Full Text Journal Articles by
Author Benjamin Davies

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A functional overlap between actively transcribed genes and chromatin boundary elements

Caroline Harrold, Matthew Gosden, Lars Hanssen, Rosa Stolper, Damien Downes, Jelena Telenius, Daniel Biggs, Chris Preece, Samy Alghadban, Jacqueline Sharpe, Benjamin Davies, Jacqueline Sloane-Stanley, Mira Kassouf, Jim Hughes, Douglas Higgs,

Abstract Mammalian genomes are subdivided into large (50-2000 kb) regions of chromatin referred to as Topologically Associating Domains (TADs or sub-TADs). Chromatin within an individual TAD contacts itself more frequently than with regions in surrounding TADs thereby directing enhancer-promoter interactions. In many cases, the borders of TADs are defined by ... Read more >>

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The Configuration of RPA, RAD51, and DMC1 Binding in Meiosis Reveals the Nature of Critical Recombination Intermediates.

Anjali Gupta Hinch, Philipp W Becker, Tao Li, Daniela Moralli, Gang Zhang, Clare Bycroft, Catherine Green, Scott Keeney, Qinghua Shi, Benjamin Davies, Peter Donnelly,

Meiotic recombination proceeds via binding of RPA, RAD51, and DMC1 to single-stranded DNA (ssDNA) substrates created after formation of programmed DNA double-strand breaks. Here we report high-resolution in vivo maps of RPA and RAD51 in meiosis, mapping their binding locations and lifespans to individual homologous chromosomes using a genetically engineered hybrid ... Read more >>

Mol. Cell (Molecular cell)
[2020, :]

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Identification of factors associated with morbidity and postoperative length of stay in surgically managed chronic subdural haematoma using electronic health records: a retrospective cohort study.

Daniel J Stubbs, Benjamin M Davies, Tom Bashford, Alexis J Joannides, Peter J Hutchinson, David K Menon, Ari Ercole, Rowan M Burnstein,

INTRODUCTION:Chronic subdural haematoma (cSDH) tends to occur in older patients, often with significant comorbidity. The incidence and effect of medical complications as well as the impact of intraoperative management strategies are now attracting increasing interest. OBJECTIVES:We used electronic health record data to study the profile of in-hospital morbidity and examine ... Read more >>

BMJ Open (BMJ open)
[2020, 10(6):e037385]

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Tackling Research Inefficiency in Degenerative Cervical Myelopathy: Illustrative Review.

Danyal Zaman Khan, Muhammad Shuaib Khan, Mark Rn Kotter, Benjamin Marshall Davies,

BACKGROUND:Degenerative cervical myelopathy (DCM) is widely accepted as the most common cause of adult myelopathy worldwide. Despite this, there is no specific term or diagnostic criteria in the International Classification of Diseases 11th Revision and no Medical Subject Headings (MeSH) or an equivalent in common literature databases. This makes searching ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2020, 9(6):e15922]

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Timing and rate of nitrogen fertilization influence maize yield and nitrogen use efficiency.

Benjamin Davies, Jeffrey A Coulter, Paulo H Pagliari,

Timing and rate of nitrogen (N) fertilizer application can influence maize (Zea mays L.) grain yield, N uptake, and nitrogen use efficiency (NUE) parameters, but results have been inconsistent across the upper Midwest. This study compared single (fall and preplant) and split applications of differing N rates for maize under ... Read more >>

PLoS ONE (PloS one)
[2020, 15(5):e0233674]

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How common is repeat surgery and multi-level treatment in Degenerative Cervical Myelopathy? Findings from a patient perspective survey.

Aref-Ali Gharooni, Ben Grodzinski, Benjamin M Davies, Mark R N Kotter,

Degenerative Cervical Myelopathy (DCM) is a common condition which causes significant disability and reduces health-related quality of life. The only evidence-based treatment and current management guidance is surgery to decompress the spinal cord and stop further damage in moderate to severe cases. However, this guidance is mainly informed by studies ... Read more >>

J Clin Neurosci (Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia)
[2020, 77:181-184]

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Clinical Trials in Urology: Predictors of Successes and Failures.

Jathin Bandari, Katherine M Theisen, Avinash Maganty, Benjamin J Davies, Jonathan G Yabes, Bruce L Jacobs,

Clinical trials serve as a critical source of information to guide evidence-based practices in urology. Conversely, trials that are abandoned consume significant resources and results are under-reported in the literature. ClinicalTrials.gov was queried for urology trials from 2006-2016. Trials were screened by two screeners for applicability to urology and disputes ... Read more >>

J. Urol. (The Journal of urology)
[2020, :101097JU0000000000001072]

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A scoping review of trials for cell-based therapies in human spinal cord injury.

