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Author Bharat Thyagarajan

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Neither Donor nor Recipient Mitochondrial Haplotypes Are Associated with Unrelated Donor Transplant Outcomes: A Validation Study from the CIBMTR.

Logan G Spector, Stephen R Spellman, Bharat Thyagarajan, Kenneth B Beckman, Cody Hoffmann, John Garbe, Theresa Hahn, Lara Sucheston-Campbell, Michaela Richardson, Todd E De For, Jakub Tolar, Michael R Verneris,

Graft-versus-host-disease (GVHD) is a multistep process that involves T-cell recognition and priming toward alloantigen, expansion, acquisition of effector function, and repeated tissue injury, resulting in clinical manifestations of the disease. All of these processes have considerable metabolic demands and understanding the key role of mitochondria in cellular metabolism as it ... Read more >>

Transplant Cell Ther (Transplantation and cellular therapy)
[2021, :]

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Novel application of nutritional biomarkers from a controlled feeding study and observational study toward dietary pattern characterization in postmenopausal women.

Marian L Neuhouser, Mary Pettinger, Johanna W Lampe, Lesley F Tinker, Stephanie M George, Jill Reedy, Xiaoling Song, Bharat Thyagarajan, Shirley A A Beresford, Ross L Prentice,

Dietary guidance emphasizes healthy dietary patterns, but supporting evidence comes from measurement-error prone self-reported diet. We explored whether nutritional biomarkers from the Women's Health Initiative Nutrition and Physical Activity Assessment Study Feeding Study (n=153; 2010-2014) and the WHI-NPAAS Observational Study (NPAAS-OS; n=450; 2006-2009) could identify biomarker signatures of dietary patterns ... Read more >>

Am J Epidemiol (American journal of epidemiology)
[2021, :]

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Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies.

Qibin Qi, Jun Li, Bing Yu, Jee-Young Moon, Jin C Chai, Jordi Merino, Jie Hu, Miguel Ruiz-Canela, Casey Rebholz, Zheng Wang, Mykhaylo Usyk, Guo-Chong Chen, Bianca C Porneala, Wenshuang Wang, Ngoc Quynh Nguyen, Elena V Feofanova, Megan L Grove, Thomas J Wang, Robert E Gerszten, Josée Dupuis, Jordi Salas-Salvadó, Wei Bao, David L Perkins, Martha L Daviglus, Bharat Thyagarajan, Jianwen Cai, Tao Wang, JoAnn E Manson, Miguel A Martínez-González, Elizabeth Selvin, Kathryn M Rexrode, Clary B Clish, Frank B Hu, James B Meigs, Rob Knight, Robert D Burk, Eric Boerwinkle, Robert C Kaplan,

<h4>Objective</h4>Tryptophan can be catabolised to various metabolites through host kynurenine and microbial indole pathways. We aimed to examine relationships of host and microbial tryptophan metabolites with incident type 2 diabetes (T2D), host genetics, diet and gut microbiota.<h4>Method</h4>We analysed associations between circulating levels of 11 tryptophan metabolites and incident T2D in ... Read more >>

Gut (Gut)
[2021, :]

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Identification of a Novel Locus for Gait Speed Decline with Aging: The Long Life Family Study.

Adam J Santanasto, Mary K Wojczynski, Ryan K Cvejkus, Shiow Lin, Lihua Wang, Bharat Thyagarajan, Kaare Christensen, Nicole Schupf, Mary F Feitosa, Ping An, Joseph M Zmuda,

<h4>Background</h4>Gait speed is a powerful indicator of health with aging. Potential genetic contributions to gait speed and its decline with aging are not well defined. We determined the heritability of and potential genetic regions underlying change in gait speed using longitudinal data from 2379 individuals belonging to 509 families in ... Read more >>

J Gerontol A Biol Sci Med Sci (The journals of gerontology. Series A, Biological sciences and medical sciences)
[2021, :]

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Multi-ethnic genome-wide association analyses of white blood cell and platelet traits in the Population Architecture using Genomics and Epidemiology (PAGE) study.

