Full Text Journal Articles by
Author Bethany B Moore

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Coronavirus induces diabetic macrophage-mediated inflammation via SETDB2.

William J Melvin, Christopher O Audu, Frank M Davis, Sriganesh B Sharma, Amrita Joshi, Aaron DenDekker, Sonya Wolf, Emily Barrett, Kevin Mangum, Xiaofeng Zhou, Monica Bame, Alex Ruan, Andrea Obi, Steven L Kunkel, Bethany B Moore, Katherine A Gallagher,

COVID-19 induces a robust, extended inflammatory "cytokine storm" that contributes to an increased morbidity and mortality, particularly in patients with type 2 diabetes (T2D). Macrophages are a key innate immune cell population responsible for the cytokine storm that has been shown, in T2D, to promote excess inflammation in response to ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(38):]

Cited: 0 times

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Experimental Models of Infectious Pulmonary Complications Following Hematopoietic Cell Transplantation.

Xiaofeng Zhou, Bethany B Moore,

Pulmonary infections remain a major cause of morbidity and mortality in hematopoietic cell transplantation (HCT) recipients. The prevalence and type of infection changes over time and is influenced by the course of immune reconstitution post-transplant. The interaction between pathogens and host immune responses is complex in HCT settings, since the ... Read more >>

Front Immunol (Frontiers in immunology)
[2021, 12:718603]

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Blood Transcriptomics Predicts Progression of Pulmonary Fibrosis and Associated Natural Killer Cells.

Yong Huang, Justin M Oldham, Shwu-Fan Ma, Avraham Unterman, Shu-Yi Liao, Andrew J Barros, Catherine A Bonham, John S Kim, Rekha Vij, Ayodeji Adegunsoye, Mary E Strek, Philip L Molyneaux, Toby M Maher, Jose D Herazo-Maya, Naftali Kaminski, Bethany B Moore, Fernando J Martinez, Imre Noth,

<b>Rationale:</b> Disease activity in idiopathic pulmonary fibrosis (IPF) remains highly variable, poorly understood, and difficult to predict. <b>Objectives:</b> To identify a predictor using short-term longitudinal changes in gene expression that forecasts future FVC decline and to characterize involved pathways and cell types. <b>Methods:</b> Seventy-four patients from COMET (Correlating Outcomes with ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2021, 204(2):197-208]

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Long-term survivors of murine sepsis are predisposed to enhanced LPS-induced lung injury and proinflammatory immune reprogramming.

Scott J Denstaedt, Angela C Bustamante, Michael W Newstead, Bethany B Moore, Theodore J Standiford, Rachel L Zemans, Benjamin H Singer,

Millions of people who survive sepsis each year are rehospitalized and die due to late pulmonary complications. To prevent and treat these complications, biomarkers and molecular mediators must be identified. Persistent immune reprogramming in the form of immunoparalysis and impaired host defense is proposed to mediate late pulmonary complications after ... Read more >>

Am J Physiol Lung Cell Mol Physiol (American journal of physiology. Lung cellular and molecular physiology)
[2021, 321(2):L451-L465]

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M2 macrophages have unique transcriptomes but conditioned media does not promote profibrotic responses in lung fibroblasts or alveolar epithelial cells in vitro.

Elissa M Hult, Stephen J Gurczynski, Bethany B Moore,

Macrophages are critical regulators of pulmonary fibrosis. Their plasticity, proximity, and ability to cross talk with structural cells of the lung make them a key cell type of interest in the regulation of lung fibrosis. Macrophages can express a variety of phenotypes, which have been historically represented through an "M1-like" ... Read more >>

Am J Physiol Lung Cell Mol Physiol (American journal of physiology. Lung cellular and molecular physiology)
[2021, 321(3):L518-L532]

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Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms.

Frank M Davis, Lam C Tsoi, William J Melvin, Aaron denDekker, Rachael Wasikowski, Amrita D Joshi, Sonya Wolf, Andrea T Obi, Allison C Billi, Xianying Xing, Christopher Audu, Bethany B Moore, Steven L Kunkel, Alan Daugherty, Hong S Lu, Johann E Gudjonsson, Katherine A Gallagher,

Abdominal aortic aneurysms (AAAs) are a life-threatening disease for which there is a lack of effective therapy preventing aortic rupture. During AAA formation, pathological vascular remodeling is driven by macrophage infiltration, and the mechanisms regulating macrophage-mediated inflammation remain undefined. Recent evidence suggests that an epigenetic enzyme, JMJD3, plays a critical ... Read more >>

J Exp Med (The Journal of experimental medicine)
[2021, 218(6):]

Cited: 2 times

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Concurrent Reductions in Spirometry Predict Mortality and Bronchiolitis Obliterans in Chronic Graft-versus-Host Disease.

