Full Text Journal Articles by
Author Bartosz Urbaniak

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CSF Proteomics of Patients with Hydrocephalus and Subarachnoid Haemorrhage.

Bartosz Sokół, Bartosz Urbaniak, Bartosz Zaremba, Norbert Wąsik, Zenon J Kokot, Roman Jankowski,

Background:The pathophysiology of brain injury following aneurysmal subarachnoid haemorrhage (SAH) is associated with numerous mediators. The aim of the study is to analyse protein changes after SAH in cerebrospinal fluid (CSF) using mass spectrometry (MS). Methods:CSF samples were obtained from forty-four control subjects, seven good outcome and ten poor outcome ... Read more >>

Transl Neurosci (Translational neuroscience)
[2019, 10:244-253]

Cited: 0 times

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Serum free amino acid levels in rheumatoid arthritis according to therapy and physical disability.

Bartosz Urbaniak, Szymon Plewa, Agnieszka Klupczynska, Dorota Sikorska, Włodzimierz Samborski, Zenon J Kokot,

BACKGROUND:In presented study the amino acid analysis was performed in serum derived from rheumatoid arthritis patients (RA) according to undertaken therapy and classification of physical disability. The results were compared with previously published data. METHODS:The levels of 31 free amino acids were determined in 50 serum samples derived from RA ... Read more >>

Cytokine (Cytokine)
[2019, 113:332-339]

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Corrigendum: Amino Acids in Cerebrospinal Fluid of Patients With Aneurysmal Subarachnoid Haemorrhage: An Observational Study.

Bartosz Sokół, Bartosz Urbaniak, Norbert Wąsik, Szymon Plewa, Agnieszka Klupczyńska, Roman Jankowski, Barbara Więckowska, Robert Juszkat, Zenon Kokot,

[This corrects the article on p. 438 in vol. 8, PMID: 28894433.]. ... Read more >>

Front Neurol (Frontiers in neurology)
[2018, 9:416]

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Proteomic pattern of cervico-vaginal fluid (CVF) in an ovarian cancer diagnosis - pilot study.

Emilia Gasiorowska, Bartosz Urbaniak, Jakub Lorek, Jan Matysiak, Ewa Nowak-Markwitz,

OBJECTIVES:High grade serous ovarian cancer (HGSC) is the most common type of ovarian cancer and is responsible for about 90% of ovarian cancer deaths. The diagnostic tests currently used do not increase the detection rates for ovarian cancer. There is a great necessity to develop new and non-invasive diagnostic tests ... Read more >>

Ginekol. Pol. (Ginekologia polska)
[2018, 89(12):688-694]

Cited: 1 time

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The feature selection approach for evaluation of potential rheumatoid arthritis markers using MALDI-TOF datasets.

Bartosz Urbaniak, Piotr Nowicki, Dorota Sikorska, Włodzimierz Samborski, Zenon J Kokot,

The selection of the most representative mass profiles, in rheumatoid arthritis (RA) serum samples was developed. This allows for selection and identification of potential biomarkers in RA serum samples.The RA and controls samples were analyzed using MALDI-TOF. Two different protein elution procedures utilizing ZipTips (E1 and E2) were examined. The ... Read more >>

Anal. Biochem. (Analytical biochemistry)
[2017, 525:29-37]

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STUDY OF OFLOXACIN ENANTIOMERS DISSOLUTION FROM SELECTED SOLID DOSAGE FORMS USING HIGH PERFORMANCE CAPILLARY ELECTROPHORESIS METHOD.

Bartosz Urbaniak, Bartlomiej Milanowski, Janina Lulek, Zenon J Kokot,

The commercially available coated tablets containing either racemic form of ofloxacin (Tarivid 200 mg, OfloHexal 200 mg and Ofloxacin-Ratiopharm 200 mg) or only levofloxacin S-(-)-isomer (Tavanic 250 mg) were examined. The aim of our study was to establish the kinetics of dissolution rate process of ofloxacin optical isomers (S-(-) and ... Read more >>

Acta Pol Pharm (Acta poloniae pharmaceutica)
[2017, 74(3):955-968]

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PRELIMINARY HIGH PERFORMANCE CAPILLARY ELECTROPHORESIS (HPCE) STUDIES OF ENZYMATIC DEGRADATION OF HYALURONIC ACID BY HYALURONIDASE IN THE PRESENCE OF POLYVALENT METAL IONS.

