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Pretreatment Risk Stratification for Endoscopic Kidney-sparing Surgery in Upper Tract Urothelial Carcinoma: An International Collaborative Study.

Beat Foerster, Mohammad Abufaraj, Surena F Matin, Mounsif Azizi, Mohit Gupta, Wei-Ming Li, Thomas Seisen, Timothy Clinton, Evanguelos Xylinas, M Carmen Mir, Donald Schweitzer, Andrea Mari, Shoji Kimura, Marco Bandini, Romain Mathieu, Ja H Ku, Gautier Marcq, Georgi Guruli, Markus Grabbert, Anna K Czech, Tim Muilwijk, Armin Pycha, David D'Andrea, Firas G Petros, Philippe E Spiess, Trinity Bivalacqua, Wen-Jeng Wu, Morgan Rouprêt, Laura-Maria Krabbe, Kees Hendricksen, Shin Egawa, Alberto Briganti, Marco Moschini, Vivien Graffeille, Wassim Kassouf, Riccardo Autorino, Axel Heidenreich, Piotr Chlosta, Steven Joniau, Francesco Soria, Phillip M Pierorazio, Shahrokh F Shariat,

<h4>Background</h4>Several groups have proposed features to identify low-risk patients who may benefit from endoscopic kidney-sparing surgery in upper tract urothelial carcinoma (UTUC).<h4>Objective</h4>To evaluate standard risk stratification features, develop an optimal model to identify ≥pT2/N+ stage at radical nephroureterectomy (RNU), and compare it with the existing unvalidated models.<h4>Design, setting, and participants</h4>This ... Read more >>

Eur Urol (European urology)
[2021, 80(4):507-515]

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Novel Classification for Upper Tract Urothelial Carcinoma to Better Risk-stratify Patients Eligible for Kidney-sparing Strategies: An International Collaborative Study.

Gautier Marcq, Beat Foerster, Mohammad Abufaraj, Surena F Matin, Mounsif Azizi, Mohit Gupta, Wei-Ming Li, Thomas Seisen, Timothy Clinton, Evanguelos Xylinas, M Carmen Mir, Donald Schweitzer, Andrea Mari, Shoji Kimura, Marco Bandini, Romain Mathieu, Ja H Ku, Georgi Guruli, Markus Grabbert, Anna K Czech, Tim Muilwijk, Armin Pycha, David D'Andrea, Firas G Petros, Philippe E Spiess, Trinity Bivalacqua, Wen-Jeng Wu, Morgan Rouprêt, Laura-Maria Krabbe, Kees Hendricksen, Shin Egawa, Alberto Briganti, Marco Moschini, Vivien Graffeille, Riccardo Autorino, Patricia John, Axel Heidenreich, Piotr Chlosta, Steven Joniau, Francesco Soria, Phillip M Pierorazio, Shahrokh F Shariat, Wassim Kassouf,

<h4>Background</h4>The European Association of Urology risk stratification dichotomizes patients with upper tract urothelial carcinoma (UTUC) into two risk categories.<h4>Objective</h4>To evaluate the predictive value of a new classification to better risk stratify patients eligible for kidney-sparing surgery (KSS).<h4>Design, setting, and participants</h4>This was a retrospective study including 1214 patients from 21 centers ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Functional Outcomes after Local Salvage Therapies for Radiation-Recurrent Prostate Cancer Patients: A Systematic Review.

Mohammad Abufaraj, Abdelmuez Siyam, Mustafa Rami Ali, Rodrigo Suarez-Ibarrola, Lin Yang, Beat Foerster, Shahrokh F Shariat,

<h4>Purpose</h4>To assess the rate and severity of functional outcomes after salvage therapy for radiation recurrent prostate cancer.<h4>Methods</h4>This systematic review of the MEDLINE/PubMed database yielded 35 studies, evaluating salvage radical prostatectomy (RP), brachytherapy (BT), high-intensity focal ultrasound (HIFU) and cryotherapy (CT) after failure of primary radiation therapy. Data on pre- and ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(2):]

Cited: 1 time

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Pre-therapy serum albumin-to-globulin ratio in patients treated with neoadjuvant chemotherapy and radical nephroureterectomy for upper tract urothelial carcinoma.

