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Author Billy Bourke

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The impact of liver disease on mortality in cystic fibrosis - a systematic review protocol

Ao Sasame, Lucy Connolly, Emer Fitzpatrick, Diarmuid Stokes, Billy Bourke, Marion Rowland,

Background Cystic fibrosis (CF) is a multiorgan disease affecting the lungs pancreas and gastrointestinal tract. Pulmonary complications are the most common manifestation of the disease. Recent advances in the treatment of pulmonary complications have resulted in substantial improvement in life expectancy. Less than 10% of persons with CF (PWCF) develop ... Read more >>

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NADPH oxidase 4 is protective and not fibrogenic in intestinal inflammation.

Emily Stenke, Gabriella Aviello, Ashish Singh, Sean Martin, Des Winter, Brian Sweeney, Michael McDermott, Billy Bourke, Seamus Hussey, Ulla G Knaus,

Dysregulated redox signaling and oxidative injury are associated with inflammatory processes and fibrosis. H<sub>2</sub>O<sub>2</sub> generation by NOX4 has been suggested as a key driver in the development of fibrosis and a small molecule drug is under evaluation in clinical trials for idiopathic pulmonary fibrosis and primary biliary cholangitis. Fibrosis is ... Read more >>

Redox Biol (Redox biology)
[2020, 37:101752]

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The impact of liver disease on mortality in cystic fibrosis - a systematic review protocol.

Ao Sasame, Lucy Connolly, Emer Fitzpatrick, Diarmuid Stokes, Billy Bourke, Marion Rowland,

Background Cystic fibrosis (CF) is a multiorgan disease affecting the lungs pancreas and gastrointestinal tract. Pulmonary complications are the most common manifestation of the disease. Recent advances in the treatment of pulmonary complications have resulted in substantial improvement in life expectancy. Less than 10% of persons with CF (PWCF) develop ... Read more >>

HRB Open Res (HRB open research)
[2020, 3:44]

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Columnar Lined Esophagus/Gastric Metaplasia Requires Careful Follow-up.

Nichola Sandys, Caitriona Loomes, Aoife Keane, Seamus Hussey, Annemarie Broderick, Michael McDermott, Maureen OʼSullivan, Billy Bourke,

J Pediatr Gastroenterol Nutr (Journal of pediatric gastroenterology and nutrition)
[2020, 71(4):e136]

Cited: 0 times

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Repeatability of transient elastography in children.

Marion Rowland, Allison McGee, Annemarie Broderick, Brendan Drumm, Lucy Connolly, Leslie E Daly, Jennifer Drummond, Emer Fitzpatrick, Barry Linnane, P Aiden McCormick, Paul McNally, Louise Rainford, Billy Bourke, , ,

BACKGROUND:Poorly performing diagnostic tests can impact patient safety. Clinical investigations must have good precision and diagnostic accuracy before widespread use in clinical practice. Transient elastography (TE) measures liver stiffness, a surrogate marker of liver fibrosis in adults and children. Studies to evaluate its repeatability and reproducibility (precision) in children are ... Read more >>

Pediatr Res (Pediatric research)
[2020, 88(4):587-592]

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Gabapentin for the treatment of pain manifestations in children with severe neurological impairment: a single-centre retrospective review.

Aedin Collins, Rory Mannion, Annemarie Broderick, Séamus Hussey, Mary Devins, Billy Bourke,

Pain, irritability and feeding intolerance are common symptoms affecting quality of life in children with severe neurological impairment (SNI). We performed a retrospective study to explore the use of gabapentinoid medications for symptom control in children with SNI. Patients attending the palliative care or gastroenterology department being treated with gabapentin ... Read more >>

BMJ Paediatr Open (BMJ paediatrics open)
[2019, 3(1):e000467]

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Colitis susceptibility in mice with reactive oxygen species deficiency is mediated by mucus barrier and immune defense defects.

