Full Text Journal Articles by
Author Bastian Dislich


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Furin controls β cell function via mTORC1 signaling

Bas Brouwers, Ilaria Coppola, Katlijn Vints, Bastian Dislich, Nathalie Jouvet, Leentje Van Lommel, Natalia Gounko, Lieven Thorrez, Frans Schuit, Stefan Lichtenthaler, Jennifer Estall, Jeroen Declercq, Bruno Ramos-Molina, John W.M. Creemers,

Abstract Furin is a proprotein convertase (PC) responsible for proteolytic activation of a wide array of precursor proteins within the secretory pathway. It maps to the PRC1 locus, a type 2 diabetes susceptibility locus, yet its specific role in pancreatic β cells is largely unknown. The aim of this study ... Read more >>

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Significance of tumour regression in lymph node metastases of gastric and gastro-oesophageal junction adenocarcinomas.

Daniel Reim, Alexander Novotny, Helmut Friess, Julia Slotta-Huspenina, Wilko Weichert, Katja Ott, Bastian Dislich, Sylvie Lorenzen, Karen Becker, Rupert Langer,

The presence of lymph node (LN) metastases is one of the most important negative prognostic factors in upper gastrointestinal carcinomas. Tumour regression similar to that in primary tumours can be observed in LN metastases after neoadjuvant therapy. We evaluated the prognostic impact of histological regression in LNs in 480 adenocarcinomas ... Read more >>

J Pathol Clin Res (The journal of pathology. Clinical research)
[2020, :]

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Chlamydia-induced curvature of the host-cell plasma membrane is required for infection.

Sebastian Hänsch, Dominik Spona, Gido Murra, Karl Köhrer, Agathe Subtil, Ana Rita Furtado, Stephan F Lichtenthaler, Bastian Dislich, Katja Mölleken, Johannes H Hegemann,

During invasion of host cells, Chlamydia pneumoniae secretes the effector protein CPn0678, which facilitates internalization of the pathogen by remodeling the target cell's plasma membrane and recruiting sorting nexin 9 (SNX9), a central multifunctional endocytic scaffold protein. We show here that the strongly amphipathic N-terminal helix of CPn0678 mediates binding ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2020, 117(5):2634-2644]

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Preservation of Epstein-Barr virus status and mismatch repair protein status along the metastatic course of gastric cancer.

Bastian Dislich, Nicola Blaser, Martin D Berger, Beat Gloor, Rupert Langer,

AIMS:Epstein-Barr virus (EBV) in-situ hybridisation and mismatch repair (MMR) protein immunohistochemistry identifies two subgroups of gastric cancer (GC) with high immunogenicity and likelihood for response to immune check-point inhibition. As tumour biology may change during the metastatic course, which can negatively influence the success of therapeutic decisions made on primary ... Read more >>

Histopathology (Histopathology)
[2020, 76(5):740-747]

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Mouse brain proteomics establishes MDGA1 and CACHD1 as in vivo substrates of the Alzheimer protease BACE1.

Jasenka Rudan Njavro, Jakob Klotz, Bastian Dislich, Johanna Wanngren, Merav D Shmueli, Julia Herber, Peer-Hendrik Kuhn, Rohit Kumar, Thomas Koeglsperger, Marcus Conrad, Wolfgang Wurst, Regina Feederle, Andreas Vlachos, Stylianos Michalakis, Peter Jedlicka, Stephan A Müller, Stefan F Lichtenthaler,

The protease beta-site APP cleaving enzyme 1 (BACE1) has fundamental functions in the nervous system. Its inhibition is a major therapeutic approach in Alzheimer's disease, because BACE1 cleaves the amyloid precursor protein (APP), thereby catalyzing the first step in the generation of the pathogenic amyloid beta (Aβ) peptide. Yet, BACE1 ... Read more >>

FASEB J. (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2020, 34(2):2465-2482]

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Correction: A specific expression profile of LC3B and p62 is associated with nonresponse to neoadjuvant chemotherapy in esophageal adenocarcinomas.

Olivia Adams, Félice A Janser, Bastian Dislich, Sabina Berezowska, Magali Humbert, Christian A Seiler, Dino Kröll, Julia Slotta-Huspenina, Marcus Feith, Katja Ott, Mario P Tschan, Rupert Langer,

[This corrects the article DOI: 10.1371/journal.pone.0197610.]. ...

PLoS ONE (PloS one)
[2019, 14(10):e0224832]

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Her2-Targeted Therapy Induces Autophagy in Esophageal Adenocarcinoma Cells.

Félice A Janser, Olivia Adams, Vanessa Bütler, Anna M Schläfli, Bastian Dislich, Christian A Seiler, Dino Kröll, Rupert Langer, Mario P Tschan,

Esophageal adenocarcinoma (EAC) is a highly lethal cancer type with an overall poor survival rate. Twenty to thirty percent of EAC overexpress the human epidermal growth factor receptor 2 (Her2), a transmembrane receptor tyrosine kinase promoting cell growth and proliferation. Patients with Her2 overexpressing breast and gastroesophageal cancer may benefit ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2018, 19(10):]

Cited: 2 times

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Stromal PD-1/PD-L1 Expression Predicts Outcome in Colon Cancer Patients.

