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A pneumococcal controlled human infection model in Malawi: Transfer of an established pneumococcal carriage model from Liverpool, UK to Blantyre, Malawi – A feasibility study

Ben Morton, Sarah Burr, Kondwani Jambo, Jamie Rylance, Marc Y.R. Henrion, Ndaziona Peter Banda, Edna Nsomba, Blessings Kapumba, Lucinda Manda-Taylor, Clemens Masesa, Daniela Ferrreira, Stephen Gordon, ,

Streptococcus pneumoniae is the leading cause of morbidity and mortality due to community acquired pneumonia, bacterial meningitis and bacteraemia worldwide. Pneumococcal conjugate vaccines protect against invasive disease, but are expensive to manufacture, limited in serotype coverage, associated with serotype replacement and demonstrate reduced effectiveness against mucosal colonisation.  As asymptomatic colonisation ... Read more >>

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A novel assay of neutrophil extracellular trap (NET) formation identifies anti-IL-8 therapies to reduce disseminated intravascular coagulation and mortality in the intensive care unit.

Simon Abrams, Ben Morton, Yasir Alhamdi, Mohmad Alsabani, Zhenxing Cheng, Steven Lane, Ingeborg Welters, Guozheng Wang, Cheng-Hock Toh,

Clin Med (Lond) (Clinical medicine (London, England))
[2020, 20(Suppl 2):s114-s115]

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The whole blood phagocytosis assay: a clinically relevant test of neutrophil function and dysfunction in community-acquired pneumonia

Jesús Reiné, Jamie Rylance, Daniela Ferreira, Shaun Pennington, Ingeborg Dorothea Welters, Robert Parker, Ben Morton,

Abstract OBJECTIVE: To refine and validate a neutrophil function assay with clinical relevance for patients with community-acquired pneumonia (CAP). Design: Two phase cross-sectional study to standardise and refine the assay in blood from healthy volunteers and test neutrophil phagocytic function in hospital patients with CAP. Participants : Phase one: Healthy ... Read more >>

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A pneumococcal controlled human infection model in Malawi: Transfer of an established pneumococcal carriage model from Liverpool, UK to Blantyre, Malawi - A feasibility study.

Ben Morton, Sarah Burr, Kondwani Jambo, Jamie Rylance, Marc Y R Henrion, Ndaziona Peter Banda, Edna Nsomba, Blessings Kapumba, Lucinda Manda-Taylor, Clemens Masesa, Daniela Ferrreira, Stephen B Gordon, ,

Streptococcus pneumoniae is the leading cause of morbidity and mortality due to community acquired pneumonia, bacterial meningitis and bacteraemia worldwide. Pneumococcal conjugate vaccines protect against invasive disease, but are expensive to manufacture, limited in serotype coverage, associated with serotype replacement and demonstrate reduced effectiveness against mucosal colonisation.  As asymptomatic colonisation ... Read more >>

Wellcome Open Res (Wellcome open research)
[2020, 5:25]

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The Sabadell score is an independent predictor of five-year outcome after critical care discharge

Ben Morton, Victoria Penston, Phillip McHale, Daniel Hungerford, Ged Dempsey,

Abstract Background: Critical care survivors frequently suffer persistent morbidity and increased risk of mortality compared to the general population. However, there are no standardised tools to identify at-risk patients to target potential interventions. Our aim was to establish whether the “Sabadell score”, a simple tool applied upon critical care discharge, ... Read more >>

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Emergency front-of-neck airway: robust theatre multidisciplinary team training optimises performance and saves time.

Peter Groom, Tamryn Miller, Tom Miller, Ben Morton,

Br J Anaesth (British journal of anaesthesia)
[2020, 124(1):e11-e13]

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Epidemiology of intra-abdominal infection and sepsis in critically ill patients: "AbSeS", a multinational observational cohort study and ESICM Trials Group Project.

Stijn Blot, Massimo Antonelli, Kostoula Arvaniti, Koen Blot, Ben Creagh-Brown, Dylan de Lange, Jan De Waele, Mieke Deschepper, Yalim Dikmen, George Dimopoulos, Christian Eckmann, Guy Francois, Massimo Girardis, Despoina Koulenti, Sonia Labeau, Jeffrey Lipman, Fernando Lipovestky, Emilio Maseda, Philippe Montravers, Adam Mikstacki, José-Artur Paiva, Cecilia Pereyra, Jordi Rello, Jean-Francois Timsit, Dirk Vogelaers, ,

PURPOSE:To describe the epidemiology of intra-abdominal infection in an international cohort of ICU patients according to a new system that classifies cases according to setting of infection acquisition (community-acquired, early onset hospital-acquired, and late-onset hospital-acquired), anatomical disruption (absent or present with localized or diffuse peritonitis), and severity of disease expression ... Read more >>

Intensive Care Med (Intensive Care Medicine)
[2019, 45(12):1703-1717]

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A Novel Assay for Neutrophil Extracellular Trap Formation Independently Predicts Disseminated Intravascular Coagulation and Mortality in Critically Ill Patients.

