Full Text Journal Articles by
Author Ben W Mol

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FIGO good practice recommendations on the use of prenatal corticosteroids to improve outcomes and minimize harm in babies born preterm.

Jane Norman, Andrew Shennan, Bo Jacobsson, Sarah J Stock, ,

For women with a singleton or a multiple pregnancy in situations where active neonatal care is appropriate, and for whom preterm birth is anticipated between 24 and 34 weeks of gestation, one course of prenatal corticosteroids should ideally be offered 18 to 72 h before preterm birth is expected to improve outcomes ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, 155(1):26-30]

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FIGO good practice recommendations for reducing preterm birth and improving child outcomes.

Bo Jacobsson, Joe Leigh Simpson, ,

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, 155(1):1-4]

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FIGO good practice recommendations on cervical cerclage for prevention of preterm birth.

Andrew Shennan, Lisa Story, Bo Jacobsson, William A Grobman, ,

Cervical cerclage is an intervention which when given to the right women can prevent preterm birth and second-trimester fetal losses. A history-indicated cerclage should be offered to women who have had three or more preterm deliveries and/or mid-trimester losses. An ultrasound-indicated cerclage should be offered to women with a cervical ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, 155(1):19-22]

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FIGO good practice recommendations on progestogens for prevention of preterm delivery.

Andrew Shennan, Natalie Suff, Joe Leigh Simpson, Bo Jacobsson, Ben W Mol, William A Grobman, ,

Women at high risk of preterm birth (either a previous spontaneous preterm birth and/or sonographic short cervix) with a singleton gestation should be offered daily vaginal progesterone or weekly 17-OHPC treatment to prevent preterm birth. Benefit is most significant in those with prior history of preterm birth and a short ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, 155(1):16-18]

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FIGO good practice recommendations on the use of pessary for reducing the frequency and improving outcomes of preterm birth.

William A Grobman, Jane Norman, Bo Jacobsson, ,

A pessary is a device made of synthetic material that is placed in the vagina and has been used for prevention of preterm birth. It has been suggested that a potential mechanism of the pessary is alteration of the cervico-uterine angle to a more posterior position, which reduces cervical compression ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, 155(1):23-25]

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FIGO good practice recommendations on reduction of preterm birth in pregnancies conceived by assisted reproductive technologies.

Ben W Mol, Bo Jacobsson, William A Grobman, Kelle Moley, ,

FIGO (the International Federation of Gynecology and Obstetrics) supports assisted reproductive technologies (ART) to achieve pregnancy and supports their availability in all nations. However, the increased frequency of preterm birth must be taken into account. Therefore, before in vitro fertilization (IVF) is started, other approaches, including expectant management, should be ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, 155(1):13-15]

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FIGO good practice recommendations on delayed umbilical cord clamping.

Ana Bianchi, Bo Jacobsson, Ben W Mol, ,

Delayed cord clamping in the first minute in preterm infants born before 34 weeks of gestation improves neonatal hematologic measures and may reduce mortality without increasing any other morbidity. In term-born babies, it also seems to improve both the short- and long-term outcomes and shows favorable scores in fine motor and ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, 155(1):34-36]

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FIGO good practice recommendations on modifiable causes of iatrogenic preterm birth.

Catalina M Valencia, Ben W Mol, Bo Jacobsson, ,

Iatrogenic preterm birth is a planned delivery that occurs before 37 weeks of gestation due to maternal and/or fetal causes. However, in some cases, such deliveries also occur with no apparent medical indication. The increasing numbers of iatrogenic preterm deliveries worldwide have led researchers to identify modifiable causes that allow the ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, 155(1):8-12]

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Assessing Research Misconduct in Randomized Controlled Trials.

