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Author Bastian Czogalla

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Breast adipose tissue macrophages (BATMs) have a stronger correlation with breast cancer survival than breast tumor stroma macrophages (BTSMs).

Lili Lin, Christina Kuhn, Nina Ditsch, Thomas Kolben, Bastian Czogalla, Susanne Beyer, Fabian Trillsch, Elisa Schmoeckel, Doris Mayr, Sven Mahner, Udo Jeschke, Anna Hester,

<h4>Background</h4>An abundance of tumor-associated macrophages has been shown to be an independent prognostic factor for a poor prognosis of human breast cancer (BC). Adipose tissue accounts for the largest proportion of the breast and has also been identified as an independent indicator of poor survival in BC. This study aims ... Read more >>

Breast Cancer Res (Breast cancer research : BCR)
[2021, 23(1):45]

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Primary platinum resistance and its prognostic impact in patients with recurrent ovarian cancer: an analysis of three prospective trials from the NOGGO study group.

Fabian Trillsch, Sven Mahner, Bastian Czogalla, Miriam Rottmann, Radoslav Chekerov, Elena Ioana Braicu, Gülten Oskay-Öczelik, Pauline Wimberger, Rolf Richter, Jalid Sehouli,

<h4>Objective</h4>Patients with platinum-resistant ovarian cancer (PROC) have a high need for reliable prognostic markers. Since significance of primary platinum resistance (PPR) versus secondary platinum resistance (SPR) was identified for patients receiving anti-angiogenic therapy, it has not been confirmed for chemotherapy only.<h4>Methods</h4>PROC patients from 3 prospective trials of the NOGGO study ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(3):e37]

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Integrin α2β1 Represents a Prognostic and Predictive Biomarker in Primary Ovarian Cancer.

Katharina Dötzer, Friederike Schlüter, Franz Edler von Koch, Christine E Brambs, Sabine Anthuber, Sergio Frangini, Bastian Czogalla, Alexander Burges, Jens Werner, Sven Mahner, Barbara Mayer,

Currently, the same first-line chemotherapy is administered to almost all patients suffering from primary ovarian cancer. The high recurrence rate emphasizes the need for precise drug treatment in primary ovarian cancer. Being crucial in ovarian cancer progression and chemotherapeutic resistance, integrins became promising therapeutic targets. To evaluate its prognostic and ... Read more >>

Biomedicines (Biomedicines)
[2021, 9(3):]

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Combined COX-2/PPARγ Expression as Independent Negative Prognosticator for Vulvar Cancer Patients.

Nadine Ansorge, Christian Dannecker, Udo Jeschke, Elisa Schmoeckel, Doris Mayr, Helene H Heidegger, Aurelia Vattai, Maximiliane Burgmann, Bastian Czogalla, Sven Mahner, Sophie Fuerst,

Vulvar cancer incidence numbers have been rising steadily over the past decades. Especially the number of young patients with vulvar cancer increased recently. Therefore, the need to identify new prognostic factors for vulvar carcinoma is more apparent. Cyclooxygenase-2 (COX-2) has long been an object of scientific interest in the context ... Read more >>

Diagnostics (Basel) (Diagnostics (Basel, Switzerland))
[2021, 11(3):]

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First Evidence for a Role of Siglec-8 in Breast Cancer.

Anna Trebo, Nina Ditsch, Tom Degenhardt, Christina Kuhn, Martina Rahmeh, Elisa Schmoeckel, Doris Mayr, Bastian Czogalla, Thomas Kolben, Sarah Meister, Sven Mahner, Udo Jeschke, Anna Hester,

Sialic acid-binding immunoglobulin-like lectins (Siglecs) are involved in various immune cell-mediated diseases. Their role in cancer is poorly investigated, and research focusses on Siglec-expression on immune cells interacting with tumor cells. This study evaluates the role of Siglec-8 in breast cancer (BC). Siglec-8 expression was analyzed immunohistochemically on 235 primary ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(4):]

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The G-Protein-Coupled Estrogen Receptor (GPER) Regulates Trimethylation of Histone H3 at Lysine 4 and Represses Migration and Proliferation of Ovarian Cancer Cells In Vitro.

