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Author Bilal Mateen

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Understanding COVID-19 trajectories from a nationwide linked electronic health record cohort of 56 million people: phenotypes, severity, waves & vaccination

Johan Thygesen, Christopher Tomlinson, Sam Hollings, Mehrdad Mizani, Alex Handy, Ashley Akbari, Amitava Banerjee, Jennifer Cooper, Alvina Lai, Ken Li, Bilal Mateen, Naveed Sattar, Reecha Sofat, Ana Torralbo, Honghan Wu, Angela Wood, Jonathan Sterne, Christina Pagel, William Whiteley, Cathie Sudlow, Harry Hemingway, Spiros Denaxas,

<h4>Background</h4> Updatable understanding of the onset and progression of individuals COVID-19 trajectories underpins pandemic mitigation efforts. In order to identify and characterize individual trajectories, we defined and validated ten COVID-19 phenotypes from linked electronic health records (EHR) on a nationwide scale using an extensible framework. <h4>Methods</h4> Cohort study of 56.6 ... Read more >>

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Derivation and validation of a type 2 diabetes treatment selection algorithm for SGLT2-inhibitor and DPP4-inhibitor therapies based on glucose-lowering efficacy: cohort study using trial and routine clinical data

John Dennis, Katherine Young, Andrew McGovern, Bilal Mateen, Sebastian Vollmer, Michael Simpson, William Henley, Rury Holman, Naveed Sattar, Ewan Pearson, Andrew Hattersley, Angus Jones, Beverley Shields,

<h4>Objective</h4> To establish whether clinical patient characteristics routinely measured in primary care can identify people with differing short-term benefits and risks for SGLT2-inhibitor and DPP4-inhibitor therapies, and to derive and validate a treatment selection algorithm to identify the likely optimal therapy for individual patients. <h4>Design</h4> Prospective cohort study. <h4>Setting</h4> Routine ... Read more >>

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Azathioprine with Allopurinol Is a Promising First-Line Therapy for Inflammatory Bowel Diseases.

Elsa L S A van Liere, Ahmed B Bayoumy, Chris J J Mulder, Ben Warner, Bu Hayee, Bilal A Mateen, Jonathan D Nolan, Nanne K H de Boer, Simon H C Anderson, Azhar R Ansari,

<h4>Background</h4>Beneficial response to first-line immunosuppressive azathioprine in patients with inflammatory bowel disease (IBD) is low due to high rates of adverse events. Co-administrating allopurinol has been shown to improve tolerability. However, data on this co-therapy as first-line treatment are scarce.<h4>Aim</h4>Retrospective comparison of long-term effectiveness and safety of first-line low-dose azathioprine-allopurinol ... Read more >>

Dig Dis Sci (Digestive diseases and sciences)
[2021, :]

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Trends in 28-Day Mortality of Critical Care Patients With Coronavirus Disease 2019 in the United Kingdom: A National Cohort Study, March 2020 to January 2021.

John M Dennis, Andrew P McGovern, Nicholas J Thomas, Harrison Wilde, Sebastian J Vollmer, Bilal A Mateen,

<h4>Objectives</h4>To determine whether the previously described trend of improving mortality in people with coronavirus disease 2019 in critical care during the first wave was maintained, plateaued, or reversed during the second wave in United Kingdom, when B117 became the dominant strain.<h4>Design</h4>National retrospective cohort study.<h4>Setting</h4>All English hospital trusts (i.e., groups of ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(11):1895-1900]

Cited: 1 time

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A quality assessment tool for artificial intelligence-centered diagnostic test accuracy studies: QUADAS-AI.

