Full Text Journal Articles by
Author Basil Akpunonu


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Amiodarone-Induced Hypothyroidism Initially Presenting as Decompensated Heart Failure and Hyponatremia

Hazem Ayesh, Cameron Burmeister, Azizullah Beran, Basil Akpunonu,

Abstract Introduction: Amiodarone is an effective antiarrhythmic, but it is associated with altering thyroid function, ranging from thyrotoxicosis to hypothyroidism. In this study, we discuss amiodarone-induced hypothyroidism (AIH) presenting with hyponatremia and myxedema. Case Presentation: A 75-year-old Caucasian man with a history of ischemic heart disease with an ejection fraction ... Read more >>

J Endocr Soc (Journal of the Endocrine Society)
[2021, 5(Suppl 1):A920-A921]

Cited: 0 times

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Peritoneal Dialysis Zoonotic Bacterial Peritonitis with Staphylococcus pseudintermedius.

Layth Dahbour, Jeffrey Gibbs, Christian Coletta, Jeannine Hummell, Mohammad Al-Sarie, Navkirat Pannu Kahlon, Basil Akpunonu,

We present the first reported case of peritoneal dialysis-associated peritonitis caused by Staphylococcus pseudintermedius, an organism that had been misclassified as S. aureus in the past. S. pseudintermedius is well recognized in the veterinary literature and noted as flora in the mouth, nares, and anus of domesticated animals. It has ... Read more >>

Case Rep Nephrol Dial (Case reports in nephrology and dialysis)
[2020, 10(2):65-70]

Cited: 0 times

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Effects of Once-Weekly Exenatide on Cardiovascular Outcomes in Type 2 Diabetes.

Rury R Holman, M Angelyn Bethel, Robert J Mentz, Vivian P Thompson, Yuliya Lokhnygina, John B Buse, Juliana C Chan, Jasmine Choi, Stephanie M Gustavson, Nayyar Iqbal, Aldo P Maggioni, Steven P Marso, Peter Öhman, Neha J Pagidipati, Neil Poulter, Ambady Ramachandran, Bernard Zinman, Adrian F Hernandez, ,

<h4>Background</h4>The cardiovascular effects of adding once-weekly treatment with exenatide to usual care in patients with type 2 diabetes are unknown.<h4>Methods</h4>We randomly assigned patients with type 2 diabetes, with or without previous cardiovascular disease, to receive subcutaneous injections of extended-release exenatide at a dose of 2 mg or matching placebo once ... Read more >>

N Engl J Med (The New England journal of medicine)
[2017, 377(13):1228-1239]

Cited: 464 times

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Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes.

Bruce Neal, Vlado Perkovic, Kenneth W Mahaffey, Dick de Zeeuw, Greg Fulcher, Ngozi Erondu, Wayne Shaw, Gordon Law, Mehul Desai, David R Matthews, ,

Background Canagliflozin is a sodium-glucose cotransporter 2 inhibitor that reduces glycemia as well as blood pressure, body weight, and albuminuria in people with diabetes. We report the effects of treatment with canagliflozin on cardiovascular, renal, and safety outcomes. Methods The CANVAS Program integrated data from two trials involving a total ... Read more >>

N Engl J Med (The New England journal of medicine)
[2017, 377(7):644-657]

Cited: 1796 times

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Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis.

Steven E Nissen, Neville D Yeomans, Daniel H Solomon, Thomas F Lüscher, Peter Libby, M Elaine Husni, David Y Graham, Jeffrey S Borer, Lisa M Wisniewski, Katherine E Wolski, Qiuqing Wang, Venu Menon, Frank Ruschitzka, Michael Gaffney, Bruce Beckerman, Manuela F Berger, Weihang Bao, A Michael Lincoff, ,

<h4>Background</h4>The cardiovascular safety of celecoxib, as compared with nonselective nonsteroidal antiinflammatory drugs (NSAIDs), remains uncertain.<h4>Methods</h4>Patients who required NSAIDs for osteoarthritis or rheumatoid arthritis and were at increased cardiovascular risk were randomly assigned to receive celecoxib, ibuprofen, or naproxen. The goal of the trial was to assess the noninferiority of celecoxib ... Read more >>

N Engl J Med (The New England journal of medicine)
[2016, 375(26):2519-2529]

Cited: 217 times

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Diffuse Autoimmune Enteropathy and Colopathy in an Adult Patient Successfully Treated With Adalimumab and a Review of the Literature.

Syed Shafae Hasan, Nauman Saleem Siddiqui, Sri Krishna Chaitanya Arudra, Luis de Las Casas, Basil Akpunonu, Ali Nawras,

Autoimmune enteropathy (AIE) is a rare disease that causes intractable diarrhea not responsive to a gluten free diet and must be distinguished from refractory sprue. It is associated with circulating autoantibodies against goblet cells and enterocytes. AIE mainly involves the small intestines, with very few cases reported in adults. Because ... Read more >>

Am J Ther (American journal of therapeutics)
[2016, 23(3):e963-8]

Cited: 7 times

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Efficacy and safety of canagliflozin when used in conjunction with incretin-mimetic therapy in patients with type 2 diabetes.

G Fulcher, D R Matthews, V Perkovic, D de Zeeuw, K W Mahaffey, C Mathieu, V Woo, C Wysham, G Capuano, M Desai, W Shaw, F Vercruysse, G Meininger, B Neal, ,

<h4>Aims</h4>To assess the efficacy and safety of canagliflozin, a sodium glucose co-transporter 2 (SGLT2) inhibitor, in patients with type 2 diabetes enrolled in the CANagliflozin cardioVascular Assessment Study (CANVAS) who were on an incretin mimetic [dipeptidyl peptidase-4 (DPP-4) inhibitor or glucagon-like peptide-1 (GLP-1) receptor agonist].<h4>Methods</h4>CANVAS is a double-blind, placebo-controlled study ... Read more >>

Diabetes Obes Metab (Diabetes, obesity & metabolism)
[2016, 18(1):82-91]

Cited: 39 times

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Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes.

