Full Text Journal Articles by
Author Beate Karges

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Diabetic Ketoacidosis at Manifestation of Type 1 Diabetes in Childhood and Adolescence—Incidence and Risk Factors.

Hugo Segerer, Michael Wurm, Julia M Grimsmann, Beate Karges, Andreas Neu, Marina Sindichakis, Katharina Warncke, Axel Dost, Reinhard W Holl,

<h4>Background</h4>Diabetic ketoacidosis (DKA) is a potentially life-threatening metabolic disorder that can occur with manifestation of type 1 diabetes mellitus (T1D). The aim of this study was to analyze the incidence of DKA at the time of the diagnosis of T1D in childhood and adolescence, the risk factors, and regional approaches ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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A Comparison of Familial and Sporadic Type 1 Diabetes Among Young Patients.

Beate Karges, Nicole Prinz, Kerstin Placzek, Nicolin Datz, Matthias Papsch, Ursula Strier, Dirk Agena, Walter Bonfig, Heiner Kentrup, Reinhard W Holl,

<h4>Objective</h4>To investigate natural course, treatment, and outcomes in familial versus sporadic type 1 diabetes.<h4>Research design and methods</h4>In a population-based study, we compared patients with onset of type 1 diabetes before the age of 20 years who had a first-degree relative with type 1 diabetes (familial diabetes) with patients with type ... Read more >>

Diabetes Care (Diabetes care)
[2021, :]

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Intermittently Scanned Glucose Values for Continuous Monitoring: Cross-Sectional Analysis of Glycemic Control and Hypoglycemia in 1809 Children and Adolescents with Type 1 Diabetes.

Torben Biester, Julia M Grimsmann, Bettina Heidtmann, Birgit Rami-Merhar, Uwe Ermer, Johannes Wolf, Markus Freff, Beate Karges, Dirk Agena, Peter Bramlage, Thomas Danne, Reinhard W Holl,

<b><i>Background and Objective:</i></b> Intermittent scanning continuous glucose monitoring (iscCGM) is increasingly used for glycemic monitoring in diabetes care. In this cross-sectional real-world analysis, iscCGM data were compared to traditional parameters of glycemic control in young people with type 1 diabetes. <b><i>Methods:</i></b> Using the DPV registry, most recent data from children ... Read more >>

Diabetes Technol Ther (Diabetes technology & therapeutics)
[2021, 23(3):160-167]

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Previous diabetic ketoacidosis as a risk factor for recurrence in a large prospective contemporary pediatric cohort: Results from the DPV initiative.

Johanna Hammersen, Sascha R Tittel, Katharina Warncke, Maria Fritsch, Kerstin Placzek, Danièle Pacaud, Beate Karges, Joachim Woelfle, Reinhard W Holl, ,

<h4>Objective</h4>To assess the role of previous episodes of diabetic ketoacidosis (DKA) and their time-lag as risk factors for recurring DKA in youth with type 1 diabetes (T1D).<h4>Research design and methods</h4>In a population-based analysis, data from 29,325 children and adolescents with T1D and at least 5 years of continuous follow-up were retrieved ... Read more >>

Pediatr Diabetes (Pediatric diabetes)
[2021, 22(3):455-462]

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Personal glycation factors and calculated HbA1c for diabetes management: Real-world data from the DPV registry.

Yongjin Xu, Julia M Grimsmann, Beate Karges, Sabine E Hofer, Thomas Danne, Reinhard W Holl, Ramzi A Ajjan, Timothy D Dunn,

Background Glycated hemoglobin A1c (HbA1c) is a key biomarker in the glycemic management of individuals with diabetes but the relationship with glucose levels can be variable. A recent kinetic model has described a calculated HbA1c (cHbA1c) that is individual-specific. Our aim was to validate the routine clinical use of this ... Read more >>

Diabetes Technol Ther (Diabetes technology & therapeutics)
[2021, :]

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Thiamine-Responsive Megaloblastic Anemia-Related Diabetes: Long-Term Clinical Outcomes in 23 Pediatric Patients From the DPV and SWEET Registries.