Simon T Abrams, Ben Morton, Yasir Alhamdi, Mohmad Alsabani, Steven Lane, Ingeborg D Welters, Guozheng Wang, Cheng-Hock Toh,

Rationale: Neutrophil extracellular traps (NETs) are important in the host defense against infection, but they also promote intravascular coagulation and multiorgan failure in animal models. Their clinical significance remains unclear, and available assays for patient care lack specificity and reliability.Objectives: To establish a novel assay and test its clinical significance.Methods: ... Read more >>

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2019, 200(7):869-880]

Cited: 2 times

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Performance of emergency surgical front of neck airway access by head and neck surgeons, general surgeons, or anaesthetists: an in situ simulation study.

Peter Groom, Louise Schofield, Natasha Hettiarachchi, Samuel Pickard, Jeremy Brown, John Sandars, Ben Morton,

BACKGROUND:The 'cannot intubate cannot oxygenate' (CICO) emergency requires urgent front of neck airway (FONA) access to prevent death. In cases reported to the 4th National Audit Project, the most successful FONA was a surgical technique, almost all of which were performed by surgeons. Subsequently, UK guidelines adopted surgical cricothyroidotomy as ... Read more >>

Br J Anaesth (British journal of anaesthesia)
[2019, 123(5):696-703]

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A mixed-methods pilot study to evaluate a collaborative anaesthetic and surgical training package for emergency surgical cricothyroidotomy.

Richard J Berwick, William Gauntlett, Sergio A Silverio, Hilary Wallace, Simon Mercer, Jeremy M Brown, John E Sandars, Ben Morton, Peter Groom,

Anaesth Intensive Care (Anaesthesia and intensive care)
[2019, 47(4):357-367]

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Two Randomized Trials of the Effect of Live Attenuated Influenza Vaccine on Pneumococcal Colonization.

Jamie Rylance, Wouter A A de Steenhuijsen Piters, Michael J Mina, Debby Bogaert, Neil French, Daniela M Ferreira, ,

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2019, 199(9):1160-1163]

Cited: 2 times

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Dynamic changes in innate immune and T cell function and composition at the nasal mucosa across the human lifespan

Jesús Reiné, Beatriz Carniel, Carla Solórzano, Elena Mitsi, Sherin Pojar, Elissavet Nikolaou, Esther German, Angela Hyder-Wright, Helen Hill, Caz Hales, Lynsey Brown, Victoria Horsley, Lisa Hughes, Seher Zaidi, Victoria Connor, Ben Morton, Andrea Collins, Jamie Rylance, Hugh Adler, Paul McNamara, Daniela Ferreira, Simon Jochems,

Abstract The very young and very old are at increased risk of serious infections, including pneumonia. This may relate to changes in the immune system as young children have limited immunological memory, while immunosenescence, inflammaging and a decreased pool of naïve immune cells are described with advanced age. How the ... Read more >>

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Assessing ethical climates in critical care and their impact on patient outcomes.

Emmanuel Okenyi, Thomas Michael Donaldson, Andrea Collins, Ben Morton, Angela Obasi,

Intensive care units with a "good" ethical environment are more likely to identify perceived excessive patient care. Patients with perceived excessive care were more likely to die and time to death was shorter in units with a "good" ethical environment. http://ow.ly/vnFP30neAZN. ... Read more >>

Breathe (Sheff) (Breathe (Sheffield, England))
[2019, 15(1):84-87]

Cited: 1 time

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Socioeconomic status and 30-day mortality after minor and major trauma: A retrospective analysis of the Trauma Audit and Research Network (TARN) dataset for England.

Philip McHale, Daniel Hungerford, David Taylor-Robinson, Thomas Lawrence, Timothy Astles, Ben Morton,

INTRODUCTION:Socioeconomic status (SES) is associated with rate and severity of trauma. However, it is unclear whether there is an independent association between SES and mortality after injury. Our aim was to assess the relationship between SES and mortality from trauma. MATERIALS AND METHODS:We conducted a secondary analysis of the Trauma ... Read more >>

PLoS ONE (PloS one)
[2018, 13(12):e0210226]

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The Early Recognition and Management of Sepsis in Sub-Saharan African Adults: A Systematic Review and Meta-Analysis.

