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Author Beth Malow

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Pilot Trial of a Sleep-Promoting Intervention for Children With Type 1 Diabetes.

Sarah S Jaser, Erin M Bergner, Emily R Hamburger, Shivani Bhatia, Morgan Lyttle, Grace E Bell, J Christopher Slaughter, Beth A Malow, Jill H Simmons,

OBJECTIVE:To assess the feasibility and acceptability of an educational sleep-promoting intervention (Sleep Coach Jr.) for school-aged children (ages 5-9) with type 1 diabetes (T1D) and their parents. METHODS:Parents and children (N = 39 dyads, mean child age = 8 years, 64% girls,) were randomized to either the Sleep Coach Jr. intervention, consisting of ... Read more >>

J Pediatr Psychol (Journal of pediatric psychology)
[2020, :]

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Treatment of insomnia in children and adolescents with autism spectrum disorder.

Althea Robinson Shelton, Beth Malow,

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, 4(10):716-717]

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Provider Perspectives on the Extension for Community Healthcare Outcomes Autism: Transition to Adulthood Program.

Nancy Cheak-Zamora, Justin G Farmer, Morgan K Crossman, Beth A Malow, Micah O Mazurek, Karen Kuhlthau, Gary Stobbe, Rachel Loftin, Mavara Mirza-Agrawal, Mark Tapia, Amy Hess, Katrina Davis, Kristin Sohl,

OBJECTIVE:Despite their complex health care needs, transition-aged youth diagnosed with autism spectrum disorder (TAY-ASD) receive few transition services and describe difficulty finding adult providers. A 12-week primary care provider (PCP) training was developed to improve the delivery of transition services for TAY-ASD [Extension for Community Healthcare Outcomes (ECHO) Autism: Transition ... Read more >>

J Dev Behav Pediatr (Journal of developmental and behavioral pediatrics : JDBP)
[2020, :]

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Characterization of genetic and phenotypic heterogeneity of obstructive sleep apnea using electronic health records.

Olivia J Veatch, Christopher R Bauer, Brendan T Keenan, Navya S Josyula, Diego R Mazzotti, Kanika Bagai, Beth A Malow, Janet D Robishaw, Allan I Pack, Sarah A Pendergrass,

BACKGROUND:Obstructive sleep apnea (OSA) is defined by frequent episodes of reduced or complete cessation of airflow during sleep and is linked to negative health outcomes. Understanding the genetic factors influencing expression of OSA may lead to new treatment strategies. Electronic health records (EHRs) can be leveraged to both validate previously ... Read more >>

BMC Med Genomics (BMC medical genomics)
[2020, 13(1):105]

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Seven-Year Experience From the National Institute of Neurological Disorders and Stroke-Supported Network for Excellence in Neuroscience Clinical Trials.

Merit Cudkowicz, Marianne K Chase, Christopher S Coffey, Dixie J Ecklund, Brenda J Thornell, Codrin Lungu, Katy Mahoney, Laurie Gutmann, Jeremy M Shefner, Kevin J Staley, Michael Bosch, Eric Foster, Jeffrey D Long, Emine O Bayman, James Torner, Jon Yankey, Richard Peters, Trevis Huff, Robin A Conwit, , Shlomo Shinnar, Donna Patch, Basil T Darras, Audrey Ellis, Roger J Packer, Karen S Marder, Claudia A Chiriboga, Claire Henchcliffe, Joyce Ann Moran, Blagovest Nikolov, Stewart A Factor, Carole Seeley, Steven M Greenberg, Anthony A Amato, Sara DeGregorio, Tanya Simuni, Tina Ward, John T Kissel, Stephen J Kolb, Amy Bartlett, Joseph F Quinn, Kellie Keith, Steven R Levine, Nadege Gilles, Patricia K Coyle, Jessica Lamb, Gil I Wolfe, Annemarie Crumlish, Luis Mejico, Muhammad Maaz Iqbal, James D Bowen, Caryl Tongco, Louis B Nabors, Khurram Bashir, Melanie Benge, Craig M McDonald, Erik K Henricson, Björn Oskarsson, Bruce H Dobkin, Catherine Canamar, Tracy A Glauser, Daniel Woo, Angela Molloy, Peggy Clark, Timothy L Vollmer, Alexander J Stein, Richard J Barohn, Mazen M Dimachkie, Jean-Baptiste Le Pichon, Michael G Benatar, Julie Steele, Lawrence Wechsler, Paula R Clemens, Christine Amity, Robert G Holloway, Christine Annis, Mark P Goldberg, Mariam Andersen, Susan T Iannaccone, A Gordon Smith, J Robinson Singleton, Mariana Doudova, E Clarke Haley, Mark S Quigg, Stephanie Lowenhaupt, Beth A Malow, Karen Adkins, David B Clifford, Mengesha A Teshome, Noreen Connolly,

Importance:One major advantage of developing large, federally funded networks for clinical research in neurology is the ability to have a trial-ready network that can efficiently conduct scientifically rigorous projects to improve the health of people with neurologic disorders. Observations:National Institute of Neurological Disorders and Stroke Network for Excellence in Neuroscience ... Read more >>

JAMA Neurol (JAMA neurology)
[2020, 77(6):755-763]

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Sleep coach intervention for teens with type 1 diabetes: Randomized pilot study.

