Full Text Journal Articles by
Author Ben Jones

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Playing through the pain: The prevalence of perceived shoulder dysfunction in uninjured rugby players using the Rugby Shoulder Score.

Richard Partner, Ben Jones, Jason Tee, Peter Francis,

This study aimed to investigate the prevalence of self-reported shoulder dysfunction using the Rugby Shoulder Score (RSS) reported in arbitrary units (AU) of rugby players available for match selection (uninjured). Cross-sectional survey. Paper survey at the mid-point of the season of uninjured players (n = 86 males (mean age (±SD): 26 ± 6.9y) from ... Read more >>

Phys Ther Sport (Physical therapy in sport : official journal of the Association of Chartered Physiotherapists in Sports Medicine)
[2022, 54:53-57]

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Moving beyond velocity derivatives; Using Global Positioning System data to extract sequential movement patterns at different levels of rugby league match-play.

Neil Collins, Ryan White, Anna Palczewska, Dan Weaving, Nick Dalton-Barron, Ben Jones,

<h4>Objectives</h4>This study aims to a) quantify the movement patterns during rugby league match-play and b) identify if differences exist by levels of competition within the movement patterns and movement units through the Sequential Movement Pattern (SMP) algorithm.<h4>Design</h4>Global Positioning System data were analysed from three competition levels; four Super League regular ... Read more >>

Eur J Sport Sci (European journal of sport science)
[2022, :1-23]

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Identification of Key Interactions of Benzimidazole Resistance-Associated Amino Acid Mutations in Ascaris β-Tubulins By Molecular Docking Simulations

Ben Jones, Arnoud H.M. Vliet, James LaCourse, Martha Betson,

Ascaris species are soil-transmitted helminths that infect humans and livestock mainly in low and middle-income countries. Benzimidazole (BZ) class drugs have predominated for many years in the treatment of Ascaris infections, but persistent use of BZs has already led to widespread resistance in other nematodes, and treatment failure is emerging ... Read more >>

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Expression of mini-G proteins specifically halt cognate GPCR trafficking and intracellular signalling

Yusman Manchanda, Zenouska Ramchunder, Maria Shchepinova, Guy Rutter, Asuka Inoue, Edward Tate, Ben Jones, Alejandra Tomas,

Mini-G proteins are engineered thermostable variants of Gα subunits designed to specifically stabilise G protein-coupled receptors (GPCRs) in their active conformation for structural analyses. Due to their smaller size and ease of use, they have become popular tools in recent years to assess specific GPCR behaviours in cells, both as ... Read more >>

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Identification of key interactions of benzimidazole resistance-associated amino acid mutations in Ascaris β-tubulins by molecular docking simulations

Ben Jones, Arnoud H.M. van Vliet, James LaCourse, Martha Betson,

Ascaris species are soil-transmitted helminths that infect humans and livestock mainly in low and middle-income countries. Benzimidazole (BZ) class drugs have predominated for many years in the treatment of Ascaris infections, but persistent use of BZs has already led to widespread resistance in other nematodes, and treatment failure is emerging ... Read more >>

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A glucagon analogue decreases body weight in mice via signalling in the liver.

Charlotte E Hinds, Bryn M Owen, David C D Hope, Philip Pickford, Ben Jones, Tricia M Tan, James S Minnion, Stephen R Bloom,

Glucagon receptor agonists show promise as components of next generation metabolic syndrome pharmacotherapies. However, the biology of glucagon action is complex, controversial, and likely context dependent. As such, a better understanding of chronic glucagon receptor (GCGR) agonism is essential to identify and mitigate potential clinical side-effects. Herein we present a ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):22577]

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Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.

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<h4>Background</h4>Aspirin has been proposed as a treatment for COVID-19 on the basis of its anti-thrombotic properties. We aimed to evaluate the efficacy and safety of aspirin in patients admitted to hospital with COVID-19.<h4>Methods</h4>In this randomised, controlled, open-label, platform trial, several possible treatments were compared with usual care in patients hospitalised ... Read more >>

Lancet (Lancet (London, England))
[2022, 399(10320):143-151]

Cited: 7 times

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Development of an expected possession value model to analyse team attacking performances in rugby league.

