Full Text Journal Articles by
Author Beate Kampmann

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A three-marker protein biosignature distinguishes tuberculosis from other respiratory diseases in Gambian children.

Toyin Togun, Clive J Hoggart, Schadrac C Agbla, Marie P Gomez, Uzochukwu Egere, Abdou K Sillah, Binta Saidy, Francis Mendy, Madhukar Pai, Beate Kampmann,

BACKGROUND:Our study aimed to identify a host cytokine biosignature that could distinguish childhood tuberculosis (TB) from other respiratory diseases (OD). METHODS:Cytokine responses in prospectively recruited children with symptoms suggestive of TB were measured in whole blood assay supernatants, harvested after overnight incubation, using a Luminex platform. We used logistic regression ... Read more >>

EBioMedicine (EBioMedicine)
[2020, 58:102909]

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Protection against mycobacterial infection: A case-control study of mycobacterial immune responses in pairs of Gambian children with discordant infection status despite matched TB exposure.

Robindra Basu Roy, Basil Sambou, Muhamed Sissoko, Beth Holder, Marie P Gomez, Uzochukwu Egere, Abdou K Sillah, Artemis Koukounari, Beate Kampmann,

BACKGROUND:Children are particularly susceptible to tuberculosis. However, most children exposed to Mycobacterium tuberculosis are able to control the pathogen without evidence of infection. Correlates of human protective immunity against tuberculosis infection are lacking, and their identification would aid vaccine design. METHODS:We recruited pairs of asymptomatic children with discordant tuberculin skin ... Read more >>

EBioMedicine (EBioMedicine)
[2020, :102891]

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Use of Resuscitation promoting factors to screen for tuberculosis infection in household-exposed children in The Gambia

Welmoed Van Loon, Marie Gomez, Dawda Jobe, Kees CLMC Franken, Tom HM Ottenhoff, Michael Corninx, Luc Kestens, Jayne Sutherland, Beate Kampmann, Leopold Tientcheu Djomkam,

Abstract Background Interferon-γ release assays (IGRA) with Resuscitation promoting factor (Rpf) proteins enhanced tuberculosis (TB) screening and diagnosis in adults but have not been evaluated in children. Children often develop paucibacillary TB and their immune response differs from that of adults, which together affect TB disease diagnostics and immunodiagnostics. We ... Read more >>

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Viral Etiology, Clinical Features and Antibiotic Use in Children <5 Years of Age in the Gambia Presenting With Influenza-like Illness.

Sheikh Jarju, Khristianne Greenhalgh, Miriam Wathuo, Mustapha Banda, Bakary Camara, Simon Mendy, Ghata Sowe, Pa Omar Dahaba, Lamin Jammeh, Yaya Bajinka, Papis Sanneh, Edrissa Jallow, Alexandra Yates, Benjamin B Lindsey, Stephen Owens, Beate Kampmann, Karen Forrest, Ed Clarke, Thushan de Silva,

BACKGROUND:Knowledge regarding the prevalence, clinical features and etiology of pediatric influenza-like illness (ILI) remains limited in African settings. Furthermore, it is likely that many children presenting with ILI receive antibiotics unnecessarily. More data are required to develop antimicrobial stewardship practice and guide effective vaccine strategies. We undertook a 1-year prospective ... Read more >>

Pediatr. Infect. Dis. J. (The Pediatric infectious disease journal)
[2020, :]

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Anticipating the impact of the COVID-19 pandemic on TB patients and TB control programmes.

Toyin Togun, Beate Kampmann, Neil Graham Stoker, Marc Lipman,

The COVID-19 pandemic has currently overtaken every other health issue throughout the world. There are numerous ways in which this will impact existing public health issues. Here we reflect on the interactions between COVID-19 and tuberculosis (TB), which still ranks as the leading cause of death from a single infectious ... Read more >>

Ann. Clin. Microbiol. Antimicrob. (Annals of clinical microbiology and antimicrobials)
[2020, 19(1):21]

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BCG vaccination-induced emergency granulopoiesis provides rapid protection from neonatal sepsis.

Byron Brook, Danny J Harbeson, Casey P Shannon, Bing Cai, Daniel He, Rym Ben-Othman, Freddy Francis, Joe Huang, Natallia Varankovich, Aaron Liu, Winnie Bao, Morten Bjerregaard-Andersen, Frederik Schaltz-Buchholzer, Lilica Sanca, Christian N Golding, Kristina Lindberg Larsen, Ofer Levy, Beate Kampmann, , Rusung Tan, Adrian Charles, James L Wynn, Frank Shann, Peter Aaby, Christine S Benn, Scott J Tebbutt, Tobias R Kollmann, Nelly Amenyogbe,

Death from sepsis in the neonatal period remains a serious threat for millions. Within 3 days of administration, bacille Calmette-Guérin (BCG) vaccination can reduce mortality from neonatal sepsis in human newborns, but the underlying mechanism for this rapid protection is unknown. We found that BCG was also protective in a ... Read more >>

Sci Transl Med (Science translational medicine)
[2020, 12(542):]

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Performance of metabonomic serum analysis for diagnostics in paediatric tuberculosis.