Sarah S Jaser, Emily R Hamburger, Erin M Bergner, Rodayne Williams, James C Slaughter, Jill H Simmons, Beth A Malow,

BACKGROUND:Teens with type 1 diabetes (T1D) experience increased sleep disturbances, which have been linked to problems with adherence and glycemic control. As such, sleep represents a novel target to improve outcomes in teens. OBJECTIVE:To evaluate the feasibility, acceptability, and preliminary efficacy of a sleep-promoting intervention in teens with T1D. RESEARCH ... Read more >>

Pediatr Diabetes (Pediatric diabetes)
[2020, 21(3):473-478]

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Application of a novel actigraphy algorithm to detect movement and sleep/wake patterns in children with autism spectrum disorder.

Megan L Alder, Fei Ye, Fan Run, Kanika Bagai, Diane B Fawkes, Barry T Peterson, Beth A Malow,

OBJECTIVE:Actigraphy is a non-intrusive method of recording rest/activity cycles as well as a surrogate for sleep/wake activity. Standard actigraphy analysis is limited in ascribing discrete movement events to wake status during sleep. We applied a novel algorithm to overnight actigraphy data recorded simultaneously with video polysomnography-electroencephalography (video PSG-EEG) to determine ... Read more >>

Sleep Med (Sleep medicine)
[2020, 71:28-34]

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Multisite validation of a simple electronic health record algorithm for identifying diagnosed obstructive sleep apnea.

Brendan T Keenan, H Lester Kirchner, Olivia J Veatch, Kenneth M Borthwick, Vicki A Davenport, John C Feemster, Maged Gendy, Thomas R Gossard, Frances M Pack, Laura Sirikulvadhana, Luke N Teigen, Paul C Timm, Beth A Malow, Timothy I Morgenthaler, Phyllis C Zee, Allan I Pack, Janet D Robishaw, Stephen F Derose,

STUDY OBJECTIVES:We examined the performance of a simple algorithm to accurately distinguish cases of diagnosed obstructive sleep apnea (OSA) and noncases using the electronic health record (EHR) across six health systems in the United States. METHODS:Retrospective analysis of EHR data was performed. The algorithm defined cases as individuals with ≥ ... Read more >>

J Clin Sleep Med (Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine)
[2020, 16(2):175-183]

Cited: 2 times

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Sleep, Growth, and Puberty After 2 Years of Prolonged-Release Melatonin in Children With Autism Spectrum Disorder.

Beth A Malow, Robert L Findling, Carmen M Schroder, Athanasios Maras, John Breddy, Tali Nir, Nava Zisapel, Paul Gringras,

OBJECTIVE:A recent 3-month double-blind, placebo-controlled study demonstrated efficacy and safety of pediatric prolonged-release melatonin (PedPRM) for insomnia in children with autism spectrum disorder. This study examined the long-term effects of PedPRM treatment on sleep, growth, body mass index, and pubertal development. METHOD:Eighty children and adolescents (2-17.5 years of age; 96% ... Read more >>

J Am Acad Child Adolesc Psychiatry (Journal of the American Academy of Child and Adolescent Psychiatry)
[2020, :]

Cited: 3 times

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Are Daylight Saving Time Changes Bad for the Brain?

Beth A Malow, Olivia J Veatch, Kanika Bagai,

JAMA Neurol (JAMA neurology)
[2020, 77(1):9-10]

Cited: 1 time

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ECHO Autism Transition: Enhancing healthcare for adolescents and young adults with autism spectrum disorder.

Micah O Mazurek, Gary Stobbe, Rachel Loftin, Beth A Malow, Mavara M Agrawal, Mark Tapia, Amy Hess, Justin Farmer, Nancy Cheak-Zamora, Karen Kuhlthau, Kristin Sohl,

Transition-age youth and young adults with autism spectrum disorder have complex healthcare needs, yet the current healthcare system is not equipped to adequately meet the needs of this growing population. Primary care providers lack training and confidence in caring for youth and young adults with autism spectrum disorder. The current ... Read more >>

Autism (Autism : the international journal of research and practice)
[2020, 24(3):633-644]

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Self-determination in young adults with autism spectrum disorder.

