Full Text Journal Articles by
Author Benjamin Lau

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Reducing 4DCBCT scan time and dose through motion compensated acquisition and reconstruction.

Benjamin King Fung Lau, Tess Reynolds, Andrew Wallis, Sandie Smith, Armia George, Paul J Keall, Jan-Jakob Sonke, Shalini K Vinod, Owen Dillon, Ricky T O'Brien,

Conventional 4DCBCT captures 1,320 projections across 4 minutes. Adaptive 4DCBCT has been developed to reduce imaging dose and scan time. This study investigated reconstruction algorithms that best complement adaptive 4DCBCT acquisition for reducing imaging dose and scan time whilst maintaining or improving image quality compared to conventional 4DCBCT acquisition using ... Read more >>

Phys Med Biol (Physics in medicine and biology)
[2021, :]

Cited: 0 times

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Structure of the Maturing 90S Pre-ribosome in Association with the RNA Exosome.

Benjamin Lau, Jingdong Cheng, Dirk Flemming, Giuseppe La Venuta, Otto Berninghausen, Roland Beckmann, Ed Hurt,

Ribosome assembly is catalyzed by numerous trans-acting factors and coupled with irreversible pre-rRNA processing, driving the pathway toward mature ribosomal subunits. One decisive step early in this progression is removal of the 5' external transcribed spacer (5'-ETS), an RNA extension at the 18S rRNA that is integrated into the huge ... Read more >>

Mol Cell (Molecular cell)
[2021, 81(2):293-303.e4]

Cited: 0 times

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Optimization of protein extraction for proteomic analyses of fresh and frozen "Musang King" durian pulps.

Xue Yi Tan, Azizah Misran, Leona Daniela Jeffery Daim, Benjamin Yii Chung Lau,

Four different methods were evaluated to extract proteins from "Musang King" durian pulps and subsequently proteins with different abundance between fresh and long term frozen storage were identified using two-dimensional polyacrylamide gel electrophoresis coupled with matrix-assisted laser desorption/ionization time-of-flight mass spectrometer analyses. The acetone-phenol method was found to produce good ... Read more >>

Food Chem (Food chemistry)
[2021, 343:128471]

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90S pre-ribosome transformation into the primordial 40S subunit.

Jingdong Cheng, Benjamin Lau, Giuseppe La Venuta, Michael Ameismeier, Otto Berninghausen, Ed Hurt, Roland Beckmann,

Production of small ribosomal subunits initially requires the formation of a 90<i>S</i> precursor followed by an enigmatic process of restructuring into the primordial pre-40<i>S</i> subunit. We elucidate this process by biochemical and cryo-electron microscopy analysis of intermediates along this pathway in yeast. First, the remodeling RNA helicase Dhr1 engages the ... Read more >>

Science (Science (New York, N.Y.))
[2020, 369(6510):1470-1476]

Cited: 2 times

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Mu-Opioids Suppress GABAergic Synaptic Transmission onto Orbitofrontal Cortex Pyramidal Neurons with Subregional Selectivity.

Benjamin K Lau, Brittany P Ambrose, Catherine S Thomas, Min Qiao, Stephanie L Borgland,

The orbitofrontal cortex (OFC) plays a critical role in evaluating outcomes in a changing environment. Administering opioids to the OFC can alter the hedonic reaction to food rewards and increase their consumption in a subregion-specific manner. However, it is unknown how mu-opioid signaling influences synaptic transmission in the OFC. Thus, ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2020, 40(31):5894-5907]

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Obesity-induced astrocyte dysfunction impairs heterosynaptic plasticity in the orbitofrontal cortex

Benjamin Lau, Ciaran Murphy-Royal, Manpreet Kaur, Min Qiao, Grant Gordon, Jaideep Bains, Stephanie Borgland,

<h4>S ummary </h4> Overconsumption of palatable, energy dense food is considered a key driver of the obesity pandemic. The orbitofrontal cortex (OFC) is critical for reward valuation of gustatory signals, yet how the OFC adapts to obesogenic diets is poorly understood. Here we show that an impairment of astrocyte glutamate ... Read more >>