Nicholas J Andreas, Robindra Basu Roy, Maria Gomez-Romero, Verena Horneffer-van der Sluis, Matthew R Lewis, Stephane S M Camuzeaux, Beatriz Jiménez, Joram M Posma, Leopold Tientcheu, Uzochukwu Egere, Abdou Sillah, Toyin Togun, Elaine Holmes, Beate Kampmann,

We applied a metabonomic strategy to identify host biomarkers in serum to diagnose paediatric tuberculosis (TB) disease. 112 symptomatic children with presumptive TB were recruited in The Gambia and classified as bacteriologically-confirmed TB, clinically diagnosed TB, or other diseases. Sera were analysed using 1H nuclear magnetic resonance (NMR) spectroscopy and ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):7302]

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What matters, most-especially now?

Beate Kampmann,

EBioMedicine (EBioMedicine)
[2020, 55:102776]

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Antibody glycosylation in pregnancy and in newborns: biological roles and implications.

Thomas F Rice, Beth Holder, Beate Kampmann,

PURPOSE OF REVIEW:Glycosylation patterns have the potential to affect the function of antibody, antibody half-life and transplacental transfer from mother to foetus. Here, we review recent advances in our understanding of how glycosylation patterns of antibodies may be altered during pregnancy, vaccination and infection. RECENT FINDINGS:During pregnancy, there is preferential ... Read more >>

Curr. Opin. Infect. Dis. (Current opinion in infectious diseases)
[2020, 33(3):225-230]

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Safety of Administering Live Vaccines During Pregnancy: A Systematic Review and Meta-Analysis of Pregnancy Outcomes.

Almudena Laris-González, Daniel Bernal-Serrano, Alexander Jarde, Beate Kampmann,

Live-attenuated vaccines (LAV) are currently contraindicated during pregnancy, given uncertain safety records for the mother-infant pair. LAV might, however, play an important role to protect them against serious emerging diseases, such as Ebola and Lassa fever. For this systematic review we searched relevant databases to identify studies published up to ... Read more >>

Vaccines (Basel) (Vaccines)
[2020, 8(1):]

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Immune predictors of oral poliovirus vaccine immunogenicity among infants in South India.

Sudhir Babji, Punithavathy Manickavasagam, Yin-Huai Chen, Nithya Jeyavelu, Nisha Vincy Jose, Ira Praharaj, Chanduni Syed, Saravanakumar Puthupalayam Kaliappan, Jacob John, Sidhartha Giri, Srinivasan Venugopal, Beate Kampmann, Edward P K Parker, Miren Iturriza-Gómara, Gagandeep Kang, Nicholas C Grassly, Holm H Uhlig,

Identification of the causes of poor oral vaccine immunogenicity in low-income countries might lead to more effective vaccines. We measured mucosal and systemic immune parameters at the time of vaccination with oral poliovirus vaccine (OPV) in 292 Indian infants aged 6-11 months, including plasma cytokines, leukocyte counts, fecal biomarkers of ... Read more >>

NPJ Vaccines (NPJ vaccines)
[2020, 5:27]

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The risk of tuberculosis in children after close exposure: a systematic review and individual-participant meta-analysis.

Leonardo Martinez, Olivia Cords, C Robert Horsburgh, Jason R Andrews, ,

BACKGROUND:Tens of millions of children are exposed to Mycobacterium tuberculosis globally every year; however, there are no contemporary estimates of the risk of developing tuberculosis in exposed children. The effectiveness of contact investigations and preventive therapy remains poorly understood. METHODS:In this systematic review and meta-analysis, we investigated the development of ... Read more >>

Lancet (Lancet (London, England))
[2020, 395(10228):973-984]

Cited: 1 time

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The burden of viral respiratory infections in young children in low-resource settings.

Uduak Okomo, Olubukola T Idoko, Beate Kampmann,

Lancet Glob Health (The Lancet. Global Health)
[2020, 8(4):e454-e455]

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Licensed Bacille Calmette-Guérin (BCG) formulations differ markedly in bacterial viability, RNA content and innate immune activation.

