Full Text Journal Articles by
Author Ben Marais

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Access to paediatric formulations for the treatment of childhood tuberculosis.

Madlen Nash, Christophe Perrin, James A Seddon, Jennifer Furin, Janika Hauser, Ben Marais, Ian Kitai, Jeffrey Starke, Lindsay McKenna,

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, 4(12):855-857]

Cited: 0 times

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COVID-19 disease spectrum in children - first insights from Africa.

Ben J Marais,

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

Cited: 0 times

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New Xpert MTB/XDR: added value and future in the field.

Arnold Bainomugisa, Christopher Gilpin, Christopher Coulter, Ben J Marais,

Eur Respir J (The European respiratory journal)
[2020, 56(5):]

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Extensive Homoplasy but No Evidence of Convergent Evolution of Repeat Numbers at MIRU Loci in Modern Mycobacterium tuberculosis Lineages.

Alexander C Outhred, Ulziijargal Gurjav, Peter Jelfs, Nadine McCallum, Qinning Wang, Grant A Hill-Cawthorne, Ben J Marais, Vitali Sintchenko,

More human deaths have been attributable to Mycobacterium tuberculosis than any other pathogen, and the epidemic is sustained by ongoing transmission. Various typing schemes have been developed to identify strain-specific differences and track transmission dynamics in affected communities, with recent introduction of whole genome sequencing providing the most accurate assessment. ... Read more >>

Front Public Health (Frontiers in public health)
[2020, 8:455]

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Is the risk of ibuprofen or other non-steroidal anti-inflammatory drugs increased in COVID-19?

Joel Vosu, Philip Britton, Annaleise Howard-Jones, David Isaacs, Alison Kesson, Ameneh Khatami, Ben Marais, Claire Nayda, Alexander Outhred,

J Paediatr Child Health (Journal of paediatrics and child health)
[2020, 56(10):1645-1646]

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Optimising social mixing strategies achieving COVID-19 herd immunity while minimising mortality in six European countries

Romain Ragonnet, Guillaume Briffoteaux, Bridget Williams, Julian Savulescu, Matthew Segal, Milinda Abayawardana, Rosalind Eggo, Daniel Tuyttens, Nouredine Melab, Ben Marais, Emma McBryde, James Trauer,

Abstract Strategies are needed to minimise the impact of COVID-19 in the medium-to-long term, until safe and effective vaccines can be used. Using a mathematical model in a formal optimisation framework, we identified contact mitigation strategies that minimised COVID-19-related mortality over a time-horizon of 15 months while achieving herd immunity ... Read more >>

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Tuberculosis in migrants - screening, surveillance and ethics.

Gabriella Scandurra, Chris Degeling, Paul Douglas, Claudia C Dobler, Ben Marais,

Tuberculosis (TB) is the leading infectious cause of human mortality and is responsible for nearly 2 million deaths every year. It is often regarded as a 'silent killer' because it predominantly affects the poor and marginalized, and disease outbreaks occur in 'slow motion' compared to Ebola or coronavirus 2 (COVID-19). ... Read more >>

Pneumonia (Nathan) (Pneumonia (Nathan Qld.))
[2020, 12:9]

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Improved urine LAM tests - the answer for child TB diagnosis?

Ben J Marais,

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

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Key advances and remaining challenges in childhood and adolescent tuberculosis.

Ben J Marais, Mark Nicol, Heather J Zar,

Paediatr Respir Rev (Paediatric respiratory reviews)
[2020, 36:25-26]

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Whole genome sequencing based differentiation between re-infection and relapse in Indian patients with tuberculosis recurrence, with and without HIV co-infection

Sivakumar Shanmugam, Nathan Bachmann, Elena Martinez, Ranjeeta Menon, Gopalan Narendran, Sujantha Narayanan, Srikanth Tripathy, Uma Devi, Shailendra Sawleshwarkar, Ben Marais, Vitali Sintchenko,

Abstract Differentiation between relapse and reinfection in cases with tuberculosis (TB) recurrence has important implications for public health, especially in patients with human immunodeficiency virus (HIV) co-infection. Forty-one paired M. tuberculosis isolates collected from 20 HIV-positive and 21 HIV-negative patients, who experienced TB recurrence after previous successful treatment, were subjected ... Read more >>

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Optimal Dose or Optimal Exposure? Consideration for Linezolid in Tuberculosis Treatment.