Nan Han, Sabine Heublein, Udo Jeschke, Christina Kuhn, Anna Hester, Bastian Czogalla, Sven Mahner, Miriam Rottmann, Doris Mayr, Elisa Schmoeckel, Fabian Trillsch,

Histone H3 lysine 4 trimethylation (H3K4me3) is one of the most recognized epigenetic regulators of transcriptional activity representing, an epigenetic modification of Histone H3. Previous reports have suggested that the broad H3K4me3 domain can be considered as an epigenetic signature for tumor-suppressor genes in human cells. G-protein-coupled estrogen receptor (GPER), ... Read more >>

Cells (Cells)
[2021, 10(3):]

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Development and Validation of a Novel 11-Gene Prognostic Model for Serous Ovarian Carcinomas Based on Lipid Metabolism Expression Profile.

Mingjun Zheng, Heather Mullikin, Anna Hester, Bastian Czogalla, Helene Heidegger, Theresa Vilsmaier, Aurelia Vattai, Anca Chelariu-Raicu, Udo Jeschke, Fabian Trillsch, Sven Mahner, Till Kaltofen,

(1) Background: Biomarkers might play a significant role in predicting the clinical outcomes of patients with ovarian cancer. By analyzing lipid metabolism genes, future perspectives may be uncovered; (2) Methods: RNA-seq data for serous ovarian cancer were downloaded from The Cancer Genome Atlas and Gene Expression Omnibus databases. The non-negative ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(23):]

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Breast Adipose Tissue Macrophages (BATMs) have a Stronger Correlation with Breast Cancer Survival than Breast Tumor Stroma Macrophages (BTSMs)

Lili Lin, Christina Kuhn, Nina Ditsch, Thomas Kolben, Bastian Czogalla, Susanne Beyer, Fabian Trillsch, Elisa Schmoeckel, Doris Mayr, Sven Mahner, Udo Jeschke, Anna Hester,

<h4>Background: </h4> An abundance of tumor-associated macrophages has been shown to be an independent prognostic factor for a poor prognosis of human breast cancer (BC). Adipose tissue accounts for the largest proportion of the breast and has also been identified as an independent indicator of poor survival in BC. This ... Read more >>

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β-arrestin 2 Is a Prognostic Factor for Survival of Ovarian Cancer Patients Upregulating Cell Proliferation.

Bastian Czogalla, Alexandra Partenheimer, Udo Jeschke, Viktoria von Schönfeldt, Doris Mayr, Sven Mahner, Alexander Burges, Manuela Simoni, Beatrice Melli, Riccardo Benevelli, Sara Bertini, Livio Casarini, Fabian Trillsch,

Establishing reliable prognostic factors as well as specific targets for new therapeutic approaches is an urgent requirement in advanced ovarian cancer. For several tumor entities, the ubiquitously spread scaffold protein β-arrestin 2, a multifunctional scaffold protein regulating signal transduction and internalization of activated G protein-coupled receptors (GPCRs), has been considered ... Read more >>

Front Endocrinol (Lausanne) (Frontiers in endocrinology)
[2020, 11:554733]

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Nuclear Enolase-1/ MBP-1 expression and its association with the Wnt signaling in epithelial ovarian cancer.

Bastian Czogalla, Alexandra Partenheimer, Susann Badmann, Elisa Schmoeckel, Doris Mayr, Thomas Kolben, Susanne Beyer, Anna Hester, Alexander Burges, Sven Mahner, Udo Jeschke, Fabian Trillsch,

<h4>Background</h4>Enolase-1, primarily known for its role in glucose metabolism, is overexpressed in various cancer entities. In contrast its alternative spliced nuclear isoform MBP-1 acts as a tumor suppressor. The aim of this study is to analyze the prognostic impact of Enolase-1/ MBP-1 and its functional significance in epithelial ovarian cancer ... Read more >>

Transl Oncol (Translational oncology)
[2021, 14(1):100910]

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Potential of platinum-resensitization by Wnt signaling modulators as treatment approach for epithelial ovarian cancer.