Nancy C Cheak-Zamora, Anna Maurer-Batjer, Beth A Malow, Ann Coleman,

This study examined rates of and contributing factors to self-determination among young adults with autism spectrum disorder. Caregivers of young adults with autism spectrum disorder, 16-25 years, from five Autism Treatment Network sites completed surveys about their young adults' transition experiences including the American Institutes for Research Self-Determination measure. Data were ... Read more >>

Autism (Autism : the international journal of research and practice)
[2020, 24(3):605-616]

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Can We Predict Which Children With Autism Will Have Obstructive Sleep Apnea?

Emily V Singer, Althea R Shelton, Beth A Malow,

J Clin Sleep Med (Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine)
[2019, 15(10):1389-1390]

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Randomized, Placebo-Controlled Trial of Ferrous Sulfate to Treat Insomnia in Children With Autism Spectrum Disorders.

Ann M Reynolds, Heidi V Connolly, Terry Katz, Suzanne E Goldman, Shelly K Weiss, Ann C Halbower, Amy M Shui, Eric A Macklin, Susan L Hyman, Beth A Malow,

BACKGROUND:Insomnia and low iron stores are common in children with autism spectrum disorders, and low iron stores have been associated with sleep disturbance. METHODS:We performed a randomized placebo-controlled trial of oral ferrous sulfate to treat insomnia in children with autism spectrum disorders and low normal ferritin levels. Twenty participants who ... Read more >>

Pediatr Neurol (Pediatric neurology)
[2020, 104:30-39]

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Pediatric Prolonged-Release Melatonin for Sleep in Children with Autism Spectrum Disorder: Impact on Child Behavior and Caregiver's Quality of Life.

Carmen M Schroder, Beth A Malow, Athanasios Maras, Raun D Melmed, Robert L Findling, John Breddy, Tali Nir, Shiri Shahmoon, Nava Zisapel, Paul Gringras,

A randomized, 13-weeks, placebo-controlled double-blind study in 125 subjects aged 2-17.5 years with Autism Spectrum Disorder or Smith-Magenis syndrome and insomnia demonstrated efficacy and safety of easily-swallowed prolonged-release melatonin mini-tablets (PedPRM; 2-5 mg) in improving sleep duration and onset. Treatment effects on child behavior and caregiver's quality of life were evaluated. PedPRM ... Read more >>

J Autism Dev Disord (Journal of autism and developmental disorders)
[2019, 49(8):3218-3230]

Cited: 5 times

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Characterization of Genetic and Phenotypic Heterogeneity of Obstructive Sleep Apnea Using Electronic Health Records

Olivia Veatch, Christopher Bauer, Navya Josyula, Diego Mazzotti, Brendan Keenan, Kanika Bagai, Beth Malow, Janet Robishaw, Allan Pack, Sarah Pendergrass,

ABSTRACT Obstructive sleep apnea (OSA) is defined by frequent episodes of reduced or complete cessation of airflow during sleep and is linked to negative health outcomes. Understanding the genetic factors influencing expression of OSA may lead to new treatment strategies. Electronic health records can be leveraged to both validate previously ... Read more >>

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Course and Predictors of Sleep and Co-occurring Problems in Children with Autism Spectrum Disorder.

Micah O Mazurek, Kristen Dovgan, Ann M Neumeyer, Beth A Malow,

The chronicity of sleep disturbance and its relation to co-occurring symptoms in children with autism spectrum disorder (ASD) are not well understood. The current study examined longitudinal relations among sleep and co-occurring symptoms in a large well-characterized sample of 437 children with ASD assessed at baseline and follow-up (M = 3.8 years later). ... Read more >>

J Autism Dev Disord (Journal of autism and developmental disorders)
[2019, 49(5):2101-2115]

Cited: 2 times

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Predicting sleep problems in children with autism spectrum disorders.

Amy M Shui, Terry Katz, Beth A Malow, Micah O Mazurek,

BACKGROUND:Sleep difficulties in children with autism spectrum disorders (ASD) have been well-established. AIMS:To develop a model to predict sleep problems in children with ASD. METHODS AND PROCEDURES:A sample of children in the Autism Speaks-Autism Treatment Network (ATN) registry without parent-reported sleep problems at baseline and with sleep problem (yes/no) data ... Read more >>

Res Dev Disabil (Research in developmental disabilities)
[2018, 83:270-279]

Cited: 2 times

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Calculating the Effects of Autism Risk Gene Variants on Dysfunction of Biological Processes Identifies Clinically-Useful Information

Olivia Veatch, Diego Mazzotti, James Sutcliffe, Robert Schultz, Ted Abel, Birkan Tunc, Susan Assouline, Edward Brodkin, Jacob Michaelson, Thomas Nickl-Jockschat, Zachary Warren, Beth Malow, Allan Pack,

Abstract Autism spectrum disorders (ASD) are neurodevelopmental conditions that are influenced by genetic factors and encompass a wide-range and severity of symptoms. The details of how genetic variation contributes to variable symptomatology are unclear, creating a major challenge for translating vast amounts of data into clinically-useful information. To determine if ... Read more >>

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Sleep in Teens With Type 1 Diabetes: Perspectives From Adolescents and Their Caregivers.

