Full Text Journal Articles by
Author Benjamin Ducarouge


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Cancer-Associated Fibroblasts Produce Netrin-1 to Control Cancer Cell Plasticity.

Pei-Ju Sung, Nicolas Rama, Jeromine Imbach, Stephany Fiore, Benjamin Ducarouge, David Neves, Huei-Wen Chen, David Bernard, Pan-Chyr Yang, Agnès Bernet, Stephane Depil, Patrick Mehlen,

Netrin-1 is upregulated in a large fraction of human neoplasms. In multiple animal models, interference with netrin-1 is associated with inhibition of tumor growth and metastasis. Although netrin-1 upregulation was initially described in cancer cells, we report here that in the human colorectal cancer database, the expression of netrin-1 and ... Read more >>

Cancer Res. (Cancer research)
[2019, 79(14):3651-3661]

Cited: 1 time

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Hepatocellular carcinoma-associated depletion of the netrin-1 receptor Uncoordinated Phenotype-5A (UNC5A) skews the hepatic unfolded protein response towards prosurvival outcomes.

Romain Barnault, Thomas Lahlali, Marie-Laure Plissonnier, Cristina Romero-López, Noémie Laverdure, Benjamin Ducarouge, Michel Rivoire, Patrick Mehlen, Fabien Zoulim, Romain Parent,

In the liver, HBV and HCV infections, exposure to toxics, genetic and metabolic disorders may induce endoplasmic reticulum (ER) stress and the unfolding protein response (UPR). The UPR allows cells to reach ER homeostasis after lumen overload, but also fosters survival of damaged cells and therefore HCC onset. Dependence receptors ... Read more >>

Biochem. Biophys. Res. Commun. (Biochemical and biophysical research communications)
[2018, 495(4):2425-2431]

Cited: 1 time

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Involvement of CRF2 signaling in enterocyte differentiation.

Benjamin Ducarouge, Marjolaine Pelissier-Rota, Rebecca Powell, Alain Buisson, Bruno Bonaz, Muriel Jacquier-Sarlin,

To determine the role of corticotropin releasing factor receptor (CRF2) in epithelial permeability and enterocyte cell differentiation.For this purpose, we used rat Sprague Dawley and various colon carcinoma cell lines (SW620, HCT8R, HT-29 and Caco-2 cell lines). Expression of CRF2 protein was analyzed by fluorescent immunolabeling in normal rat colon ... Read more >>

World J. Gastroenterol. (World journal of gastroenterology)
[2017, 23(28):5127-5145]

Cited: 4 times

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Non-canonical NOTCH3 signalling limits tumour angiogenesis.

Shuheng Lin, Ana Negulescu, Sirisha Bulusu, Benjamin Gibert, Jean-Guy Delcros, Benjamin Ducarouge, Nicolas Rama, Nicolas Gadot, Isabelle Treilleux, Pierre Saintigny, Olivier Meurette, Patrick Mehlen,

Notch signalling is a causal determinant of cancer and efforts have been made to develop targeted therapies to inhibit the so-called canonical pathway. Here we describe an unexpected pro-apoptotic role of Notch3 in regulating tumour angiogenesis independently of the Notch canonical pathway. The Notch3 ligand Jagged-1 is upregulated in a ... Read more >>

Nat Commun (Nature communications)
[2017, 8:16074]

Cited: 9 times

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Regulation by miR181 family of the dependence receptor CDON tumor suppressive activity in neuroblastoma.

Benjamin Gibert, Céline Delloye-Bourgeois, Charles-Henry Gattolliat, Olivier Meurette, Solen Le Guernevel, Joanna Fombonne, Benjamin Ducarouge, Fabrice Lavial, Frantz Bouhallier, Marion Creveaux, Ana Maria Negulescu, Jean Bénard, Isabelle Janoueix-Lerosey, Annick Harel-Bellan, Olivier Delattre, Patrick Mehlen,

BACKGROUND: The Sonic Hedgehog (SHH) signaling pathway plays an important role in neural crest cell fate during embryonic development and has been implicated in the progression of multiple cancers that include neuroblastoma, a neural crest cell-derived disease. While most of the SHH signaling is mediated by the well-described canonical pathway ... Read more >>

J. Natl. Cancer Inst. (Journal of the National Cancer Institute)
[2014, 106(11):]

Cited: 10 times

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CRF2 signaling is a novel regulator of cellular adhesion and migration in colorectal cancer cells.

Benjamin Ducarouge, Marjolaine Pelissier-Rota, Michèle Lainé, Nadine Cristina, Yvan Vachez, Jean-Yves Scoazec, Bruno Bonaz, Muriel Jacquier-Sarlin,

Stress has been proposed to be a tumor promoting factor through the secretion of specific neuromediators, such as Urocortin2 and 3 (Ucn2/3), however its role in colorectal cancer (CRC) remains elusive. We observed that Ucn2/3 and their receptor the Corticotropin Releasing Factor receptor 2 (CRF2) were up-regulated in high grade ... Read more >>

PLoS ONE (PloS one)
[2013, 8(11):e79335]

Cited: 11 times

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Enterocytic differentiation is modulated by lipid rafts-dependent assembly of adherens junctions.

Nicolas T Chartier, Michèle G Lainé, Benjamin Ducarouge, Christiane Oddou, Bruno Bonaz, Corinne Albiges-Rizo, Muriel R Jacquier-Sarlin,

Integrity of the epithelial barrier is determined by apical junctional complexes which also participate in the signalling pathways inducing intestinal cell differentiation. Lipid rafts (LR) have been proposed to play a role in the organization and the function of these intercellular complexes. This study investigated potential mechanisms by which LR ... Read more >>

Exp. Cell Res. (Experimental cell research)
[2011, 317(10):1422-1436]

Cited: 6 times

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Cyclin-dependent kinase 2/cyclin E complex is involved in p120 catenin (p120ctn)-dependent cell growth control: a new role for p120ctn in cancer.

Nicolas T Chartier, Christiane I Oddou, Michèle G Lainé, Benjamin Ducarouge, Christiane A Marie, Marc R Block, Muriel R Jacquier-Sarlin,

Depending on its cellular localization, p120 catenin (p120ctn) can participate in various processes, such as cadherin-dependent cell-cell adhesion, actin cytoskeleton remodeling, and intracellular trafficking. Recent studies also indicate that p120ctn could regulate cell proliferation and contact inhibition. This report describes a new function of p120ctn in the regulation of cell ... Read more >>

Cancer Res. (Cancer research)
[2007, 67(20):9781-9790]

Cited: 25 times

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