David N O'Dwyer, Yizhuo Wang, Dawson Myers, Bethany B Moore, Susan Murray, Gregory A Yanik,

Ann Am Thorac Soc (Annals of the American Thoracic Society)
[2021, 18(4):720-723]

Cited: 0 times

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Elevated inflammatory responses and targeted therapeutic intervention in a preclinical mouse model of ataxia-telangiectasia lung disease.

Rudel A Saunders, Thomas F Michniacki, Courtney Hames, Hilary A Moale, Carol Wilke, Molly E Kuo, Johnathan Nguyen, Andrea J Hartlerode, Bethany B Moore, JoAnn M Sekiguchi,

Ataxia-telangiectasia (A-T) is an autosomal recessive, multisystem disorder characterized by cerebellar degeneration, cancer predisposition, and immune system defects. A major cause of mortality in A-T patients is severe pulmonary disease; however, the underlying causes of the lung complications are poorly understood, and there are currently no curative therapeutic interventions. In ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):4268]

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CCR2 Mediates Chronic LPS-Induced Pulmonary Inflammation and Hypoalveolarization in a Murine Model of Bronchopulmonary Dysplasia.

Tracy X Cui, Alexander E Brady, Christina T Fulton, Ying-Jian Zhang, Liza M Rosenbloom, Adam M Goldsmith, Bethany B Moore, Antonia P Popova,

The histopathology of bronchopulmonary dysplasia (BPD) includes hypoalveolarization and interstitial thickening due to abnormal myofibroblast accumulation. Chorioamnionitis and sepsis are major risk factors for BPD development. The cellular mechanisms leading to these lung structural abnormalities are poorly understood. We used an animal model with repeated lipopolysaccharide (LPS) administration into the ... Read more >>

Front Immunol (Frontiers in immunology)
[2020, 11:579628]

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Microengineered 3D pulmonary interstitial mimetics highlight a critical role for matrix degradation in myofibroblast differentiation.

Daniel L Matera, Katarina M DiLillo, Makenzee R Smith, Christopher D Davidson, Ritika Parikh, Mohammed Said, Carole A Wilke, Isabelle M Lombaert, Kelly B Arnold, Bethany B Moore, Brendon M Baker,

Fibrosis, characterized by aberrant tissue scarring from activated myofibroblasts, is often untreatable. Although the extracellular matrix becomes increasingly stiff and fibrous during disease progression, how these physical cues affect myofibroblast differentiation in 3D is poorly understood. Here, we describe a multicomponent hydrogel that recapitulates the 3D fibrous structure of interstitial ... Read more >>

Sci Adv (Science advances)
[2020, 6(37):]

Cited: 10 times

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The evolving role of the lung microbiome in pulmonary fibrosis.

Jay H Lipinski, Bethany B Moore, David N O'Dwyer,

Mucosal surfaces are constantly exposed to a microbiome consisting of microorganisms that heavily influence human immunity and health. In the lung these microorganisms consist of bacteria, viruses, and fungi and exist in a relatively low biomass state. Bacterial communities of the lung modulate local inflammation and correlate with changes in ... Read more >>

Am J Physiol Lung Cell Mol Physiol (American journal of physiology. Lung cellular and molecular physiology)
[2020, 319(4):L675-L682]

Cited: 4 times

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Epigenetic regulation of the PGE2 pathway modulates macrophage phenotype in normal and pathologic wound repair.

Frank M Davis, Lam C Tsoi, Rachael Wasikowski, Aaron denDekker, Amrita Joshi, Carol Wilke, Hongping Deng, Sonya Wolf, Andrea Obi, Steven Huang, Allison C Billi, Scott Robinson, Jay Lipinski, William J Melvin, Christopher O Audu, Stephan Weidinger, Steven L Kunkel, Andrew Smith, Johann E Gudjonsson, Bethany B Moore, Katherine A Gallagher,

Macrophages are a primary immune cell involved in inflammation, and their cell plasticity allows for transition from an inflammatory to a reparative phenotype and is critical for normal tissue repair following injury. Evidence suggests that epigenetic alterations play a critical role in establishing macrophage phenotype and function during normal and ... Read more >>

JCI Insight (JCI insight)
[2020, 5(17):]

Cited: 6 times

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Identification of a unique temporal signature in blood and BAL associated with IPF progression.