Yao Hu, Stephanie A Bien, Katherine K Nishimura, Jeffrey Haessler, Chani J Hodonsky, Antoine R Baldassari, Heather M Highland, Zhe Wang, Michael Preuss, Colleen M Sitlani, Genevieve L Wojcik, Ran Tao, Mariaelisa Graff, Laura M Huckins, Quan Sun, Ming-Huei Chen, Abdou Mousas, Paul L Auer, Guillaume Lettre, , Charles Kooperberg,

<h4>Background</h4>Circulating white blood cell and platelet traits are clinically linked to various disease outcomes and differ across individuals and ancestry groups. Genetic factors play an important role in determining these traits and many loci have been identified. However, most of these findings were identified in populations of European ancestry (EA), ... Read more >>

BMC Genomics (BMC genomics)
[2021, 22(1):432]

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Prediction of False-Positive Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Molecular Results in a High-Throughput Open-Platform System.

Ryan J Martinez, Nathan Pankratz, Matthew Schomaker, Jerry Daniel, Kenneth Beckman, Amy B Karger, Bharat Thyagarajan, Patricia Ferreri, Sophia L Yohe, Andrew C Nelson,

Widespread high-throughput testing for identification of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection by reverse transcriptase PCR has been a foundation in the response to the coronavirus disease 2019 (COVID-19) pandemic. Quality assurance metrics for these reverse transcriptase PCR tests are still evolving as testing becomes widely implemented. As ... Read more >>

J Mol Diagn (The Journal of molecular diagnostics : JMD)
[2021, :]

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Circulating Procollagen Type III N-Terminal Peptide and Physical Function in Adults from the Long Life Family Study.

Adam J Santanasto, Ryan K Cvejkus, Mary K Wojczynski, Megan M Marron, Nicole Schupf, Kaare Christensen, Bharat Thyagarajan, Joseph M Zmuda,

<h4>Background</h4>Circulating levels of procollagen type III N-terminal peptide (P3NP) may reflect increased fibrosis of skeletal muscle and other tissues with aging. Herein, we tested if P3NP was associated with baseline and 7-year change in physical function.<h4>Method</h4>Participants (n = 400) were from the Long Life Family Study, a study of exceptional ... Read more >>

J Gerontol A Biol Sci Med Sci (The journals of gerontology. Series A, Biological sciences and medical sciences)
[2021, 76(7):1273-1279]

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Influence of Stress, Gender, and Minority Status on Cardiovascular Disease Risk in the Hispanic/Latino Community: Protocol for a Longitudinal Observational Cohort Study.

Tonia Poteat, Linda C Gallo, Audrey Harkness, Carmen R Isasi, Phoenix Matthews, Neil Schneiderman, Bharat Thyagarajan, Martha L Daviglus, Daniela Sotres-Alvarez, Krista M Perreira,

<h4>Background</h4>Hispanic/Latino sexual and gender minorities (SGM) are the fastest growing ethnic group of SGM in the United States. Cardiovascular disease (CVD) is a leading cause of morbidity and mortality among Hispanics/Latinos. SGM inequities in CVD risk have been identified as early as young adulthood, and minority stress has been identified ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2021, 10(5):e28997]

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Associations of Age, Sex, Race/Ethnicity, and Education With 13 Epigenetic Clocks in a Nationally Representative U.S. Sample: The Health and Retirement Study.

Eileen M Crimmins, Bharat Thyagarajan, Morgan E Levine, David R Weir, Jessica Faul,

<h4>Background</h4>Many DNA methylation-based indicators have been developed as summary measures of epigenetic aging. We examine the associations between 13 epigenetic clocks, including 4 second generation clocks, as well as the links of the clocks to social, demographic, and behavioral factors known to be related to health outcomes: sex, race/ethnicity, socioeconomic ... Read more >>

J Gerontol A Biol Sci Med Sci (The journals of gerontology. Series A, Biological sciences and medical sciences)
[2021, 76(6):1117-1123]

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One-Step Multiplexed Droplet Digital Polymerase Chain Reaction for Quantification of p190 BCR-ABL1 Fusion Transcript in B-Lymphoblastic Leukemia.

