Full Text Journal Articles by
Author Bernhard Rauch

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Long noncoding RNA NEAT1 modulates immune cell functions and is suppressed in early onset myocardial infarction patients.

Martina Gast, Bernhard H Rauch, Arash Haghikia, Shinichi Nakagawa, Jan Haas, Andrea Stroux, David Schmidt, Paul Schumann, Stefan Weiss, Lars Jensen, Adelheid Kratzer, Nicolle Kraenkel, Christian Müller, Daniela Börnigen, Tetsuro Hirose, Stefan Blankenberg, Felicitas Escher, Anja A Kühl, Andreas W Kuss, Benjamin Meder, Ulf Landmesser, Tanja Zeller, Wolfgang Poller,

AIMS:Inflammation is a key driver of atherosclerosis and myocardial infarction (MI), and beyond proteins and microRNAs (miRs), long noncoding RNAs (lncRNAs) have been implicated in inflammation control. To obtain further information on the possible role of lncRNAs in the context of atherosclerosis, we obtained comprehensive transcriptome maps of circulating immune ... Read more >>

Cardiovasc. Res. (Cardiovascular research)
[2019, 115(13):1886-1906]

Cited: 0 times

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Protease-activated receptor 2 deficiency mediates cardiac fibrosis and diastolic dysfunction.

Julian Friebel, Alice Weithauser, Marco Witkowski, Bernhard H Rauch, Konstantinos Savvatis, Andrea Dörner, Termeh Tabaraie, Mario Kasner, Verena Moos, Diana Bösel, Michael Gotthardt, Michael H Radke, Max Wegner, Peter Bobbert, Dirk Lassner, Carsten Tschöpe, Heinz-Peter Schutheiss, Stephan B Felix, Ulf Landmesser, Ursula Rauch,

AIMS:Heart failure with preserved ejection fraction (HFpEF) and pathological cardiac aging share a complex pathophysiology, including extracellular matrix remodelling (EMR). Protease-activated receptor 2 (PAR2) deficiency is associated with EMR. The roles of PAR1 and PAR2 have not been studied in HFpEF, age-dependent cardiac fibrosis, or diastolic dysfunction (DD). METHODS AND ... Read more >>

Eur. Heart J. (European heart journal)
[2019, 40(40):3318-3332]

Cited: 0 times

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Hirudins of the Asian medicinal leech, Hirudinaria manillensis: same same, but different.

Phil Lukas, Robert Wolf, Bernhard H Rauch, Jan-Peter Hildebrandt, Christian Müller,

Blood coagulation in vertebrates is a complex mechanism that involves the precisely coordinated and regulated action of a cascade of factors in order to prevent excessive blood loss upon wounding. Any blood sucking ectoparasite, however, has to circumvent this mechanism to ensure the uptake of an adequate blood meal. Inhibitors ... Read more >>

Parasitol. Res. (Parasitology research)
[2019, 118(7):2223-2233]

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Patient and care-giver productivity loss and indirect costs associated with cardiovascular events in Europe: A wake-up call for primary prevention.

Bernhard Rauch,

Eur J Prev Cardiol (European journal of preventive cardiology)
[2019, 26(14):1556-1558]

Cited: 0 times

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The Role of Platelets in Cancer Pathophysiology: Focus on Malignant Glioma.

Sascha Marx, Yong Xiao, Marcel Baschin, Maximilian Splittstöhser, Robert Altmann, Eileen Moritz, Gabriele Jedlitschky, Sandra Bien-Möller, Henry W S Schroeder, Bernhard H Rauch,

The link between thrombocytosis and malignancy has been well known for many years and its associations with worse outcomes have been reported mainly for solid tumors. Besides measuring platelet count, it has become popular to assess platelet function in the context of malignant diseases during the last decade. Malignant gliomas ... Read more >>

Cancers (Basel) (Cancers)
[2019, 11(4):]

Cited: 2 times

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L-Carnitine-Mediated Tumor Cell Protection and Poor Patient Survival Associated with OCTN2 Overexpression in Glioblastoma Multiforme.

