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Fiber reinforced GelMA hydrogel to induce the regeneration of corneal stroma.

Bin Kong, Yun Chen, Rui Liu, Xi Liu, Changyong Liu, Zengwu Shao, Liming Xiong, Xianning Liu, Wei Sun, Shengli Mi,

Regeneration of corneal stroma has always been a challenge due to its sophisticated structure and keratocyte-fibroblast transformation. In this study, we fabricate grid poly (ε-caprolactone)-poly (ethylene glycol) microfibrous scaffold and infuse the scaffold with gelatin methacrylate (GelMA) hydrogel to obtain a 3 D fiber hydrogel construct; the fiber spacing is adjusted ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):1435]

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Artificial Intelligence Distinguishes COVID-19 from Community Acquired Pneumonia on Chest CT.

Lin Li, Lixin Qin, Zeguo Xu, Youbing Yin, Xin Wang, Bin Kong, Junjie Bai, Yi Lu, Zhenghan Fang, Qi Song, Kunlin Cao, Daliang Liu, Guisheng Wang, Qizhong Xu, Xisheng Fang, Shiqin Zhang, Juan Xia, Jun Xia,

Background Coronavirus disease has widely spread all over the world since the beginning of 2020. It is desirable to develop automatic and accurate detection of COVID-19 using chest CT. Purpose To develop a fully automatic framework to detect COVID-19 using chest CT and evaluate its performances. Materials and Methods In ... Read more >>

Radiology (Radiology)
[2020, :200905]

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Knockout of MD1 contributes to sympathetic hyperactivity and exacerbates ventricular arrhythmias following heart failure with preserved ejection fraction via NLRP3 inflammasome activation.

Hong-Jie Yang, Bin Kong, Wei Shuai, Jing-Jing Zhang, He Huang,

NEW FINDINGS:What is the central question of this study? In this study, we investigated whether MD1 interacted with the sympathetic nerves in ventricular arrhythmia (VA) during heart failure with preserved ejection fraction (HFpEF). What is the main finding and its importance? Mice with HFpEF showed increased susceptibility to VA, adverse ... Read more >>

Exp. Physiol. (Experimental physiology)
[2020, 105(6):966-978]

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Loss of myeloid differentiation protein 1 promotes atrial fibrillation in heart failure with preserved ejection fraction.

Wei Shuai, Bin Kong, Hongjie Yang, Hui Fu, He Huang,

AIMS:Myeloid differentiation protein 1 (MD1) is expressed in the mammalian heart and exerts an anti-arrhythmic effect. Atrial fibrillation (AF) is closely related to heart failure with preserved ejection fraction (HFpEF). The potential impact of MD1 on AF vulnerability in an HFpEF model is not clear. METHODS AND RESULTS:MD1 knock-out and ... Read more >>

ESC Heart Fail (ESC heart failure)
[2020, 7(2):626-638]

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3,3-Dimethyl-1-butanol attenuates cardiac remodeling in pressure-overload-induced heart failure mice.

Guangji Wang, Bin Kong, Wei Shuai, Hui Fu, Xiaobo Jiang, He Huang,

Trimethylamine N-oxide (TMAO) is closely related to cardiovascular diseases, particularly heart failure (HF). Recent studies shows that 3,3-dimethyl-1-butanol (DMB) can reduce plasma TMAO levels. However, the role of DMB in overload-induced HF is not well understood. In this research study, we explored the effects and the underlying mechanisms of DMB ... Read more >>

J. Nutr. Biochem. (The Journal of nutritional biochemistry)
[2020, 78:108341]

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Percutaneous retrieval of a dislocated LAmbre left atrial appendage occluder in a canine model.

Guangji Wang, Bin Kong, Yu Liu, He Huang,

BACKGROUND:Dislocated left atrial appendage (LAA) occluders can be retrieved by percutaneous intervention when performing device embolization into the left atrium (LA), aorta (AO), or left ventricle (LV). However, few reports exist regarding LAmbre LAA occluder dislocation. OBJECTIVE:The study was aimed to explore the outcome of retrieving dislocated LAmbre LAA occluder. ... Read more >>

J. Cardiovasc. Electrophysiol. (Journal of cardiovascular electrophysiology)
[2020, 31(2):529-535]

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The effect of MD1 on potassium and L-type calcium current of cardiomyocytes from high-fat diet mice.