Asimenia Angelidou, Maria-Giulia Conti, Joann Diray-Arce, Christine S Benn, Frank Shann, Mihai G Netea, Mark Liu, Lakshmi Prasad Potluri, Guzman Sanchez-Schmitz, Robert Husson, Al Ozonoff, Beate Kampmann, Simon Daniël van Haren, Ofer Levy,

BACKGROUND:Bacille Calmette-Guérin (BCG), the live attenuated tuberculosis vaccine, is manufactured under different conditions across the globe generating formulations that may differ in clinical efficacy. Innate immune recognition of live BCG contributes to immunogenicity suggesting that differences in BCG viability may contribute to divergent activity of licensed formulations. METHODS:We compared BCG-Denmark ... Read more >>

Vaccine (Vaccine)
[2020, 38(9):2229-2240]

Cited: 1 time

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Safety and immunogenicity of a novel 10-valent pneumococcal conjugate vaccine candidate in adults, toddlers, and infants in The Gambia-Results of a phase 1/2 randomized, double-blinded, controlled trial.

Ed Clarke, Adedapo O Bashorun, Michael Okoye, Ama Umesi, Mariama Badjie Hydara, Ikechukwu Adigweme, Rajeev Dhere, Vistasp Sethna, Beate Kampmann, David Goldblatt, Andi Tate, Debra H Weiner, Jorge Flores, Mark R Alderson, Steve Lamola,

BACKGROUND:A more affordable pneumococcal conjugate vaccine (PCV) that provides comparable protection to current PCVs is needed to ensure sustainable access in resource-limited settings. Serum Institute of India Pvt. Ltd.'s PCV candidate (SIIPL-PCV) has the potential to meet this need as manufacturing efficiency has been optimized and the vaccine targets the ... Read more >>

Vaccine (Vaccine)
[2020, 38(2):399-410]

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Respiratory syncytial, parainfluenza and influenza virus infection in young children with acute lower respiratory infection in rural Gambia.

Grant A Mackenzie, Aminata Vilane, Rasheed Salaudeen, Lenny Hogerwerf, Sharon van den Brink, Lisa A Wijsman, Pieter Overduin, Thierry K S Janssens, Thushan I de Silva, Marianne A B van der Sande, Beate Kampmann, Adam Meijer,

Respiratory viral infections contribute significantly to morbidity and mortality worldwide, but representative data from sub-Saharan Africa are needed to inform vaccination strategies. We conducted population-based surveillance in rural Gambia using standardized criteria to identify and investigate children with acute lower respiratory infection (ALRI). Naso- and oropharyngeal swabs were collected. Each ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):17965]

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Adolescent tuberculosis.

Kathryn J Snow, Andrea T Cruz, James A Seddon, Rashida A Ferrand, Silvia S Chiang, Jennifer A Hughes, Beate Kampmann, Steve M Graham, Peter J Dodd, Rein M Houben, Justin T Denholm, Susan M Sawyer, Katharina Kranzer,

Adolescence is characterised by a substantial increase in the incidence of tuberculosis, a known fact since the early 20th century. Most of the world's adolescents live in low-income and middle-income countries where tuberculosis remains common, and where they comprise a quarter of the population. Despite this, adolescents have not yet ... Read more >>

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, 4(1):68-79]

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Immunization: vital progress, unfinished agenda.

Peter Piot, Heidi J Larson, Katherine L O'Brien, John N'kengasong, Edmond Ng, Samba Sow, Beate Kampmann,

Vaccination against infectious diseases has changed the future of the human species, saving millions of lives every year, both children and adults, and providing major benefits to society as a whole. Here we show, however, that national and sub-national coverage of vaccination varies greatly and major unmet needs persist. Although ... Read more >>

Nature (Nature)
[2019, 575(7781):119-129]

Cited: 6 times

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Aetiology of invasive bacterial infection and antimicrobial resistance in neonates in sub-Saharan Africa: a systematic review and meta-analysis in line with the STROBE-NI reporting guidelines.

Uduak Okomo, Edem N K Akpalu, Kirsty Le Doare, Anna Roca, Simon Cousens, Alexander Jarde, Mike Sharland, Beate Kampmann, Joy E Lawn,

BACKGROUND:Aetiological data for neonatal infections are essential to inform policies and programme strategies, but such data are scarce from sub-Saharan Africa. We therefore completed a systematic review and meta-analysis of available data from the African continent since 1980, with a focus on regional differences in aetiology and antimicrobial resistance (AMR) ... Read more >>

Lancet Infect Dis (The Lancet. Infectious Diseases)
[2019, 19(11):1219-1234]

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Tracking coverage, dropout and multidimensional equity gaps in immunisation systems in West Africa, 2000-2017.