Viknesh Sounderajah, Hutan Ashrafian, Sherri Rose, Nigam H Shah, Marzyeh Ghassemi, Robert Golub, Charles E Kahn, Andre Esteva, Alan Karthikesalingam, Bilal Mateen, Dale Webster, Dan Milea, Daniel Ting, Darren Treanor, Dominic Cushnan, Dominic King, Duncan McPherson, Ben Glocker, Felix Greaves, Leanne Harling, Johan Ordish, Jérémie F Cohen, Jon Deeks, Mariska Leeflang, Matthew Diamond, Matthew D F McInnes, Melissa McCradden, Michael D Abràmoff, Pasha Normahani, Sheraz R Markar, Stephanie Chang, Xiaoxuan Liu, Susan Mallett, Shravya Shetty, Alastair Denniston, Gary S Collins, David Moher, Penny Whiting, Patrick M Bossuyt, Ara Darzi,

Nat Med (Nature medicine)
[2021, 27(10):1663-1665]

Cited: 2 times

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Diarrhoea and preadmission antibiotic exposure in COVID-19: a retrospective cohort study of 1153 hospitalised patients.

Bilal Akhter Mateen, Sandip Samanta, Sebastian Tullie, Sarah O'Neill, Zillah Cargill, Gillian Kelly, Ewen Brennan, Mehul Patel, Mohammad Al-Agil, James Galloway, James Teo, Debbie L Shawcross, Alexandra J Kent, Bu'Hussain Hayee,

<h4>Objective</h4>The aims of this study were to describe community antibiotic prescribing patterns in individuals hospitalised with COVID-19, and to determine the association between experiencing diarrhoea, stratified by preadmission exposure to antibiotics, and mortality risk in this cohort.<h4>Design/methods</h4>Retrospective study of the index presentations of 1153 adult patients with COVID-19, admitted between ... Read more >>

BMJ Open Gastroenterol (BMJ open gastroenterology)
[2021, 8(1):]

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The association between mechanical ventilator compatible bed occupancy and mortality risk in intensive care patients with COVID-19: a national retrospective cohort study.

Harrison Wilde, Thomas Mellan, Iwona Hawryluk, John M Dennis, Spiros Denaxas, Christina Pagel, Andrew Duncan, Samir Bhatt, Seth Flaxman, Bilal A Mateen, Sebastian J Vollmer,

<h4>Background</h4>The literature paints a complex picture of the association between mortality risk and ICU strain. In this study, we sought to determine if there is an association between mortality risk in intensive care units (ICU) and occupancy of beds compatible with mechanical ventilation, as a proxy for strain.<h4>Methods</h4>A national retrospective ... Read more >>

BMC Med (BMC medicine)
[2021, 19(1):213]

Cited: 3 times

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Development and assessment of a machine learning tool for predicting emergency admission in Scotland

James Liley, Gergo Bohner, Samuel Emerson, Bilal Mateen, Katie Borland, David Carr, Scott Heald, Samuel Oduro, Jill Ireland, Keith Moffat, Rachel Porteous, Stephen Riddell, Nathan Cunningham, Chris Holmes, Katrina Payne, Sebastian Vollmer, Catalina Vallejos, Louis Aslett,

<h4>ABSTRACT</h4> Avoiding emergency hospital admission (EA) is advantageous to individual health and the healthcare system. We develop a statistical model estimating risk of EA for most of the Scottish population (> 4.8 M individuals) using electronic health records, such as hospital episodes and prescribing activity. We demonstrate good predictive accuracy ... Read more >>

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A national retrospective study of the association between serious operational problems and COVID-19 specific intensive care mortality risk.

Harrison Wilde, John M Dennis, Andrew P McGovern, Sebastian J Vollmer, Bilal A Mateen,

<h4>Objectives</h4>To describe the relationship between reported serious operational problems (SOPs), and mortality for patients with COVID-19 admitted to intensive care units (ICUs).<h4>Design</h4>English national retrospective cohort study.<h4>Setting</h4>89 English hospital trusts (i.e. small groups of hospitals functioning as single operational units).<h4>Patients</h4>All adults with COVID-19 admitted to ICU between 2nd April and 1st ... Read more >>

PLoS One (PloS one)
[2021, 16(7):e0255377]

Cited: 1 time

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Developing a reporting guideline for artificial intelligence-centred diagnostic test accuracy studies: the STARD-AI protocol.