Wei Shuai, Bin Kong, Hui Fu, Xiaobo Jiang, He Huang,

Myeloid differentiation protein 1 (MD1) is exerted an anti-arrhythmic effect in obese mice. Therefore, we sought to clarify whether MD1 can alter the electrophysiological remodeling of cardiac myocytes from obese mice by regulating voltage-gated potassium current and calcium current. MD1 knock-out (KO) and wild type (WT) mice were given a ... Read more >>

Channels (Austin) (Channels (Austin, Tex.))
[2020, 14(1):181-189]

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Learning tree-structured representation for 3D coronary artery segmentation.

Bin Kong, Xin Wang, Junjie Bai, Yi Lu, Feng Gao, Kunlin Cao, Jun Xia, Qi Song, Youbing Yin,

Extensive research has been devoted to the segmentation of the coronary artery. However, owing to its complex anatomical structure, it is extremely challenging to automatically segment the coronary artery from 3D coronary computed tomography angiography (CCTA). Inspired by recent ideas to use tree-structured long short-term memory (LSTM) to model the ... Read more >>

Comput Med Imaging Graph (Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society)
[2020, 80:101688]

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The therapeutic potential of targeting CD40-TRAF6 pathway in cardiovascular diseases.

Peng Zhong, Minxiao Chen, Bin Kong, Hui Fu, Jingjing Zhang, He Huang,

Int. J. Cardiol. (International journal of cardiology)
[2019, 297:118]

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MD-1 Deficiency Accelerates Myocardial Inflammation and Apoptosis in Doxorubicin-Induced Cardiotoxicity by Activating the TLR4/MAPKs/Nuclear Factor kappa B (NF-κB) Signaling Pathway.

Ying-Jun Zhang, He Huang, Yu Liu, Bin Kong, Guangji Wang,

BACKGROUND Myocardial apoptosis and inflammation play important roles in doxorubicin (DOX)-caused cardiotoxicity. Our prior studies have characterized the effects of myeloid differentiation protein 1(MD-1) in pathological cardiac remodeling and myocardial ischemia/reperfusion (I/R) injury, but its participations and potential molecular mechanisms in DOX-caused cardiotoxicity remain unknown. MATERIAL AND METHODS In the ... Read more >>

Med. Sci. Monit. (Medical science monitor : international medical journal of experimental and clinical research)
[2019, 25:7898-7907]

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The Value of the CHADS2 and CHA2DS2-VASc Score for Predicting the Prognosis in Lacunar Stroke with or without Atrial Fibrillation Patients.

Hong-Jie Yang, Guang-Ji Wang, Wei Shuai, Cai-Jie Shen, Bin Kong, He Huang,

BACKGROUND:The CHADS2 and CHA2DS2-VASc scoring systems have been proved efficacy to stratify stroke and thromboembolism risk in patients with atrial fibrillation (AF). Whether CHADS2 and CHA2DS2-VASc score has predictive value for the prognosis in lacunar stroke (LS) patients remains unclear. METHODS:A total of 763 consecutive patients with LS (mean age: ... Read more >>

J Stroke Cerebrovasc Dis (Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association)
[2019, 28(11):104143]

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[Correlation of prostate peripheral zone thickness with benign prostatic hyperplasia/ lower urinary tract symptoms: An update].

Bin Kong, Xu Hou, Jin-Yi Yang,

BPH is a most common benign disease causing dysuria in old and middle-aged males. Studies show that the total prostate volume (TPV) is not necessarily correlated with the severity of lower urinary tract symptoms (LUTS). All BPH hyperplastic nodules occur in the prostate transitional zone and the glandular region around ... Read more >>

Zhonghua Nan Ke Xue (Zhonghua nan ke xue = National journal of andrology)
[2019, 25(8):744-748]

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Loss of MD1 increases vulnerability to ventricular arrhythmia in diet-induced obesity mice via enhanced activation of the TLR4/MyD88/CaMKII signaling pathway.

Wei Shuai, Bin Kong, Hui Fu, Caijie Shen, He Huang,

BACKGROUND AND AIM:Obesity is an important risk factor for ventricular arrhythmia (VA), and myeloid differentiation protein 1 (MD1) has been reported to decrease in obese hearts. Nevertheless, underlying mechanisms linking MD1 and VA have not been fully studied. This study aims to investigate the regulatory role of MD1 in VA ... Read more >>

Nutr Metab Cardiovasc Dis (Nutrition, metabolism, and cardiovascular diseases : NMCD)
[2019, 29(9):991-998]

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The value of the left atrial appendage orifice perimeter of 3D model based on 3D TEE data in the choice of device size of LAmbre™ occluder.

