Full Text Journal Articles by
Author Benedict D Michael

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An extraordinary World Encephalitis Day.

Ava Easton, Benedict D Michael,

Lancet Neurol (The Lancet. Neurology)
[2021, 20(3):172]

Cited: 0 times

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Spectrum, Risk Factors, and Outcomes of Neurological and Psychiatric Complications of COVID-19: A UK-Wide Cross-Sectional Surveillance Study

Amy Ross Russell, Marc Hardwick, Athavan Jeyanantham, Laura White, Saumitro Deb, Girvan Burnside, Harriet Joy, Craig Smith, Tom Pollak, Timothy Nicholson, Nicholas WS Davies, Hadi Manji, Ava Easton, Stephen Ray, Michael Zandi, Jonathan Coles, David Menon, Aravinthan Varatharaj, Beth McCausland, Mark Ellul, Naomi Thomas, Gerome Breen, Stephen Keddie, Michael Lunn, Rustam Al-Shahi Salman, Alan Carson, Eileen Joyce, Martin Turner, Laura Benjamin, Tom Solomon, Rachel Kneen, Sarah Pett, Rhys Thomas, Benedict Michael, Ian Galea,

Background: SARS-CoV2 is associated with neurological and psychiatric complications including cerebrovascular events, encephalopathy and peripheral nerve disease. Detailed clinical data, including factors associated with recovery, is lacking, hampering prediction modelling and targeted therapeutic interventions. We studied COVID-associated neurological and psychiatric complications, to investigate the key clinical features, including those associated ... Read more >>

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Neuropsychiatric complications of covid-19.

Matthew Butler, Thomas A Pollak, Alasdair G Rooney, Benedict D Michael, Timothy R Nicholson,

BMJ (BMJ (Clinical research ed.))
[2020, 371:m3871]

Cited: 3 times

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Characterising neuropsychiatric disorders in patients with COVID-19 - Authors' reply.

Aravinthan Varatharaj, Thomas A Pollak, Timothy R Nicholson, Jonathan P Coles, Laura A Benjamin, Alan Carson, Rhys H Thomas, Benedict D Michael, ,

Lancet Psychiatry (The lancet. Psychiatry)
[2020, 7(11):934-935]

Cited: 0 times

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Update on the diagnosis and management of autoimmune encephalitis.

Mark A Ellul, Greta Wood, Harriet Van Den Tooren, Ava Easton, Ashik Babu, Benedict D Michael,

In recent years, autoimmunity has been increasingly recognised as an important cause of encephalitis. Many different antibodies are now known to target antigens on the neuronal surface, and some of these are associated with characteristic clinical presentations, although seronegative cases are also recognised. Autoimmune encephalitis may mimic other conditions, including ... Read more >>

Clin Med (Lond) (Clinical medicine (London, England))
[2020, 20(4):389-392]

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Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study.

Aravinthan Varatharaj, Naomi Thomas, Mark A Ellul, Nicholas W S Davies, Thomas A Pollak, Elizabeth L Tenorio, Mustafa Sultan, Ava Easton, Gerome Breen, Michael Zandi, Jonathan P Coles, Hadi Manji, Rustam Al-Shahi Salman, David K Menon, Timothy R Nicholson, Laura A Benjamin, Alan Carson, Craig Smith, Martin R Turner, Tom Solomon, Rachel Kneen, Sarah L Pett, Ian Galea, Rhys H Thomas, Benedict D Michael, ,

<h4>Background</h4>Concerns regarding potential neurological complications of COVID-19 are being increasingly reported, primarily in small series. Larger studies have been limited by both geography and specialty. Comprehensive characterisation of clinical syndromes is crucial to allow rational selection and evaluation of potential therapies. The aim of this study was to investigate the ... Read more >>

Lancet Psychiatry (The lancet. Psychiatry)
[2020, 7(10):875-882]

Cited: 87 times

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Autoimmune encephalitis as an increasingly recognised cause of non-convulsive status epilepticus: A retrospective, multicentre evaluation of patient characteristics and electroencephalography (EEG) results.