Ryan J Martinez, Qing Kang, Davis Nennig, Nathanael G Bailey, Noah A Brown, Bryan L Betz, Muneesh Tewari, Bharat Thyagarajan, Veronika Bachanova, Pawel Mroz,

<h4>Context.—</h4>Quantification and detection of the t(9;22) (BCR-ABL1) translocation in chronic myelogenous leukemia and B-lymphoblastic leukemia are important for directing treatment protocols and monitoring disease relapse. However, quantification using traditional reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) is dependent on a calibration curve and is prone to laboratory-to-laboratory variation. Droplet digital ... Read more >>

Arch Pathol Lab Med (Archives of pathology & laboratory medicine)
[2021, :]

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Heterogeneity of the Predictive Polygenic Risk Scores for Coronary Heart Disease Age-at-Onset in Three Different Coronary Heart Disease Family-Based Ascertainments.

Mary F Feitosa, Allison L Kuipers, Mary K Wojczynski, Lihua Wang, Emma Barinas-Mitchell, Alexander M Kulminski, Bharat Thyagarajan, Joseph H Lee, Thomas Perls, Kaare Christensen, Anne B Newman, Joseph M Zmuda, Michael A Province,

<h4>Background</h4>Polygenic risk scores (PRS) for coronary heart disease (CHD) may contribute to assess the overall risk of CHD. We evaluated how PRS may influence CHD risk when the distribution of age-at-onset, sex, and family health history differ significantly.<h4>Methods</h4>Our study included 3 family-based ascertainments: LLFS (Long Life Family Study, N<sub>Individuals</sub>=4572), which ... Read more >>

Circ Genom Precis Med (Circulation. Genomic and precision medicine)
[2021, 14(3):e003201]

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Genetic association analysis of the cardiovascular biomarker: N-terminal fragment of pro-B-type natriuretic peptide (NT-proBNP).

Yuan Yang, Joseph M Zmuda, Mary K Wojczynski, Bharat Thyagarajan, Kaare Christensen, Ryan K Cvejkus, Allison L Kuipers,

<h4>Background</h4>NT-proBNP is a biomarker of cardiovascular disease (CVD). Little is known about the heritability and genetic variants associated with NT-proBNP. Therefore, we estimated the heritability of and examined genetic associations of SNPs in the BNP gene region with circulating NT-proBNP and prevalent CVD in 4,331 participants from the Long Life ... Read more >>

PLoS One (PloS one)
[2021, 16(3):e0248726]

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Quest for a summary measure of biological age: the health and retirement study.

Eileen M Crimmins, Bharat Thyagarajan, Jung Ki Kim, David Weir, Jessica Faul,

Measures of biological age and its components have been shown to provide important information about individual health and prospective change in health as there is clear value in being able to assess whether someone is experiencing accelerated or decelerated aging. However, how to best assess biological age remains a question. ... Read more >>

Geroscience (GeroScience)
[2021, 43(1):395-408]

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Seroprevalence and determinants of Helicobacter pylori infection in the Hispanic Community Health Study/Study of Latinos.

Sabrina H Tsang, M Larissa Avilés-Santa, Christian C Abnet, Maximo O Brito, Martha L Daviglus, Sylvia Wassertheil-Smoller, Sheila F Castañeda, Sharon Minnerath, Gregory A Talavera, Barry I Graubard, Bharat Thyagarajan, M Constanza Camargo,

<h4>Background and aims</h4>Helicobacter pylori infection is the primary known risk factor for gastric cancer. Despite the global decline in H. pylori prevalence, this infection remains a major public health concern in developing areas, including Latin America. Our study aimed to determine H. pylori seroprevalence and identified its determinants among Hispanics/Latinos ... Read more >>

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2021, :]

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Association of liver enzymes with incident diabetes in US Hispanic/Latino adults.