Matthias A Fink, Heiko Paland, Susann Herzog, Markus Grube, Silke Vogelgesang, Kerstin Weitmann, Angela Bialke, Wolfgang Hoffmann, Bernhard H Rauch, Henry W S Schroeder, Sandra Bien-Möller,

PURPOSE:Apoptotic dysregulation, redox adaptive mechanisms, and resilience to hypoxia are major causes of glioblastoma (GBM) resistance to therapy. Commonly known as crucial factors in energy metabolism, OCTN2 (SLC22A5) and its substrate L-carnitine (LC) are increasingly recognized as actors in cytoprotection. This study provides a comprehensive expression and survival analysis of ... Read more >>

Clin. Cancer Res. (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2019, 25(9):2874-2886]

Cited: 1 time

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Additional effects of psychological interventions on subjective and objective outcomes compared with exercise-based cardiac rehabilitation alone in patients with cardiovascular disease: A systematic review and meta-analysis.

Christian Albus, Christoph Herrmann-Lingen, Katrin Jensen, Matthes Hackbusch, Nina Münch, Catharina Kuncewicz, Maurizio Grilli, Bernhard Schwaab, Bernhard Rauch, ,

BACKGROUND:Exercise-based cardiac rehabilitation (ebCR) often includes various psychological interventions for lifestyle change or distress management. However, the additional benefit of specific psychological interventions on depression, anxiety, quality of life, cardiac morbidity and cardiovascular or total mortality is not well investigated. DESIGN:Systematic review and meta-analysis. METHODS:Randomized controlled trials and controlled cohort ... Read more >>

Eur J Prev Cardiol (European journal of preventive cardiology)
[2019, 26(10):1035-1049]

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Inositol hexakisphosphate increases the size of platelet aggregates.

Maria A Brehm, Ulrike Klemm, Christoph Rehbach, Nina Erdmann, Katra Kolšek, Hongying Lin, Camilo Aponte-Santamaría, Frauke Gräter, Bernhard H Rauch, Andrew M Riley, Georg W Mayr, Barry V L Potter, Sabine Windhorst,

The inositol phosphates, InsP5 and InsP6, have recently been identified as binding partners of fibrinogen, which is critically involved in hemostasis by crosslinking activated platelets at sites of vascular injury. Here, we investigated the putative physiological role of this interaction and found that platelets increase their InsP6 concentration upon stimulation ... Read more >>

Biochem. Pharmacol. (Biochemical pharmacology)
[2019, 161:14-25]

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Immune system-mediated atherosclerosis caused by deficiency of long non-coding RNA MALAT1 in ApoE-/-mice.

Martina Gast, Bernhard H Rauch, Shinichi Nakagawa, Arash Haghikia, Andrzej Jasina, Jan Haas, Neetika Nath, Lars Jensen, Andrea Stroux, Andreas Böhm, Julian Friebel, Ursula Rauch, Carsten Skurk, Stefan Blankenberg, Tanja Zeller, Kannanganattu V Prasanth, Benjamin Meder, Andreas Kuss, Ulf Landmesser, Wolfgang Poller,

Aims:The immune system is considered a key driver of atherosclerosis, and beyond proteins and microRNAs (miRs), long non-coding RNAs (lncRNAs) are implicated in immune control. We previously described that lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is involved in cardiac innate immunity in a myocarditis model. Here, we investigated the ... Read more >>

Cardiovasc. Res. (Cardiovascular research)
[2019, 115(2):302-314]

Cited: 6 times

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Exercise Prescription in Patients with Different Combinations of Cardiovascular Disease Risk Factors: A Consensus Statement from the EXPERT Working Group.

Dominique Hansen, Josef Niebauer, Veronique Cornelissen, Olga Barna, Daniel Neunhäuserer, Christoph Stettler, Cajsa Tonoli, Eugenio Greco, Robert Fagard, Karin Coninx, Luc Vanhees, Massimo F Piepoli, Roberto Pedretti, Gustavo Rovelo Ruiz, Ugo Corrà, Jean-Paul Schmid, Constantinos H Davos, Frank Edelmann, Ana Abreu, Bernhard Rauch, Marco Ambrosetti, Simona Sarzi Braga, Paul Beckers, Maurizio Bussotti, Pompilio Faggiano, Esteban Garcia-Porrero, Evangelia Kouidi, Michel Lamotte, Rona Reibis, Martijn A Spruit, Tim Takken, Carlo Vigorito, Heinz Völler, Patrick Doherty, Paul Dendale,