Gabriella Aviello, Ashish K Singh, Sharon O'Neill, Emer Conroy, William Gallagher, Giuseppe D'Agostino, Alan W Walker, Billy Bourke, Dimitri Scholz, Ulla G Knaus,

Reactive oxygen species (ROS) generated by NADPH oxidases (NOX/DUOX) provide antimicrobial defense, redox signaling, and gut barrier maintenance. Inactivating NOX variants are associated with comorbid intestinal inflammation in chronic granulomatous disease (CGD; NOX2) and pediatric inflammatory bowel disease (IBD; NOX1); however Nox-deficient mice do not reflect human disease susceptibility. Here ... Read more >>

Mucosal Immunol (Mucosal immunology)
[2019, 12(6):1316-1326]

Cited: 3 times

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NAPDH Oxidases in Inflammatory Bowel Disease.

Emily Stenke, Billy Bourke, Ulla G Knaus,

Inflammatory bowel diseases (IBD), categorized as ulcerative colitis (UC), Crohn's disease (CD), or IBD-undetermined (IBDU), are increasing in incidence. IBD is understood to result from environmental factors interacting with a pre-existing genetic susceptibility. Approximately 1% of all patients with inflammatory bowel disease (IBD) are diagnosed before the age of 6 years, ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2019, 1982:695-713]

Cited: 1 time

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Correction to: NADPH Oxidases in Inflammatory Bowel Disease.

Emily Stenke, Billy Bourke, Ulla G Knaus,

The title of Chapter 38 was published with a typo error. It should read "NADPH Oxidases in Inflammatory Bowel Disease", whereas the title was mistakenly printed as "NAPDH Oxidases in Inflammatory Bowel Disease" and the book has been updated for this error. ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2019, 1982:C1]

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The use of stool specimens reveals Helicobacter pylori strain diversity in a cohort of adolescents and their family members in a developed country.

Brendan Dolan, Lucy Burkitt-Gray, Stephen Shovelin, Billy Bourke, Brendan Drumm, Marion Rowland, Marguerite Clyne,

Helicobacter pylori infection occurs within families but the transmission route is unknown. The use of stool specimens to genotype strains facilitates inclusion of complete families in transmission studies. Therefore, we aimed to use DNA from stools to analyze strain diversity in H. pylori infected families. We genotyped H. pylori strains ... Read more >>

Int J Med Microbiol (International journal of medical microbiology : IJMM)
[2018, 308(2):247-255]

Cited: 2 times

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Crohn's Strictures-Moving Away from the Knife.

Emily Stenke, Billy Bourke, Ulla Knaus,

Crohn's disease (CD) is a lifelong inflammatory bowel disease with a rapidly rising incidence in the pediatric population. A common complication of CD is the development of fibrotic strictures, which may be present at initial diagnosis or develop many years later. Clinical presentation depends on stricture location and degree of ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2017, 5:141]

Cited: 2 times

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Erratum to: Assays to Study the Interaction of Campylobacter jejuni with the Mucosal Surface.

Marguerite Clyne, Gina Duggan, Ciara Dunne, Brendan Dolan, Luis Alvarez, Billy Bourke,

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2017, 1512:E1]

Cited: 0 times

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Assays to Study the Interaction of Campylobacter jejuni with the Mucosal Surface.

Marguerite Clyne, Gina Duggan, Ciara Dunne, Brendan Dolan, Luis Alvarez, Billy Bourke,

Mucosal colonization and overcoming the mucosal barrier are essential steps in the establishment of infection by Campylobacter jejuni. The interaction between C. jejuni and host cells, including binding and invasion, is thought to be the key virulence factor important for pathogenesis of C. jejuni infections in animals or humans. The ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2017, 1512:129-147]

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Relaxation of DNA supercoiling leads to increased invasion of epithelial cells and protein secretion by Campylobacter jejuni.