James W Mitchell, Sofia R Valdoleiros, Samantha Jefferson, Brython Hywel, Tom Solomon, Anthony G Marson, Benedict D Michael,

<h4>Purpose</h4>Status epilepticus (SE) is a severe condition of unrelenting seizures requiring urgent identification and treatment. SE may be unprovoked, occurring in someone with epilepsy, or may be provoked by acute intracranial disease or metabolic derangement. Increasingly encephalitis, particularly autoimmune types, is reported to cause refractory seizures. Whilst convulsive SE is ... Read more >>

Seizure (Seizure)
[2020, 80:153-156]

Cited: 0 times

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A call for a global COVID-19 Neuro Research Coalition.

Andrea Sylvia Winkler, Samuel Knauss, Erich Schmutzhard, Matilde Leonardi, Alessandro Padovani, Foad Abd-Allah, Augustina Charway-Felli, Julius Valentin Emmrich, Thirugnanam Umapathi, Parthasarthy Satishchandra, Fan Kee Hoo, Josep Dalmau, Celia Oreja-Guevara, Maria Lúcia Brito Ferreira, Bettina Pfausler, Benedict D Michael, Fabrizio Tagliavini, Günter Höglinger, Matthias Endres, Christine Klein, Bernhard Hemmer, William Carroll, James Sejvar, Tom Solomon,

Lancet Neurol (The Lancet. Neurology)
[2020, 19(6):482-484]

Cited: 4 times

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Antiepileptic drugs for seizure control in people with neurocysticercosis.

Marta Frackowiak, Monika Sharma, Tejinder Singh, Amrith Mathew, Benedict D Michael,

<h4>Background</h4>Neurocysticercosis is the most common parasitic infection of the brain. Epilepsy is the most common clinical presentation, though it may also present with headache, symptoms of raised intracranial pressure, hydrocephalus and ocular symptoms depending upon the localisation of the parasitic cysts. Anthelmintic drugs, anti-oedema drugs, such as steroids, and antiepileptic ... Read more >>

Cochrane Database Syst Rev (The Cochrane database of systematic reviews)
[2019, 10:CD009027]

Cited: 0 times

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Clobazam add-on therapy for drug-resistant epilepsy.

Rebecca Bresnahan, Kirsty J Martin-McGill, John Williamson, Benedict D Michael, Anthony G Marson,

<h4>Background</h4>Epilepsy affects approximately 1% of the population, with up to 30% of patients continuing to have seizures, despite antiepileptic drug treatment. Clobazam is a 1,5-benzodiazepine and is commonly used as an add-on treatment for drug-resistant epilepsy. This review is an updated version of the original Cochrane Review, first published in ... Read more >>

Cochrane Database Syst Rev (The Cochrane database of systematic reviews)
[2019, 10:CD004154]

Cited: 2 times

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Herpes simplex virus encephalitis in a patient receiving ustekinumab associated with extensive cerebral oedema and brainshift successfully treated by immunosuppression with dexamethasone.

Harriet Kay Van Den Tooren, Viraj Bharambe, Nicholas Silver, Benedict D Michael,

Herpes simplex virus (HSV) encephalitis affects 2-4 people per million/year. Immunocompomised patients can have atypical presentations of HSV encephalitis, including a lack of cerebrospinal fluid (CSF) pleocytosis. We present the case of a patient who was receiving ustekinumab therapy for psoriasis which inhibits interleukin (IL)-12 and IL-23 signalling pathways. The ... Read more >>

BMJ Case Rep (BMJ case reports)
[2019, 12(8):]

Cited: 1 time

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Parasitic encephalitis in immunocompetent individuals - Authors' reply.

Arun Venkatesan, Benedict D Michael, John C Probasco, Romergryko G Geocadin, Tom Solomon,

Lancet (Lancet (London, England))
[2019, 394(10202):915]

Cited: 0 times

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Encephalitis.

Marta Frackowiak, Ava Easton, Benedict D Michael,

Br J Hosp Med (Lond) (British journal of hospital medicine (London, England : 2005))
[2019, 80(4):C32-C34]

Cited: 0 times

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Acute encephalitis in immunocompetent adults.

