujuan Zhu, Bin Kong, Yutong Huang, Dewen Yan, Hui Tan, Luoran Shang,

Designing strategies to utilize the synergistic effect of probiotics and prebiotics is a promising way in treating metabolic-related diseases. Here, inspired by the mutually promotable but mutually incompatible characteristics of Yin and Yang, dual-core microcapsules that encapsulate <i>Lactobacillus</i> and <i>Bacillus subtilis</i> into separate compartments were presented through electrostatically driven microfluidics. ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2020, 12(38):42586-42594]

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Cold-inducible RNA-binding protein (CIRP) in inflammatory diseases: Molecular insights of its associated signalling pathways.

Peng Zhong, Jianye Peng, Mingjie Yuan, Bin Kong, He Huang,

Cold-inducible RNA-binding protein (CIRP) was previously identified as an intracellular stress-response protein, which can respond to a variety of stress conditions by changing its expression and regulating mRNA stability through its binding site on the 3'-UTR of its targeted mRNAs. Recently, extracellular CIRP (eCIRP) was discovered to be present in ... Read more >>

Scand J Immunol (Scandinavian journal of immunology)
[2021, 93(1):e12949]

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Shensong Yangxin Protects Against Metabolic Syndrome-Induced Ventricular Arrhythmias by Inhibiting Electrical Remodeling.

Hong-Jie Yang, Bin Kong, Wei Shuai, Jing-Jing Zhang, He Huang,

Shensong Yangxin (SSYX) is a traditional Chinese medicine, which has been proven to improve the clinical symptoms of arrhythmia. However, the role of SSYX in metabolic syndrome (MetS)-induced electrical remodeling remains to be fully elucidated. Here, we sought to clarify whether SSYX can alter the electrophysiological remodeling of cardiac myocytes ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:993]

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MD1 deletion exaggerates cardiomyocyte autophagy induced by heart failure with preserved ejection fraction through ROS/MAPK signalling pathway.

Hong-Jie Yang, Bin Kong, Wei Shuai, Jing-Jing Zhang, He Huang,

In our previous studies, we reported that myeloid differentiation protein 1 (MD1) serves as a negative regulator in several cardiovascular diseases. However, the role of MD1 in heart failure with preserved ejection fraction (HFpEF) and the underlying mechanisms of its action remain unclear. Eight-week-old MD1-knockout (MD1-KO) and wild-type (WT) mice ... Read more >>

J Cell Mol Med (Journal of cellular and molecular medicine)
[2020, 24(16):9300-9312]

Cited: 1 time

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Fiber reinforced GelMA hydrogel to induce the regeneration of corneal stroma.

Bin Kong, Yun Chen, Rui Liu, Xi Liu, Changyong Liu, Zengwu Shao, Liming Xiong, Xianning Liu, Wei Sun, Shengli Mi,

Regeneration of corneal stroma has always been a challenge due to its sophisticated structure and keratocyte-fibroblast transformation. In this study, we fabricate grid poly (ε-caprolactone)-poly (ethylene glycol) microfibrous scaffold and infuse the scaffold with gelatin methacrylate (GelMA) hydrogel to obtain a 3 D fiber hydrogel construct; the fiber spacing is adjusted ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):1435]

Cited: 1 time

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Knockout of MD1 contributes to sympathetic hyperactivity and exacerbates ventricular arrhythmias following heart failure with preserved ejection fraction via NLRP3 inflammasome activation.

Hong-Jie Yang, Bin Kong, Wei Shuai, Jing-Jing Zhang, He Huang,

<h4>New findings</h4>What is the central question of this study? In this study, we investigated whether MD1 interacted with the sympathetic nerves in ventricular arrhythmia (VA) during heart failure with preserved ejection fraction (HFpEF). What is the main finding and its importance? Mice with HFpEF showed increased susceptibility to VA, adverse ... Read more >>

Exp Physiol (Experimental physiology)
[2020, 105(6):966-978]

Cited: 1 time

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Using Artificial Intelligence to Detect COVID-19 and Community-acquired Pneumonia Based on Pulmonary CT: Evaluation of the Diagnostic Accuracy.