Benjamin Pradere, David D'Andrea, Victor M Schuettfort, Beat Foerster, Fahad Quhal, Keiichiro Mori, Mohammad Abufaraj, Vitaly Margulis, Marine Deuker, Alberto Briganti, Tim Muilwijk, Kees Hendricksen, Yair Lotan, Pierre Karakiewic, Shahrokh F Shariat, ,

<h4>Purpose</h4>The accurate selection of patients who are most likely to benefit from neoadjuvant chemotherapy is an important challenge in oncology. Serum AGR has been found to be associated with oncological outcomes in various malignancies. We assessed the association of pre-therapy serum albumin-to-globulin ratio (AGR) with pathologic response and oncological outcomes ... Read more >>

World J Urol (World journal of urology)
[2021, 39(7):2567-2577]

Cited: 1 time

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The Performance of Tumor Size as Risk Stratification Parameter in Upper Tract Urothelial Carcinoma (UTUC).

Beat Foerster, Mohammad Abufaraj, Andrea Mari, Thomas Seisen, Marco Bandini, Donald Schweitzer, Anna K Czech, Marco Moschini, David D'Andrea, Marco Bianchi, Kees Hendricksen, Morgan Rouprêt, Alberto Briganti, Bas W G van Rhijn, Piotr Chłosta, Pierre Colin, Hubert John, Shahrokh F Shariat,

<h4>Introduction</h4>The objective of this study was to evaluate the performance of different tumor diameters for identifying ≥ pT2 upper tract urothelial carcinoma (UTUC) at radical nephroureterectomy.<h4>Patients and methods</h4>This was a multi-institutional retrospective study that included 932 patients who underwent radical nephroureterectomy for nonmetastatic UTUC between 2000 and 2016. Tumor sizes were ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, 19(3):272.e1-272.e7]

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Impact of Sex on Response to Neoadjuvant Chemotherapy in Patients with Upper-tract Urothelial Cancer.

David D'Andrea, Beat Foerster, Surena F Matin, Ja H Ku, Tim Muilwijk, Leonardo L Monteiro, Ross Liao, Firas G Petros, Philippe E Spiess, Trinity J Bivalacqua, Kees Hendricksen, Bas W G van Rhijn, Ahmad Shabsigh, Alberto Briganti, Steven Joniau, Wassim Kassouf, Phillip M Pierorazio, Vitaly Margulis, Andrea Necchi, Shahrokh F Shariat, ,

Eur Urol Open Sci (European urology open science)
[2020, 19:16-19]

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Efficacy of Preoperative Chemotherapy for High Risk Upper Tract Urothelial Carcinoma.

Beat Foerster, Mohammad Abufaraj, Firas Petros, Mounsif Azizi, Mohit Gupta, Donald Schweitzer, Vitaly Margulis, Takehiro Iwata, Shoji Kimura, Ahmad Shabsigh, Alberto Briganti, Ja H Ku, Tim Muilwijk, Wassim Kassouf, Surena F Matin, Philippe E Spiess, Phillip M Pierorazio, Kees Hendricksen, Shahrokh F Shariat, ,

PURPOSE:The impact of preoperative chemotherapy in patients with upper urinary tract urothelial carcinoma remains poorly investigated. We assessed the rates of pathological complete response (pT0N0/X) and downstaging (pT1N0/X or less) at radical nephroureterectomy after preoperative chemotherapy and evaluated their impact on survival. MATERIALS AND METHODS:This was an international observational study ... Read more >>

J Urol (The Journal of urology)
[2020, 203(6):1101-1108]

Cited: 3 times

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Expression of urokinase-type plasminogen activator system in non-metastatic prostate cancer.