Ben Morton, Marie Stolbrink, Wanjiku Kagima, Jamie Rylance, Kevin Mortimer,

Sepsis is a common cause of morbidity and mortality in sub-Saharan African adults. Standardised management pathways have been documented to improve the survival of adults with sepsis from high-resource settings. Our aim was to assess the current evidence base for early sepsis interventions (recognition, empirical antibiotics, and resuscitation) in resource-poor ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2018, 15(9):]

Cited: 1 time

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Effect of Live Attenuated Influenza Vaccine on Pneumococcal Carriage

Jamie Rylance, Wouter de Steenhuijsen Piters, Sherin Pojar, Elissavet Nikolaou, Esther German, Elena Mitsi, Simon Jochems, Beatriz Carniel, Carla Solórzano, Jesús Reiné, Jenna Gritzfeld, Mei Ling J.N. Chu, Kayleigh Arp, Angela Hyder-Wright, Helen Hill, Caz Hales, Rachel Robinson, Cath Lowe, Hugh Adler, Seher Zaidi, Victoria Connor, Lepa Lazarova, Katherine Piddock, India Wheeler, Emma Smith, Ben Morton, John Blakey, Hassan Burhan, Artemis Koukounari, Duolao Wang, Michael Mina, Stephen Gordon, Debby Bogaert, Neil French, Daniela Ferreira,

Abstract The widely used nasally-administered Live Attenuated Influenza Vaccine (LAIV) alters the dynamics of naturally occurring nasopharyngeal carriage of Streptococcus pneumoniae in animal models. Using a human experimental model (serotype 6B) we tested two hypotheses: 1) LAIV increased the density of S. pneumoniae in those already colonised; 2) LAIV administration ... Read more >>

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Augmented Passive Immunotherapy with P4 Peptide Improves Phagocyte Activity in Severe Sepsis.

Ben Morton, Elena Mitsi, Shaun H Pennington, Jesús Reiné, Angela D Wright, Robert Parker, Ingeborg D Welters, John D Blakey, Gowrisankar Rajam, Edwin W Ades, Daniela M Ferreira, Duolao Wang, Aras Kadioglu, Stephen B Gordon,

INTRODUCTION:Antimicrobial resistance threatens to undermine treatment of severe infection; new therapeutic strategies are urgently needed. Preclinical work shows that augmented passive immunotherapy with P4 peptide increases phagocytic activity and shows promise as a novel therapeutic strategy. Our aim was to determine ex vivo P4 activity in a target population of ... Read more >>

Shock (Shock (Augusta, Ga.))
[2016, 46(6):635-641]

Cited: 4 times

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Long-Term Outcome Following Tracheostomy in Critical Care: A Systematic Review.

Ged A Dempsey, Ben Morton, Clare Hammell, Lisa T Williams, Catrin Tudur Smith, Terence Jones,

The prevalence and impact of longer-term outcomes following percutaneous tracheostomy, particularly tracheal stenosis, are unclear. Previous meta-analyses addressing this problem have been confounded by the low prevalence of tracheal stenosis and a limited number of studies.Embase, PubMed-Medline, and the Cochrane Central Register of Clinical Trials were searched to identify all ... Read more >>

Crit. Care Med. (Critical care medicine)
[2016, 44(3):617-628]

Cited: 7 times

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First human challenge testing of a pneumococcal vaccine. Double-blind randomized controlled trial.

Andrea M Collins, Angela D Wright, Elena Mitsi, Jenna F Gritzfeld, Carole A Hancock, Shaun H Pennington, Duolao Wang, Ben Morton, Daniela M Ferreira, Stephen B Gordon,

New vaccines are urgently needed to protect the vulnerable from bacterial pneumonia. Clinical trials of pneumonia vaccines are slow and costly, requiring tens of thousands of patients. Studies of pneumococcal vaccine efficacy against colonization have been proposed as a novel method to down-select between vaccine candidates.Using our safe and reproducible ... Read more >>

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2015, 192(7):853-858]

Cited: 15 times

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A Retrospective Evaluation of Critical Care Blood Culture Yield - Do Support Services Contribute to the "Weekend Effect"?

Ben Morton, Shankara Nagaraja, Andrea Collins, Shaun H Pennington, John D Blakey,

The "weekend effect" describes an increase in adverse outcomes for patients admitted at the weekend. Critical care units have moved to higher intensity working patterns to address this with some improved outcomes. However, support services have persisted with traditional working patterns. Blood cultures are an essential diagnostic tool for patients ... Read more >>

PLoS ONE (PloS one)
[2015, 10(10):e0141361]

Cited: 8 times

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Immunomodulatory adjuvant therapy in severe community-acquired pneumonia.

Ben Morton, Shaun Harry Pennington, Stephen B Gordon,

Severe pneumonia has a high mortality (38.2%) despite evidence-based therapy. Rising rates of antimicrobial resistance increase the urgency to develop new treatment strategies. Multiple adjuvant therapies for pneumonia have been investigated but none are currently licensed. Profound immune dysregulation occurs in patients with severe infection. An initial hyper-inflammatory response is ... Read more >>

Expert Rev Respir Med (Expert review of respiratory medicine)
[2014, 8(5):587-596]

Cited: 8 times

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