Till Kaltofen, Valentina Preinfalk, Stephanie Schwertler, Patricia Fraungruber, Helene Heidegger, Theresa Vilsmaier, Aurelia Vattai, Bastian Czogalla, Doris Mayr, Sven Mahner, Udo Jeschke, Fabian Trillsch,

<h4>Purpose</h4>Canonical Wnt/ β-catenin pathway is one mechanism being activated in platinum-resistant epithelial ovarian cancer (EOC). Detecting potential targets for Wnt pathway modulation as a putative future therapeutic approach was the aim of this study.<h4>Methods</h4>Biological effects of different Wnt modulators (SB216763, XAV939 and triptolide) on the EOC cell lines A2780 and ... Read more >>

J Cancer Res Clin Oncol (Journal of cancer research and clinical oncology)
[2020, 146(10):2559-2574]

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Cytoplasmic versus nuclear THR alpha expression determines survival of ovarian cancer patients.

Nina Ditsch, Sabine Heublein, Udo Jeschke, Cornelia Sattler, Christina Kuhn, Anna Hester, Bastian Czogalla, Fabian Trillsch, Sven Mahner, Jutta Engel, Doris Mayr, Elisa Schmoeckel,

<h4>Purpose</h4>Thyroid hormone receptors (THR) have manifold functions and are involved in the carcinogenesis of several tumor types. Within this study, we aimed to investigate the expression pattern (nuclear versus cytoplasmic) of the THR alpha and its impact on patients survival in ovarian cancer (OvCa).<h4>Methods</h4>The presence of the thyroid hormone receptors ... Read more >>

J Cancer Res Clin Oncol (Journal of cancer research and clinical oncology)
[2020, 146(8):1923-1932]

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M2 Macrophages Infiltrating Epithelial Ovarian Cancer Express MDR1: A Feature That May Account for the Poor Prognosis.

Susann Badmann, Sabine Heublein, Doris Mayr, Anna Reischer, Yue Liao, Thomas Kolben, Susanne Beyer, Anna Hester, Christine Zeder-Goess, Alexander Burges, Sven Mahner, Udo Jeschke, Fabian Trillsch, Bastian Czogalla,

Multi drug resistance protein 1 (MDR1) expression on tumor cells has been widely investigated in context of drug resistance. However, the role of MDR1 on the immune cell infiltrate of solid tumors remains unknown. The aim of this study was to analyze the prognostic significance of a MDR1+ immune cell ... Read more >>

Cells (Cells)
[2020, 9(5):]

Cited: 5 times

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Sirtuin1 expression and survival in endometrial and clear-cell uterine cancer.

Susanne Beyer, Fangfang Chen, Sarah Meister, Bastian Czogalla, Theresa M Kolben, Anna Hester, Alexander Burges, Fabian Trillsch, Elisa Schmöckel, Doris Mayr, Artur Mayerhofer, Sven Mahner, Udo Jeschke, Thomas Kolben,

Several risk factors like obesity and hyperlipidemia were described for endometrial cancer. Here, the nuclear NAD-dependent histone-deacetylase Sirtuin1 (SIRT1) seems to be important. SIRT1 is also involved in cell regulatory mechanisms and can serve as tumor promotor or suppressor. Its role in tumor biology is not clear yet. In this ... Read more >>

Histochem Cell Biol (Histochemistry and cell biology)
[2020, 154(2):189-195]

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H3K4me3 Is a Potential Mediator for Antiproliferative Effects of Calcitriol (1α,25(OH)2D3) in Ovarian Cancer Biology.