Shoji Kimura, David D'Andrea, Takehiro Iwata, Beat Foerster, Florian Janisch, Mehdi Kardoust Parizi, Marco Moschini, Alberto Briganti, Marko Babjuk, Piotr Chlosta, Pierre I Karakiewicz, Dmitry Enikeev, Leonid M Rapoport, Veronica Seebacher, Shin Egawa, Mohammad Abufaraj, Shahrokh F Shariat,

<h4>Purpose</h4>To investigate the prognostic role of expression of urokinase-type plasminogen activator system members, such as urokinase-type activator (uPA), uPA-receptor (uPAR), and plasminogen activator inhibitor-1 (PAI-1), in patients treated with radical prostatectomy (RP) for prostate cancer (PCa).<h4>Methods</h4>Immunohistochemical staining for uPA system was performed on a tissue microarray of specimens from 3121 ... Read more >>

World J Urol (World journal of urology)
[2020, 38(10):2501-2511]

Cited: 1 time

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Diagnostic Value of 18F-fluorodeoxyglucose Positron Emission Tomography with Computed Tomography for Lymph Node Staging in Patients with Upper Tract Urothelial Carcinoma.

Charlotte S Voskuilen, Donald Schweitzer, Jørgen Bjerggaard Jensen, Anna M Nielsen, Steven Joniau, Tim Muilwijk, Andrea Necchi, Mounsif Azizi, Philippe E Spiess, Alberto Briganti, Marco Bandini, Karolien Goffin, Kirsten Bouchelouche, Erik van Werkhoven, Shahrokh F Shariat, Evanguelos Xylinas, Nessn H Azawi, Ja Hyeon Ku, Beat Foerster, Bas W G van Rhijn, Erik Vegt, Kees Hendricksen,

<h4>Background</h4>Presence of lymph node metastases (LNM) is an important prognostic factor for cancer-specific survival (CSS) in patients with upper tract urothelial carcinoma (UTUC). In various neoplasms, <sup>18</sup>F-fluorodeoxyglucose positron emission tomography with computed tomography (FDG-PET/CT) is an established modality for preoperative lymph node (LN) staging. In UTUC, the diagnostic value of ... Read more >>

Eur Urol Oncol (European urology oncology)
[2020, 3(1):73-79]

Cited: 3 times

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Comparison of perioperative complications and health-related quality of life between robot-assisted and open radical cystectomy: A systematic review and meta-analysis.

Shoji Kimura, Takehiro Iwata, Beat Foerster, Nicola Fossati, Alberto Briganti, Yasutomo Nasu, Shin Egawa, Mohammad Abufaraj, Shahrokh F Shariat,

To compare postoperative complications and health-related quality of life of patients undergoing robot-assisted radical cystectomy with those of patients undergoing open radical cystectomy. A systematic search was carried out according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. A pooled meta-analysis was carried out to assess the ... Read more >>

Int J Urol (International journal of urology : official journal of the Japanese Urological Association)
[2019, 26(8):760-774]

Cited: 5 times

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Performance of [68Ga] Ga-PSMA 11 PET for detecting prostate cancer in the lymph nodes before salvage lymph node dissection: a systematic review and meta-analysis.

Shoji Kimura, Mohammad Abufaraj, Florian Janisch, Takehiro Iwata, Mehdi Kardoust Parizi, Beat Foerster, Nicola Fossati, Alberto Briganti, Shin Egawa, Markus Hartenbach, Shahrokh F Shariat,

<h4>Background</h4>Salvage lymph node dissection (sLND) for nodal recurrence in prostate cancer (PCa) patients with biochemical recurrence (BCR) is still not recommended in current guidelines, because of the diagnostic inaccuracy of current conventional imaging. To assess the performance of [<sup>68</sup>Ga] Ga-prostate-specific membrane antigen conjugate 11 positron emission tomography (PSMA-PET) in detecting ... Read more >>

Prostate Cancer Prostatic Dis (Prostate cancer and prostatic diseases)
[2020, 23(1):1-10]

Cited: 4 times

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Optimal Management of Upper Tract Urothelial Carcinoma: an Unmet Need.

Mounsif Azizi, Salim K Cheriyan, Charles C Peyton, Beat Foerster, Shahrokh F Shariat, Philippe E Spiess,

OPINION STATEMENT:Upper tract urothelial carcinoma (UTUC) is a rare genitourinary entity of the renal pelvis and the ureter characterized by a more aggressive disease phenotype when compared with urothelial carcinoma of the bladder (UCB) with more than half of UTUC cases presenting with invasive disease at diagnosis compared to 20% ... Read more >>

Curr Treat Options Oncol (Current treatment options in oncology)
[2019, 20(5):40]

Cited: 3 times

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Incidence and survival outcomes in patients with upper urinary tract urothelial carcinoma diagnosed with variant histology and treated with nephroureterectomy.