Wentao Li, Esmée M Bordewijk, Ben W Mol,

Randomized controlled trials (RCTs) serve as the pillar of evidence-based medicine and guide medical practice. Compromised data integrity in RCTs undermines the authority of this valuable tool for science and puts patients at risk. Although a large number of retractions due to data issues in obstetrics and gynecology have occurred ... Read more >>

Obstet Gynecol (Obstetrics and gynecology)
[2021, 138(3):338-347]

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Comparing levonorgestrel intrauterine system versus hysteroscopic resection in patients with postmenstrual spotting related to a niche in the caesarean scar (MIHYS NICHE trial): protocol of a randomised controlled trial.

Chuqing He, Xiaoqing He, Yan Liang, Taotao Sun, Li Yan, Chenfeng Zhu, Xiaoya Zhao, Li Xie, Ben W Mol, Jian Zhang, J A F Huirne,

<h4>Introduction</h4>Recently, the rate of caesarean sections (CS) worldwide has risen and CS-associated complications such as niche have increased substantially. Until now, evidence-based clinical guidelines for the treatment of niche-related symptoms remain absent. In patients with postmenstrual spotting, it has not been studied if the effect of levonorgestrel 52 mg intrauterine system ... Read more >>

BMJ Open (BMJ open)
[2021, 11(8):e045770]

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Effect of an individualised nutritional intervention on gestational diabetes mellitus prevention in a high-risk population screened by a prediction model: study protocol for a multicentre randomised controlled trial.

Chenjie Zhang, Lulu Wang, Wenguang Sun, Lei Chen, Chen Zhang, Hong Li, Jiale Yu, Jianxia Fan, Huijuan Ruan, Tao Zheng, Dongling Wu, Shaojing Li, Huan Lu, Man Wang, Ben W Mol, Hefeng Huang, Yanting Wu,

<h4>Background</h4>The ability of a preventive nutritional intervention to reduce the morbidity of gestational diabetes mellitus (GDM) remains controversial. We aim to assess whether GDM can be prevented by an individualised nutritional intervention in pregnant women who are at high risk for the disease based on a prediction model.<h4>Methods/design</h4>A multicentre randomised ... Read more >>

BMC Pregnancy Childbirth (BMC pregnancy and childbirth)
[2021, 21(1):586]

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The effect of a hysteroscopic niche resection compared with Levonorgestrel-releasing intrauterine device on postmenstrual spotting in patients with a symptomatic niche in the uterine cesarean scar: A prospective cohort study.

Xiaoqing He, Li Yan, Chuqing He, Chenfeng Zhu, Ben W Mol, Jian Zhang, J A F Huirne,

<h4>Objective</h4>To compare the effect of a hysteroscopic niche resection with a Levonorgestrel-releasing intrauterine device (LNG-IUD, 52 mg) on postmenstrual spotting duration in patients with a symptomatic niche in the uterine cesarean scar.<h4>Study design</h4>This prospective cohort study was conducted at the International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai ... Read more >>

Eur J Obstet Gynecol Reprod Biol (European journal of obstetrics, gynecology, and reproductive biology)
[2021, 265:66-73]

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External validation of prognostic models to predict stillbirth using the International Prediction of Pregnancy Complications (IPPIC) Network database: an individual participant data meta-analysis.

J Allotey, R Whittle, K I E Snell, M Smuk, R Townsend, P von Dadelszen, A E P Heazell, L Magee, G C S Smith, J Sandall, B Thilaganathan, J Zamora, R D Riley, A Khalil, S Thangaratinam, ,

<h4>Objective</h4>Stillbirth is a potentially preventable complication of pregnancy. Identifying women at risk can guide decisions on closer surveillance or timing of birth to prevent fetal death. Prognostic models have been developed to predict the risk of stillbirth, but none have yet been externally validated. We externally validated published prediction models ... Read more >>

Ultrasound Obstet Gynecol (Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology)
[2021, :]

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Research misconduct tests: putting patients' interests first.

Madelon van Wely, Esmee M Bordewijk, Rik van Eekelen, Rui Wang, Marian Showell, Ben W Mol, Wentao Li,

J Clin Epidemiol (Journal of clinical epidemiology)
[2021, :]

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Randomized Controlled Trials on COVID-19 Should Be Accurate and Trustworthy.