Alice G Willison, Sam Smith, Benjamin M Davies, Mark R N Kotter, Susan C Barnett,

Spinal cord injury (SCI) is associated with significant and life-long disability. Yet, despite decades of research, no regenerative treatment has reached clinical practice. Cell-based therapies are one possible regenerative strategy beginning to transfer to human trials from a more extensive pre-clinical basis. We therefore conducted a scoping review to synthesise ... Read more >>

Spinal Cord (Spinal cord)
[2020, :]

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Tibial Tuberosity Fracture in an Elderly Gentleman: An Unusual Injury Pattern.

Emma Brown, Mohammad Taaha Sohail, Jonathan West, Benjamin Davies, Georgios Mamarelis, Mohammad Zain Sohail,

Avulsion fracture of the tibial tuberosity is an infrequent injury in adolescents and an extremely rare occurrence in adults. We describe the case of an 86-year-old gentleman presenting after a fall, sustaining injury to the left knee. Radiographs of the left knee showed avulsion fracture of the tibial tuberosity. The ... Read more >>

Case Rep Orthop (Case reports in orthopedics)
[2020, 2020:8650927]

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Strong Conflict of Interest Policies are not Associated With Decreased Industry Payments to Academic Urology Departments.

Jathin Bandari, Natalie M Pace, Austin J Lee, Omar M Ayyash, Todd S Yecies, Bruce L Jacobs, Benjamin J Davies,

OBJECTIVE:To identify whether institutions with strong conflicts of interest (COI) policies receive less industry payments than those with weaker policies. While industry-physician interactions can have collaborative benefits, financial COI can undermine preservation of the integrity of professional judgment and public trust. To address this concern, academic institutions have adopted COI ... Read more >>

Urology (Urology)
[2020, 140:51-55]

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Diagnostic Delays Lead to Greater Disability in Degenerative Cervical Myelopathy and Represent a Health Inequality.

Daniel H Pope, Oliver D Mowforth, Benjamin M Davies, Mark R N Kotter,

STUDY DESIGN:Online survey. OBJECTIVE:This study seeks to quantify delays faced, determine demographics of patients most likely to face delay, and determine whether delays affect surgical management and outcomes. SUMMARY OF BACKGROUND DATA:Patients report significant delays in diagnosis of degenerative cervical myelopathy (DCM). METHODS:Seven hundred seventy-eighty patients with self-reported DCM recruited ... Read more >>

Spine (Spine)
[2020, 45(6):368-377]

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Degenerative Cervical Myelopathy: A Brief Review of Past Perspectives, Present Developments, and Future Directions.

Aria Nouri, Joseph S Cheng, Benjamin Davies, Mark Kotter, Karl Schaller, Enrico Tessitore,

Degenerative cervical myelopathy (DCM) is the most common cause of spinal cord injury in developed countries; its prevalence is increasing due to the ageing of the population. DCM causes neurological dysfunction and is a significant cause of disability in the elderly. It has important negative impacts on the quality of ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(2):]

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Spinal Research - A Field in Need of Standardization.

Danyal Z Khan, Benjamin M Davies, Mark R N Kotter,

J. Rheumatol. (The Journal of rheumatology)
[2020, 47(4):633-634]

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Decrease in Urologic Discharge Opioid Prescribing after Mandatory Query of Statewide Prescription Drug Monitoring Program.

John M Myrga, Liam C Macleod, Jathin Bandari, Bruce L Jacobs, Benjamin J Davies,

OBJECTIVE:To examine the effectiveness of the introduction of the Pennsylvania Prescription Drug Monitoring Program (PDMP) on discharge postoperative opioid prescriptions in patients undergoing major urologic procedures within a large single tertiary care hospital. Opioids have historically been prescribed to control postoperative pain, but with growing concern regarding opioid overdose, misuse, ... Read more >>

Urology (Urology)
[2020, 139:84-89]

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Increasing use of positron emission tomography among medicare beneficiaries undergoing radical cystectomy.

Avinash Maganty, Robert M Turner, Jonathan G Yabes, Dwight E Heron, Jeffrey R Gingrich, Benjamin J Davies, Bruce L Jacobs,

OBJECTIVE:To examine factors associated with PET scan use in the pre-operative evaluation of patients diagnosed with bladder cancer. METHODS:Using SEER-Medicare data, we identified bladder cancer patients who underwent radical cystectomy from 2006 to 2011 (n = 4,138). The primary outcome was PET scan use within 6 months before surgery. To examine predictors of ... Read more >>

Eur J Cancer Care (Engl) (European journal of cancer care)
[2020, :e13230]

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The Acquisition of Productive Plural Morphology by Children With Hearing Loss.

Benjamin Davies, Nan Xu Rattanasone, Aleisha Davis, Katherine Demuth,

Purpose Normal-hearing (NH) children acquire plural morphemes at different rates, with the segmental allomorphs /-s, -z/ (e.g., cat-s) being acquired before the syllabic allomorph /-əz/ (e.g., bus-es). Children with hearing loss (HL) have been reported to show delays in the production of plural morphology, raising the possibility that this might ... Read more >>

J. Speech Lang. Hear. Res. (Journal of speech, language, and hearing research : JSLHR)
[2020, 63(2):552-568]

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Gender Gap in Industry Relationships and Scholarly Impact Among Academic Urologists in the United States.