Eoin Scanlan, Laura Ardill, Matthew V X Whelan, Claire Shortt, Jarlath E Nally, Billy Bourke, Tadhg Ó Cróinín,

Invasion of intestinal epithelial cells by Campylobacter jejuni is a critical step during infection of the intestine by this important human pathogen. In this study we investigated the role played by DNA supercoiling in the regulation of invasion of epithelial cells and the mechanism by which this could be mediated. ... Read more >>

Mol Microbiol (Molecular microbiology)
[2017, 104(1):92-104]

Cited: 3 times

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Methods to Assess the Direct Interaction of C. jejuni with Mucins.

Marguerite Clyne, Gina Duggan, Julie Naughton, Billy Bourke,

Studies of the interaction of bacteria with mucus-secreting cells can be complemented at a more mechanistic level by exploring the interaction of bacteria with purified mucins. Here we describe a far Western blotting approach to show how C. jejuni proteins separated by SDS PAGE and transferred to a membrane or ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2017, 1512:107-115]

Cited: 1 time

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DNA Supercoiling Regulates the Motility of Campylobacter jejuni and Is Altered by Growth in the Presence of Chicken Mucus.

Claire Shortt, Eoin Scanlan, Amber Hilliard, Chiara E Cotroneo, Billy Bourke, Tadhg Ó Cróinín,

<h4>Unlabelled</h4>Campylobacter jejuni is the leading cause of bacterial gastroenteritis in humans, but relatively little is known about the global regulation of virulence factors during infection of chickens or humans. This study identified DNA supercoiling as playing a key role in regulating motility and flagellar protein production and found that this ... Read more >>

mBio (mBio)
[2016, 7(5):]

Cited: 8 times

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NADPH oxidase-derived H2O2 subverts pathogen signaling by oxidative phosphotyrosine conversion to PB-DOPA.

Luis A Alvarez, Lidija Kovačič, Javier Rodríguez, Jan-Hendrik Gosemann, Malgorzata Kubica, Gratiela G Pircalabioru, Florian Friedmacher, Ada Cean, Alina Ghişe, Mihai B Sărăndan, Prem Puri, Simon Daff, Erika Plettner, Alex von Kriegsheim, Billy Bourke, Ulla G Knaus,

Strengthening the host immune system to fully exploit its potential as antimicrobial defense is vital in countering antibiotic resistance. Chemical compounds released during bidirectional host-pathogen cross-talk, which follows a sensing-response paradigm, can serve as protective mediators. A potent, diffusible messenger is hydrogen peroxide (H2O2), but its consequences on extracellular pathogens ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2016, 113(37):10406-10411]

Cited: 12 times

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Defensive Mutualism Rescues NADPH Oxidase Inactivation in Gut Infection.

Gratiela Pircalabioru, Gabriella Aviello, Malgorzata Kubica, Alexander Zhdanov, Marie-Helene Paclet, Lorraine Brennan, Rosanne Hertzberger, Dmitri Papkovsky, Billy Bourke, Ulla G Knaus,

NOX/DUOX family of NADPH oxidases are expressed in diverse tissues and are the primary enzymes for the generation of reactive oxygen species (ROS). The intestinal epithelium expresses NOX1, NOX4, and DUOX2, whose functions are not well understood. To address this, we generated mice with complete or epithelium-restricted deficiency in the ... Read more >>

Cell Host Microbe (Cell host & microbe)
[2016, 19(5):651-663]

Cited: 21 times

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Clinical and genetic characterisation of infantile liver failure syndrome type 1, due to recessive mutations in LARS.

Jillian P Casey, Suzanne Slattery, Melanie Cotter, A A Monavari, Ina Knerr, Joanne Hughes, Eileen P Treacy, Deirdre Devaney, Michael McDermott, Eoghan Laffan, Derek Wong, Sally Ann Lynch, Billy Bourke, Ellen Crushell,

<h4>Background</h4>Recessive LARS mutations were recently reported to cause a novel syndrome, infantile liver failure syndrome type 1 (ILFS1), in six Irish Travellers. We have since identified four additional patients, including one of Ashkenazi origin, representing the largest ILFS1 cohort to date. Our study aims to define the ILFS1 clinical phenotype ... Read more >>

J Inherit Metab Dis (Journal of inherited metabolic disease)
[2015, 38(6):1085-1092]

Cited: 9 times

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Chronic infections of the small intestine.