Arun Venkatesan, Benedict D Michael, John C Probasco, Romergryko G Geocadin, Tom Solomon,

Encephalitis is a condition of inflammation of the brain parenchyma, occurs as a result of infectious or autoimmune causes, and can lead to encephalopathy, seizures, focal neurological deficits, neurological disability, and death. Viral causes account for the largest proportion, but in the last decade there has been growing recognition of ... Read more >>

Lancet (Lancet (London, England))
[2019, 393(10172):702-716]

Cited: 8 times

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Incidence, aetiology, and sequelae of viral meningitis in UK adults: a multicentre prospective observational cohort study.

Fiona McGill, Michael J Griffiths, Laura J Bonnett, Anna Maria Geretti, Benedict D Michael, Nicholas J Beeching, David McKee, Paula Scarlett, Ian J Hart, Kenneth J Mutton, Agam Jung, Guleed Adan, Alison Gummery, Wan Aliaa Wan Sulaiman, Katherine Ennis, Antony P Martin, Alan Haycox, Alastair Miller, Tom Solomon, ,

<h4>Background</h4>Viral meningitis is increasingly recognised, but little is known about the frequency with which it occurs, or the causes and outcomes in the UK. We aimed to determine the incidence, causes, and sequelae in UK adults to improve the management of patients and assist in health service planning.<h4>Methods</h4>We did a ... Read more >>

Lancet Infect Dis (The Lancet. Infectious diseases)
[2018, 18(9):992-1003]

Cited: 14 times

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CSF/plasma HIV-1 RNA discordance even at low levels is associated with up-regulation of host inflammatory mediators in CSF.

Sam Nightingale, Benedict D Michael, Martin Fisher, Alan Winston, Mark Nelson, Steven Taylor, Andrew Ustianowski, Jonathan Ainsworth, Richard Gilson, Lewis Haddow, Edmund Ong, Clifford Leen, Jane Minton, Frank Post, Apostolos Beloukas, Ray Borrow, Munir Pirmohamed, Anna Maria Geretti, Saye Khoo, Tom Solomon,

<h4>Introduction</h4>HIV-1 RNA can be found at higher levels in cerebrospinal fluid (CSF) than in plasma, termed CSF/plasma discordance. The clinical significance of CSF/plasma discordance is not known and the degree of discordance considered important varies. We aimed to determine whether a panel of CSF cytokines, chemokines and associated mediators were ... Read more >>

Cytokine (Cytokine)
[2016, 83:139-146]

Cited: 9 times

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Antiepileptic drugs for the primary and secondary prevention of seizures in viral encephalitis.

Sanjay Pandey, Chaturbhuj Rathore, Benedict D Michael,

<h4>Background</h4>Viral encephalitis is characterised by diverse clinical and epidemiological features. Seizures are an important clinical manifestation and are associated with increased mortality and morbidity. Patients may have seizures during the acute illness or they may develop after recovery. There are no recommendations regarding the use of antiepileptic drugs for the ... Read more >>

Cochrane Database Syst Rev (The Cochrane database of systematic reviews)
[2016, (5):CD010247]

Cited: 0 times

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Characteristic Cytokine and Chemokine Profiles in Encephalitis of Infectious, Immune-Mediated, and Unknown Aetiology.

Benedict D Michael, Michael J Griffiths, Julia Granerod, David Brown, Nicholas W S Davies, Ray Borrow, Tom Solomon,

<h4>Background</h4>Encephalitis is parenchymal brain inflammation due to infectious or immune-mediated processes. However, in 15-60% the cause remains unknown. This study aimed to determine if the cytokine/chemokine-mediated host response can distinguish infectious from immune-mediated cases, and whether this may give a clue to aetiology in those of unknown cause.<h4>Methods</h4>We measured 38 ... Read more >>

PLoS One (PloS one)
[2016, 11(1):e0146288]

Cited: 18 times

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'Twas the night before Grand Round ….