Stefania Zamboni, Beat Foerster, Mohammad Abufaraj, Thomas Seisen, Morgan Roupret, Pierre Colin, Alexandre De la Taille, Carlo Di Bona, Benoit Peyronnet, Karim Bensalah, Roman Herout, Manfred Peter Wirth, Vladimir Novotny, Francesco Soria, Piotr Chlosta, Alessandro Antonelli, Claudio Simeone, Philipp Baumeister, Agostino Mattei, Francesco Montorsi, Giuseppe Simone, Michele Gallucci, Kazumasa Matsumoto, Pierre I Karakiewicz, Alberto Briganti, Evanguelos Xylinas, Shahrokh F Shariat, Marco Moschini, , ,

OBJECTIVE:To evaluate the incidence and survival outcomes of histological variants of upper tract urothelial carcinoma (UTUC) treated with radical nephroureterectomy (RNU). MATERIALS AND METHODS:We retrospectively analysed data from 1610 patients treated with RNU for clinically non-metastatic UTUC between 1990 and 2016 in several centres participating in the UTUC Collaboration. Histological ... Read more >>

BJU Int (BJU international)
[2019, 124(5):738-745]

Cited: 3 times

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Oncologic outcomes after robot-assisted versus open radical cystectomy: a systematic review and meta-analysis.

Takehiro Iwata, Shoji Kimura, Beat Foerster, Nicola Fossati, Alberto Briganti, Pierre I Karakiewicz, Kilian M Gust, Shin Egawa, Yasutomo Nasu, Mohammad Abufaraj, Shahrokh F Shariat,

<h4>Purpose</h4>The efficacy of RARC in oncologic outcomes compared ORC is controversial. We assess potential differences in oncologic outcomes between robot-assisted radical cystectomy (RARC) and open radical cystectomy (ORC).<h4>Methods</h4>We performed the literature search systematically according to the Preferred Reporting Items for Systematic Review and Meta-analysis statement. A pooled meta-analysis was performed ... Read more >>

World J Urol (World journal of urology)
[2019, 37(8):1557-1570]

Cited: 6 times

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Perioperative blood transfusion affects oncologic outcomes after nephrectomy for renal cell carcinoma: A systematic review and meta-analysis.

Takehiro Iwata, Shoji Kimura, Beat Foerster, Mohammad Abufaraj, Pierre I Karakiewicz, Felix Preisser, Yasutomo Nasu, Shahrokh F Shariat,

AIM:To investigate the association of perioperative blood transfusion (PBT) with oncologic outcomes in patients with renal cell carcinoma (RCC), we conducted a systematic review and meta-analysis of the literature to clarify the long-term oncologic effect of PBT in patients undergoing nephrectomy for RCC. MATERIALS AND METHODS:We searched the MEDLINE, Web ... Read more >>

Urol Oncol (Urologic oncology)
[2019, 37(4):273-281]

Cited: 2 times

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Prognostic Value of Concomitant Carcinoma In Situ in the Radical Cystectomy Specimen: A Systematic Review and Meta-Analysis.

Shoji Kimura, Andrea Mari, Beat Foerster, Mohammad Abufaraj, Mihai D Vartolomei, Judith Stangl-Kremser, Pierre I Karakiewicz, Shin Egawa, Shahrokh F Shariat,

<h4>Purpose</h4>We investigated the prognostic impact of concomitant carcinoma in situ in radical cystectomy specimens.<h4>Materials and methods</h4>We performed a systematic review and meta-analysis using MEDLINE®, Scopus®, Web of Science™ and The Cochrane Library to identify eligible studies published until October 2017. Studies were eligible for analysis if they compared patients with ... Read more >>

J Urol (The Journal of urology)
[2019, 201(1):46-53]

Cited: 0 times

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Endocavitary treatment for upper tract urothelial carcinoma: A meta-analysis of the current literature.