Dan Jia, Qing Zhou, Hong-Ning Song, Lan Zhang, Jin-Ling Chen, Yu Liu, Bin Kong, Fa-Zhi He, Yi-Jia Wang, Yuan-Ting Yang,

Preoperative optimal selection of the occluder size is crucial in percutaneous left atrial appendage (LAA) occlusion, and the maximal width of the LAA orifice is the main reference index, however it can not fully meet the practical operation requirements. We retrospectively analyzed three-dimensional (3D) transesophageal echocardiography (TEE) and computed tomography ... Read more >>

Int J Cardiovasc Imaging (The international journal of cardiovascular imaging)
[2019, 35(10):1841-1851]

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Myeloid differentiation protein 1 protected myocardial function against high-fat stimulation induced pathological remodelling.

Cai-Jie Shen, Bin Kong, Wei Shuai, Yu Liu, Guang-Ji Wang, Min Xu, Jing-Jing Zhao, Jin Fang, Hui Fu, Xiao-Bo Jiang, He Huang,

Myeloid differentiation 1 (MD-1) is a secreted protein that regulates the immune response of B cell through interacting with radioprotective 105 (RP105). Disrupted immune response may contribute to the development of cardiac diseases, while the roles of MD-1 remain elusive. Our studies aimed to explore the functions and molecular mechanisms ... Read more >>

J. Cell. Mol. Med. (Journal of cellular and molecular medicine)
[2019, 23(8):5303-5316]

Cited: 2 times

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DLC-3 suppresses cellular proliferation, migration, and invasion in triple-negative breast cancer by the Wnt/β-catenin pathway.

Bin Kong, Zhi-Dong Lv, Jing Xia, Li-Ying Jin, Zhao-Chuan Yang,

Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype. Our study investigated the functional role of DLC-3 in TNBC. The expression of DLC-3 was assessed by immunohistochemistry in TNBC to evaluate the clinicopathologic significance of DLC-3. Recombinant lentiviral vectors encoding the DLC-3 gene were constructed for transfection into ... Read more >>

Int J Clin Exp Pathol (International journal of clinical and experimental pathology)
[2019, 12(4):1224-1232]

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Targeted ablation of cardiac sympathetic neurons improves ventricular electrical remodelling in a canine model of chronic myocardial infarction.

Liang Xiong, Yu Liu, Mingmin Zhou, Guangji Wang, Dajun Quan, Caijie Shen, Wei Shuai, Bin Kong, Congxin Huang, He Huang,

Aims:The purpose of this study was to evaluate the cardiac electrophysiologic effects of targeted ablation of cardiac sympathetic neurons (TACSN) in a canine model of chronic myocardial infarction (MI). Methods and results:Thirty-eight anaesthetized dogs were randomly assigned into the sham-operated, MI, and MI-TACSN groups, respectively. Myocardial infarction-targeted ablation of cardiac ... Read more >>

Europace (Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology)
[2018, 20(12):2036-2044]

Cited: 4 times

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MD1 Deficiency Promotes Inflammatory Atrial Remodelling Induced by High-Fat Diets.

Wei Shuai, Bin Kong, Hui Fu, Caijie Shen, Xiaobo Jiang, He Huang,

BACKGROUND:Myeloid differentiation protein 1 (MD1) is expressed in various tissues, including the heart. However, the role of MD1 in obesity-related atrial remodelling remains incompletely understood. Here, this study intends to determine the regulatory role and underlying mechanisms of MD1 in obesity-related atrial remodelling. METHODS:A high-fat diet (HFD) feeding was performed ... Read more >>

Can J Cardiol (The Canadian journal of cardiology)
[2019, 35(2):208-216]

Cited: 2 times

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Loss of MD1 exacerbates myocardial ischemia/reperfusion injury and susceptibility to ventricular arrhythmia.