Lin Li, Lixin Qin, Zeguo Xu, Youbing Yin, Xin Wang, Bin Kong, Junjie Bai, Yi Lu, Zhenghan Fang, Qi Song, Kunlin Cao, Daliang Liu, Guisheng Wang, Qizhong Xu, Xisheng Fang, Shiqin Zhang, Juan Xia, Jun Xia,

Background Coronavirus disease 2019 (COVID-19) has widely spread all over the world since the beginning of 2020. It is desirable to develop automatic and accurate detection of COVID-19 using chest CT. Purpose To develop a fully automatic framework to detect COVID-19 using chest CT and evaluate its performance. Materials and ... Read more >>

Radiology (Radiology)
[2020, 296(2):E65-E71]

Cited: 57 times

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3,3-Dimethyl-1-butanol attenuates cardiac remodeling in pressure-overload-induced heart failure mice.

Guangji Wang, Bin Kong, Wei Shuai, Hui Fu, Xiaobo Jiang, He Huang,

Trimethylamine N-oxide (TMAO) is closely related to cardiovascular diseases, particularly heart failure (HF). Recent studies shows that 3,3-dimethyl-1-butanol (DMB) can reduce plasma TMAO levels. However, the role of DMB in overload-induced HF is not well understood. In this research study, we explored the effects and the underlying mechanisms of DMB ... Read more >>

J Nutr Biochem (The Journal of nutritional biochemistry)
[2020, 78:108341]

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Loss of myeloid differentiation protein 1 promotes atrial fibrillation in heart failure with preserved ejection fraction.

Wei Shuai, Bin Kong, Hongjie Yang, Hui Fu, He Huang,

AIMS:Myeloid differentiation protein 1 (MD1) is expressed in the mammalian heart and exerts an anti-arrhythmic effect. Atrial fibrillation (AF) is closely related to heart failure with preserved ejection fraction (HFpEF). The potential impact of MD1 on AF vulnerability in an HFpEF model is not clear. METHODS AND RESULTS:MD1 knock-out and ... Read more >>

ESC Heart Fail (ESC heart failure)
[2020, 7(2):626-638]

Cited: 1 time

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Percutaneous retrieval of a dislocated LAmbre left atrial appendage occluder in a canine model.

Guangji Wang, Bin Kong, Yu Liu, He Huang,

BACKGROUND:Dislocated left atrial appendage (LAA) occluders can be retrieved by percutaneous intervention when performing device embolization into the left atrium (LA), aorta (AO), or left ventricle (LV). However, few reports exist regarding LAmbre LAA occluder dislocation. OBJECTIVE:The study was aimed to explore the outcome of retrieving dislocated LAmbre LAA occluder. ... Read more >>

J Cardiovasc Electrophysiol (Journal of cardiovascular electrophysiology)
[2020, 31(2):529-535]

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The effect of MD1 on potassium and L-type calcium current of cardiomyocytes from high-fat diet mice.

Wei Shuai, Bin Kong, Hui Fu, Xiaobo Jiang, He Huang,

Myeloid differentiation protein 1 (MD1) is exerted an anti-arrhythmic effect in obese mice. Therefore, we sought to clarify whether MD1 can alter the electrophysiological remodeling of cardiac myocytes from obese mice by regulating voltage-gated potassium current and calcium current. MD1 knock-out (KO) and wild type (WT) mice were given a ... Read more >>

Channels (Austin) (Channels (Austin, Tex.))
[2020, 14(1):181-189]

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Learning tree-structured representation for 3D coronary artery segmentation.