Ben W Mol,

Am J Trop Med Hyg (The American journal of tropical medicine and hygiene)
[2021, :]

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Making miscarriage matter.

Krystle Chong, Wentao Li, Ian Roberts, Ben W Mol,

Lancet (Lancet (London, England))
[2021, 398(10302):743-744]

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Development and validation of a risk prediction model of preterm birth for women with preterm labour symptoms (the QUIDS study): A prospective cohort study and individual participant data meta-analysis.

Sarah J Stock, Margaret Horne, Merel Bruijn, Helen White, Kathleen A Boyd, Robert Heggie, Lisa Wotherspoon, Lorna Aucott, Rachel K Morris, Jon Dorling, Lesley Jackson, Manju Chandiramani, Anna L David, Asma Khalil, Andrew Shennan, Gert-Jan van Baaren, Victoria Hodgetts-Morton, Tina Lavender, Ewoud Schuit, Susan Harper-Clarke, Ben W Mol, Richard D Riley, Jane E Norman, John Norrie,

<h4>Background</h4>Timely interventions in women presenting with preterm labour can substantially improve health outcomes for preterm babies. However, establishing such a diagnosis is very challenging, as signs and symptoms of preterm labour are common and can be nonspecific. We aimed to develop and externally validate a risk prediction model using concentration ... Read more >>

PLoS Med (PLoS medicine)
[2021, 18(7):e1003686]

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Anti-Mullerian hormone (AMH) test information on Australian and New Zealand fertility clinic websites: a content analysis.

Tessa Copp, Brooke Nickel, Sarah Lensen, Karin Hammarberg, Devora Lieberman, Jenny Doust, Ben W Mol, Kirsten McCaffery,

<h4>Objectives</h4>The anti-Mullerian hormone (AMH) test has been promoted as a way to inform women about their future fertility. However, data consistently show the test is a poor predictor of natural fertility potential for an individual woman. As fertility centre websites are often a primary source of information for reproductive information, ... Read more >>

BMJ Open (BMJ open)
[2021, 11(7):e046927]

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Intrauterine injection of HCG before embryo transfer: a parallel, double-blind randomized trial.

Karim S Abdallah, Ahmad Makhlouf, Esraa Badran, Ihab M El-Nashar, Tarek K Al-Hussaini, Tarek Farghaly, Hazem S Mohamed, Ben W Mol, Ahmed M Abdelmagied,

<h4>Research question</h4>Does intrauterine administration of HCG before embryo transfer improve live birth rate during IVF cycles?<h4>Design</h4>A parallel, randomized controlled trial conducted between July 2018 and February 2020. Infertile women (n = 181) scheduled for fresh or vitrified-warmed embryo transfer after IVF carried out for any indication were randomized in a 1:1 ratio ... Read more >>

Reprod Biomed Online (Reproductive biomedicine online)
[2021, :]

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Widespread implementation of a low-cost telehealth service in the delivery of antenatal care during the COVID-19 pandemic: an interrupted time-series analysis.

Kirsten R Palmer, Michael Tanner, Miranda Davies-Tuck, Andrea Rindt, Kerrie Papacostas, Michelle L Giles, Kate Brown, Helen Diamandis, Rebecca Fradkin, Alice E Stewart, Daniel L Rolnik, Andrew Stripp, Euan M Wallace, Ben W Mol, Ryan J Hodges,

<h4>Background</h4>Little evidence is available on the use of telehealth for antenatal care. In response to the COVID-19 pandemic, we developed and implemented a new antenatal care schedule integrating telehealth across all models of pregnancy care. To inform this clinical initiative, we aimed to assess the effectiveness and safety of telehealth ... Read more >>

Lancet (Lancet (London, England))
[2021, 398(10294):41-52]

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Phosphodiesterase-5 inhibitors in Pregnancy: Systematic review and meta-analysis of maternal and perinatal safety and clinical outcomes.