Xiaobo Jiang, Bin Kong, Wei Shuai, Caijie Shen, Fan Yang, Hui Fu, He Huang,

Myeloid differentiation protein 1(MD1), also known as lymphocyte antigen 86 (LY86), plays an important role in the toll-like receptor 4 (TLR4) signaling pathway. Recent studies show that MD1 is involved in regulating pressure overload-induced cardiac structural and electrical remodeling. However, the effect of MD1 on myocardial ischemia-reperfusion (I/R) injury and ... Read more >>

Eur. J. Pharmacol. (European journal of pharmacology)
[2019, 844:79-86]

Cited: 2 times

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YY1-induced upregulation of lncRNA KCNQ1OT1 regulates angiotensin II-induced atrial fibrillation by modulating miR-384b/CACNA1C axis.

Caijie Shen, Bin Kong, Yu Liu, Liang Xiong, Wei Shuai, Guangji Wang, Dajun Quan, He Huang,

Recent years, the role of long non-coding RNAs (lncRNAs) in atrial fibrillation (AF) has been gradually elucidated. In the current study, we measured the expression of ten AF-related lncRNAs to do qRT-PCR analysis. LncRNA KCNQ1 overlapping transcript 1 (KCNQ1OT1) was found to be significantly upregulated in AF model and Ang-II-induced ... Read more >>

Biochem. Biophys. Res. Commun. (Biochemical and biophysical research communications)
[2018, 505(1):134-140]

Cited: 2 times

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Aberrantly Expressed Genes and miRNAs in Slow Transit Constipation Based on RNA-Seq Analysis.

Shipeng Zhao, Qiang Chen, Xianwu Kang, Bin Kong, Zhuo Wang,

Background:This study aims to identify the key genes and miRNAs in slow transit constipation (STC). Methods:MRNA and miRNA expression profiling were obtained. Differentially expressed genes (DEGs) and miRNAs were identified followed by the regulatory network construction. Functional annotation analysis and protein-protein interaction (PPI) network were conducted. The electronic validation was ... Read more >>

Biomed Res Int (BioMed research international)
[2018, 2018:2617432]

Cited: 1 time

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Targeted ablation of cardiac sympathetic neurons attenuates adverse postinfarction remodelling and left ventricular dysfunction.

Liang Xiong, Yu Liu, Mingmin Zhou, Guangji Wang, Dajun Quan, Wei Shuai, Caijie Shen, Bin Kong, Congxin Huang, He Huang,

NEW FINDINGS:What is the central question of this study? Can targeted ablation of cardiac sympathetic neurons suppress myocardial infarction-induced adverse cardiac remodelling and left ventricular dysfunction? What is the main finding and its importance? Targeted ablation of cardiac sympathetic neurons significantly alleviated sympathetic remodelling and neuroendocrine activation, attenuated cardiac hypertrophy ... Read more >>

Exp. Physiol. (Experimental physiology)
[2018, 103(9):1221-1229]

Cited: 2 times

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Engineering of Corneal Tissue through an Aligned PVA/Collagen Composite Nanofibrous Electrospun Scaffold.

Zhengjie Wu, Bin Kong, Rui Liu, Wei Sun, Shengli Mi,

Corneal diseases are the main reason of vision loss globally. Constructing a corneal equivalent which has a similar strength and transparency with the native cornea, seems to be a feasible way to solve the shortage of donated cornea. Electrospun collagen scaffolds are often fabricated and used as a tissue-engineered cornea, ... Read more >>

Nanomaterials (Basel) (Nanomaterials (Basel, Switzerland))
[2018, 8(2):]

Cited: 1 time

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Th17 cells regulate the production of CXCL1 in breast cancer.

Kai Ma, Lihua Yang, Ruowu Shen, Bin Kong, Wenting Chen, Jie Liang, Guoqing Tang, Bei Zhang,

Recently, the link between inflammation and cancer has been targeted for the prevention or treatment of malignant tumours. We aimed to investigate the relationship between Th17 cells and CXCL1 in breast cancer and the biological effects of CXCL1 on breast cancer. In vivo, the Th17 cell frequency in the peripheral ... Read more >>

Int. Immunopharmacol. (International immunopharmacology)
[2018, 56:320-329]

Cited: 1 time

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Corrigendum to "Role of CaMKII in free fatty acid/hyperlipidemia-induced cardiac remodeling both in vitro and in vivo" [J. Mol. Cell. Cardiol. 109 (2017) 1-16].

Peng Zhong, Dajun Quan, Jianye Peng, Xiaoju Xiong, Yu Liu, Bin Kong, He Huang,

J. Mol. Cell. Cardiol. (Journal of molecular and cellular cardiology)
[2018, 121:306]

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