Bin Kong, Xin Wang, Junjie Bai, Yi Lu, Feng Gao, Kunlin Cao, Jun Xia, Qi Song, Youbing Yin,

Extensive research has been devoted to the segmentation of the coronary artery. However, owing to its complex anatomical structure, it is extremely challenging to automatically segment the coronary artery from 3D coronary computed tomography angiography (CCTA). Inspired by recent ideas to use tree-structured long short-term memory (LSTM) to model the ... Read more >>

Comput Med Imaging Graph (Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society)
[2020, 80:101688]

Cited: 1 time

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Long-Term Safety and Efficacy of Percutaneous Left Atrial Appendage Closure with the LAmbre Device

Guangji Wang, Bin Kong, Yu Liu, He Huang,

<h4>Background</h4> Left atrial appendage closure (LAAC) using the LAmbre device has been associated with prevention of stroke in patients with nonvalvular atrial fibrillation (AF). Here, we interrogated the long-term safety and efficacy of using the LAmbre device in percutaneous LAAC. <h4>Methods</h4> We analyzed 56 records of patients with ... Read more >>

J Interv Cardiol (Journal of interventional cardiology)
[2020, 2020:]

Cited: 0 times

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The therapeutic potential of targeting CD40-TRAF6 pathway in cardiovascular diseases.

Peng Zhong, Minxiao Chen, Bin Kong, Hui Fu, Jingjing Zhang, He Huang,

Int J Cardiol (International journal of cardiology)
[2019, 297:118]

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MD-1 Deficiency Accelerates Myocardial Inflammation and Apoptosis in Doxorubicin-Induced Cardiotoxicity by Activating the TLR4/MAPKs/Nuclear Factor kappa B (NF-κB) Signaling Pathway.

Ying-Jun Zhang, He Huang, Yu Liu, Bin Kong, Guangji Wang,

BACKGROUND Myocardial apoptosis and inflammation play important roles in doxorubicin (DOX)-caused cardiotoxicity. Our prior studies have characterized the effects of myeloid differentiation protein 1(MD-1) in pathological cardiac remodeling and myocardial ischemia/reperfusion (I/R) injury, but its participations and potential molecular mechanisms in DOX-caused cardiotoxicity remain unknown. MATERIAL AND METHODS In the ... Read more >>

Med Sci Monit (Medical science monitor : international medical journal of experimental and clinical research)
[2019, 25:7898-7907]

Cited: 2 times

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The Value of the CHADS2 and CHA2DS2-VASc Score for Predicting the Prognosis in Lacunar Stroke with or without Atrial Fibrillation Patients.

Hong-Jie Yang, Guang-Ji Wang, Wei Shuai, Cai-Jie Shen, Bin Kong, He Huang,

<h4>Background</h4>The CHADS<sub>2</sub> and CHA<sub>2</sub>DS<sub>2</sub>-VASc scoring systems have been proved efficacy to stratify stroke and thromboembolism risk in patients with atrial fibrillation (AF). Whether CHADS<sub>2</sub> and CHA<sub>2</sub>DS<sub>2</sub>-VASc score has predictive value for the prognosis in lacunar stroke (LS) patients remains unclear.<h4>Methods</h4>A total of 763 consecutive patients with LS (mean age: 66 ... Read more >>

J Stroke Cerebrovasc Dis (Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association)
[2019, 28(11):104143]

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Loss of MD1 increases vulnerability to ventricular arrhythmia in diet-induced obesity mice via enhanced activation of the TLR4/MyD88/CaMKII signaling pathway.

Wei Shuai, Bin Kong, Hui Fu, Caijie Shen, He Huang,

<h4>Background and aim</h4>Obesity is an important risk factor for ventricular arrhythmia (VA), and myeloid differentiation protein 1 (MD1) has been reported to decrease in obese hearts. Nevertheless, underlying mechanisms linking MD1 and VA have not been fully studied. This study aims to investigate the regulatory role of MD1 in VA ... Read more >>

Nutr Metab Cardiovasc Dis (Nutrition, metabolism, and cardiovascular diseases : NMCD)
[2019, 29(9):991-998]

Cited: 3 times

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[Correlation of prostate peripheral zone thickness with benign prostatic hyperplasia/ lower urinary tract symptoms: An update].

Bin Kong, Xu Hou, Jin-Yi Yang,

BPH is a most common benign disease causing dysuria in old and middle-aged males. Studies show that the total prostate volume (TPV) is not necessarily correlated with the severity of lower urinary tract symptoms (LUTS). All BPH hyperplastic nodules occur in the prostate transitional zone and the glandular region around ... Read more >>

Zhonghua Nan Ke Xue (Zhonghua nan ke xue = National journal of andrology)
[2019, 25(8):744-748]

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