Beat Foerster, David D'Andrea, Mohammad Abufaraj, Stephan Broenimann, Pierre I Karakiewicz, Morgan Rouprêt, Paolo Gontero, Seth P Lerner, Shahrokh F Shariat, Francesco Soria,

<h4>Purpose</h4>To assess the oncologic impact of adjuvant endocavitary instillation after kidney-sparing surgery (KSS) in the treatment of upper tract urothelial carcinoma (UTUC).<h4>Methods</h4>A meta-analysis of the available literature was performed using PUBMED and MEDLINE on June 2018. No time or language restrictions were applied. All included participants were substratified into 2 ... Read more >>

Urol Oncol (Urologic oncology)
[2019, 37(7):430-436]

Cited: 5 times

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Prognostic value of modified Glasgow Prognostic Score in non-muscle-invasive bladder cancer.

Shoji Kimura, David D' Andrea, Francesco Soria, Beat Foerster, Mohammad Abufaraj, Mihai D Vartolomei, Takehiro Iwata, Pierre I Karakiewicz, Michael Rink, Kilian M Gust, Shin Egawa, Shahrokh F Shariat,

<h4>Purpose</h4>To investigate the prognostic value of preoperative modified Glasgow Prognostic Score (mGPS) in patients with non-muscle-invasive bladder cancer (NMIBC) treated with transurethral resection of bladder with or without intravesical therapy.<h4>Material and methods</h4>We retrospectively reviewed our medical records to identify 1,096 consecutive patients with NMIBC treated with transurethral resection of bladder. ... Read more >>

Urol Oncol (Urologic oncology)
[2019, 37(3):179.e19-179.e28]

Cited: 8 times

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Micropapillary Urothelial Carcinoma of the Bladder: A Systematic Review and Meta-analysis of Disease Characteristics and Treatment Outcomes.

Mohammad Abufaraj, Beat Foerster, Eva Schernhammer, Marco Moschini, Shoji Kimura, Melanie R Hassler, Mark A Preston, Pierre I Karakiewicz, Mesut Remzi, Shahrokh F Shariat,

CONTEXT:The optimal treatment of urothelial bladder cancer (UBC) with micropapillary (MP) variant histology is not clear. OBJECTIVE:To review the current literature on disease characteristics and treatment outcomes of MP UBC. EVIDENCE ACQUISITION:A systematic search was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement and the ... Read more >>

Eur Urol (European urology)
[2019, 75(4):649-658]

Cited: 14 times

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Development and external validation of a pathological nodal staging score for patients with clear cell renal cell carcinoma.

Malte Rieken, Stephen A Boorjian, Luis A Kluth, Umberto Capitanio, Alberto Briganti, R Houston Thompson, Bradley C Leibovich, Laura-Maria Krabbe, Vitaly Margulis, Jay D Raman, Mikhail Regelman, Pierre I Karakiewicz, Morgan Rouprêt, Mohammad Abufaraj, Beat Foerster, Mithat Gönen, Shahrokh F Shariat,

<h4>Objectives</h4>To develop and externally validate a model that quantifies the likelihood that a pathologically node-negative patient with clear cell renal cell carcinoma (cRCC) has, indeed, no lymph node metastasis (LNM).<h4>Patients and methods</h4>Data from 1389 patients treated with radical nephrectomy (RN) and lymph node dissection (LND) were analyzed. For external validation, ... Read more >>

World J Urol (World journal of urology)
[2019, 37(8):1631-1637]

Cited: 3 times

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Role of serum cholinesterase in patients treated with salvage radical prostatectomy.

Mihai Dorin Vartolomei, David D'Andrea, Daher C Chade, Francesco Soria, Shoji Kimura, Beat Foerster, Mohammad Abufaraj, Romain Mathieu, Marco Moschini, Morgan Rouprêt, Alberto Briganti, Pierre I Karakiewicz, Shahrokh F Shariat,

<h4>Background</h4>Serum cholinesterase (ChE) a serine hydrolase that catalyses the hydrolysis of esters of choline, is involved in cellular proliferation and differentiation, therefore affecting carcinogenesis. The aim of this study was to understand the prognostic role of preoperative serum ChE in patients with radiation-recurrent prostate cancer (CaP) treated with salvage radical ... Read more >>

Urol Oncol (Urologic oncology)
[2019, 37(2):123-129]

Cited: 3 times

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Comparative Effectiveness in Perioperative Outcomes of Robotic versus Open Radical Cystectomy: Results from a Multicenter Contemporary Retrospective Cohort Study.