Hannah Yejin Kim, Shashikant Srivastava, Hemanth Kumar Ak, Ben J Marais, Jan-Willem Alffenaar,

Antimicrob Agents Chemother (Antimicrobial agents and chemotherapy)
[2020, 64(7):]

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Vitamin D Supplements for Prevention of Tuberculosis Infection and Disease.

Davaasambuu Ganmaa, Buyanjargal Uyanga, Xin Zhou, Garmaa Gantsetseg, Baigali Delgerekh, Davaasambuu Enkhmaa, Dorjnamjil Khulan, Saranjav Ariunzaya, Erdenebaatar Sumiya, Batbileg Bolortuya, Jutmaan Yanjmaa, Tserenkhuu Enkhtsetseg, Ankhbat Munkhzaya, Murneren Tunsag, Polyna Khudyakov, James A Seddon, Ben J Marais, Ochirbat Batbayar, Ganbaatar Erdenetuya, Bazarsaikhan Amarsaikhan, Donna Spiegelman, Jadambaa Tsolmon, Adrian R Martineau,

BACKGROUND:Vitamin D metabolites support innate immune responses to Mycobacterium tuberculosis. Data from phase 3, randomized, controlled trials of vitamin D supplementation to prevent tuberculosis infection are lacking. METHODS:We randomly assigned children who had negative results for M. tuberculosis infection according to the QuantiFERON-TB Gold In-Tube assay (QFT) to receive a ... Read more >>

N Engl J Med (The New England journal of medicine)
[2020, 383(4):359-368]

Cited: 1 time

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Should I be worried about carrying the virus that causes COVID-19 home on my clothes?

Annaleise Howard-Jones, Sulaiman Almuzam, Philip Britton, David Isaacs, Alison Kesson, Ameneh Khatami, Ben Marais, Claire Nayda, Alexander Outhred, Joel Yuso,

J Paediatr Child Health (Journal of paediatrics and child health)
[2020, 56(6):980]

Cited: 1 time

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Port-site infection due to nontuberculous mycobacteria following laparoscopic surgery.

Waniganeththi Arachchige Manori Piyumal Samaranayake, Alison Margaret Kesson, Jonathan Saul Karpelowsky, Alexander Conrad Outhred, Ben Jacobus Marais,

Nontuberculous mycobacteria (NTM) are commonly found in soil and water and can cause nosocomial infections by contaminating equipment and disinfectants solution used in hospitals. NTM port-site infection after laparoscopic surgery is increasingly observed, but its clinical features, management, and prevention have not been reviewed adequately. We performed a comprehensive literature ... Read more >>

Int J Mycobacteriol (International journal of mycobacteriology)
[2020, 9(3):231-238]

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To what extent do children transmit SARS-CoV-2 virus?

David Isaacs, Philip Britton, Annaleise Howard-Jones, Alison Kesson, Ameneh Khatami, Ben Marais, Claire Nayda, Alexander Outhred,

J Paediatr Child Health (Journal of paediatrics and child health)
[2020, 56(6):978-979]

Cited: 2 times

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Modelling insights into the COVID-19 pandemic.

Michael T Meehan, Diana P Rojas, Adeshina I Adekunle, Oyelola A Adegboye, Jamie M Caldwell, Evelyn Turek, Bridget M Williams, Ben J Marais, James M Trauer, Emma S McBryde,

Coronavirus disease 2019 (COVID-19) is a newly emerged infectious disease caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that was declared a pandemic by the World Health Organization on 11th March, 2020. Response to this ongoing pandemic requires extensive collaboration across the scientific community in an attempt to contain ... Read more >>

Paediatr Respir Rev (Paediatric respiratory reviews)
[2020, 35:64-69]

Cited: 1 time

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Tuberculosis in children: screening, diagnosis and management.