Katharina Warncke, Nicole Prinz, Violeta Iotova, Desiree Dunstheimer, Nicolin Datz, Beate Karges, Mallikarjun V Jali, Dorothea Linsenmeyer, Birthe Susanne Olsen, Monika Seiwald, Priya Prahalad, Gideon de Sousa, Danièle Pacaud, ,

<h4>Objectives</h4>To describe clinical presentation and long-term outcomes in a large cohort of children diagnosed with thiamine-responsive megaloblastic anemia (TRMA)-related diabetes.<h4>Methods</h4>Data from the Diabetes Patienten Verlaufsdokumentation (DPV) and Better control in Pediatric and Adolescent diabeteS: Working to crEate CEnTers of Reference (SWEET) registries were used to identify cases. Complementary information was ... Read more >>

Can J Diabetes (Canadian journal of diabetes)
[2020, :]

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Use of insulin pump therapy is associated with reduced hospital-days in the long-term: a real-world study of 48,756 pediatric patients with type 1 diabetes.

Marie Auzanneau, Beate Karges, Andreas Neu, Thomas Kapellen, Stefan A Wudy, Corinna Grasemann, Gabriele Krauch, Eva Maria Gerstl, Gerhard Däublin, Reinhard W Holl,

In pediatric diabetes, insulin pump therapy is associated with less acute complications but inpatient pump education may lead to more hospital days. We investigated the number of hospital days associated with pump vs. injection therapy between 2009 and 2018 in 48,756 patients with type 1 diabetes < 20 years of ... Read more >>

Eur J Pediatr (European journal of pediatrics)
[2021, 180(2):597-606]

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Children with onset-ketoacidosis are admitted to the nearest hospital available, regardless of center size.

Katrin Nagl, Joachim Rosenbauer, Andreas Neu, Thomas M Kapellen, Beate Karges, Tanja Rojacher, Julia Hermann, Birgit Rami-Merhar, Reinhard W Holl, ,

Background To investigate longitudinal trends of admissions with diabetic ketoacidosis (DKA) in new-onset type 1 diabetes (T1D) and subsequent duration of hospitalization in association with structural health care properties, such as size of treatment facility, population density and linear distance between home and treatment centers. Methods Data from 24,321 German ... Read more >>

J Pediatr Endocrinol Metab (Journal of pediatric endocrinology & metabolism : JPEM)
[2020, 33(6):751-759]

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Three-Variate Longitudinal Patterns of Metabolic Control, Body Mass Index, and Insulin Dose during Puberty in a Type 1 Diabetes Cohort: A Group-Based Multitrajectory Analysis.

Anke Schwandt, Oliver Kuss, Desiree Dunstheimer, Beate Karges, Thomas Kapellen, Thomas Meissner, Michael Witsch, Monika Flury, Stefanie Straubinger, Reinhard W Holl, ,

OBJECTIVE:To analyze the interrelationship of metabolic control, age- and sex-adjusted body mass index, and daily insulin dose and to identify heterogeneous multivariate developmental curves from childhood to young adulthood in a large cohort of children with type 1 diabetes (T1D) STUDY DESIGN: Data were extracted from the diabetes follow-up registry ... Read more >>

J Pediatr (The Journal of pediatrics)
[2020, 218:64-71.e3]

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Diagnosis, Therapy and Follow-Up of Diabetes Mellitus in Children and Adolescents.

Andreas Neu, Jutta Bürger-Büsing, Thomas Danne, Axel Dost, Martin Holder, Reinhard W Holl, Paul-Martin Holterhus, Thomas Kapellen, Beate Karges, Olga Kordonouri, Karin Lange, Susanne Müller, Klemens Raile, Roland Schweizer, Simone von Sengbusch, Rainer Stachow, Verena Wagner, Susanna Wiegand, Ralph Ziegler,

Exp Clin Endocrinol Diabetes (Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association)
[2019, 127(S 01):S39-S72]

Cited: 1 time

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Hospitalization in Pediatric Diabetes: A Nationwide Analysis of all Admission Causes for Germany in 2015.