Francesco Soria, Marco Moschini, David D'andrea, Mohammad Abufaraj, Beat Foerster, Romain Mathiéu, Killian M Gust, Paolo Gontero, Giuseppe Simone, Anoop Meraney, Suprita Krishna, Badrinath Konety, Morgan Rouprêt, Matthew Perry, Edward Rowe, Guillaume Ploussard, Stephen A Boorjian, Peter Wiklund, Prasanna Sooriakumaran, Shahrokh F Shariat,

<h4>Background</h4>The comparative effectiveness of robotic-assisted radical cystectomy (RARC) versus open radical cystectomy (ORC) in terms of perioperative outcomes is still a matter of debate affecting payors, physicians, and patients.<h4>Objective</h4>To evaluate comparative perioperative and longer-term morbidity of RARC versus ORC in a multicenter contemporary retrospective cohort of patients.<h4>Design, setting, and participants</h4>This ... Read more >>

Eur Urol Focus (European urology focus)
[2020, 6(6):1233-1239]

Cited: 10 times

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Clinical value of cholinesterase in the prediction of biochemical recurrence after radical prostatectomy.

David D'Andrea, Francesco Soria, Mohammad Abufaraj, Kilian Gust, Beat Foerster, Mihai D Vartolomei, Shoji Kimura, Andrea Mari, Alberto Briganti, Mesut Remzi, Christian K Seitz, Romain Mathieu, Pierre I Karakiewicz, Shahrokh F Shariat,

<h4>Purpose</h4>To evaluate the predictive and prognostic role as well as the clinical impact on decision-making of serum cholinesterase (ChoE) levels in patients treated with radical prostatectomy for clinically nonmetastatic prostate cancer.<h4>Materials and methods</h4>We conducted a retrospective analysis of our multi institutional database. Preoperative ChoE was evaluated as continuous and dichotomized ... Read more >>

Urol Oncol (Urologic oncology)
[2018, 36(12):528.e7-528.e13]

Cited: 1 time

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External Beam Radiotherapy Increases the Risk of Bladder Cancer When Compared with Radical Prostatectomy in Patients Affected by Prostate Cancer: A Population-based Analysis.

Marco Moschini, Emanuele Zaffuto, Pierre I Karakiewicz, David D Andrea, Beat Foerster, Mohammad Abufaraj, Francesco Soria, Agostino Mattei, Francesco Montorsi, Alberto Briganti, Shahrokh F Shariat,

<h4>Background</h4>Long-term survival can be achieved in patients affected by localized prostate cancer (PCa) treated with either radical prostatectomy (RP) or external beam radiotherapy (EBRT). However, development of a second primary tumor is still poorly investigated.<h4>Objective</h4>To investigate the impact of RP and EBRT on subsequent risk of developing bladder (BCa) and/or ... Read more >>

Eur Urol (European urology)
[2019, 75(2):319-328]

Cited: 5 times

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Prognostic Value of Serum Cholinesterase in Non-muscle-invasive Bladder Cancer.

Shoji Kimura, Francesco Soria, David D'Andrea, Beat Foerster, Mohammad Abufaraj, Mihai D Vartolomei, Pierre I Karakiewicz, Romain Mathieu, Marco Moschini, Michael Rink, Shin Egawa, Shahrokh F Shariat, Kilian M Gust,

<h4>Background</h4>Serum cholinesterase (ChE) has been reported to be a prognostic factor in several cancers, but its relationship with oncologic outcomes of non-muscle-invasive bladder cancer (NMIBC) has not yet been well-studied.<h4>Materials and methods</h4>We retrospectively assessed 1117 patients with NMIBC undergoing transurethral resection of the bladder. Cox regression analyses were performed to ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2018, 16(6):e1123-e1132]

Cited: 2 times

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