Annaleise R Howard-Jones, Ben J Marais,

PURPOSE OF REVIEW:The present review focuses on recent advances and current challenges in screening, diagnosis and management of tuberculosis (TB) in children, encompassing TB infection and TB disease, and public health priorities for screening and family engagement. RECENT FINDINGS:Although awareness has improved in recent years that children in TB endemic ... Read more >>

Curr Opin Pediatr (Current opinion in pediatrics)
[2020, 32(3):395-404]

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Predictors of Unlikely Bacterial Pneumonia and Adverse Pneumonia Outcome in Children Admitted to a Hospital in Central Vietnam.

Phuong T K Nguyen, Hoang T Tran, Thach S Tran, Dominic A Fitzgerald, Stephen M Graham, Ben J Marais,

BACKGROUND:Pneumonia is the leading cause of antibiotic use and hospitalization in Vietnam. There is a need for better prediction of unlikely bacterial pneumonia and adverse pneumonia outcome in order to guide hospital admission and improve rational antibiotic use. METHODS:All children under 5 admitted with pneumonia (per clinician assessment) to the ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, 70(8):1733-1741]

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Zoonotic tuberculosis-a call for an open One Health debate.

Alimuddin Zumla, Dorothy Yeboah-Manu, Anita L Michel, Esam I Azhar, Jordi B Torrelles, Simeon I Cadmus, Sharon L Kendall, Jeremiah M Chakaya, Ben Marais, Richard Kock,

Lancet Infect Dis (The Lancet. Infectious diseases)
[2020, 20(6):642-644]

Cited: 1 time

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Successful Treatment of a Severe Vision-Threatening Paradoxical Tuberculous Reaction with Infliximab: First Pediatric Use.

Yara-Natalie Abo, Nigel Curtis, Coen Butters, Thomas H Rozen, Ben J Marais, Amanda Gwee,

A 7-year-old girl with tuberculous (TB) meningitis developed optochiasmatic arachnoiditis, a vision-threatening paradoxical reaction, after starting TB treatment including adjunctive steroid therapy. She was treated with infliximab with complete recovery. This is the first report of the use of a tissue necrosis factor α inhibitor for the treatment of a ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2020, 39(4):e42-e45]

Cited: 0 times

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Preventing tuberculosis in children: A global health emergency.

Anja Reuter, James A Seddon, Ben J Marais, Jennifer Furin,

It is estimated that 20 million children are exposed to tuberculosis (TB) each year, making TB a global paediatric health emergency. TB preventative efforts have long been overlooked. With the view of achieving "TB elimination" in "our lifetime", this paper explores challenges and potential solutions in the TB prevention cascade, ... Read more >>

Paediatr Respir Rev (Paediatric respiratory reviews)
[2020, 36:44-51]

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Programmatic versus personalised approaches to managing the global epidemic of multidrug-resistant tuberculosis.

Jeremiah Muhwa Chakaya, Ben Marais, Philipp du Cros, Francine Ntoumi, Sayoki Mfinanga, Nathan Kapata, Seyed Ehtesham Hasnain, Ruvandhi Nathavitharana, Alimuddin Zumla,

Lancet Respir Med (The Lancet. Respiratory medicine)
[2020, 8(4):334-335]

Cited: 0 times

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Challenging the management of drug-resistant tuberculosis.

Hannah Yejin Kim, Scott K Heysell, Stella Mpagama, Ben J Marais, Jan-Willem Alffenaar,

Lancet (Lancet (London, England))
[2020, 395(10226):783]

Cited: 0 times

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Tackling long-term morbidity and mortality after successful tuberculosis treatment.

Ben J Marais, Jeremiah Chakaya, Soumya Swaminathan, Greg J Fox, Nasreen Z Ehtesham, Francine Ntoumi, Lynn Zijenah, Markus Maurer, Alimuddin Zumla,

Lancet Infect Dis (The Lancet. Infectious diseases)
[2020, 20(6):641-642]

Cited: 0 times

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Questions raised by COVID-19 case descriptions.

Philip N Britton, Ben J Marais,

J Paediatr Child Health (Journal of paediatrics and child health)
[2020, 56(4):652]

Cited: 0 times

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