Bartosz Urbaniak, Szymon Plewa, Zenon Jozef Kokot,

The aim of this study was, at first, to examine the influence of metal ions on digestion process of hyaluronic acid by hyaluronidase (HAse) using high performance capillary electrophoresis (HPCE) method. The influence of copper(H), zinc(Il), manganese(II) ions on enzymatic degradation of HA by hyaluronidase enzyme (HA-se) were investigated. Secondly, ... Read more >>

Acta Pol Pharm (Acta poloniae pharmaceutica)
[2017, 74(1):41-51]

Cited: 1 time

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Activation of Prodrug Treosulfan at pH 7.4 and 37°C Accompanied by Hydrolysis of Its Active Epoxides: Kinetic Studies with Clinical Relevance.

Michał Romański, Bartosz Urbaniak, Zenon Kokot, Franciszek K Główka,

Treosulfan (TREO), originally registered for treatment of ovarian cancer, is currently being investigated for conditioning prior to hematopoietic stem cell transplantation. TREO is a prodrug, which undergoes a pH- and temperature-dependent two-step conversion to active monoepoxide [S,S-EBDM, (2S,3S)-1,2-epoxybutane-3,4-diol-4-methanesulfonate] and diepoxide [S,S-DEB, (2S,3S)-1,2:3,4-diepoxybutane]. In this paper, the kinetics of the nonenzymatic ... Read more >>

J Pharm Sci (Journal of pharmaceutical sciences)
[2015, 104(12):4433-4442]

Cited: 7 times

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Spectroscopic investigations of fluoroquinolones metal ion complexes.

Bartosz Urbaniak, Zenon J Kokot,

The complex formation reaction, between fluoroquinolones (FQ): ciprofloxacin (CPX), enoxacin (ENX), enrofloxacin (ENRX), lomefloxacin (LOMX), levofloxacin (LEVX), ofloxacin (OFX), norfloxacin (NFX), sparfloxacin (SPRX) and aluminum(III), iron(III), copper(II) and zinc(II) ions were investigated. The spectrophotometic titration method in a wide range of pH was utilized for estimation of complex formation equilibrium. ... Read more >>

Acta Pol Pharm (Acta poloniae pharmaceutica)
[2013, 70(4):621-629]

Cited: 1 time

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The pharmacokinetics of the effervescent vs. conventional tramadol/paracetamol fixed-dose combination tablet in patients after total gastric resection.

Edyta Szałek, Agnieszka Karbownik, Dawid Murawa, Karol Połom, Bartosz Urbaniak, Tomasz Grabowski, Anna Wolc, Aleksandra Więckiewicz, Edmund Grześkowiak, Zenon J Kokot, Paweł Murawa, Paweł Burchardt, Sławomir Cieśla,

BACKGROUND:Tramadol/paracetamol is a fixed-dose combination prescribed for the relief of moderate to severe pain. The combination acts synergistically and guarantees the rapid onset of paracetamol and the prolonged analgesic effect of tramadol with good tolerability. These drugs are often used in various formulations in the treatment of patients with postoperative ... Read more >>

Pharmacol Rep (Pharmacological reports : PR)
[2014, 66(1):159-164]

Cited: 2 times

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A new method for determination of hyaluronidase activity in biological samples using capillary zone electrophoresis.

Jan Matysiak, Paweł Dereziński, Bartosz Urbaniak, Agnieszka Klupczyńska, Anna Zalewska, Zenon J Kokot,

The aim of the study was to develop a new capillary zone electrophoresis (CZE) method for determination of enzymatic activity of hyaluronidase. The method permits monitoring of the process of hyaluronic acid digestion by hyaluronidase. Studies were performed using CZE instrument equipped with capillary of 64.5 cm total length, 56 ... Read more >>

Biomed. Chromatogr. (Biomedical chromatography : BMC)
[2013, 27(8):1070-1078]

Cited: 3 times

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Comparison of the pharmacokinetics of paracetamol from two generic products in patients after total gastric resection.