Marie Auzanneau, Joachim Rosenbauer, Andrea Icks, Beate Karges, Andreas Neu, Ralph Ziegler, Wolfgang Marg, Thomas Kapellen, Paul-Martin Holterhus, Reinhard W Holl,

<h4>Introduction</h4>Regarding pediatric diabetes, hospital admission for acute complications of type 1 diabetes (T1D) has often been investigated, but little is known about other causes of hospitalization. This study aimed to explore the total burden of hospitalization in individuals with diabetes<20 years of age in Germany.<h4>Methods</h4>Using the German Diagnosis-Related Groups data ... Read more >>

Exp Clin Endocrinol Diabetes (Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association)
[2020, 128(9):615-623]

Cited: 1 time

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Temporal Trends and Contemporary Use of Insulin Pump Therapy and Glucose Monitoring Among Children, Adolescents, and Adults With Type 1 Diabetes Between 1995 and 2017.

Louisa van den Boom, Beate Karges, Marie Auzanneau, Birgit Rami-Merhar, Eggert Lilienthal, Simone von Sengbusch, Nicolin Datz, Carmen Schröder, Thomas Kapellen, Markus Laimer, Sebastian M Schmid, Heiko Müller, Johannes Wolf, Reinhard W Holl,

OBJECTIVE:To investigate temporal trends and contemporary use of insulin pump therapy and glucose monitoring in type 1 diabetes. RESEARCH DESIGN AND METHODS:In a population-based study, we analyzed the use of insulin pump therapy, continuous glucose monitoring (CGM), and self-monitoring of blood glucose (SMBG) from 1995 to 2017 in patients with ... Read more >>

Diabetes Care (Diabetes care)
[2019, 42(11):2050-2056]

Cited: 11 times

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Decreasing Trends in Mean HbA1c Are Not Associated With Increasing Rates of Severe Hypoglycemia in Children: A Longitudinal Analysis of Two Contemporary Population-Based Pediatric Type 1 Diabetes Registries From Australia and Germany/Austria Between 1995 and 2016.

Aveni Haynes, Julia M Hermann, Helen Clapin, Sabine E Hofer, Beate Karges, Timothy W Jones, Elizabeth A Davis, Reinhard W Holl, ,

<h4>Objective</h4>To investigate temporal trends in glycemic control and severe hypoglycemia rates for pediatric patients with type 1 diabetes from 1995 to 2016 by analyzing data from the longitudinal, prospective, population-based German/Austrian (Diabetes Patient History Documentation [DPV]) and Western Australian (Western Australian Children's Diabetes Database [WACDD]) diabetes registries.<h4>Research design and methods</h4>Patients ... Read more >>

Diabetes Care (Diabetes care)
[2019, 42(9):1630-1636]

Cited: 2 times

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Diagnosis, Therapy and Follow-up of Diabetes Mellitus in Children and Adolescents.

Andreas Neu, Jutta Bürger-Büsing, Thomas Danne, Axel Dost, Martin Holder, Reinhard W Holl, Paul-Martin Holterhus, Thomas Kapellen, Beate Karges, Olga Kordonouri, Karin Lange, Susanne Müller, Klemens Raile, Roland Schweizer, Simone von Sengbusch, Rainer Stachow, Verena Wagner, Susanna Wiegand, Ralph Ziegler,

Exp Clin Endocrinol Diabetes (Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association)
[2019, 127(6):341-352]

Cited: 1 time

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ISPAD Clinical Practice Consensus Guidelines 2018: Assessment and management of hypoglycemia in children and adolescents with diabetes.