Simin Hua, Qibin Qi, Jorge R Kizer, Jessica Williams-Nguyen, Howard D Strickler, Bharat Thyagarajan, Martha Daviglus, Gregory A Talavera, Neil Schneiderman, Scott J Cotler, Jianwen Cai, Robert Kaplan, Carmen R Isasi,

<h4>Introduction</h4>Non-alcoholic fatty liver disease (NAFLD) has been associated with increased risk of incident diabetes. But such evidence is lacking in the Hispanic/Latino population, which has high prevalence of obesity and NAFLD.<h4>Methods</h4>We conducted a prospective cohort study of 6,928 adults of Hispanic/Latino background who had no diabetes, did not report excessive ... Read more >>

Diabet Med (Diabetic medicine : a journal of the British Diabetic Association)
[2021, 38(8):e14522]

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Digital Technology Differentiates Graphomotor and Information Processing Speed Patterns of Behavior.

Stacy L Andersen, Benjamin Sweigart, Nancy W Glynn, Mary K Wojczynski, Bharat Thyagarajan, Jonas Mengel-From, Stephen Thielke, Thomas T Perls, David J Libon, Rhoda Au, Stephanie Cosentino, Paola Sebastianion, ,

<h4>Background</h4>Coupling digital technology with traditional neuropsychological test performance allows collection of high-precision metrics that can clarify and/or define underlying constructs related to brain and cognition.<h4>Objective</h4>To identify graphomotor and information processing trajectories using a digitally administered version of the Digit Symbol Substitution Test (DSST).<h4>Methods</h4>A subset of Long Life Family Study participants ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2021, 82(1):17-32]

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Cancer Treatment-Induced Accelerated Aging in Cancer Survivors: Biology and Assessment.

Shuo Wang, Anna Prizment, Bharat Thyagarajan, Anne Blaes,

Rapid improvements in cancer survival led to the realization that many modalities used to treat or control cancer may cause accelerated aging in cancer survivors. Clinically, "accelerated aging" phenotypes in cancer survivors include secondary cancers, frailty, chronic organ dysfunction, and cognitive impairment, all of which can impact long-term health and ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(3):]

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The presence of emphysema on chest imaging and mid-life cognition.

Benjamin E Henkle, Laura A Colangelo, Mark T Dransfield, Lifang Hou, David R Jacobs, Brian T Joyce, Carrie L Pistenmaa, Rachel K Putman, Steve Sidney, Bharat Thyagarajan, George R Washko, Kristine Yaffe, Ravi Kalhan, Ken M Kunisaki,

<h4>Background</h4>Airflow obstruction is associated with cognitive dysfunction but studies have not assessed how emphysema, a structural phenotype of lung disease, might be associated with cognitive function independent from pulmonary function measured by spirometry. We aimed to determine the relationship between the presence of visually detectable emphysema on chest computed tomography ... Read more >>

ERJ Open Res (ERJ open research)
[2021, 7(1):]

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Differences in Predicted Warfarin Dosing Requirements Between Hmong and East Asians Using Genotype-Based Dosing Algorithms.

Boguang Sun, Ya-Feng Wen, Kathleen A Culhane-Pera, Muaj Lo, Txia Xiong, Koobmeej Lee, Kerui Peng, Bharat Thyagarajan, Jeffrey R Bishop, Heather Zierhut, Robert J Straka,

<h4>Introduction</h4>Warfarin's narrow therapeutic index and high variability in dosage requirements make dosage selection critical. Genetic factors are known to impact warfarin dosage selection. The Hmong are a unique Asian subpopulation numbering over 278,000 in the United States whose participation in genetics-based research is virtually nonexistent. The translational significance of early ... Read more >>

Pharmacotherapy (Pharmacotherapy)
[2021, 41(3):265-276]

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APOE alleles' association with cognitive function differs across Hispanic/Latino groups and genetic ancestry in the study of Latinos-investigation of neurocognitive aging (HCHS/SOL).

Einat Granot-Hershkovitz, Wassim Tarraf, Nuzulul Kurniansyah, Martha Daviglus, Carmen R Isasi, Robert Kaplan, Melissa Lamar, Krista M Perreira, Sylvia Wassertheil-Smoller, Ariana Stickel, Bharat Thyagarajan, Donglin Zeng, Myriam Fornage, Charles S DeCarli, Hector M González, Tamar Sofer,

<h4>Introduction</h4>Apolipoprotein E (APOE) alleles are associated with cognitive decline, mild cognitive impairment (MCI), and Alzheimer's disease in Whites, but have weaker and inconsistent effects reported in Latinos. We hypothesized that this heterogeneity is due to ancestry-specific genetic effects.<h4>Methods</h4>We investigated the associations of the APOE alleles with significant cognitive decline and MCI in 4183 Latinos, ... Read more >>

Alzheimers Dement (Alzheimer's & dementia : the journal of the Alzheimer's Association)
[2021, 17(3):466-474]

Cited: 2 times

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Use of Potentially Inappropriate Medications in Older Allogeneic Hematopoietic Cell Transplantation Recipients.