Viknesh Sounderajah, Hutan Ashrafian, Robert M Golub, Shravya Shetty, Jeffrey De Fauw, Lotty Hooft, Karel Moons, Gary Collins, David Moher, Patrick M Bossuyt, Ara Darzi, Alan Karthikesalingam, Alastair K Denniston, Bilal Akhter Mateen, Daniel Ting, Darren Treanor, Dominic King, Felix Greaves, Jonathan Godwin, Jonathan Pearson-Stuttard, Leanne Harling, Matthew McInnes, Nader Rifai, Nenad Tomasev, Pasha Normahani, Penny Whiting, Ravi Aggarwal, Sebastian Vollmer, Sheraz R Markar, Trishan Panch, Xiaoxuan Liu, ,

<h4>Introduction</h4>Standards for Reporting of Diagnostic Accuracy Study (STARD) was developed to improve the completeness and transparency of reporting in studies investigating diagnostic test accuracy. However, its current form, STARD 2015 does not address the issues and challenges raised by artificial intelligence (AI)-centred interventions. As such, we propose an AI-specific version ... Read more >>

BMJ Open (BMJ open)
[2021, 11(6):e047709]

Cited: 2 times

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Linked electronic health records for research on a nationwide cohort of more than 54 million people in England: data resource.

Angela Wood, Rachel Denholm, Sam Hollings, Jennifer Cooper, Samantha Ip, Venexia Walker, Spiros Denaxas, Ashley Akbari, Amitava Banerjee, William Whiteley, Alvina Lai, Jonathan Sterne, Cathie Sudlow, ,

<h4>Objective</h4>To describe a novel England-wide electronic health record (EHR) resource enabling whole population research on covid-19 and cardiovascular disease while ensuring data security and privacy and maintaining public trust.<h4>Design</h4>Data resource comprising linked person level records from national healthcare settings for the English population, accessible within NHS Digital's new trusted research ... Read more >>

BMJ (BMJ (Clinical research ed.))
[2021, 373:n826]

Cited: 6 times

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The disproportionate excess mortality risk of COVID-19 in younger people with diabetes warrants vaccination prioritisation.

Andrew P McGovern, Nick J Thomas, Sebastian J Vollmer, Andrew T Hattersley, Bilal A Mateen, John M Dennis,

Diabetologia (Diabetologia)
[2021, 64(5):1184-1186]

Cited: 6 times

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Improving Survival of Critical Care Patients With Coronavirus Disease 2019 in England: A National Cohort Study, March to June 2020.

John M Dennis, Andrew P McGovern, Sebastian J Vollmer, Bilal A Mateen,

<h4>Objectives</h4>To measure temporal trends in survival over time in people with severe coronavirus disease 2019 requiring critical care (high dependency unit or ICU) management, and to assess whether temporal variation in mortality was explained by changes in patient demographics and comorbidity burden over time.<h4>Design</h4>Retrospective observational cohort; based on data reported ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(2):209-214]

Cited: 65 times

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Hospital bed capacity and usage across secondary healthcare providers in England during the first wave of the COVID-19 pandemic: a descriptive analysis.

Bilal Akhter Mateen, Harrison Wilde, John M Dennis, Andrew Duncan, Nick Thomas, Andrew McGovern, Spiros Denaxas, Matt Keeling, Sebastian Vollmer,

<h4>Objective</h4>In this study, we describe the pattern of bed occupancy across England during the peak of the first wave of the COVID-19 pandemic.<h4>Design</h4>Descriptive survey.<h4>Setting</h4>All non-specialist secondary care providers in England from 27 March27to 5 June 2020.<h4>Participants</h4>Acute (non-specialist) trusts with a type 1 (ie, 24 hours/day, consultant-led) accident and emergency department (n=125), ... Read more >>

BMJ Open (BMJ open)
[2021, 11(1):e042945]

Cited: 9 times

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A national retrospective cohort study of mechanical ventilator availability and its association with mortality risk in intensive care patients with COVID-19