Billy Bourke, Seamus Hussey,

<h4>Purpose of review</h4>Chronic infections of the small intestine cause significant morbidity and mortality globally. This review focuses on the recent advances in the field of our understanding of selected intestinal infections.<h4>Recent findings</h4>Primary and secondary immunodeficiency increase the susceptibility to many chronic intestinal infections. Endoscopy and intestinal biopsies are central to ... Read more >>

Curr Opin Gastroenterol (Current opinion in gastroenterology)
[2015, 31(2):104-110]

Cited: 1 time

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Outcomes of children after esophagogastroduodenoscopy for chronic abdominal pain.

Billy Bourke,

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2015, 13(2):409]

Cited: 1 time

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Outcome in patients with cystic fibrosis liver disease.

Marion Rowland, Cliona Gallagher, Charles G Gallagher, Risteárd Ó Laoide, Gerard Canny, Anne Marie Broderick, Jennifer Drummond, Peter Greally, Dubhfeasa Slattery, Leslie Daly, Noel G McElvaney, Billy Bourke,

<h4>Background</h4>Liver disease is an important complication in CF.<h4>Aims</h4>To determine if CFLD is a risk factor for mortality in CF, and which baseline characteristics predict all-cause mortality.<h4>Methods</h4>Irish children with CFLD, and their age and gender matched controls were enrolled at baseline and reviewed after 10years to determine which characteristics predict mortality.<h4>Results</h4>72/84 ... Read more >>

J Cyst Fibros (Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society)
[2015, 14(1):120-126]

Cited: 16 times

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Divergent mechanisms of interaction of Helicobacter pylori and Campylobacter jejuni with mucus and mucins.

Julie Ann Naughton, Karina Mariño, Brendan Dolan, Colm Reid, Ronan Gough, Mary E Gallagher, Michelle Kilcoyne, Jared Q Gerlach, Lokesh Joshi, Pauline Rudd, Stephen Carrington, Billy Bourke, Marguerite Clyne,

Helicobacter pylori and Campylobacter jejuni colonize the stomach and intestinal mucus, respectively. Using a combination of mucus-secreting cells, purified mucins, and a novel mucin microarray platform, we examined the interactions of these two organisms with mucus and mucins. H. pylori and C. jejuni bound to distinctly different mucins. C. jejuni ... Read more >>

Infect Immun (Infection and immunity)
[2013, 81(8):2838-2850]

Cited: 30 times

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Interaction of microbes with mucus and mucins: recent developments.

Julie Naughton, Gina Duggan, Billy Bourke, Marguerite Clyne,

Due to the recent rapid expansion in our understanding of the composition of the gut microflora and the consequences of altering that composition the question of how bacteria colonise mucus layers and interact with components of mucus, such as mucin, is now receiving widespread attention. Using a combination of mucus ... Read more >>

Gut Microbes (Gut microbes)
[2014, 5(1):48-52]

Cited: 14 times

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Cj1411c encodes for a cytochrome P450 involved in Campylobacter jejuni 81-176 pathogenicity.

Luis A J Alvarez, Billy Bourke, Gratiela Pircalabioru, Atanas Y Georgiev, Ulla G Knaus, Simon Daff, Nicolae Corcionivoschi,

Cytochrome P450s are b-heme-containing enzymes that are able to introduce oxygen atoms into a wide variety of organic substrates. They are extremely widespread in nature having diverse functions at both biochemical and physiological level. The genome of C. jejuni 81-176 encodes a single cytochrome P450 (Cj1411c) that has no close ... Read more >>

PLoS One (PloS one)
[2013, 8(9):e75534]

Cited: 3 times

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