Full Text Journal Articles by
Author Bartley Griffith

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Models of Shear-Induced Platelet Activation and Numerical Implementation With Computational Fluid Dynamics Approaches.

Dong Han, Jiafeng Zhang, Bartley P Griffith, Zhongjun J Wu,

Shear-induced platelet activation is one of the critical outcomes when blood is exposed to elevated shear stress. Excessively activated platelets in the circulation can lead to thrombus formation and platelet consumption, resulting in serious adverse events such as thromboembolism and bleeding. While experimental observations reveal that it is related to ... Read more >>

J Biomech Eng (Journal of biomechanical engineering)
[2022, 144(4):]

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An ex-vivo comparison of partial thromboplastin time and activated clotting time for heparin anticoagulation in an ovine model.

Zachary B K Berk, Aakash Shah, Wenji Sun, Bartley P Griffith, Zhongjun J Wu,

<h4>Background</h4>Sheep are a primary model of mechanical circulatory support (MAC) with heparin anticoagulation therapy frequently being monitored by activated clotting time (ACT) due to ease and cost. In patients undergoing long-term heparin therapy, other anticoagulation monitoring strategies, such as activated partial thromboplastin time (aPTT) have proven to be more reliable ... Read more >>

Artif Organs (Artificial organs)
[2021, :]

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Numerical study of the effect of LVAD inflow cannula positioning on thrombosis risk.

Ge He, Lu Han, Jiafeng Zhang, Aakash Shah, David J Kaczorowski, Bartley P Griffith, Zhongjun Wu,

Left ventricular assist devices (LVADs) have been increasingly used as a therapy for patients with end-stage heart failure. However, a growing number of clinical observations have shown that LVADs are associated with thromboembolic events, which are potentially related to the changes in intraventricular flow. Particularly, the flow fields around the ... Read more >>

Comput Methods Biomech Biomed Engin (Computer methods in biomechanics and biomedical engineering)
[2021, :1-9]

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Neutrophil dysfunction due to continuous mechanical shear exposure in mechanically assisted circulation in vitro.

Wenji Sun, Jiafeng Zhang, Aakash Shah, Katherin Arias, Zachary Berk, Bartley P Griffith, Zhongjun J Wu,

<h4>Objective</h4>Leukocytes play an important role in the body's immune system. The aim of this study was to assess alterations in neutrophil phenotype and function in pump-assisted circulation in vitro.<h4>Methods</h4>Human blood was circulated for four hours in three circulatory flow loops with a CentriMag blood pump operated at a flow of ... Read more >>

Artif Organs (Artificial organs)
[2021, :]

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Flow characteristics and hemolytic performance of the new Breethe centrifugal blood pump in comparison with the CentriMag and Rotaflow pumps.

Ge He, Jiafeng Zhang, Aakash Shah, Zachary B Berk, Lu Han, Han Dong, Bartley P Griffith, Zhongjun J Wu,

Blood pumps have been increasingly used in mechanically assisted circulation for ventricular assistance and extracorporeal membrane oxygenation support or during cardiopulmonary bypass for cardiac surgery. However, there have always been common complications such as thrombosis, hemolysis, bleeding, and infection associated with current blood pumps in patients. The development of more ... Read more >>

Int J Artif Organs (The International journal of artificial organs)
[2021, 44(11):829-837]

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The growth of xenotransplanted hearts can be reduced with growth hormone receptor knockout pig donors.

Corbin E Goerlich, Bartley Griffith, Peter Hanna, Susie N Hong, David Ayares, Avneesh K Singh, Muhammad M Mohiuddin,

<h4>Objective</h4>Genetically engineered pigs are thought to be an alternative organ source for patients in end-stage heart failure unable to receive a timely allograft. However, cardiac xenografts exhibit growth and diastolic heart failure within 1 month after transplantation. Grafts function for up to 6 months, but only after administration of temsirolimus and afterload-reducing ... Read more >>

J Thorac Cardiovasc Surg (The Journal of thoracic and cardiovascular surgery)
[2021, :]

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Comparison of two individualized antithrombotic protocols in HeartWare HVAD recipients.