Thomas Sawczuk, Anna Palczewska, Ben Jones,

This study aimed to evaluate team attacking performances in rugby league via expected possession value (EPV) models. Location data from 59,233 plays in 180 Super League matches across the 2019 Super League season were used. Six EPV models were generated using arbitrary zone sizes (EPV-308 and EPV-77) or aggregated according ... Read more >>

PLoS One (PloS one)
[2021, 16(11):e0259536]

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Hepatocyte cholesterol content modulates glucagon receptor signalling

Emma Rose McGlone, Bertie Ansell, Cecilia Dunsterville, Wanling Song, David Carling, Alejandra Tomas, Stephen Bloom, Mark Sansom, Tricia Tan, Ben Jones,

<h4>Summary</h4> Glucagon decreases liver fat, and non-alcoholic fatty liver disease (NAFLD) is associated with hepatic glucagon resistance. Increasingly it is recognised that the function of G protein-coupled receptors can be regulated by their local plasma membrane lipid environment. The aim of this study was to evaluate the effects of experimentally ... Read more >>

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Characterization of the β-tubulin gene family in Ascaris lumbricoides and Ascaris suum and its implication for the molecular detection of benzimidazole resistance.

Sara Roose, Russell W Avramenko, Stephen M J Pollo, James D Wasmuth, Shaali Ame, Mio Ayana, Martha Betson, Piet Cools, Daniel Dana, Ben P Jones, Zeleke Mekonnen, Arianna Morosetti, Abhinaya Venkatesan, Johnny Vlaminck, Matthew L Workentine, Bruno Levecke, John S Gilleard, Peter Geldhof,

<h4>Background</h4>The treatment coverage of control programs providing benzimidazole (BZ) drugs to eliminate the morbidity caused by soil-transmitted helminths (STHs) is unprecedently high. This high drug pressure may result in the development of BZ resistance in STHs and so there is an urgent need for surveillance systems detecting molecular markers associated ... Read more >>

PLoS Negl Trop Dis (PLoS neglected tropical diseases)
[2021, 15(9):e0009777]

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Sequential movement pattern-mining (SMP) in field-based team-sport: A framework for quantifying spatiotemporal data and improve training specificity?

Ryan White, Anna Palczewska, Dan Weaving, Neil Collins, Ben Jones,

Athlete external load is typically quantified as volumes or discretised threshold values using distance, speed and time. A framework accounting for the movement sequences of athletes has previously been proposed using radio frequency data. This study developed a framework to identify sequential movement sequences using GPS-derived spatiotemporal data in team-sports ... Read more >>

J Sports Sci (Journal of sports sciences)
[2021, :1-11]

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The Training of Medium- to Long-Distance Sprint Performance in Football Code Athletes: A Systematic Review and Meta-analysis.

Ben Nicholson, Alex Dinsdale, Ben Jones, Kevin Till,

<h4>Background</h4>Within the football codes, medium-distance (i.e., > 20 m and ≤ 40 m) and long-distance (i.e., > 40 m) sprint performance and maximum velocity sprinting are important capacities for success. Despite this, no research has identified the most effective training methods for enhancing medium- to long-distance sprint outcomes.<h4>Objectives</h4>This systematic review with meta-analysis aimed to (1) analyse the ability of ... Read more >>

Sports Med (Sports medicine (Auckland, N.Z.))
[2021, :]

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Quantifying head acceleration exposure via instrumented mouthguards (iMG): a validity and feasibility study protocol to inform iMG suitability for the TaCKLE project.

Gregory Tierney, Daniel Weaving, James Tooby, Marwan Al-Dawoud, Sharief Hendricks, Gemma Phillips, Keith A Stokes, Kevin Till, Ben Jones,

Instrumented mouthguards (iMGs) have the potential to quantify head acceleration exposures in sport. The Rugby Football League is looking to deploy iMGs to quantify head acceleration exposures as part of the Tackle and Contact Kinematics, Loads and Exposure (TaCKLE) project. iMGs and associated software platforms are novel, thus limited validation ... Read more >>

BMJ Open Sport Exerc Med (BMJ open sport & exercise medicine)
[2021, 7(3):e001125]

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The metabolomic effects of tripeptide gut hormone infusion compared to Roux-en-Y gastric bypass and caloric restriction.