Jacqueline Wyss, Bastian Dislich, Viktor H Koelzer, José A Galván, Heather Dawson, Marion Hädrich, Daniel Inderbitzin, Alessandro Lugli, Inti Zlobec, Martin D Berger,

INTRODUCTION:The programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) axis plays an important role in controlling immune suppression by down-regulating T effector cell activities, enabling tumor cells to escape from the host's antitumor immunsurveillance. While only a small part of colon cancer cells express PD-L1, we sought to ... Read more >>

Clin Colorectal Cancer (Clinical colorectal cancer)
[2019, 18(1):e20-e38]

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A specific expression profile of LC3B and p62 is associated with nonresponse to neoadjuvant chemotherapy in esophageal adenocarcinomas.

Olivia Adams, Félice A Janser, Bastian Dislich, Sabina Berezowska, Magali Humbert, Christian A Seiler, Dino Kroell, Julia Slotta-Huspenina, Marcus Feith, Katja Ott, Mario P Tschan, Rupert Langer,

Paclitaxel is a powerful chemotherapeutic drug, used for the treatment of many cancer types, including esophageal adenocarcinomas (EAC). Autophagy is a lysosome-dependent degradation process maintaining cellular homeostasis. Defective autophagy has been implicated in cancer biology and therapy resistance. We aimed to assess the impact of autophagy on chemotherapy response in ... Read more >>

PLoS ONE (PloS one)
[2018, 13(6):e0197610]

Cited: 4 times

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Risk factors for esophageal cancer: emphasis on infectious agents.

Hala El-Zimaity, Vincenzo Di Pilato, Maria Novella Ringressi, Iva Brcic, Shanmugarajah Rajendra, Rupert Langer, Bastian Dislich, Monika Tripathi, Maha Guindi, Robert Riddell,

Risk factors for esophageal cancer include genetic factors (such as tylosis) and infectious agents. A variety of organisms have been implicated in esophageal carcinogenesis, either directly or indirectly. In this review, we explore the normal esophageal flora and how it may be controlled, and also the variety of organisms that ... Read more >>

Ann. N. Y. Acad. Sci. (Annals of the New York Academy of Sciences)
[2018, 1434(1):319-332]

Cited: 1 time

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Application of the 8th edition of the AJCC yTNM staging system shows improved prognostication in a single center cohort of esophageal carcinomas.

Dino Kröll, Laura Noser, Suna Erdem, Federico Storni, Dominik Arnold, Bastian Dislich, Inti Zlobec, Daniel Candinas, Christian A Seiler, Rupert Langer,

BACKGROUND:The 8th edition of the AJCC TNM staging system presents for the first time a specific classification for esophageal carcinomas treated with neoadjuvant therapy (yTNM8). In this single center study, we applied the novel staging system in a "real life" case series and compared the prognostic value of yTNM8 with ... Read more >>

Surg Oncol (Surgical oncology)
[2018, 27(1):100-105]

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Expression patterns of programmed death-ligand 1 in esophageal adenocarcinomas: comparison between primary tumors and metastases.

Bastian Dislich, Alexandra Stein, Christian A Seiler, Dino Kröll, Sabina Berezowska, Inti Zlobec, José Galvan, Julia Slotta-Huspenina, Axel Walch, Rupert Langer,

Expression analysis of programmed death-ligand 1 (PD-L1) may be helpful in guiding clinical decisions for immune checkpoint inhibition therapy, but testing by immunohistochemistry may be hampered by heterogeneous staining patterns within tumors and expression changes during metastatic course. PD-L1 expression (clone SP142) was investigated in esophageal adenocarcinomas using tissue microarrays ... Read more >>

Cancer Immunol. Immunother. (Cancer immunology, immunotherapy : CII)
[2017, 66(6):777-786]

Cited: 3 times

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High intratumoural but not peritumoural inflammatory host response is associated with better prognosis in primary resected oesophageal adenocarcinomas.

Alexandra V Stein, Bastian Dislich, Annika Blank, Lars Guldener, Dino Kröll, Christian A Seiler, Rupert Langer,

The host inflammatory response plays an important role in many solid malignancies. Studies on oesophageal adenocarcinomas (EACs) point towards a beneficial role of pronounced immunoreaction, however, congruent results have yet to be obtained. We analysed 111 primary resected EAC using a tissue microarray containing three cores of the tumour centre ... Read more >>

Pathology (Pathology)
[2017, 49(1):30-37]

Cited: 5 times

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Prognostic relevance of autophagy markers LC3B and p62 in esophageal adenocarcinomas.

Olivia Adams, Bastian Dislich, Sabina Berezowska, Anna M Schläfli, Christian A Seiler, Dino Kröll, Mario P Tschan, Rupert Langer,

Esophageal adenocarcinomas (EAC) are aggressive tumors with considerable rates of chemoresistance. Autophagy is a lysosome-dependent degradation process, characterized by the formation of vesicles called autophagosomes, and has been implicated in cancer. Protein light chain 3 B (LC3B) and p62 are associated with autophagosomal membranes and degraded. We aimed to assess ... Read more >>

Oncotarget (Oncotarget)
[2016, 7(26):39241-39255]

Cited: 16 times

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Control of Homeostasis and Dendritic Cell Survival by the GTPase RhoA.