Harrison Wilde, Thomas Mellan, Iwona Hawryluk, John Dennis, Spiros Denaxas, Christina Pagel, Andrew Duncan, Samir Bhatt, Seth Flaxman, Bilal Mateen, Sebastian Vollmer,

<h4>Objectives: </h4> To determine if there is an association between survival rates in intensive care units (ICU) and occupancy of the unit on the day of admission. <h4>Design:</h4> National retrospective observational cohort study during the COVID-19 pandemic. <h4>Setting:</h4> 90 English hospital trusts (i.e. groups of hospitals functioning as single operational ... Read more >>

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The role of impulsivity in neurorehabilitation: A prospective cohort study of a potential cognitive biomarker for fall risk?

Bilal A Mateen, Ndidi Boakye, Raphael Sonabend, Noreen Russell, Alessia Saverino,

<h4>Background</h4>Executive dysregulation and impulsivity can both predispose individuals to risk-prone actions. Although the risk of falls is well established in people with poor executive function, its association to impulsivity is less clear.<h4>Purpose</h4>To describe and assess the prognostic capabilities of the relationship between impulsivity, executive function, functional capability, and falls in ... Read more >>

J Neuropsychol (Journal of neuropsychology)
[2021, 15(3):379-395]

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A semi-supervised approach for rapidly creating clinical biomarker phenotypes in the UK Biobank using different primary care EHR and clinical terminology systems.

Spiros Denaxas, Anoop D Shah, Bilal A Mateen, Valerie Kuan, Jennifer K Quint, Natalie Fitzpatrick, Ana Torralbo, Ghazaleh Fatemifar, Harry Hemingway,

<h4>Objectives</h4>The UK Biobank (UKB) is making primary care electronic health records (EHRs) for 500 000 participants available for COVID-19-related research. Data are extracted from four sources, recorded using five clinical terminologies and stored in different schemas. The aims of our research were to: (a) develop a semi-supervised approach for bootstrapping EHR ... Read more >>

JAMIA Open (JAMIA open)
[2020, 3(4):545-556]

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Type 2 Diabetes and COVID-19-Related Mortality in the Critical Care Setting: A National Cohort Study in England, March-July 2020.

John M Dennis, Bilal A Mateen, Raphael Sonabend, Raphael Sonabend, Nicholas J Thomas, Kashyap A Patel, Andrew T Hattersley, Spiros Denaxas, Spiros Denaxas, Andrew P McGovern, Sebastian J Vollmer,

<h4>Objective</h4>To describe the relationship between type 2 diabetes and all-cause mortality among adults with coronavirus disease 2019 (COVID-19) in the critical care setting.<h4>Research design and methods</h4>This was a nationwide retrospective cohort study in people admitted to hospital in England with COVID-19 requiring admission to a high dependency unit (HDU) or ... Read more >>

Diabetes Care (Diabetes care)
[2021, 44(1):50-57]

Cited: 33 times

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The "Is mpMRI Enough" or IMRIE Study: A Multicentre Evaluation of Prebiopsy Multiparametric Magnetic Resonance Imaging Compared with Biopsy.

Thomas Stonier, Nick Simson, Taimur Shah, Niyati Lobo, Tarik Amer, Su-Min Lee, Edward Bass, Edwin Chau, Alistair Grey, Neil McCartan, Peter Acher, Imran Ahmad, Nimalan Arumainayagam, Dominic Brown, Alex Chapman, Deborah Elf, Thomas Hartington, Ibrahim Ibrahim, Hing Leung, Sidath Liyanage, Catherine Lovegrove, Theo Malthouse, Bilal Mateen, Kiki Mistry, Iain Morrison, Sarika Nalagatla, Raj Persad, Alvan Pope, Heminder Sokhi, Hira Syed, Sergey Tadtayev, Meera Tharmaratnam, Ahmed Qteishat, Saiful Miah, Mark Emberton, Caroline Moore, Tom Walton, Ben Eddy, Hashim U Ahmed,