Ben Jones, Caroline Sands, Kleopatra Alexiadou, James Minnion, George Tharakan, Preeshila Behary, Ahmed R Ahmed, Sanjay Purkayastha, Matthew R Lewis, Stephen Bloom, Jia V Li, Tricia M Tan,

<h4>Context</h4>The gut-derived peptide hormones glucagon-like peptide-1 (GLP-1), oxyntomodulin (OXM), and peptide YY (PYY) are regulators of energy intake and glucose homeostasis, and are thought to contribute to the glucose-lowering effects of bariatric surgery.<h4>Objective</h4>To establish the metabolomic effects of a combined infusion of GLP-1, OXM and PYY (tripeptide "GOP") in comparison ... Read more >>

J Clin Endocrinol Metab (The Journal of clinical endocrinology and metabolism)
[2021, :]

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Coaches' Assessment of Players Physical Performance: Subjective and Objective Measures are needed when Profiling Players.

Sam McCormack, Ben Jones, Dave Elliott, Dave Rotheram, Kevin Till,

This mixed methods study aimed to assess the agreement between coaches ranking of youth rugby league players compared against objective physical performance data and gather coaches' subjective descriptions of their players performance. Five hundred and eight male rugby league players (U16 <i>n</i> = 255, U18 <i>n</i> = 253) completed a fitness testing battery of ... Read more >>

Eur J Sport Sci (European journal of sport science)
[2021, :1-11]

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Completeness of reporting and risks of overstating impact in cluster randomised trials: a systematic review.

Elizabeth L Turner, Alyssa C Platt, John A Gallis, Kaitlin Tetreault, Christina Easter, Joanne E McKenzie, Stephen Nash, Andrew B Forbes, Karla Hemming, ,

Overstating the impact of interventions through incomplete or inaccurate reporting can lead to inappropriate scale-up of interventions with low impact. Accurate reporting of the impact of interventions is of great importance in global health research to protect scarce resources. In global health, the cluster randomised trial design is commonly used ... Read more >>

Lancet Glob Health (The Lancet. Global health)
[2021, 9(8):e1163-e1168]

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Acylation of the Incretin Peptide Exendin-4 Directly Impacts Glucagon-Like Peptide-1 Receptor Signaling and Trafficking.

Maria Lucey, Tanyel Ashik, Amaara Marzook, Yifan Wang, Joëlle Goulding, Atsuro Oishi, Johannes Broichhagen, David J Hodson, James Minnion, Yuval Elani, Ralf Jockers, Stephen J Briddon, Stephen R Bloom, Alejandra Tomas, Ben Jones,

The glucagon-like peptide-1 receptor (GLP-1R) is a class B G protein-coupled receptor and mainstay therapeutic target for the treatment of type 2 diabetes and obesity. Recent reports have highlighted how biased agonism at the GLP-1R affects sustained glucose-stimulated insulin secretion through avoidance of desensitization and downregulation. A number of GLP-1R ... Read more >>

Mol Pharmacol (Molecular pharmacology)
[2021, 100(4):319-334]

Cited: 3 times

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Receptor Activity-Modifying Protein 2 (RAMP2) alters glucagon receptor trafficking in hepatocytes with functional effects on receptor signalling.

Emma Rose McGlone, Yusman Manchanda, Ben Jones, Phil Pickford, Asuka Inoue, David Carling, Stephen R Bloom, Tricia Tan, Alejandra Tomas,

<h4>Objectives</h4>Receptor Activity-Modifying Protein 2 (RAMP2) is a chaperone protein which allosterically binds to and interacts with the glucagon receptor (GCGR). The aims of this study were to investigate the effects of RAMP2 on GCGR trafficking and signalling in the liver, where glucagon (GCG) is important for carbohydrate and lipid metabolism.<h4>Methods</h4>Subcellular ... Read more >>

Mol Metab (Molecular metabolism)
[2021, 53:101296]

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The Duration-specific Peak Average Running Speeds of European Super League Academy Rugby League Match Play.

Sarah Whitehead, Kevin Till, Dan Weaving, Nick Dalton-Barron, Matt Ireton, Ben Jones,

<h4>Abstract</h4>Whitehead, S, Till, K, Weaving, D, Dalton-Barron, N, Ireton, M, and Jones, B. Duration-specific peak average running speeds of European Super League Academy rugby league match play. J Strength Cond Res 35(7): 1964-1971, 2021-This study aimed to quantify the duration-specific peak average running speeds of Academy-level rugby league match play, ... Read more >>

J Strength Cond Res (Journal of strength and conditioning research)
[2021, 35(7):1964-1971]

Cited: 1 time

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Cyclic Imine Pinnatoxin G is Cytotoxic to Cancer Cell Lines via Nicotinic Acetylcholine Receptor-Driven Classical Apoptosis.