Natalie M Pace, Avinash Maganty, Nalyn Siripong, Austin J Lee, Da Huang, Jathin Bandari, Bruce L Jacobs, Benjamin J Davies,

OBJECTIVES:To examine the distribution of industry payments to male and female academic urologists and the relationship between industry funding, academic rank, and scholarly impact. MATERIAL AND METHODS:Academic urologists from 131 programs with publicly available websites were compiled. Gender, rank, fellowship training, and scholarly impact metrics were recorded. Data from the ... Read more >>

Urology (Urology)
[2020, 139:90-96]

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Genetics of Degenerative Cervical Myelopathy: A Systematic Review and Meta-Analysis of Candidate Gene Studies.

Daniel H Pope, Benjamin M Davies, Oliver D Mowforth, A Ramsay Bowden, Mark R N Kotter,

Degenerative cervical myelopathy (DCM) is estimated to be the most common cause of adult spinal cord impairment. Evidence that is suggestive of a genetic basis to DCM has been increasing over the last decade. A systematic search was conducted in MEDLINE, EMBASE, Cochrane, and HuGENet databases from their origin up ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(1):]

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Quantitative analysis of medical students' and physicians' knowledge of degenerative cervical myelopathy.

Mueez Waqar, Jane Wilcock, Jayne Garner, Benjamin Davies, Mark Kotter,

OBJECTIVES:We have previously identified a delay in general practitioner (GP) referrals for patients with degenerative cervical myelopathy (DCM). The aim of this study was to evaluate whether an education gap existed for DCM along the GP training pathway by quantitatively assessing training in, and knowledge of, this condition. DESIGN:Gap analysis: ... Read more >>

BMJ Open (BMJ open)
[2020, 10(1):e028455]

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Cord compression defined by MRI is the driving factor behind the decision to operate in Degenerative Cervical Myelopathy despite poor correlation with disease severity.

Bryn Hilton, Jennifer Tempest-Mitchell, Benjamin M Davies, Jibin Francis, Richard J Mannion, Rikin Trivedi, Ivan Timofeev, John R Crawford, Douglas Hay, Rodney J Laing, Peter J Hutchinson, Mark R N Kotter,

OBJECTIVES:The mainstay treatment for Degenerative Cervical Myelopathy (DCM) is surgical decompression. Not all cases, however, are suitable for surgery. Recent international guidelines advise surgery for moderate to severe disease as well as progressive mild disease. The goal of this study was to examine the factors in current practice that drive ... Read more >>

PLoS ONE (PloS one)
[2019, 14(12):e0226020]

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Letter to the Editor. The need for research prioritization in cervical myelopathy.

Oliver Daniel Mowforth, Michelle Louise Starkey, Mark Reinhard Kotter, Benjamin Marshall Davies,

J Neurosurg Spine (Journal of neurosurgery. Spine)
[2020, :1-3]

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Comparison of Neoadjuvant and Adjuvant Chemotherapy in Muscle-invasive Bladder Cancer.

Liam C Macleod, Mina M Fam, Jonathan G Yabes, Nathan E Hale, Robert M Turner, Samia H Lopa, Jeffrey R Gingrich, Tudor Borza, Ted A Skolarus, Benjamin J Davies, Bruce L Jacobs,

BACKGROUND:We use observational methods to compare impact of perioperative chemotherapy timing (ie, neoadjuvant and adjuvant) on overall survival (OS) in muscle-invasive bladder cancer because there is no head-to-head randomized trial, and patient factors may influence decision-making. PATIENTS AND METHODS:Using Surveillance, Epidemiology, and End Results-Medicare data, we identified patients receiving cystectomy ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2020, 18(3):201-209.e2]

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Larval thermal characteristics of multiple ixodid ticks underlie their range dynamics

Alicia Fieler, Andrew Rosendale, David Farrow, Megan Dunlevy, Benjamin Davies, Kennan Oyen, Joshua Benoit,

Abstract Temperature is a major factor that impacts tick populations by limiting geographic range of different species. Little is known about the thermal characteristics of these pests outside of a few studies on survival related to thermal tolerance. In this study, thermal tolerance limits, thermal preference, impact of temperature on ... Read more >>

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Responsibility and the limits of patient choice.

Benjamin Davies,

Patients are generally assumed to have the right to choices about treatment, including the right to refuse treatment, which is constrained by considerations of cost-effectiveness. Independently, many people support the idea that patients who are responsible for their ill health should incur penalties that non-responsible patients do not face. Surprisingly, ... Read more >>

Bioethics (Bioethics)
[2020, 34(5):459-466]

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Editorial Comment.

Kelly R Pekala, Benjamin J Davies, Bruce L Jacobs,

J. Urol. (The Journal of urology)
[2020, 203(3):551-552]

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