Katy C Norman, David N O'Dwyer, Margaret L Salisbury, Katarina M DiLillo, Vibha N Lama, Meng Xia, Stephen J Gurczynski, Eric S White, Kevin R Flaherty, Fernando J Martinez, Susan Murray, Bethany B Moore, Kelly B Arnold,

Idiopathic pulmonary fibrosis (IPF) is a progressive and heterogeneous interstitial lung disease of unknown origin with a low survival rate. There are few treatment options available due to the fact that mechanisms underlying disease progression are not well understood, likely because they arise from dysregulation of complex signaling networks spanning ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):12049]

Cited: 1 time

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Ineffectual Type 2-to-Type 1 Alveolar Epithelial Cell Differentiation in Idiopathic Pulmonary Fibrosis: Persistence of the KRT8hi Transitional State.

Peng Jiang, Rafael Gil de Rubio, Steven M Hrycaj, Stephen J Gurczynski, Kent A Riemondy, Bethany B Moore, M Bishr Omary, Karen M Ridge, Rachel L Zemans,

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2020, 201(11):1443-1447]

Cited: 13 times

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Master manipulators: how herpesviruses alter immune responses to RSV.

Stephen J Gurczynski, Bethany B Moore,

Mucosal Immunol (Mucosal immunology)
[2020, 13(5):715-716]

Cited: 0 times

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The Role of HHV-6 in Idiopathic Pulmonary Fibrosis Remains to Be Determined.

Nikolas C Victoria, Xiaofeng Zhou, Bethany B Moore,

Chest (Chest)
[2020, 157(6):1681-1682]

Cited: 0 times

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TNF-α regulates diabetic macrophage function through the histone acetyltransferase MOF.

Aaron D denDekker, Frank M Davis, Amrita D Joshi, Sonya J Wolf, Ronald Allen, Jay Lipinski, Brenda Nguyen, Joseph Kirma, Dylan Nycz, Jennifer Bermick, Bethany B Moore, Johann E Gudjonsson, Steven L Kunkel, Katherine A Gallagher,

A critical component of wound healing is the transition from the inflammatory phase to the proliferation phase to initiate healing and remodeling of the wound. Macrophages are critical for the initiation and resolution of the inflammatory phase during wound repair. In diabetes, macrophages display a sustained inflammatory phenotype in late ... Read more >>

JCI Insight (JCI insight)
[2020, 5(5):]

Cited: 3 times

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TLR3 absence confers increased survival with improved macrophage activity against pneumonia.

Madathilparambil V Suresh, Vladislav A Dolgachev, Boya Zhang, Sanjay Balijepalli, Samantha Swamy, Jashitha Mooliyil, Georgia Kralovich, Bivin Thomas, David Machado-Aranda, Monita Karmakar, Sanjeev Lalwani, Arulselvi Subramanian, Arun Anantharam, Bethany B Moore, Krishnan Raghavendran,

Toll-like receptor 3 (TLR3) is a pathogen recognition molecule associated with viral infection with double-stranded RNA (dsRNA) as its ligand. We evaluated the role of TLR3 in bacterial pneumonia using Klebsiella pneumoniae (KP). WT and TLR3-/- mice were subjected to a lethal model of KP. Alveolar macrophage polarization, bactericidal activity, ... Read more >>

JCI Insight (JCI insight)
[2019, 4(23):]

Cited: 1 time

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Radiographic Honeycombing and Altered Lung Microbiota in Patients with Idiopathic Pulmonary Fibrosis.

Robert P Dickson, Gary B Huffnagle, Kevin R Flaherty, Eric S White, Fernando J Martinez, John R Erb-Downward, Bethany B Moore, David N O'Dwyer,

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2019, 200(12):1544-1547]

Cited: 9 times

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Inhibition of the stem cell factor 248 isoform attenuates the development of pulmonary remodeling disease.

Andrew Rasky, David M Habiel, Susan Morris, Matthew Schaller, Bethany B Moore, Sem Phan, Steven L Kunkel, Martin Phillips, Cory Hogaboam, Nicholas W Lukacs,

Stem cell factor (SCF) and its receptor c-kit have been implicated in inflammation, tissue remodeling, and fibrosis. Ingenuity Integrated Pathway Analysis of gene expression array data sets showed an upregulation of SCF transcripts in idiopathic pulmonary fibrosis (IPF) lung biopsies compared with tissue from nonfibrotic lungs that are further increased ... Read more >>

Am J Physiol Lung Cell Mol Physiol (American journal of physiology. Lung cellular and molecular physiology)
[2020, 318(1):L200-L211]

Cited: 2 times

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Stem cell transplantation impairs dendritic cell trafficking and herpesvirus immunity.