Jessica M Turner, Francesca Russo, Jan DePREST, Ben W Mol, Sailesh Kumar,

<h4>Objective</h4>Phosphodiesterase-5 inhibitors have recently been used for the treatment of severe early onset pre-eclampsia and fetal growth restriction. There are however concerns that they may increase the risk of neonatal morbidity and mortality. The aim of this systematic review was to assess the safety profile and clinical outcomes of phosphodiesterase-5 ... Read more >>

Am J Obstet Gynecol (American journal of obstetrics and gynecology)
[2021, :]

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Child outcomes after induction of labour or expectant management in women with preterm prelabour rupture of membranes between 34 and 37 weeks of gestation: study protocol of the PPROMEXIL Follow-up trial. A long-term follow-up study of the randomised controlled trials PPROMEXIL and PPROMEXIL-2.

Annemijn A de Ruigh, Noor E Simons, Janneke Van 't Hooft, Aleid G van Wassenaer-Leemhuis, Cornelieke S H Aarnoudse-Moens, Madelon van Wely, Gert-Jan van Baaren, Floortje Vlemmix, D P van der Ham, Augustinus S P van Teeffelen, Ben W Mol, Tessa J Roseboom, Eva Pajkrt,

<h4>Introduction</h4>Late preterm prelabour rupture of membranes (PROM between 34<sup>+0</sup> and 36<sup>+6</sup> weeks gestational age) is an important clinical dilemma. Previously, two large Dutch randomised controlled trials (RCTs) compared induction of labour (IoL) to expectant management (EM). Both trials showed that early delivery does not reduce the risk of neonatal sepsis ... Read more >>

BMJ Open (BMJ open)
[2021, 11(6):e046046]

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Re: Vascular endothelial growth factor C/A 2578 gene polymorphism and umbilical artery doppler in preeclamptic women. Mowad HH, Abougabal KM, Fahim AS, Shehata NAA, Ali HAA, Nasser MZ. Pregnancy Hypertens. 2019 Oct;18:173-178.

Ben W Mol,

Pregnancy Hypertens (Pregnancy hypertension)
[2021, 25:169-170]

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Development of a core outcome set for interventions to prevent stillbirth.

Bobae V Kim, Edoardo C Aromataris, Philippa Middleton, Rosemary Townsend, Shakila Thangaratinam, James M N Duffy, Willem de Lint, Suzette Coat, Vicki Flenady, Asma Khalil, Ben W Mol,

<h4>Aims</h4>To develop a core outcome set for trials investigating interventions to prevent stillbirth.<h4>Materials & methods</h4>Outcomes identified from a systematic literature review and semi-structured interviews with parents in Australia and the UK were entered into a two-round online Delphi survey and focus group/consensus meetings.<h4>Results</h4>A core outcome set containing 11 outcomes in ... Read more >>

Aust N Z J Obstet Gynaecol (The Australian & New Zealand journal of obstetrics & gynaecology)
[2021, :]

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Micronized progesterone plus dydrogesterone versus micronized progesterone alone for luteal phase support in frozen-thawed cycles (MIDRONE): a prospective cohort study.

Lan N Vuong, Toan D Pham, Khanh T Q Le, Trung T Ly, Ho L Le, Diem T N Nguyen, Vu N A Ho, Vinh Q Dang, Tuan H Phung, Robert J Norman, Ben W Mol, Tuong M Ho,

<h4>Study question</h4>Does the addition of oral dydrogesterone to vaginal progesterone as luteal phase support improve pregnancy outcomes during frozen embryo transfer (FET) cycles compared with vaginal progesterone alone?<h4>Summary answer</h4>Luteal phase support with oral dydrogesterone added to vaginal progesterone had a higher live birth rate and lower miscarriage rate compared with ... Read more >>

Hum Reprod (Human reproduction (Oxford, England))
[2021, 36(7):1821-1831]

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