Nan Han, Udo Jeschke, Christina Kuhn, Anna Hester, Bastian Czogalla, Sven Mahner, Miriam Rottmann, Doris Mayr, Elisa Schmoeckel, Fabian Trillsch,

Posttranslational histone modification plays an important role in tumorigenesis. Histone modification is a dynamic response of chromatin to various signals, such as the exposure to calcitriol (1α,25(OH)<sub>2</sub>D<sub>3</sub>). Recent studies suggested that histone modification levels could be used to predict patient outcomes in various cancers. Our study evaluated the expression level ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(6):]

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Cytoplasmic VDR expression as an independent risk factor for ovarian cancer.

Bastian Czogalla, Eileen Deuster, Yue Liao, Doris Mayr, Elisa Schmoeckel, Cornelia Sattler, Thomas Kolben, Anna Hester, Sophie Fürst, Alexander Burges, Sven Mahner, Udo Jeschke, Fabian Trillsch,

The vitamin D receptor (VDR), primarily known as a crucial mediator of calcium homeostasis and metabolism, has been shown to play a significant role in various cancer entities. Previous studies have focused on vitamin D and its receptor in gynecological cancers, noting that the receptor is upregulated in epithelial ovarian ... Read more >>

Histochem Cell Biol (Histochemistry and cell biology)
[2020, 154(4):421-429]

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High Galectin-7 and Low Galectin-8 Expression and the Combination of both are Negative Prognosticators for Breast Cancer Patients.

Anna Trebo, Nina Ditsch, Christina Kuhn, Helene Hildegard Heidegger, Christine Zeder-Goess, Thomas Kolben, Bastian Czogalla, Elisa Schmoeckel, Sven Mahner, Udo Jeschke, Anna Hester,

Galectins are commonly overexpressed in cancer cells and their expression pattern is often associated with the aggressiveness and metastatic phenotype of the tumor. This study investigates the prognostic influence of the expression of galectin7 (Gal-7) and galectin8 (Gal-8) in tumor cell cytoplasm, nucleus and on surrounding immune cells. Primary breast ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(4):]

Cited: 1 time

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PD-L1 expression and survival in p16-negative and -positive squamous cell carcinomas of the vulva.

Bastian Czogalla, Deborah Pham, Fabian Trillsch, Miriam Rottmann, Julia Gallwas, Alexander Burges, Sven Mahner, Thomas Kirchner, Udo Jeschke, Doris Mayr, Elisa Schmoeckel,

AIM:Programmed death-ligand 1 (PD-L1) has become a widely used predictive biomarker for therapy with checkpoint inhibitors in a variety of cancers. Here, we studied the expression of PD-L1 in squamous cell carcinomas of the vulva (SCCV) with regard to HPV status via its surrogate marker p16. Additionally, the status of PD-L1 ... Read more >>

J Cancer Res Clin Oncol (Journal of cancer research and clinical oncology)
[2020, 146(3):569-577]

Cited: 4 times

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THR alpha and its subtypes alpha1 and alpha2 are prognostic markers for survival of ovarian cancer patients

Nina Ditsch, Sabine Heublein, Udo Jeschke, Cornelia Sattler, Christina Kuhn, Anna Hester, Bastian Czogalla, Fabian Trillsch, Sven Mahner, Jutta Engel, Doris Mayr, Elisa Schmoeckel,

<h4>Background: </h4> Ovarian cancer is most lethal in comparison to all other gynecological cancer cases. Within this study, we aimed to investigate the expression of the thyroid hormone receptor alpha and its influence on patient survival in ovarian cancer (OvCa). Methods The presence of the thyroid hormone receptors ... Read more >>

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EP3 receptor is a prognostic factor in TA-MUC1-negative ovarian cancer.

Bastian Czogalla, Christina Kuhn, Sabine Heublein, Elisa Schmöckel, Doris Mayr, Thomas Kolben, Fabian Trillsch, Alexander Burges, Sven Mahner, Udo Jeschke, Anna Hester,

PURPOSE:Prostaglandin-mediated inflammatory reactions play a major role in different cancers. Recently, it has been observed that prostaglandin E2-receptor 3 (EP3) might be an independent prognostic factor for overall survival in cervical and endometrial cancer. The role of EP3 expression in ovarian cancer is currently unknown. METHODS:EP3 expression was analyzed by ... Read more >>

J Cancer Res Clin Oncol (Journal of cancer research and clinical oncology)
[2019, 145(10):2519-2527]

Cited: 4 times

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EP3 receptor antagonist L798,106 reduces proliferation and migration of SK-BR-3 breast cancer cells.