Carol A Wilke, Mathew M Chadwick, Paul R Chan, Bethany B Moore, Xiaofeng Zhou,

Long-term survivors after hematopoietic stem cell transplantation are at high risk of infection, which accounts for one-third of all deaths related to stem cell transplantation. Little is known about the cause of inferior host defense after immune cell reconstitution. Here, we exploited a murine syngeneic BM transplantation (BMT) model of ... Read more >>

JCI Insight (JCI insight)
[2019, 4(18):]

Cited: 3 times

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Sepsis Induces Prolonged Epigenetic Modifications in Bone Marrow and Peripheral Macrophages Impairing Inflammation and Wound Healing.

Frank M Davis, Matthew A Schaller, Aaron Dendekker, Amrita D Joshi, Andrew S Kimball, Holly Evanoff, Carol Wilke, Andrea T Obi, William J Melvin, Karen Cavassani, Melissa Scola, Beau Carson, Stephanie Moser, Victoria Blanc, Milo Engoren, Bethany B Moore, Steven L Kunkel, Katherine A Gallagher,

<h4>Objective</h4>Sepsis represents an acute life-threatening disorder resulting from a dysregulated host response. For patients who survive sepsis, there remains long-term consequences, including impaired inflammation, as a result of profound immunosuppression. The mechanisms involved in this long-lasting deficient immune response are poorly defined. Approach and Results: Sepsis was induced using the ... Read more >>

Arterioscler Thromb Vasc Biol (Arteriosclerosis, thrombosis, and vascular biology)
[2019, 39(11):2353-2366]

Cited: 4 times

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First-Onset Herpesviral Infection and Lung Injury in Allogeneic Hematopoietic Cell Transplantation.

Xiaofeng Zhou, David N O'Dwyer, Meng Xia, Holly K Miller, Paul R Chan, Kelsey Trulik, Mathew M Chadwick, Timothy C Hoffman, Camille Bulte, Kevin Sekerak, Carol A Wilke, Swapneel J Patel, Wayne M Yokoyama, Susan Murray, Gregory A Yanik, Bethany B Moore,

<b>Rationale:</b> "Noninfectious" pulmonary complications are significant causes of morbidity and mortality after allogeneic hematopoietic cell transplant. Early-onset viral reactivations or infections are common after transplant. Whether the first-onset viral infection causes noninfectious pulmonary complications is unknown. <b>Objectives:</b> To determine whether the first-onset viral infection within 100 days after transplant predisposes ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2019, 200(1):63-74]

Cited: 10 times

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SIRT3 Regulates Macrophage-Mediated Inflammation in Diabetic Wound Repair.

Anna M Boniakowski, Aaron D denDekker, Frank M Davis, Amrita Joshi, Andrew S Kimball, Matthew Schaller, Ron Allen, Jennifer Bermick, Dylan Nycz, Mary E Skinner, Scott Robinson, Andrea T Obi, Bethany B Moore, Johann E Gudjonsson, David Lombard, Steve L Kunkel, Katherine A Gallagher,

Control of inflammation is critical for the treatment of nonhealing wounds, but a delicate balance exists between early inflammation that is essential for normal tissue repair and the pathologic inflammation that can occur later in the repair process. This necessitates the development of novel therapies that can target inflammation at ... Read more >>

J Invest Dermatol (The Journal of investigative dermatology)
[2019, 139(12):2528-2537.e2]

Cited: 9 times

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Lung Microbiota Contribute to Pulmonary Inflammation and Disease Progression in Pulmonary Fibrosis.

David N O'Dwyer, Shanna L Ashley, Stephen J Gurczynski, Meng Xia, Carol Wilke, Nicole R Falkowski, Katy C Norman, Kelly B Arnold, Gary B Huffnagle, Margaret L Salisbury, MeiLan K Han, Kevin R Flaherty, Eric S White, Fernando J Martinez, John R Erb-Downward, Susan Murray, Bethany B Moore, Robert P Dickson,

<b>Rationale:</b> Idiopathic pulmonary fibrosis (IPF) causes considerable global morbidity and mortality, and its mechanisms of disease progression are poorly understood. Recent observational studies have reported associations between lung dysbiosis, mortality, and altered host defense gene expression, supporting a role for lung microbiota in IPF. However, the causal significance of altered ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2019, 199(9):1127-1138]

Cited: 49 times

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