Whereas exercise training is key in the management of patients with cardiovascular disease (CVD) risk (obesity, diabetes, dyslipidaemia, hypertension), clinicians experience difficulties in how to optimally prescribe exercise in patients with different CVD risk factors. Therefore, a consensus statement for state-of-the-art exercise prescription in patients with combinations of CVD risk ... Read more >>

Sports Med (Sports medicine (Auckland, N.Z.))
[2018, 48(8):1781-1797]

Cited: 3 times

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Platelet activation parameters and platelet-leucocyte-conjugate formation in glioblastoma multiforme patients.

Sascha Marx, Maximilian Splittstöhser, Frederik Kinnen, Eileen Moritz, Christy Joseph, Sebastian Paul, Heiko Paland, Carolin Seifert, Madlen Marx, Andreas Böhm, Edzard Schwedhelm, Kerstin Holzer, Stephan Singer, Christoph A Ritter, Sandra Bien-Möller, Henry W S Schroeder, Bernhard H Rauch,

Patients with glioblastoma multiforme (GBM) suffer from an increased incidence of vascular thrombotic events. However, key influencing factors of the primary hemostasis have not been characterized in GBM patients to date. Thus, the present study determines the activation level of circulating platelets in GBM patients, in-vitro reactivity to agonist-induced platelet ... Read more >>

Oncotarget (Oncotarget)
[2018, 9(40):25860-25876]

Cited: 1 time

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Signaling Crosstalk of TGF-β/ALK5 and PAR2/PAR1: A Complex Regulatory Network Controlling Fibrosis and Cancer.

Hendrik Ungefroren, Frank Gieseler, Roland Kaufmann, Utz Settmacher, Hendrik Lehnert, Bernhard H Rauch,

Both signaling by transforming growth factor-β (TGF-β) and agonists of the G Protein-coupled receptors proteinase-activated receptor-1 (PAR1) and -2 (PAR2) have been linked to tissue fibrosis and cancer. Intriguingly, TGF-β and PAR signaling either converge on the regulation of certain matrix genes overexpressed in these pathologies or display mutual regulation ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2018, 19(6):]

Cited: 3 times

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Socioeconomic status: A powerful but still neglected modulator of cardiovascular risk.

Bernhard Rauch,

Eur J Prev Cardiol (European journal of preventive cardiology)
[2018, 25(9):981-984]

Cited: 1 time

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Targeting sphingosine-1-phosphate lyase as an anabolic therapy for bone loss.

Sarah Weske, Mithila Vaidya, Alina Reese, Karin von Wnuck Lipinski, Petra Keul, Julia K Bayer, Jens W Fischer, Ulrich Flögel, Jens Nelsen, Matthias Epple, Marta Scatena, Edzard Schwedhelm, Marcus Dörr, Henry Völzke, Eileen Moritz, Anke Hannemann, Bernhard H Rauch, Markus H Gräler, Gerd Heusch, Bodo Levkau,

Sphingosine-1-phosphate (S1P) signaling influences bone metabolism, but its therapeutic potential in bone disorders has remained unexplored. We show that raising S1P levels in adult mice through conditionally deleting or pharmacologically inhibiting S1P lyase, the sole enzyme responsible for irreversibly degrading S1P, markedly increased bone formation, mass and strength and substantially ... Read more >>

Nat. Med. (Nature medicine)
[2018, 24(5):667-678]

Cited: 9 times

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Release of Platelet-Derived Sphingosine-1-Phosphate Involves Multidrug Resistance Protein 4 (MRP4/ABCC4) and Is Inhibited by Statins.

Katja Vogt, Shailaja Mahajan-Thakur, Robert Wolf, Susanne Bröderdorf, Conny Vogel, Andreas Böhm, Christoph A Ritter, Markus Gräler, Stefan Oswald, Andreas Greinacher, Heyo K Kroemer, Gabriele Jedlitschky, Bernhard H Rauch,

Sphingosine-1-phosphate (S1P) is a potent lipid mediator released from activated platelets by an adenosine triphosphate (ATP)-dependent export mechanism. A candidate transport protein is the multidrug resistance protein 4 (MRP4/ABCC4), an ATP-dependent transporter highly expressed in platelets. Furthermore, several statins are known to affect platelet functions and exhibit antithrombotic properties. This ... Read more >>

Thromb. Haemost. (Thrombosis and haemostasis)
[2018, 118(1):132-142]

Cited: 1 time

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Associations of Omega-3 Fatty Acid Supplement Use With Cardiovascular Disease Risks: Meta-analysis of 10 Trials Involving 77 917 Individuals.