Jennifer B Green, M Angelyn Bethel, Paul W Armstrong, John B Buse, Samuel S Engel, Jyotsna Garg, Robert Josse, Keith D Kaufman, Joerg Koglin, Scott Korn, John M Lachin, Darren K McGuire, Michael J Pencina, Eberhard Standl, Peter P Stein, Shailaja Suryawanshi, Frans Van de Werf, Eric D Peterson, Rury R Holman, ,

<h4>Background</h4>Data are lacking on the long-term effect on cardiovascular events of adding sitagliptin, a dipeptidyl peptidase 4 inhibitor, to usual care in patients with type 2 diabetes and cardiovascular disease.<h4>Methods</h4>In this randomized, double-blind study, we assigned 14,671 patients to add either sitagliptin or placebo to their existing therapy. Open-label use ... Read more >>

N Engl J Med (The New England journal of medicine)
[2015, 373(3):232-242]

Cited: 1014 times

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Cognitive function and brain structure in persons with type 2 diabetes mellitus after intensive lowering of blood pressure and lipid levels: a randomized clinical trial.

Jeff D Williamson, Lenore J Launer, R Nick Bryan, Laura H Coker, Ronald M Lazar, Hertzel C Gerstein, Anne M Murray, Mark D Sullivan, Karen R Horowitz, Jingzhong Ding, Santica Marcovina, Laura Lovato, James Lovato, Karen L Margolis, Christos Davatzikos, Joshua Barzilay, Henry N Ginsberg, Peter E Linz, Michael E Miller, ,

<h4>Importance</h4>Persons with type 2 diabetes mellitus (T2DM) are at increased risk for decline in cognitive function, reduced brain volume, and increased white matter lesions in the brain. Poor control of blood pressure (BP) and lipid levels are risk factors for T2DM-related cognitive decline, but the effect of intensive treatment on ... Read more >>

JAMA Intern Med (JAMA internal medicine)
[2014, 174(3):324-333]

Cited: 66 times

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Stenting and medical therapy for atherosclerotic renal-artery stenosis.

Christopher J Cooper, Timothy P Murphy, Donald E Cutlip, Kenneth Jamerson, William Henrich, Diane M Reid, David J Cohen, Alan H Matsumoto, Michael Steffes, Michael R Jaff, Martin R Prince, Eldrin F Lewis, Katherine R Tuttle, Joseph I Shapiro, John H Rundback, Joseph M Massaro, Ralph B D'Agostino, Lance D Dworkin, ,

<h4>Background</h4>Atherosclerotic renal-artery stenosis is a common problem in the elderly. Despite two randomized trials that did not show a benefit of renal-artery stenting with respect to kidney function, the usefulness of stenting for the prevention of major adverse renal and cardiovascular events is uncertain.<h4>Methods</h4>We randomly assigned 947 participants who had ... Read more >>

N Engl J Med (The New England journal of medicine)
[2014, 370(1):13-22]

Cited: 324 times

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Association of depression with accelerated cognitive decline among patients with type 2 diabetes in the ACCORD-MIND trial.

Mark D Sullivan, Wayne J Katon, Laura C Lovato, Michael E Miller, Anne M Murray, Karen R Horowitz, R Nick Bryan, Hertzel C Gerstein, Santica Marcovina, Basil E Akpunonu, Janice Johnson, Jean Francois Yale, Jeff Williamson, Lenore J Launer,

<h4>Importance</h4>Depression has been identified as a risk factor for dementia among patients with type 2 diabetes mellitus but the cognitive domains and patient groups most affected have not been identified.<h4>Objective</h4>To determine whether comorbid depression in patients with type 2 diabetes accelerates cognitive decline.<h4>Design</h4>A 40-month cohort study of participants in the ... Read more >>

JAMA Psychiatry (JAMA psychiatry)
[2013, 70(10):1041-1047]

Cited: 44 times

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Infective endocarditis and the new AHA guideline.

Basil E Akpunonu, Samih Bittar, Richard C Phinney, Mohammed Taleb,

Infective endocarditis (IE) is becoming a disease of the elderly because of the aging process and increased use of intravascular devices. If undetected, IE has a poor prognosis. Previous guidelines had become cumbersome, and with unintended consequences, ie, excess antibiotic use, potential risk for acquisition of multiple-drug-resistant organisms and adverse ... Read more >>

Geriatrics (Basel) (Geriatrics (Basel, Switzerland))
[2008, 63(8):12-19]

Cited: 2 times

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Recognition and management of aortic stenosis in the elderly.

Basil E Akpunonu,

Geriatrics (Basel) (Geriatrics (Basel, Switzerland))
[2008, 63(4):1 p following 31; author reply 1 p following 31]

Cited: 0 times

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Trends in racial disparities in care.

Basil E Akpunonu, Anand B Mutgi, Sadik A Khuder,

N Engl J Med (The New England journal of medicine)
[2005, 353(19):2081-5; author reply 2081-5]

Cited: 1 time

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Erectile dysfunction.

Basil E Akpunonu, Anand B Mutgi,

Cleve Clin J Med (Cleveland Clinic journal of medicine)
[2005, 72(8):639-40; author reply 640]

Cited: 1 time

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