Anna Hester, Barbara Salzmann, Martina Rahmeh, Thomas Kolben, Bastian Czogalla, Nina Ditsch, Sven Mahner, Udo Jeschke, Theresa Maria Kolben,

<b>Purpose:</b> COX-2 overexpression and elevated levels of prostaglandin E2 (PGE2) play an important role in breast cancer carcinogenesis. Recently, expression of the PGE2 receptor EP3 has been shown to be a positive prognostic factor in breast cancer. This study analyzes the functional aspects of targeting EP3 in breast cancer cell ... Read more >>

Onco Targets Ther (OncoTargets and therapy)
[2019, 12:6053-6068]

Cited: 3 times

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Extracapsular Lymph Node Involvement in Ovarian Carcinoma.

Sabine Heublein, Heiko Schulz, Frederik Marmé, Martin Angele, Bastian Czogalla, Alexander Burges, Sven Mahner, Doris Mayr, Udo Jeschke, Elisa Schmoeckel,

Ovarian cancer (OC) spread to retro-peritoneal lymph nodes is detected in about one out of two patients at primary diagnosis. Whether the histologic pattern of lymph node involvement i.e., intra-(ICG) or extracapsular (ECG) cancer growth may affect patients' prognosis remains unknown. The aim of the current study was to analyze ... Read more >>

Cancers (Basel) (Cancers)
[2019, 11(7):]

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Correlation of NRF2 and progesterone receptor and its effects on ovarian cancer biology.

Bastian Czogalla, Maja Kahaly, Doris Mayr, Elisa Schmoeckel, Beate Niesler, Anna Hester, Christine Zeder-Göß, Thomas Kolben, Alexander Burges, Sven Mahner, Udo Jeschke, Fabian Trillsch,

Purpose:This study aimed to investigate the potential prognostic impact of nuclear factor erythroid 2-related factor 2 (NRF2) and progesterone receptor A (PRA)/progesterone receptor B (PRB) in ovarian cancer patients which might be the rationale for putative new treatment strategies. Patients and methods:The presence of NRF2 and PRA/PRB was investigated in ... Read more >>

Cancer Manag Res (Cancer management and research)
[2019, 11:7673-7684]

Cited: 2 times

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Correlation of the Aryl Hydrocarbon Receptor with FSHR in Ovarian Cancer Patients.

Eileen Deuster, Doris Mayr, Anna Hester, Thomas Kolben, Christine Zeder-Göß, Alexander Burges, Sven Mahner, Udo Jeschke, Fabian Trillsch, Bastian Czogalla,

Expression of the aryl hydrocarbon receptor (AhR) has been described in various tumor entities from different organs. However, its role in ovarian cancer has not been thoroughly investigated. We aimed to elucidate the prognostic impact of AhR, its correlation with the follicle-stimulating hormone receptor (FSHR), and their functional role in ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2019, 20(12):]

Cited: 5 times

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Involvement of ILR4α and TLR4 in miscarriages.

Theresa Maria Kolben, Elisabeth Rogatsch, Anna Hester, Christina Kuhn, Elisa Schmoeckel, Bastian Czogalla, Sven Mahner, Udo Jeschke, Thomas Kolben,

<h4>Background</h4>The purpose of this study was to analyze the involvement of signaling via Interleukin-4-Receptor α (IL4Rα) and Toll like receptor (TLR) 4 at the fetomaternal interface in the process of early pregnancy.<h4>Patients and methods</h4>Placenta specimens of 46 patients in early pregnancy were analyzed (normal pregnancy (n = 15), spontaneous (n = 15) and habitual ... Read more >>

J Reprod Immunol (Journal of reproductive immunology)
[2019, 131:36-43]

Cited: 2 times

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