Mitchell R Clarke, Ben Jones, Chloe L M Squires, Floriane M Imhoff, D Tim Harwood, Lesley Rhodes, Andrew I Selwood, Paul S McNabb, Sarah K Baird,

Pinnatoxin G is a cyclic imine neurotoxin produced by dinoflagellates that has been reported in shellfish. Like other members of the pinnatoxin family, it has been shown to have its effects via antagonism of the nicotinic acetylcholine receptors, with preferential binding to the α7 subunit often upregulated in cancer. Because ... Read more >>

J Nat Prod (Journal of natural products)
[2021, 84(7):2035-2042]

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Team Sport Risk Exposure Framework-2 (TS-REF-2) to identify sports activities and contacts at increased SARS-CoV-2 transmission risk during the COVID-19 pandemic.

Ben Jones, Gemma Phillips, Clive Beggs, James Calder, Matthew Cross, Neil Pearce, Clint Readhead, Jenifer Smith, Keith A Stokes, Simon Kemp,

Br J Sports Med (British journal of sports medicine)
[2021, 55(23):1317-1318]

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Using Principal Component Analysis to Compare the Physical Qualities Between Academy and International Youth Rugby League Players.

Sam McCormack, Ben Jones, Sean Scantlebury, Neil Collins, Cameron Owen, Kevin Till,

<h4>Purpose</h4>To compare the physical qualities between academy and international youth rugby league (RL) players using principal component analysis.<h4>Methods</h4>Six hundred fifty-four males (age = 16.7 [1.4] y; height = 178.4 [13.3] cm; body mass = 82.2 [14.5] kg) from 11 English RL academies participated in this study. Participants completed anthropometric, power (countermovement jump), strength ... Read more >>

Int J Sports Physiol Perform (International journal of sports physiology and performance)
[2021, :1-8]

Cited: 1 time

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Does perceived wellness influence technical-tactical match performance? A study in youth international rugby using partial least squares correlation analysis.

Carlos Ramírez-López, Kevin Till, Dan Weaving, Andy Boyd, Alexis Peeters, Grant Beasley, Sam Bradley, Pierosario Giuliano, Charlie Venables, Ben Jones,

The purpose of this study was to determine the relationship between matchday wellness status and a technical-tactical performance construct during rugby match-play. One hundred and thirty-three male rugby union players (73 forwards and 60 backs) from five under-18 national squads who participated in the under-18 Six Nations competition completed a ... Read more >>

Eur J Sport Sci (European journal of sport science)
[2021, :1-9]

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Evaluation of efficacy- versus affinity-driven agonism with biased GLP-1R ligands P5 and exendin-F1.

Amaara Marzook, Shiqian Chen, Phil Pickford, Maria Lucey, Yifan Wang, Ivan R Corrêa, Johannes Broichhagen, David J Hodson, Victoria Salem, Guy A Rutter, Tricia M Tan, Stephen R Bloom, Alejandra Tomas, Ben Jones,

The glucagon-like peptide-1 receptor (GLP-1R) is an important regulator of glucose homeostasis and has been successfully targeted for the treatment of type 2 diabetes. Recently described biased GLP-1R agonists with selective reductions in β-arrestin versus G protein coupling show improved metabolic actions in vivo. However, two prototypical G protein-favouring GLP-1R ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2021, 190:114656]

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Latent variable dose-response modelling of external training load measures and musculoskeletal responses in elite rugby league players.

Dan Weaving, Nicholas Dalton Barron, Jeremy A Hickmans, Clive Beggs, Ben Jones, Tannath J Scott,

Establishing dose-response relationships between training load and fatigue can help the planning of training. The aim was to establish the relative importance of external training load measurements to relate to the musculoskeletal response on a group and individual player level. Sixteen elite male rugby league players were monitored across three ... Read more >>

J Sports Sci (Journal of sports sciences)
[2021, 39(21):2418-2426]

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