Mary B Abraham, Timothy W Jones, Diana Naranjo, Beate Karges, Abiola Oduwole, Martin Tauschmann, David M Maahs,

Pediatr Diabetes (Pediatric diabetes)
[2018, 19 Suppl 27:178-192]

Cited: 16 times

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Correction: Reinauer et al., The Clinical Course of Patients with Preschool Manifestation of Type 1 Diabetes Is Independent of the HLA DR-DQ Genotype. Genes 2017, 8, 146.

Christina Reinauer, Joachim Rosenbauer, Christina Bächle, Christian Herder, Michael Roden, Sian Ellard, Elisa De Franco, Beate Karges, Reinhard W Holl, Jürgen Enczmann, Thomas Meissner,

The article entitled "The Clinical Course of Patients with Preschool Manifestation of Type 1 Diabetes is Independent of the HLA DR-DQ Genotype" contained a calculation error in Table 2 and the statistical methods used were not completely described.[...]. ... Read more >>

Genes (Basel) (Genes)
[2018, 9(1):]

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Relationship of Serum Fetuin A with Metabolic and Clinical Parameters in German Children and Adolescents with Type 1 Diabetes.

Christina Reinauer, Thomas Reinehr, Christina Baechle, Beate Karges, Julia Seyfarth, Katharina Foertsch, Martin Schebek, Joachim Woelfle, Michael Roden, Reinhard W Holl, Joachim Rosenbauer, Thomas Meissner,

The hepatokine fetuin A is upregulated in the metabolic syndrome and in type 2 diabetes (T2D), while its role in adolescent type 1 diabetes (T1D) is unclear. We assessed the relationship between circulating fetuin A levels and metabolic control, comorbidities, and complications in adolescent T1D patients.We studied the relationship between ... Read more >>

Horm Res Paediatr (Hormone research in paediatrics)
[2018, 89(2):73-81]

Cited: 2 times

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Complications With Insulin Pump Therapy vs Insulin Injection Therapy-Reply.

Beate Karges, Elisabeth Binder, Joachim Rosenbauer,

JAMA (JAMA)
[2018, 319(5):503-504]

Cited: 0 times

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Hospital admission in children and adolescents with or without type 1 diabetes from Germany: An analysis of statutory health insurance data on 12 million subjects.

Barbara Bohn, Anke Schwandt, Peter Ihle, Andrea Icks, Joachim Rosenbauer, Beate Karges, Reinhard W Holl,

OBJECTIVE:To compare the chance of hospital admissions in children and adolescents with type 1 diabetes (T1D) to that without T1D from Germany. METHODS:Data were provided by the German information system for health care data which contains information on all patients with a statutory health insurance. The years 2009 and 2011 ... Read more >>

Pediatr Diabetes (Pediatric diabetes)
[2018, 19(4):721-726]

Cited: 1 time

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Lipoprotein-associated phospholipase A2 activity in obese adolescents with and without type 2 diabetes.

Julia Seyfarth, Thomas Reinehr, Annika Hoyer, Christina Reinauer, Christina Bächle, Beate Karges, Ertan Mayatepek, Michael Roden, Sabine E Hofer, Susanna Wiegand, Joachim Woelfle, Wieland Kiess, Joachim Rosenbauer, Reinhard W Holl, Thomas Meissner,

Lipoprotein-associated phospholipase A2 (Lp-PLA2) was identified as a strong predictor for cardiovascular events. Furthermore, it is highly associated with obesity. The role of Lp-PLA2 in diabetes mellitus is controversial and analyses, especially in adolescents with type 2 diabetes (T2D), are missing. Therefore, we compared Lp-PLA2 activity between two obese age-, ... Read more >>

J Inherit Metab Dis (Journal of inherited metabolic disease)
[2018, 41(1):73-79]

Cited: 1 time

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Sleep and glycemic control in adolescents with type 1 diabetes.

