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Author Ben Jones

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Identification of key interactions of benzimidazole resistance-associated amino acid mutations in Ascaris β-tubulins by molecular docking simulations.

Ben P Jones, Arnoud H M van Vliet, E James LaCourse, Martha Betson,

Ascaris species are soil-transmitted helminths that infect humans and livestock mainly in low and middle-income countries. Benzimidazole (BZ) class drugs have predominated for many years in the treatment of Ascaris infections, but persistent use of BZs has already led to widespread resistance in other nematodes, and treatment failure is emerging ... Read more >>

Sci Rep (Scientific reports)
[2022, 12(1):13725]

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Sulfonated red and far-red rhodamines to visualize SNAP- and Halo-tagged cell surface proteins.

Ramona Birke, Julia Ast, Dorien A Roosen, Joon Lee, Kilian Roßmann, Christiane Huhn, Bettina Mathes, Michael Lisurek, David Bushiri, Han Sun, Ben Jones, Martin Lehmann, Joshua Levitz, Volker Haucke, David J Hodson, Johannes Broichhagen,

The (in)ability to permeate membranes is a key feature of chemical biology probes that defines their suitability for specific applications. Here we report sulfonated rhodamines that endow xanthene dyes with cellular impermeability for analysis of surface proteins. We fuse charged sulfonates to red and far-red dyes to obtain Sulfo549 and ... Read more >>

Org Biomol Chem (Organic & biomolecular chemistry)
[2022, 20(30):5967-5980]

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