Richard J B Ellis, Barnaby N Hirons, Alexandra E May, David J McCreary, Nicholas D Peterson, Leonard M Quinn, Besa Ziso, Michael Bonello, Brython Hywel, Benedict D Michael, Sean D Brown, Benjamin D Murray, Duncan M Rogers, Matt Barrett, Mark Doran,

Med J Aust (The Medical journal of Australia)
[2015, 203(11):457]

Cited: 0 times

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Controversies in HIV-associated neurocognitive disorders.

Sam Nightingale, Alan Winston, Scott Letendre, Benedict D Michael, Justin C McArthur, Saye Khoo, Tom Solomon,

Cross-sectional studies show that around half of individuals infected with HIV-1 have some degree of cognitive impairment despite the use of antiretroviral drugs. However, prevalence estimates vary depending on the population and methods used to assess cognitive impairment. Whether asymptomatic patients would benefit from routine screening for cognitive difficulties is ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2014, 13(11):1139-1151]

Cited: 111 times

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Clobazam monotherapy for partial-onset or generalized-onset seizures.

Ravindra Arya, Vidhu Anand, Sushil K Garg, Benedict D Michael,

<h4>Background</h4>There is a need to expand monotherapy options available to a clinician for the treatment of new partial-onset or generalized-onset seizures. A Cochrane systematic review for clobazam monotherapy is expected to define its place in the treatment of new-onset or untreated seizures and highlight gaps in evidence.<h4>Objectives</h4>To evaluate the efficacy, ... Read more >>

Cochrane Database Syst Rev (The Cochrane database of systematic reviews)
[2014, (10):CD009258]

Cited: 4 times

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Antiepileptic drugs for the primary and secondary prevention of seizures in viral encephalitis.

Sanjay Pandey, Chaturbhuj Rathore, Benedict D Michael,

<h4>Background</h4>Viral encephalitis is characterised by diverse clinical and epidemiological features. Seizures are an important clinical manifestation and associated with increased mortality and morbidity. Patients may have seizures during the acute illness or they may develop after recovery. There are no recommendations regarding the use of antiepileptic drugs for the primary ... Read more >>

Cochrane Database Syst Rev (The Cochrane database of systematic reviews)
[2014, (10):CD010247]

Cited: 3 times

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Test them all; an easily diagnosed and readily treatable cause of dementia with life-threatening consequences if missed.

Sam Nightingale, Benedict D Michael, Sylviane Defres, Laura A Benjamin, Tom Solomon,

Pract Neurol (Practical neurology)
[2013, 13(6):354-356]

Cited: 3 times

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Neurological manifestations of influenza infection in children and adults: results of a National British Surveillance Study.

Anu Goenka, Benedict D Michael, Elizabeth Ledger, Ian J Hart, Michael Absoud, Gabriel Chow, James Lilleker, Michael Lunn, David McKee, Deirdre Peake, Karen Pysden, Mark Roberts, Enitan D Carrol, Ming Lim, Shivaram Avula, Tom Solomon, Rachel Kneen,

<h4>Background</h4>The emergence of influenza A(H1N1) 2009 was met with increased reports of associated neurological manifestations. We aimed to describe neurological manifestations of influenza in adults and children in the United Kingdom that presented at this time.<h4>Methods</h4>A 2-year surveillance study was undertaken through the British adult and pediatric neurological surveillance units ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2014, 58(6):775-784]

Cited: 55 times

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Suboptimal management of central nervous system infections in children: a multi-centre retrospective study.

Christine Kelly, Aman Sohal, Benedict D Michael, Andrew Riordan, Tom Solomon, Rachel Kneen, ,

<h4>Objective</h4>We aimed to audit the regional management of central nervous system (CNS) infection in children.<h4>Methods</h4>The study was undertaken in five district general hospitals and one tertiary paediatric hospital in the Mersey region of the UK. Children admitted to hospital with a suspected CNS infection over a three month period were ... Read more >>

BMC Pediatr (BMC pediatrics)
[2012, 12:145]

Cited: 16 times

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