Theingi Aung, Jim Halsey, Daan Kromhout, Hertzel C Gerstein, Roberto Marchioli, Luigi Tavazzi, Johanna M Geleijnse, Bernhard Rauch, Andrew Ness, Pilar Galan, Emily Y Chew, Jackie Bosch, Rory Collins, Sarah Lewington, Jane Armitage, Robert Clarke, ,

Importance:Current guidelines advocate the use of marine-derived omega-3 fatty acids supplements for the prevention of coronary heart disease and major vascular events in people with prior coronary heart disease, but large trials of omega-3 fatty acids have produced conflicting results. Objective:To conduct a meta-analysis of all large trials assessing the ... Read more >>

JAMA Cardiol (JAMA cardiology)
[2018, 3(3):225-234]

Cited: 62 times

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Proteinase-Activated Receptor 2 May Drive Cancer Progression by Facilitating TGF-β Signaling.

Hendrik Ungefroren, David Witte, Bernhard H Rauch, Utz Settmacher, Hendrik Lehnert, Frank Gieseler, Roland Kaufmann,

The G protein-coupled receptor proteinase-activated receptor 2 (PAR2) has been implicated in various aspects of cellular physiology including inflammation, obesity and cancer. In cancer, it usually acts as a driver of cancer progression in various tumor types by promoting invasion and metastasis in response to activation by serine proteinases. Recently, ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2017, 18(11):]

Cited: 2 times

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Association of Glioblastoma Multiforme Stem Cell Characteristics, Differentiation, and Microglia Marker Genes with Patient Survival.

Sandra Bien-Möller, Ellen Balz, Susann Herzog, Laura Plantera, Silke Vogelgesang, Kerstin Weitmann, Carolin Seifert, Matthias A Fink, Sascha Marx, Angela Bialke, Chitra Venugopal, Sheila K Singh, Wolfgang Hoffmann, Bernhard H Rauch, Henry W S Schroeder,

Patients with glioblastoma multiforme (GBM) are at high risk to develop a relapse despite multimodal therapy. Assumedly, glioma stem cells (GSCs) are responsible for treatment resistance of GBM. Identification of specific GSC markers may help to develop targeted therapies. Here, we performed expression analyses of stem cell (ABCG2, CD44, CD95, ... Read more >>

Stem Cells Int (Stem Cells International)
[2018, 2018:9628289]

Cited: 6 times

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Protease-Activated Receptor PAR-4: An Inducible Switch between Thrombosis and Vascular Inflammation?

Anke C Fender, Bernhard H Rauch, Tobias Geisler, Karsten Schrör,

Thrombin triggers activation of platelets through protease-activated receptor 1 (PAR-1) and PAR-4. Both receptors are widely expressed and exert multiple platelet-independent functions. PAR signalling contributes to healing responses after injury, by promoting cytokine activity and cellular growth and mobility. Uncontrolled PAR activation, however, can prevent timely resolution of inflammation, enhance ... Read more >>

Thromb. Haemost. (Thrombosis and haemostasis)
[2017, 117(11):2013-2025]

Cited: 0 times

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Accelerated renal function decline in obese post myocardial infarction patients - is weight reduction per se an adequate therapeutic consequence?

Bernhard Rauch,

Eur J Prev Cardiol (European journal of preventive cardiology)
[2018, 25(1):87-89]

Cited: 0 times

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Sphingosine 1-phosphate (S1P) signaling in glioblastoma multiforme-A systematic review.

Shailaja Mahajan-Thakur, Sandra Bien-Möller, Sascha Marx, Henry Schroeder, Bernhard H Rauch,

The multifunctional sphingosine-1-phosphate (S1P) is a lipid signaling molecule and central regulator in the development of several cancer types. In recent years, intriguing information has become available regarding the role of S1P in the progression of Glioblastoma multiforme (GBM), the most aggressive and common brain tumor in adults. S1P modulates ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2017, 18(11):]

Cited: 9 times

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Aspirin Inhibits Platelet-Derived Sphingosine-1-Phosphate Induced Endothelial Cell Migration.