<h4>Background</h4>Multiparametric magnetic resonance imaging (mpMRI) is now recommended prebiopsy in numerous healthcare regions based on the findings of high-quality studies from expert centres. Concern remains about reproducibility of mpMRI to rule out clinically significant prostate cancer (csPCa) in real-world settings.<h4>Objective</h4>To assess the diagnostic performance of mpMRI for csPCa in a ... Read more >>

Eur Urol Focus (European urology focus)
[2021, 7(5):1027-1034]

Cited: 3 times

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Improving COVID-19 critical care mortality over time in England: A national cohort study, March to June 2020

John Dennis, Andrew McGovern, Sebastian Vollmer, Bilal Mateen,

<h4>Objectives</h4> To determine the trend in mortality risk over time in people with severe COVID-19 requiring critical care (high intensive unit [HDU] or intensive care unit [ICU]) management. <h4>Methods</h4> We accessed national English data on all adult COVID-19 specific critical care admissions from the COVID-19 Hospitalisation in England Surveillance System ... Read more >>

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Digital Health Management During and Beyond the COVID-19 Pandemic: Opportunities, Barriers, and Recommendations.

Becky Inkster, Ross O'Brien, Emma Selby, Smriti Joshi, Vinod Subramanian, Madhura Kadaba, Knut Schroeder, Suzi Godson, Kerstyn Comley, Sebastian J Vollmer, Bilal A Mateen,

During the coronavirus disease (COVID-19) crisis, digital technologies have become a major route for accessing remote care. Therefore, the need to ensure that these tools are safe and effective has never been greater. We raise five calls to action to ensure the safety, availability, and long-term sustainability of these technologies: ... Read more >>

JMIR Ment Health (JMIR mental health)
[2020, 7(7):e19246]

Cited: 12 times

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A geotemporal survey of hospital bed saturation across England during the first wave of the COVID-19 Pandemic

Bilal Mateen, Harrison Wilde, John Dennis, Andrew Duncan, Nicholas Thomas, Andrew McGovern, Spiros Denaxas, Matt Keeling, Sebastian Vollmer,

<h4>Background</h4> Non-pharmacological interventions were introduced based on modelling studies which suggested that the English National Health Service (NHS) would be overwhelmed by the COVID-19 pandemic. In this study, we describe the pattern of bed occupancy across England during the first wave of the pandemic, January 31st to June 5th 2020. ... Read more >>

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Building the future of financial healthcare technology practices

Becky Inkster, Andrea Stevenson, Bilal Mateen, Peggy Loo,

<p>Given the demands for services that intersect financial health and well-being, and that people are increasingly operationalizing their digital footprints, we argue for the co-evolution of healthcare practices and financial technology. Innovation bridged across finance, health and technology could inform new practice/operating models, whilst fostering environments that value and prioritize ... Read more >>

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A semi-supervised approach for rapidly creating clinical biomarker phenotypes in the UK Biobank using different primary care EHR and clinical terminology systems

Spiros Denaxas, Anoop Shah, Bilal Mateen, Valerie Kuan, Jennifer Quint, Natalie Fitzpatrick, Ana Torralbo, Ghazaleh Fatemifar, Harry Hemingway,

<h4>Objectives</h4> The UK Biobank (UKB) is making primary care Electronic Health Records (EHR) for 500,000 participants available for COVID-19-related research. Data are extracted from four sources, recorded using five clinical terminologies and stored in different schemas. The aims of our research were to: a) develop a semi-supervised approach for bootstrapping ... Read more >>

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Electronic Health Records to Predict Gestational Diabetes Risk.

Bilal A Mateen, Anna L David, Spiros Denaxas,

Gestational diabetes mellitus is a common pregnancy complication associated with significant adverse health outcomes for both women and infants. Effective screening and early prediction tools as part of routine clinical care are needed to reduce the impact of the disease on the baby and mother. Using large-scale electronic health records, ... Read more >>

Trends Pharmacol Sci (Trends in pharmacological sciences)
[2020, 41(5):301-304]

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