Erik N Sorensen, Michael E Plazak, Lynn M Dees, Wyatt J Klass, Luke A Ziegler, Shannon N Ledroux, Bartley P Griffith, Erika D Feller,

We previously reported low rates of pump thrombosis and hemorrhagic stroke, but increased bleeding, under our original antithrombosis protocol (P1) in HeartWare recipients. We designed and implemented a revised protocol (P2) to reduce complexity and bleeding. Thrombelastography and PFA-100 guide antiplatelet titration. Goals for P2 were altered to decrease antiplatelet ... Read more >>

Artif Organs (Artificial organs)
[2021, :]

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CENTRIFUGAL-FLOW LVAD INFLOW CANNULA POSITION: PREOPERATIVE INFLUENCES AND POSTOPERATIVE OUTCOMES

Erik Sorensen, Bartley Griffith, Erika Feller, Lynn Dees, David Kaczorowski,

<h4>Background: </h4> We previously demonstrated better inflow cannula (IFC) position and reduced pump thrombosis with a centrifugal-flow LVAD (CF-LVAD) compared to an axial-flow device. We hypothesized that implant technique and patient anatomy would affect CF-LVAD IFC positioning and that malposition would impact LV unloading and outcomes. <h4>Methods:</h4> Pre- and postoperative ... Read more >>

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Blood Cardioplegia Induction, Perfusion Storage and Graft Dysfunction in Cardiac Xenotransplantation.

Corbin E Goerlich, Bartley Griffith, Avneesh K Singh, Mohamed Abdullah, Shreya Singireddy, Irina Kolesnik, Billeta Lewis, Faith Sentz, Ivan Tatarov, Alena Hershfeld, Tianshu Zhang, Erik Strauss, Patrick Odonkor, Brittney Williams, Ali Tabatabai, Adnan Bhutta, David Ayares, David J Kaczorowski, Muhammad M Mohiuddin,

<h4>Background</h4>Perioperative cardiac xenograft dysfunction (PCXD) describes a rapidly developing loss of cardiac function after xenotransplantation. PCXD occurs despite genetic modifications to increase compatibility of the heart. We report on the incidence of PCXD using static preservation in ice slush following crystalloid or blood-based cardioplegia versus continuous cold perfusion with XVIVO<sup>©</sup> ... Read more >>

Front Immunol (Frontiers in immunology)
[2021, 12:667093]

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Peripheral cannulation for extracorporeal membrane oxygenation yields superior neurologic outcomes in adult patients who experienced cardiac arrest following cardiac surgery.

Lauren E Levy, David J Kaczorowski, Chetan Pasrija, Gregory Boyajian, Michael Mazzeffi, Eric Krause, Aakash Shah, Ronson Madathil, Kristopher B Deatrick, Daniel Herr, Bartley P Griffith, James S Gammie, Bradley S Taylor, Mehrdad Ghoreishi,

<h4>Background</h4>Extracorporeal cardiopulmonary resuscitation (ECPR) for refractory cardiac arrest has improved mortality in post-cardiac surgery patients; however, loss of neurologic function remains one of the main and devastating complications. We reviewed our experience with ECPR and investigated the effect of cannulation strategy on neurologic outcome in adult patients who experienced cardiac ... Read more >>

Perfusion (Perfusion)
[2021, :2676591211018129]

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Catheter-based interventions versus medical and surgical approaches in acute pulmonary embolism.

Rafael S Cires-Drouet, Khanjan Nagarsheth, David J Kaczorowski, Shahab Toursavadkohi, Kristopher Deatrick, Ronson J Madathil, Kevin M Jones, Steven Liskov, Jeffrey Fitch, Michelle Sayad, Chetan Pasrija, Minerva Mayorga-Carlin, Daniel Herr, John D Sorkin, Bartley Griffith, Brajesh K Lal, James S Gammie,

<h4>Objective</h4>Catheter-based intervention (CBI) has become an increasingly popular option for treating pulmonary embolism (PE); however, the real benefits are unknown. The purpose of the present study was to compare the outcomes of patients treated with CBI with the outcomes of those treated with medical or surgical approaches.<h4>Methods</h4>We performed a retrospective ... Read more >>

J Vasc Surg Venous Lymphat Disord (Journal of vascular surgery. Venous and lymphatic disorders)
[2021, 9(6):1382-1390]

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Ultrasound-assisted catheter directed thrombolysis for pulmonary embolus during extracorporeal membrane oxygenation.

Douglas Tran, Nicole Hays, Aakash Shah, Chetan Pasrija, Rafael S Cires-Drouet, Shahab A Toursavadkohi, Michael A Mazzeffi, Daniel L Herr, Ronson J Madathil, James S Gammie, Bartley P Griffith, Kristopher B Deatrick, David J Kaczorowski,

<h4>Background</h4>Acute pulmonary embolism (PE) is the third most common cause of cardiovascular death. For patients who are hemodynamically unstable, veno-arterial extracorporeal membrane oxygenation (VA-ECMO) support has been shown to provide hemodynamic stability, and allow time for definitive treatment and recovery. Ultrasound-assisted catheter directed thrombolysis (USAT) has the potential to be ... Read more >>

J Card Surg (Journal of cardiac surgery)
[2021, 36(8):2685-2691]

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Venoarterial Extracorporeal Membrane Oxygenation via Direct Axillary Artery Cannulation.