Julia von Schnurbein, Claudia Boettcher, Stephanie Brandt, Beate Karges, Desiree Dunstheimer, Angela Galler, Christian Denzer, Friederike Denzer, Heike Vollbach, Martin Wabitsch, Till Roenneberg, Celine Vetter,

<h4>Background</h4>Increasing evidence link sleep curtailment and circadian misalignment with adverse metabolic outcome. Adolescents might be most affected, given their late sleep timing and early school and work start times.<h4>Objective</h4>Our aim was to examine the impact of poor sleeping habits on glycemic control in adolescents with type 1 diabetes.<h4>Subjects and methods</h4>This ... Read more >>

Pediatr Diabetes (Pediatric diabetes)
[2018, 19(1):143-149]

Cited: 9 times

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Association of Insulin Pump Therapy vs Insulin Injection Therapy With Severe Hypoglycemia, Ketoacidosis, and Glycemic Control Among Children, Adolescents, and Young Adults With Type 1 Diabetes.

Beate Karges, Anke Schwandt, Bettina Heidtmann, Olga Kordonouri, Elisabeth Binder, Ulrike Schierloh, Claudia Boettcher, Thomas Kapellen, Joachim Rosenbauer, Reinhard W Holl,

<h4>Importance</h4>Insulin pump therapy may improve metabolic control in young patients with type 1 diabetes, but the association with short-term diabetes complications is unclear.<h4>Objective</h4>To determine whether rates of severe hypoglycemia and diabetic ketoacidosis are lower with insulin pump therapy compared with insulin injection therapy in children, adolescents, and young adults with ... Read more >>

JAMA (JAMA)
[2017, 318(14):1358-1366]

Cited: 51 times

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Dominant TNFα and impaired IL-2 cytokine profiles of CD4+ T cells from children with type-1 diabetes.

Julia Seyfarth, Katharina Förtsch, Heinz Ahlert, Hans-Juergen Laws, Beate Karges, Rene Deenen, Karl Köhrer, Ertan Mayatepek, Thomas Meissner, Marc Jacobsen,

Aberrantly activated CD4<sup>+</sup> T memory cells play a central role in the development of type-1-diabetes. Interleukin-7 promotes generation of autoimmune memory T cells and increased Interleukin-7 availability is associated with type-1-diabetes susceptibility. T-cell-mediated immune pathology at onset of type-1-diabetes is well defined, but characteristics of long-term symptomatic disease stages remain ... Read more >>

Immunol Cell Biol (Immunology and cell biology)
[2017, 95(7):630-639]

Cited: 2 times

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The Clinical Course of Patients with Preschool Manifestation of Type 1 Diabetes Is Independent of the HLA DR-DQ Genotype.

Christina Reinauer, Joachim Rosenbauer, Christina Bächle, Christian Herder, Michael Roden, Sian Ellard, Elisa De Franco, Beate Karges, Reinhard W Holl, Jürgen Enczmann, Thomas Meissner,

Major histocompatibility complex class II genes are considered major genetic risk factors for autoimmune diabetes. We analysed Human Leukocyte Antigen (HLA) DR and DQ haplotypes in a cohort with early-onset (age < 5 years), long term type 1 diabetes (T1D) and explored their influence on clinical and laboratory parameters.Intermediate resolution ... Read more >>

Genes (Basel) (Genes)
[2017, 8(5):]

Cited: 0 times

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QT prolongation caused by insulin-induced hypoglycaemia - An interventional study in 119 individuals.

Stella Kacheva, Beate Karges, Katrin Göller, Nikolaus Marx, Karl Mischke, Wolfram Karges,

<h4>Aims</h4>Hypoglycaemia is associated with increased risk of cardiovascular events and mortality in patients with diabetes, but the extent and mechanisms of this link are ill defined. We here prospectively studied cardiac repolarization abnormalities during insulin-induced hypoglycaemia in humans.<h4>Methods</h4>119 individuals (69 males, age 47.5±13.4years, range 18-82years) were assessed during hypoglycaemia after ... Read more >>

Diabetes Res Clin Pract (Diabetes research and clinical practice)
[2017, 123:165-172]

Cited: 7 times

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