Oghenebrume Wariri, Bassey Edem, Esin Nkereuwem, Oluwatosin O Nkereuwem, Gregory Umeh, Ed Clark, Olubukola T Idoko, Terna Nomhwange, Beate Kampmann,

Background:Several West African countries are unlikely to achieve the recommended Global Vaccine Action Plan (GVAP) immunisation coverage and dropout targets in a landscape beset with entrenched intra-country equity gaps in immunisation. Our aim was to assess and compare the immunisation coverage, dropout and equity gaps across 15 West African countries ... Read more >>

BMJ Glob Health (BMJ global health)
[2019, 4(5):e001713]

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Antibody responses to yellow fever vaccine in 9 to 11-month-old Malian and Ghanaian children.

Olubukola T Idoko, Nuredin Mohammed, Patrick Ansah, Abraham Hodgson, Milagritos D Tapia, Samba O Sow, Paanchali R Chowdhury, Matthias Niedrig, Elmar Saathoff, Beate Kampmann,

Background: The World Health Organization recommends use of a single yellow fever (YF) vaccine dose for life and fractional doses in outbreaks when there are limited vaccine stocks. In endemic regions, this vaccine is given as part of routine infant immunization programs around 9 months of age. There is a ... Read more >>

Expert Rev Vaccines (Expert review of vaccines)
[2019, 18(8):867-875]

Cited: 2 times

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The evolving research agenda for paediatric tuberculosis infection.

James A Seddon, Elizabeth Whittaker, Beate Kampmann, Deborah A Lewinsohn, Muhammad Osman, Anneke C Hesseling, Roxana Rustomjee, Farhana Amanullah,

Following exposure to tuberculosis and subsequent infection, children often progress to tuberculosis disease more rapidly than adults. And yet the natural history of tuberculosis in children, as a continuum from exposure to infection and then to disease, is poorly understood. Children are rarely diagnosed with tuberculosis infection in routine care ... Read more >>

Lancet Infect Dis (The Lancet. Infectious Diseases)
[2019, 19(9):e322-e329]

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Effect of a Russian-backbone live-attenuated influenza vaccine with an updated pandemic H1N1 strain on shedding and immunogenicity among children in The Gambia: an open-label, observational, phase 4 study.

Benjamin B Lindsey, Ya Jankey Jagne, Edwin P Armitage, Anika Singanayagam, Hadijatou J Sallah, Sainabou Drammeh, Elina Senghore, Nuredin I Mohammed, David Jeffries, Katja Höschler, John S Tregoning, Adam Meijer, Ed Clarke, Tao Dong, Wendy Barclay, Beate Kampmann, Thushan I de Silva,

BACKGROUND:The efficacy and effectiveness of the pandemic H1N1 (pH1N1) component in live attenuated influenza vaccine (LAIV) is poor. The reasons for this paucity are unclear but could be due to impaired replicative fitness of pH1N1 A/California/07/2009-like (Cal09) strains. We assessed whether an updated pH1N1 strain in the Russian-backbone trivalent LAIV ... Read more >>

Lancet Respir Med (The Lancet. Respiratory medicine)
[2019, 7(8):665-676]

Cited: 2 times

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Immunogenicity of pneumococcal conjugate vaccine formulations containing pneumococcal proteins, and immunogenicity and reactogenicity of co-administered routine vaccines - A phase II, randomised, observer-blind study in Gambian infants.

Aderonke Odutola, Martin O C Ota, Martin Antonio, Ezra O Ogundare, Yauba Saidu, Patrick K Owiafe, Archibald Worwui, Olubukola T Idoko, Olumuyiwa Owolabi, Beate Kampmann, Brian M Greenwood, Mark Alderson, Magali Traskine, Kristien Swinnen, Vincent Verlant, Kurt Dobbelaere, Dorota Borys,

BACKGROUND:Two conserved pneumococcal proteins, pneumolysin toxoid (dPly) and pneumococcal histidine triad protein D (PhtD), combined with 10 polysaccharide conjugates from the pneumococcal non-typeable Haemophilus influenzae protein D-conjugate vaccine (PHiD-CV) in two investigational pneumococcal vaccine (PHiD-CV/dPly/PhtD) formulations were immunogenic and well-tolerated when administered to Gambian children. Here, we report immunogenicity of ... Read more >>

Vaccine (Vaccine)
[2019, 37(19):2586-2599]

Cited: 2 times

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An Auto-luminescent Fluorescent BCG Whole Blood Assay to Enable Evaluation of Paediatric Mycobacterial Responses Using Minimal Blood Volumes.

Robindra Basu Roy, Basil Sambou, Iria Uhía, Sophie Roetynck, Brian D Robertson, Beate Kampmann,

Introduction: Understanding protective human immunity against mycobacteria is critical to developing and evaluating new vaccines against tuberculosis. Children are the most susceptible population to infection, disease, and death from tuberculosis, but also have the strongest evidence of BCG-inducible protection. Limited amounts of blood can be obtained for research purposes in ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2019, 7:151]

Cited: 1 time

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