Amin Polzin, Betül Knoop, Andreas Böhm, Lisa Dannenberg, Mark Zurek, Tobias Zeus, Malte Kelm, Bodo Levkau, Bernhard H Rauch,

Aspirin plays a crucial role in the prevention of cardiovascular diseases. We previously described that aspirin has effects beyond inhibition of platelet aggregation, as it inhibited thrombin-mediated release of sphingosine-1-phosphate (S1P) from human platelets. S1P is a bioactive lipid with important functions on inflammation and apoptosis. In endothelial cells (EC), ... Read more >>

Pharmacology (Pharmacology)
[2018, 101(1-2):72-75]

Cited: 1 time

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Transforming Growth Factor-β1/Activin Receptor-like Kinase 5-Mediated Cell Migration is Dependent on the Protein Proteinase-Activated Receptor 2 but not on Proteinase-Activated Receptor 2-Stimulated Gq-Calcium Signaling.

Hendrik Ungefroren, David Witte, Koichiro Mihara, Bernhard H Rauch, Petra Henklein, Olaf Jöhren, Shirin Bonni, Utz Settmacher, Hendrik Lehnert, Morley D Hollenberg, Roland Kaufmann, Frank Gieseler,

Transforming growth factor-β (TGF-β), serine proteinases such as trypsin, and proteinase-activated receptor 2 (PAR2) promote tumor development by stimulating invasion and metastasis. Previously, we found that in cancer cells derived from pancreatic ductal adenocarcinoma (PDAC) PAR2 protein is necessary for TGF-β1-dependent cell motility. Here, we show in the same cells ... Read more >>

Mol. Pharmacol. (Molecular pharmacology)
[2017, 92(5):519-532]

Cited: 5 times

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The European Association of Preventive Cardiology Exercise Prescription in Everyday Practice and Rehabilitative Training (EXPERT) tool: A digital training and decision support system for optimized exercise prescription in cardiovascular disease. Concept, definitions and construction methodology.

Dominique Hansen, Paul Dendale, Karin Coninx, Luc Vanhees, Massimo F Piepoli, Josef Niebauer, Veronique Cornelissen, Roberto Pedretti, Eva Geurts, Gustavo R Ruiz, Ugo Corrà, Jean-Paul Schmid, Eugenio Greco, Constantinos H Davos, Frank Edelmann, Ana Abreu, Bernhard Rauch, Marco Ambrosetti, Simona S Braga, Olga Barna, Paul Beckers, Maurizio Bussotti, Robert Fagard, Pompilio Faggiano, Esteban Garcia-Porrero, Evangelia Kouidi, Michel Lamotte, Daniel Neunhäuserer, Rona Reibis, Martijn A Spruit, Christoph Stettler, Tim Takken, Cajsa Tonoli, Carlo Vigorito, Heinz Völler, Patrick Doherty,

Background Exercise rehabilitation is highly recommended by current guidelines on prevention of cardiovascular disease, but its implementation is still poor. Many clinicians experience difficulties in prescribing exercise in the presence of different concomitant cardiovascular diseases and risk factors within the same patient. It was aimed to develop a digital training ... Read more >>

Eur J Prev Cardiol (European journal of preventive cardiology)
[2017, 24(10):1017-1031]

Cited: 20 times

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Corrigendum to "Exercise-based cardiac rehabilitation in twelve European countries: Results of the European Cardiac Rehabilitation Registry" [Int. J. Cardiol. 228 (2017) 58-67].

Werner Benzer, Bernhard Rauch, Jean-Paul Schmid, Ann Dorthe Zwisler, Paul Dendale, Constantinos H Davos, Evangelia Kouidi, Attila Simon, Ana Abreu, Nana Pogosova, Dan Gaita, Bojan Miletic, Gerd Bönner, Taoufik Ouarrak, Hannah McGee, ,

Int. J. Cardiol. (International journal of cardiology)
[2017, 242:50]

Cited: 0 times

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