Shuai Li, Bastian Dislich, Cord H Brakebusch, Stefan F Lichtenthaler, Thomas Brocker,

Tissues accommodate defined numbers of dendritic cells (DCs) in highly specific niches where different intrinsic and environmental stimuli control DC life span and numbers. DC homeostasis in tissues is important, because experimental changes in DC numbers influence immunity and tolerance toward various immune catastrophes and inflammation. However, the precise molecular ... Read more >>

J. Immunol. (Journal of immunology (Baltimore, Md. : 1950))
[2015, 195(9):4244-4256]

Cited: 1 time

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Regulated intramembrane proteolysis and degradation of murine epithelial cell adhesion molecule mEpCAM.

Matthias Hachmeister, Karolina D Bobowski, Sebastian Hogl, Bastian Dislich, Akio Fukumori, Carola Eggert, Brigitte Mack, Heidi Kremling, Sannia Sarrach, Fabian Coscia, Wolfgang Zimmermann, Harald Steiner, Stefan F Lichtenthaler, Olivier Gires,

Epithelial cell adhesion molecule EpCAM is a transmembrane glycoprotein, which is highly and frequently expressed in carcinomas and (cancer-)stem cells, and which plays an important role in the regulation of stem cell pluripotency. We show here that murine EpCAM (mEpCAM) is subject to regulated intramembrane proteolysis in various cells including ... Read more >>

PLoS ONE (PloS one)
[2013, 8(8):e71836]

Cited: 13 times

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QARIP: a web server for quantitative proteomic analysis of regulated intramembrane proteolysis.

Dmitry N Ivankov, Natalya S Bogatyreva, Peter Hönigschmid, Bastian Dislich, Sebastian Hogl, Peer-Hendrik Kuhn, Dmitrij Frishman, Stefan F Lichtenthaler,

Regulated intramembrane proteolysis (RIP) is a critical mechanism for intercellular communication and regulates the function of membrane proteins through sequential proteolysis. RIP typically starts with ectodomain shedding of membrane proteins by extracellular membrane-bound proteases followed by intramembrane proteolysis of the resulting membrane-tethered fragment. However, for the majority of RIP proteases ... Read more >>

Nucleic Acids Res. (Nucleic acids research)
[2013, 41(Web Server issue):W459-64]

Cited: 10 times

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Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains.

Sebastian Hogl, Frauke van Bebber, Bastian Dislich, Peer-Hendrik Kuhn, Christian Haass, Bettina Schmid, Stefan F Lichtenthaler,

The aspartyl protease BACE1 cleaves neuregulin 1 and is involved in myelination and is a candidate drug target for Alzheimer's disease, where it acts as the β-secretase cleaving the amyloid precursor protein. However, little is known about other substrates in vivo. Here, we provide a proteomic workflow for BACE1 substrate ... Read more >>

Proteomics (Proteomics)
[2013, 13(9):1519-1527]

Cited: 13 times

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The Membrane-Bound Aspartyl Protease BACE1: Molecular and Functional Properties in Alzheimer's Disease and Beyond.

Bastian Dislich, Stefan F Lichtenthaler,

The β-site APP cleaving enzyme 1 (BACE1) is a transmembrane aspartyl protease involved in Alzheimer's disease (AD) pathogenesis and in myelination. BACE1 initiates the generation of the pathogenic amyloid β-peptide, which makes BACE1 a major drug target for AD. BACE1 also cleaves and activates neuregulin 1, thereby contributing to postnatal ... Read more >>

Front Physiol (Frontiers in physiology)
[2012, 3:8]

Cited: 32 times

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Specific amino acids in the BAR domain allow homodimerization and prevent heterodimerization of sorting nexin 33.

Bastian Dislich, Manuel E Than, Stefan F Lichtenthaler,

SNX33 (sorting nexin 33) is a homologue of the endocytic protein SNX9 and has been implicated in actin polymerization and the endocytosis of the amyloid precursor protein. SNX33 belongs to the large family of BAR (Bin/amphiphysin/Rvs) domain-containing proteins, which alter cellular protein trafficking by modulating cellular membranes and the cytoskeleton. ... Read more >>

Biochem. J. (The Biochemical journal)
[2011, 433(1):75-83]

Cited: 8 times

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A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein.

Susanne Schöbel, Stephanie Neumann, Maren Hertweck, Bastian Dislich, Peer-Hendrik Kuhn, Elisabeth Kremmer, Brian Seed, Ralf Baumeister, Christian Haass, Stefan F Lichtenthaler,

Ectodomain shedding of the amyloid precursor protein (APP) by the two proteases alpha- and beta-secretase is a key regulatory event in the generation of the Alzheimer disease amyloid beta peptide (Abeta). beta-Secretase catalyzes the first step in Abeta generation, whereas alpha-secretase cleaves within the Abeta domain, prevents Abeta generation, and ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2008, 283(21):14257-14268]

Cited: 51 times

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