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Mu-opioids suppress GABAergic synaptic transmission onto orbitofrontal cortex pyramidal neurons with subregional selectivity

Benjamin Lau, Brittany Ambrose, Catherine Thomas, Min Qiao, Stephanie Borgland,

The orbitofrontal cortex (OFC) plays a critical role in evaluating outcomes in a changing environment. Administering opioids to the OFC can alter the hedonic reaction to food rewards and increase their consumption in a subregion specific manner. However, it is unknown how mu-opioid signalling influences synaptic transmission in the OFC. ... Read more >>

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A new mouse line with reduced GluA2 Q/R site RNA editing exhibits loss of dendritic spines, hippocampal CA1-neuron loss, learning and memory impairments and NMDA receptor-independent seizure vulnerability.

Lyndsey M Konen, Amanda L Wright, Gordon A Royle, Gary P Morris, Benjamin K Lau, Patrick W Seow, Raphael Zinn, Luke T Milham, Christopher W Vaughan, Bryce Vissel,

Calcium (Ca<sup>2+</sup>)-permeable AMPA receptors may, in certain circumstances, contribute to normal synaptic plasticity or to neurodegeneration. AMPA receptors are Ca<sup>2+</sup>-permeable if they lack the GluA2 subunit or if GluA2 is unedited at a single nucleic acid, known as the Q/R site. In this study, we examined mice engineered with a ... Read more >>

Mol Brain (Molecular brain)
[2020, 13(1):27]

Cited: 2 times

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Opioid presynaptic disinhibition of the midbrain periaqueductal grey descending analgesic pathway.

Benjamin K Lau, Bryony L Winters, Christopher W Vaughan,

<h4>Background and purpose</h4>The midbrain periaqueductal grey (PAG) plays a central role in modulating pain through a descending pathway that projects indirectly to the spinal cord via the rostroventral medial medulla (RVM). While opioids are potent analgesics that target the PAG, their cellular actions on descending projection neurons are unclear.<h4>Experimental approach</h4>Patch ... Read more >>

Br J Pharmacol (British journal of pharmacology)
[2020, 177(10):2320-2332]

Cited: 1 time

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Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.

Jingdong Cheng, Jochen Ba├čler, Paulina Fischer, Benjamin Lau, Nikola Kellner, Ruth Kunze, Sabine Griesel, Martina Kallas, Otto Berninghausen, Daniela Strauss, Roland Beckmann, Ed Hurt,

Eukaryotic ribosome biogenesis involves RNA folding and processing that depend on assembly factors and small nucleolar RNAs (snoRNAs). The 90S (SSU-processome) is the earliest pre-ribosome structurally analyzed, which was suggested to assemble stepwise along the growing pre-rRNA from 5' > 3', but this directionality may not be accurate. Here, by ... Read more >>

Mol Cell (Molecular cell)
[2019, 75(6):1256-1269.e7]

Cited: 5 times

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Application of Proteomics Technologies in Oil Palm Research.

Benjamin Yii Chung Lau, Abrizah Othman, Umi Salamah Ramli,

Proteomics technologies were first applied in the oil palm research back in 2008. Since proteins are the gene products that are directly correspond to phenotypic traits, proteomic tools hold a strong advantage above other molecular tools to comprehend the biological and molecular mechanisms in the oil palm system. These emerging ... Read more >>

Protein J (The protein journal)
[2018, 37(6):473-499]

Cited: 0 times

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First metatarsophalangeal fusion using joint specific dorsal plate with interfragmentary screw augmentation: Clinical and radiological outcomes.

Ahmed Latif, Baljinder S Dhinsa, Benjamin Lau, Ali Abbasian,

BACKGROUND:This study reports the outcome of a plating system for arthrodesis of the first metatarsophalangeal joint (1st MTPJ) that incorporates a lag compression screw within a low profile titanium plate with a predetermined contour. This is the first report of the outcomes of this implant from a non-affiliated centre. PATIENT ... Read more >>

Foot Ankle Surg (Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons)
[2019, 25(2):132-136]

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Endocannabinoid modulation of homeostatic and non-homeostatic feeding circuits.