Aakash Shah, Ronson J Madathil, Bartley P Griffith, David J Kaczorowski,

Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is an effective means of support for patients awaiting cardiac or cardiopulmonary transplantation. Typically, peripheral cannulation via the femoral vessels is preferred. However, an alternative is use of the axillary or subclavian artery, which is typically performed via a graft. Here we present the case ... Read more >>

Innovations (Phila) (Innovations (Philadelphia, Pa.))
[2021, 16(3):297-299]

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Progressive Genetic Modifications with Growth Hormone Receptor Knockout Extends Cardiac Xenograft Survival to 9 Months

Muhammad Mohiuddin, Corbin Goerlich, Avneesh Singh, Tianshu Zhang, Ivan Tatarov, Billeta Lewis, Faith Sentz, Alena Hershfeld, Gheorghe Braileanu, Patrick Odonkor, Erik Strauss, Brittney Williams, Allen Burke, Jamie Hittman, Adnan Bhutta, Ali Tabatabai, Anuj Gupta, Todd Vaught, Lorri Sorrells, Kasinath Kuravi, Amy Dandro, Will Eyestone, David Kaczorowski, David Ayares, Bartley Griffith,

We report orthotopic (life-supporting) survival of genetically engineered porcine cardiac xenografts (with 3-9 progressive gene modifications) for almost 9 months in baboon recipients. This work builds on our previously reported heterotopic cardiac xenograft (3 gene modifications) survival up to 945 days with an anti-CD40 monoclonal antibody-based immunosuppression. In this current ... Read more >>

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Inflow Cannula Position Influences Improvement in Mitral Regurgitation After Ventricular Assist Device Implantation.

Chetan Pasrija, Mariem A Sawan, Erik Sorensen, James S Gammie, Ronson Madathil, Douglas Tran, Libin Wang, Van-Khue Ton, Erika Feller, Bartley P Griffith, Zachary N Kon, David J Kaczorowski,

Significant residual mitral regurgitation (MR) after left ventricular assist device (LVAD) implantation has been associated with increased morbidity and mortality. The effect of cannula position on improvement of preexisting MR has yet to be evaluated. Consecutive patients who underwent centrifugal LVAD implantation with >mild preoperative MR and without concomitant mitral ... Read more >>

ASAIO J (ASAIO journal (American Society for Artificial Internal Organs : 1992))
[2021, 67(4):423-429]

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Commentary: Uplifting or down the rabbit hole?

Bartley P Griffith,

JTCVS Tech (JTCVS techniques)
[2021, 7:197-198]

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Clinical Outcomes of Pregnant and Postpartum Extracorporeal Membrane Oxygenation Patients.

Allison S Lankford, Jonathan H Chow, Amanda M Jackson, Marianne Wallis, Samuel M Galvagno, Andrew M Malinow, Ozhan M Turan, Jay A Menaker, Sarah D Crimmins, Raymond Rector, David Kaczorowski, Bartley Griffith, Zachary Kon, Daniel Herr, Michael A Mazzeffi,

<h4>Background</h4>The use of extracorporeal membrane oxygenation (ECMO) as a rescue therapy for cardiopulmonary failure is expanding in critical care medicine. In this case series, we describe the clinical outcomes of 21 consecutive pregnant or postpartum patients that required venovenous (VV) or venoarterial (VA) ECMO. Our objective was to characterize maternal ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2021, 132(3):777-787]

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Minimally Invasive Left Ventricular Assist Device Insertion Facilitates Subsequent Heart Transplant.

Joseph Rabin, Luke A Ziegler, Sarah Cipriano, Ronson J Madathil, Erika D Feller, Erik N Sorensen, Bartley P Griffith, David J Kaczorowski,

<h4>Objective</h4>We have observed that minimally invasive left ventricular assist device (LVAD) insertion leads to more facile re-entry and easier cardiac transplantation. We hypothesize minimally invasive LVAD implantation results in improved outcomes at the time of subsequent heart transplant.<h4>Methods</h4>All adults undergoing cardiac transplantation between October 2015 and March 2019 at our ... Read more >>

Innovations (Phila) (Innovations (Philadelphia, Pa.))
[2021, 16(2):157-162]

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Neutrophil injury and function alterations induced by high mechanical shear stress with short exposure time.