Divya Bhargava, Mukta Arora, Todd E DeFor, Claudio G Brunstein, Bharat Thyagarajan, Najla El Jurdi, Shernan G Holtan, Armin Rashidi, Erica Warlick, Vidhyalakshmi Ramesh, John Rogosheske, Smita Bhatia, Daniel J Weisdorf,

The use of potentially inappropriate medications (PIMs) using Beers criteria and its impact on older allogeneic hematopoietic cell transplantation (HCT) recipients is not known. Here the use of any PIMs and their therapeutic classes in reduced-intensity conditioning allogeneic HCT recipients were compared between older (≥65 years; n = 114) and younger (40 to ... Read more >>

Biol Blood Marrow Transplant (Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation)
[2020, 26(12):2329-2334]

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Genetics of Malignant Hyperthermia: A Brief Update.

David Beebe, Vikram V Puram, Srdjan Gajic, Bharat Thyagarajan, Kumar G Belani,

Malignant hyperthermia susceptibility (MHS) and the associated condition malignant hyperthermia (MH) are rare but well-known disorders in the field of anesthesiology. MHS is usually determined by a history of a family member developing a positive episode during general anesthesia and then confirmed by an invasive caffeine halothane contracture test (CHCT). ... Read more >>

J Anaesthesiol Clin Pharmacol (Journal of anaesthesiology, clinical pharmacology)
[2020, 36(4):552-555]

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Diabetes and kidney cancer risk among post-menopausal women: The Iowa women's health study.

Shuo Wang, Mark D Lo Galbo, Cindy Blair, Bharat Thyagarajan, Kristin E Anderson, DeAnn Lazovich, Anna Prizment,

<h4>Background</h4>Many studies have reported a positive association between diabetes and kidney cancer. However, it is unclear whether diabetes is a risk factor for kidney cancer independent of other risk factors, such as obesity and hypertension. We comprehensively examined the association of diabetes and its duration with incident kidney cancer in ... Read more >>

Maturitas (Maturitas)
[2021, 143:190-196]

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Randomised clinical study: oral aspirin 325 mg daily vs placebo alters gut microbial composition and bacterial taxa associated with colorectal cancer risk.

Anna E Prizment, Christopher Staley, Guillaume C Onyeaghala, Sithara Vivek, Bharat Thyagarajan, Robert J Straka, Ryan T Demmer, Dan Knights, Katie A Meyer, Aasma Shaukat, Michael J Sadowsky, Timothy R Church,

<h4>Background</h4>Aspirin is associated with decreased risk of colorectal cancer (CRC), potentially by modulating the gut microbiome.<h4>Aims</h4>To evaluate the effect of aspirin on the gut microbiome in a double-blinded, randomised placebo-controlled pilot trial.<h4>Methods</h4>Healthy volunteers aged 50-75 received a standard dose of aspirin (325 mg, N = 30) or placebo (N = 20) once daily for 6 weeks ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2020, 52(6):976-987]

Cited: 6 times

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Lung Function and Gene Expression of Pathogen Recognition Pathway Receptors: the Cardia Lung Study.

Ramya Ramasubramanian, Ravi Kalhan, David R Jacobs, George R Washko, Lifang Hou, Myron D Gross, Weihua Guan, Bharat Thyagarajan,

Activation of toll-like receptors (TLR1, TLR5, TLR6) and downstream markers (CCR1, MAPK14, ICAM1) leads to increased systemic inflammation. Our objective was to study the association between the gene expression levels of these six genes and lung function (Forced Expiratory Volume in one second (FEV<sub>1</sub>), Forced Vital Capacity (FVC) and FEV<sub>1</sub>/FVC). ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):9360]

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