Full Text Journal Articles by
Author Betty C Chen


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Iatrogenic pediatric hydroxocobalamin overdose.

Benjamin T Friedman, Betty C Chen, Andrew J Latimer, Matthew J Valento,

INTRODUCTION:Hydroxocobalamin, a precursor molecule to vitamin B12, has emerged as the preferred empiric treatment for patients rescued from enclosed-space fires with concern for inhalational injury and potential concomitant cyanide toxicity. Limited data exist on the effects of hydroxocobalamin toxicity, particularly in pediatric patients. CASE REPORT:We report a case of a ... Read more >>

Am J Emerg Med (The American Journal of Emergency Medicine)
[2019, 37(7):1394.e1-1394.e2]

Cited: 0 times

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Reversal of Pediatric Opioid Toxicity with Take-Home Naloxone: a Case Report.

Jacob A Lebin, Betty C Chen, Matthew J Valento,

BACKGROUND:Take-home naloxone, an opioid antagonist, has become part of a multimodal approach to curbing opioid-related mortality. However, there is little information about the utility of take-home naloxone in pediatric patients. We report a case of opioid toxicity after exposure to methadone in a pediatric patient, which was successfully reversed with ... Read more >>

J Med Toxicol (Journal of medical toxicology : official journal of the American College of Medical Toxicology)
[2019, 15(2):134-135]

Cited: 1 time

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Clozapine Intoxication Mimicking Acute Stroke.

Jacob A Lebin, Joshua D Villarreal, Betty C Chen, M Kennedy Hall,

Clozapine is an atypical antipsychotic drug prescribed for treatment-resistant schizophrenia. The risk of adverse hematologic, cardiovascular, and neurologic effects has tempered its use, and reports of overdoses remain rare. We report a case of accidental acute clozapine intoxication in a clozapine-naïve patient, who presented with symptoms mimicking acute stroke and ... Read more >>

Clin Pract Cases Emerg Med (Clinical practice and cases in emergency medicine)
[2018, 2(2):155-157]

Cited: 0 times

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Flibanserin toxicity in a toddler following ingestion.

Nicholas Granzella, Betty C Chen, Geoffrey S Baird, Matthew Valento,

INTRODUCTION:Flibanserin is a medication recently approved by the FDA for treatment of generalized hypoactive sexual desire disorder (HSDD) in premenopausal women. Its mechanism of action is not fully understood but is thought to modulate serotonin receptors and increase levels of norepinephrine and dopamine. While much is known about toxicity of ... Read more >>

Clin Toxicol (Phila) (Clinical toxicology (Philadelphia, Pa.))
[2018, 56(3):226-228]

Cited: 0 times

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Regarding "Phenobarbital for Acute Alcohol Withdrawal: A Prospective Randomized Double-Blind Placebo-Controlled Study".

Morgan A A Riggan, Kate Hayman, Betty C Chen, Robert S Hoffman,

J Emerg Med (The Journal of emergency medicine)
[2016, 50(6):895-896]

Cited: 0 times

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Death following intentional ingestion of e-liquid.

Betty C Chen, Steven B Bright, Amit Raj Trivedi, Matthew Valento,

Electronic cigarette (e-cigarette) use is growing within the United States, resulting in both intentional and unintentional exposures to concentrated liquid nicotine or "e-liquid." Nicotine has been culpable for severe poisoning and deaths in the past. However, sources of nicotine have traditionally been from cigarettes, cigars, or pesticides. Fatalities due to ... Read more >>

Clin Toxicol (Phila) (Clinical toxicology (Philadelphia, Pa.))
[2015, 53(9):914-916]

Cited: 17 times

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Should transient physiologic effects following lipid administration be attributed to a cellular signaling mechanism without cellular data?

Betty C Chen, Mark Taylor, Melissa Langevin, Robert S Hoffman,

Crit. Care Med. (Critical care medicine)
[2013, 41(11):e389]

Cited: 0 times

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Hemodialysis for the treatment of pulmonary hemorrhage from dabigatran overdose.

Betty C Chen, Nijal R Sheth, Kobena A Dadzie, Silas W Smith, Lewis S Nelson, Robert S Hoffman, James F Winchester,

Dabigatran is an oral direct thrombin inhibitor indicated for thromboembolism prophylaxis in patients with nonvalvular atrial fibrillation. Since its approval in the United States in 2010, dabigatran-associated hemorrhages have garnered much attention because bleeding rates were higher than initially expected. Additionally, reversing anticoagulation remains challenging. Traditional modes of reversing warfarin-associated ... Read more >>

Am. J. Kidney Dis. (American journal of kidney diseases : the official journal of the National Kidney Foundation)
[2013, 62(3):591-594]

Cited: 25 times

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Hemorrhagic complications associated with dabigatran use.

Betty C Chen, Aaron D Viny, Fiona M Garlich, Paul Basciano, Mary Ann Howland, Silas W Smith, Robert S Hoffman, Lewis S Nelson,

OBJECTIVE: Dabigatran is a direct thrombin inhibitor approved for anticoagulation in non-valvular atrial fibrillation and, in some countries, for thromboembolism prophylaxis following select orthopedic surgeries. Despite decreased rates of thromboembolism, bleeding remains a risk due to the inability to conveniently monitor anticoagulant effect and the lack of a reversal agent. ... Read more >>

Clin Toxicol (Phila) (Clinical toxicology (Philadelphia, Pa.))
[2012, 50(9):854-857]

Cited: 28 times

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Performance in appropriate Rh testing and treatment with Rh immunoglobulin in the emergency department.

Richard T Griffey, Betty C Chen, Nicholas W Krehbiel,

STUDY OBJECTIVE: The quality measure "Rh immunoglobulin administration for Rh-negative women at risk for fetal blood exposure" was recently endorsed by the National Quality Forum. No published data have shown a related performance gap in US emergency departments (EDs). We determine performance in a US ED for appropriate Rh testing ... Read more >>

Ann Emerg Med (Annals of emergency medicine)
[2012, 59(4):285-293]

Cited: 2 times

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A case report of porphyria variegata management in the emergency department.

Betty C Chen, Richard T Griffey,

BACKGROUND: Porphyria variegata (VP) is one of the hepatic porphyrias that results from the deficiency of protoporphyrinogen oxidase, an enzyme in the heme synthesis pathway. The name porphyria variegata refers to its many presentations, which include various neuropsychiatric and cutaneous manifestations. Emergency department (ED) presentations due to VP are most ... Read more >>

J Emerg Med (The Journal of emergency medicine)
[2012, 43(4):e235-8]

Cited: 0 times

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A transient N-O-linked Pauson-Khand strategy for the synthesis of the deschloro carbocyclic core of the palau'amines and styloguanidines.

Stefan G Koenig, Stefan M Miller, Kristi A Leonard, Ralf S Löwe, Betty C Chen, David J Austin,

A stereocontrolled route to the deschloro cyclopentyl core of the palau'amines and styloguanidines has been developed. This strategy makes use of the intramolecular Pauson-Khand cyclization of an enyne with a "transient N-O tether" to construct a five-membered carbocycle in a diastereoselective fashion. [reaction: see text] ... Read more >>

Org. Lett. (Organic letters)
[2003, 5(13):2203-2206]

Cited: 20 times

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