Edyta Szałek, Agnieszka Kamińska, Dawid Murawa, Karol Połom, Bartosz Urbaniak, Matylda Sobiech, Edmund Grześkowiak, Tomasz Grabowski, Anna Wolc, Zenon J Kokot, Paweł Murawa,

Gastrectomy leads to pathophysiological changes within the alimentary tract, which may affect drug absorption and pharmacokinetic parameters (PK). The need to apply orally administered analgesics in this group of patients is often related with alternative application of currently available generic products. Thus, from the clinical point of view it is ... Read more >>

Pharmacol Rep (Pharmacological reports : PR)
[2011, 63(6):1518-1525]

Cited: 1 time

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New CZE-DAD method for honeybee venom analysis and standardization of the product.

Zenon J Kokot, Jan Matysiak, Bartosz Urbaniak, Paweł Dereziński,

The aim of this study was to develop a new precise and accurate CZE-DAD method for honeybee venom analysis using cytochrome c as an internal standard. The 64.5 cm total length, 56 cm effective length, 75 μm ID, and 360 μm OD uncoated fused-silica capillary was used. The samples were ... Read more >>

Anal Bioanal Chem (Analytical and bioanalytical chemistry)
[2011, 399(7):2487-2494]

Cited: 7 times

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Analysis of the factors that significantly influence the stability of fluoroquinolone-metal complexes.

Bartosz Urbaniak, Zenon J Kokot,

The aim of the present study was to evaluate factors contributing to the differences between the overall stability constants (logbeta(pqr)) of the fluoroquinolone-metal ion complexes. The experiments were performed using potentiometric titration method in wide pH range. The overall stability constants (logbeta(pqr)) were determined using the Hyperquad program. Complexation equilibria ... Read more >>

Anal. Chim. Acta (Analytica Chimica Acta)
[2009, 647(1):54-59]

Cited: 9 times

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Flavonoid profiling among wild type and related GM wheat varieties.

Jean-Robert Ioset, Bartosz Urbaniak, Karine Ndjoko-Ioset, Judith Wirth, Frédéric Martin, Wilhelm Gruissem, Kurt Hostettmann, Christof Sautter,

Pleiotropic effects are one of the main concerns regarding genetically modified organisms (GMOs). This includes unintended side effects of the transgene or its genome insertion site on the regulation of other endogenous genes, which could potentially cause the accumulation of different secondary metabolites that may have not only an impact ... Read more >>

Plant Mol. Biol. (Plant molecular biology)
[2007, 65(5):645-654]

Cited: 24 times

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Exploration and Swiss field-testing of a viral gene for specific quantitative resistance against smuts and bunts in wheat.

Thomas Schlaich, Bartosz Urbaniak, Marie-Laure Plissonnier, Nicole Malgras, Christof Sautter,

The viral gene for the killer protein 4 (KP4) has been explored for its antifungal effect in genetically modified wheat to defeat specifically the seed-transmitted smut and bunt diseases. In vitro both important seed-transmitted diseases of wheat, loose smut (Ustilago tritici) and stinking smut (Tilletia caries), are susceptible to KP4, ... Read more >>

Adv. Biochem. Eng. Biotechnol. (Advances in biochemical engineering/biotechnology)
[2007, 107:97-112]

Cited: 2 times

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Increased field resistance to Tilletia caries provided by a specific antifungal virus gene in genetically engineered wheat.

Thomas Schlaich, Bartosz M Urbaniak, Nicole Malgras, Elisabeth Ehler, Christof Birrer, Lukas Meier, Christof Sautter,

The field performance of a viral gene in two Swiss wheat (Triticum aestivum) varieties showed 10% increased fungal resistance against Tilletia caries (stinking smut). To the best of our knowledge, this is the first report of improved resistance against any fungus in the field achieved by genetic engineering in wheat. ... Read more >>

Plant Biotechnol. J. (Plant biotechnology journal)
[2006, 4(1):63-75]

Cited: 12 times

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Validation of HPLC method for determination of six fluoroquinolones: cinoxacin, ciprofloxacin, enoxacin, lomefloxacin, norfloxacin and ofloxacin.

Zenon Kokot, Bartosz Urbaniak,

Acta Pol Pharm (Acta poloniae pharmaceutica)
[2004, 61 Suppl:64-66]

Cited: 1 time

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