Benjamin K Lau, Daniela Cota, Luigia Cristino, Stephanie L Borgland,

The endocannabinoid system has emerged as a key player in the control of eating. Endocannabinoids, including 2-arachidonoylglycerol (2-AG) and anandamide (AEA), modulate neuronal activity via cannabinoid 1 receptors (CB1Rs) in multiple nuclei of the hypothalamus to induce or inhibit food intake depending on nutritional and hormonal status, suggesting that endocannabinoids ... Read more >>

Neuropharmacology (Neuropharmacology)
[2017, 124:38-51]

Cited: 21 times

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Projection-Target-Defined Effects of Orexin and Dynorphin on VTA Dopamine Neurons.

Corey Baimel, Benjamin K Lau, Min Qiao, Stephanie L Borgland,

Circuit-specific signaling of ventral tegmental area (VTA) dopamine neurons drives different aspects of motivated behavior, but the neuromodulatory control of these circuits is unclear. We tested the actions of co-expressed lateral hypothalamic peptides, orexin A (oxA) and dynorphin (dyn), on projection-target-defined dopamine neurons in mice. We determined that VTA dopamine ... Read more >>

Cell Rep (Cell reports)
[2017, 18(6):1346-1355]

Cited: 36 times

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Endocannabinoids control vesicle release mode at midbrain periaqueductal grey inhibitory synapses.

Karin R Aubrey, Geoffrey M Drew, Hyo-Jin Jeong, Benjamin K Lau, Christopher W Vaughan,

<h4>Key points</h4>The midbrain periaqueductal grey (PAG) forms part of an endogenous analgesic system which is tightly regulated by the neurotransmitter GABA. The role of endocannabinoids in regulating GABAergic control of this system was examined in rat PAG slices. Under basal conditions GABAergic neurotransmission onto PAG output neurons was multivesicular. Activation ... Read more >>

J Physiol (The Journal of physiology)
[2017, 595(1):165-178]

Cited: 6 times

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Unusual association between cardiac, skeletal, urogenital and renal abnormalities.

Maria Goryaeva, Mark Christopher Sykes, Benjamin Lau, Simon West,

We present a 33-year-old woman with an array of congenital abnormalities. She has been diagnosed with polycystic kidney disease (PCKD) with no detectable mutations in PKD1 or PKD2, spina bifida occulta, thoracic skeletal abnormalities, a uterus didelphys and a patent foramen ovale (PFO). There are several associations reported in the ... Read more >>

BMJ Case Rep (BMJ case reports)
[2016, 2016:]

Cited: 0 times

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Application of a Mass Spectrometric Approach to Detect the Presence of Fatty Acid Biosynthetic Phosphopeptides.

Benjamin Yii Chung Lau, Stefan Clerens, James D Morton, Jolon M Dyer, Santanu Deb-Choudhury, Umi Salamah Ramli,

The details of plant lipid metabolism are relatively well known but the regulation of fatty acid production at the protein level is still not understood. Hence this study explores the importance of phosphorylation as a mechanism to control the activity of fatty acid biosynthetic enzymes using low and high oleic ... Read more >>

Protein J (The protein journal)
[2016, 35(2):163-170]

Cited: 5 times

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Age-Dependent D1-D2 Receptor Coactivation in the Lateral Orbitofrontal Cortex Potentiates NMDA Receptors and Facilitates Cognitive Flexibility.

Jennifer L Thompson, Jinhui Yang, Benjamin Lau, Shuai Liu, Corey Baimel, Lauren E Kerr, Fang Liu, Stephanie L Borgland,

The orbitofrontal cortex (OFC) integrates information about the environment to guide decision-making. Glutamatergic synaptic transmission mediated through N-methyl-d-aspartate receptors is required for optimal functioning of the OFC. Additionally, abnormal dopamine signaling in this region has been implicated in impulsive behavior and poor cognitive flexibility. Yet, despite the high prevalence of ... Read more >>

Cereb Cortex (Cerebral cortex (New York, N.Y. : 1991))
[2016, 26(12):4524-4539]

Cited: 4 times

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Technological aspects of delivering cryotherapy for prostate cancer.