Erin M Bergner, Rodayne Williams, Emily R Hamburger, Morgan Lyttle, Angelia C Davis, Beth Malow, Jill H Simmons, Cindy Lybarger, Rose Capin, Sarah S Jaser,

PURPOSE:The purpose of this study is to identify barriers, facilitators, and consequences of obtaining sufficient sleep in adolescents with type 1 diabetes. METHODS:Semistructured interviews were conducted with 25 adolescents (52% female, mean age = 15.6 years) and 25 caregivers. Interviews were transcribed and coded using Atlas.ti. A thematic analytic approach ... Read more >>

Diabetes Educ (The Diabetes educator)
[2018, 44(6):541-548]

Cited: 3 times

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Long-Term Efficacy and Safety of Pediatric Prolonged-Release Melatonin for Insomnia in Children with Autism Spectrum Disorder.

Athanasios Maras, Carmen M Schroder, Beth A Malow, Robert L Findling, John Breddy, Tali Nir, Shiri Shahmoon, Nava Zisapel, Paul Gringras,

Objective: A recent double-blind randomized placebo-controlled study demonstrated 3-month efficacy and safety of a novel pediatric-appropriate prolonged-release melatonin (PedPRM) for insomnia in children and adolescents with autism spectrum disorder (ASD) and neurogenetic disorders (NGD) with/without attention-deficit/hyperactivity disorder comorbidity. Long-term efficacy and safety of PedPRM treatment was studied. Methods: A prospective, ... Read more >>

J Child Adolesc Psychopharmacol (Journal of child and adolescent psychopharmacology)
[2018, 28(10):699-710]

Cited: 11 times

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Family-Driven Goals to Improve Care for Children With Autism Spectrum Disorder.

Katherine R Bellesheim, Lynn Cole, Daniel L Coury, Larry Yin, Susan E Levy, Meghan A Guinnee, Kirsten Klatka, Beth A Malow, Terry Katz, Jane Taylor, Kristin Sohl,

OBJECTIVES:Constipation and insomnia are not consistently identified and treated in children with autism spectrum disorder (ASD) despite their high prevalence and deleterious impact in this population. To standardize care, a constipation practice pathway and an insomnia practice pathway were previously developed by Autism Treatment Network clinicians. Our objective was to ... Read more >>

Pediatrics (Pediatrics)
[2018, 142(3):]

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Modification of the Children's Sleep Habits Questionnaire for Children with Autism Spectrum Disorder.

Terry Katz, Amy M Shui, Cynthia R Johnson, Amanda L Richdale, Ann M Reynolds, Lawrence Scahill, Beth A Malow,

Sleep problems are common in children with autism spectrum disorder (ASD) and adversely impact daytime functioning. Although no questionnaires have been developed to assess sleep in children with ASD, the 33-item Children's Sleep Habits Questionnaire (CSHQ) is widely used in this population. We examined the factor structure of the CSHQ ... Read more >>

J Autism Dev Disord (Journal of autism and developmental disorders)
[2018, 48(8):2629-2641]

Cited: 2 times

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Sleep habits in adolescents with type 1 diabetes: Variability in sleep duration linked with glycemic control.

Niral J Patel, Kimberly L Savin, Sachini N Kahanda, Beth A Malow, Lauren A Williams, Gray Lochbihler, Sarah S Jaser,

OBJECTIVE:To describe adolescents' sleep on school and weekend nights using multiple methods and to examine the links between sleep variability, quality, and duration with diabetes indicators. METHODS:Adolescents with type 1 diabetes (N = 65, mean age = 15.0, 52.3% female, mean HbA1c = 8.9% or 74 mmol/mol) wore an actigraph and kept daily diaries recording sleep, activities, ... Read more >>

Pediatr Diabetes (Pediatric diabetes)
[2018, :]

Cited: 5 times

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Obstructive Sleep Apnea and Otolaryngologic Manifestations in Children with Pseudohypoparathyroidism.

Kathleen L Curley, Sachini Kahanda, Katia M Perez, Beth A Malow, Ashley H Shoemaker,

BACKGROUND/AIMS:Pseudohypoparathyroidism (PHP) is a rare, genetic disorder. Patients with PHP may have increased prevalence of obstructive sleep apnea (OSA) but this has not been prospectively studied. METHODS:We enrolled children aged 6-18 years with PHP and matched controls. Evaluation included physical examination, medical history, and polysomnography. RESULTS:Fifteen children with PHP type ... Read more >>

Horm Res Paediatr (Hormone research in paediatrics)
[2018, 89(3):178-183]

Cited: 1 time

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