Benjamin Lau, Taimur Tariq Shah, Massimo Valerio, Sami Hamid, Hashim Uddin Ahmed, Manit Arya,

Since the era of prostate specific antigen (PSA) testing, there has been a stage and grade migration seen with prostate cancer along with a reduction in mortality. Subsequently, concerns have been raised about the over treatment of patients following the diagnosis of localized prostate cancers. Cryotherapy, in which extremely low ... Read more >>

Expert Rev Med Devices (Expert review of medical devices)
[2015, 12(2):183-190]

Cited: 1 time

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Endocannabinoid modulation by FAAH and monoacylglycerol lipase within the analgesic circuitry of the periaqueductal grey.

Benjamin K Lau, Geoffrey M Drew, Vanessa A Mitchell, Christopher W Vaughan,

<h4>Background and purpose</h4>Endogenous cannabinoids (endocannabinoids) in the periaqueductal grey (PAG) play a vital role in mediating stress-induced analgesia. This analgesic effect of endocannabinoids is enhanced by pharmacological inhibition of their degradative enzymes. However, the specific effects of endocannabinoids and the inhibitors of their degradation are largely unknown within this pain-modulating ... Read more >>

Br J Pharmacol (British journal of pharmacology)
[2014, 171(23):5225-5236]

Cited: 6 times

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Focal cryotherapy of localized prostate cancer: a systematic review of the literature.

Taimur Tariq Shah, Hashim Ahmed, Abi Kanthabalan, Benjamin Lau, Maneesh Ghei, Barry Maraj, Manit Arya,

Radical/whole gland treatment for prostate cancer has significant side-effects. Therefore focal treatments such as cryotherapy have been used to treat localized lesions whilst aiming to provide adequate cancer control with minimal side-effects. We performed a systematic review of Pubmed/Medline and Cochrane databases' to yield 9 papers for primary focal prostate ... Read more >>

Expert Rev Anticancer Ther (Expert review of anticancer therapy)
[2014, 14(11):1337-1347]

Cited: 24 times

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Descending modulation of pain: the GABA disinhibition hypothesis of analgesia.

Benjamin K Lau, Christopher W Vaughan,

Within the central nervous system, descending systems exist to endogenously modulate our perception of pain. Of particular interest is a descending pathway which projects via the midbrain periaqueductal grey (PAG) and rostral ventromedial medulla (RVM) to inhibit ascending nociceptive transmission at the spinal cord dorsal horn. This descending PAG-RVM system ... Read more >>

Curr Opin Neurobiol (Current opinion in neurobiology)
[2014, 29:159-164]

Cited: 62 times

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Menthol enhances phasic and tonic GABAA receptor-mediated currents in midbrain periaqueductal grey neurons.

Benjamin K Lau, Shafinaz Karim, Ann K Goodchild, Christopher W Vaughan, Geoffrey M Drew,

<h4>Background and purpose</h4>Menthol, a naturally occurring compound in the essential oil of mint leaves, is used for its medicinal, sensory and fragrant properties. Menthol acts via transient receptor potential (TRPM8 and TRPA1) channels and as a positive allosteric modulator of recombinant GABAA receptors. Here, we examined the actions of menthol ... Read more >>

Br J Pharmacol (British journal of pharmacology)
[2014, 171(11):2803-2813]

Cited: 18 times

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Targeting the endogenous cannabinoid system to treat neuropathic pain.

Benjamin K Lau, Christopher W Vaughan,

Front Pharmacol (Frontiers in pharmacology)
[2014, 5:28]

Cited: 9 times

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Selective inhibition of cell proliferation by lycopene in MCF-7 breast cancer cells in vitro: a proteomic analysis.

Padma T Uppala, Tixieanna Dissmore, Benjamin H S Lau, Tracy Andacht, Sujatha Rajaram,

Lycopene, a red pigmented carotenoid present in many fruits and vegetables such as tomatoes, has been associated with the reduced risk of breast cancer. This study sought to identify proteins modulated by lycopene during cell proliferation of the breast cancer cell line MCF-7 to gain an understanding into its mechanism ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2013, 27(4):595-601]

Cited: 13 times

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