Wenji Sun, Shigang Wang, Jiafeng Zhang, Katherin Arias, Bartley P Griffith, Zhongjun J Wu,

High mechanical shear stresses (HMSS) can cause damage to blood, which manifests as morphologic changes, shortened life span, biochemical alterations, and complete rupture of blood cells and proteins, leading to the alterations of normal blood function. The aim of this study is to determine the state of neutrophil activation and ... Read more >>

Artif Organs (Artificial organs)
[2021, 45(6):577-586]

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A Minimally Invasive Approach to Left Ventricular Assist Device Insertion Facilitates Subsequent Explant.

Luke A Ziegler, Gregory J Bittle, Wyatt J Klass, Erik N Sorensen, Ronson J Madathil, Erika D Feller, Bartley P Griffith, David J Kaczorowski,

A minimally invasive approach to left ventricular assist device (LVAD) insertion may benefit patients at the time of implant, but whether the approach to LVAD insertion influences the outcome of subsequent cardiovascular reoperations is unknown. Here we present the case of a 50-year-old male who underwent LVAD insertion through a ... Read more >>

Innovations (Phila) (Innovations (Philadelphia, Pa.))
[2021, 16(1):104-107]

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Complete percutaneous decannulation from femoral venoarterial extracorporeal membrane oxygenation.

Aakash Shah, Mehrdad Ghoreishi, Bradley S Taylor, Shahab Toursavadkohi, David J Kaczorowski, ,

<h4>Objectives</h4>To evaluate the clinical outcomes and perioperative complications associated with complete percutaneous decannulation of femoral venoarterial extracorporeal membrane oxygenation (VA-ECMO) with the MANTA closure device.<h4>Methods</h4>This is a retrospective analysis of a single surgeon consecutive series of 14 patients at a single center who underwent decannulation from VA-ECMO, 10 of whom ... Read more >>

JTCVS Tech (JTCVS techniques)
[2021, 6:75-81]

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Less-Invasive Aortic Valve Replacement: Trends and Outcomes From The Society of Thoracic Surgeons Database.

Mehrdad Ghoreishi, Vinod H Thourani, Vinay Badhwar, Malek Massad, Lars Svensson, Bradley S Taylor, Chetan Pasrija, James S Gammie, Jeffery P Jacobs, Morgan Cox, Maria Grau-Sepulveda, Matthew Brennan, Bartley P Griffith, Jeffrey C Milliken, Khaled Abdelhady, Zachary Kon,

<h4>Background</h4>This study compares outcomes of conventional and less-invasive (LI) approaches for aortic valve replacement (AVR) using The Society of Thoracic Surgeons database.<h4>Methods</h4>Between 2011 and 2017, we identified 122,474 patients undergoing isolated primary AVR. Patients were categorized into 3 groups: (1) full sternotomy (FS) (n = 98,549; 78%), (2) partial sternotomy (PS) ... Read more >>

Ann Thorac Surg (The Annals of thoracic surgery)
[2021, 111(4):1216-1223]

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Model-Based Design and Optimization of Blood Oxygenators.

Ge He, Tao Zhang, Jiafeng Zhang, Bartley P Griffith, Zhongjun J Wu,

Blood oxygenators, also known as artificial lungs, are widely used in cardiopulmonary bypass surgery to maintain physiologic oxygen (O<sub>2</sub>) and carbon dioxide (CO<sub>2</sub>) levels in blood, and also serve as respiratory assist devices to support patients with lung failure. The time- and cost-consuming method of trial and error is initially ... Read more >>

J Med Device (Journal of medical devices)
[2020, 14(4):041001]

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Computed tomography angiography as an adjunct to computational fluid dynamics for prediction of oxygenator thrombus formation.

Robert G Conway, Jiafeng Zhang, Jean Jeudy, Charles Evans, Tieluo Li, Zhongjun Jon Wu, Bartley P Griffith,

<h4>Introduction</h4>Extracorporeal membrane oxygenation circuit performance can be compromised by oxygenator thrombosis. Stagnant blood flow in the oxygenator can increase the risk of thrombus formation. To minimize thrombogenic potential, computational fluid dynamics is frequently applied for identification of stagnant flow conditions. We investigate the use of computed tomography angiography to identify ... Read more >>

Perfusion (Perfusion)
[2021, 36(3):285-292]

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Strategic application of modular risk components to safely increase lung transplantation volume.

Chetan Pasrija, Nathaniel Parchment, Douglas Tran, Kristen Mackowick, Francesca Boulos, Aldo Iacono, June Kim, Bartley P Griffith, Pablo G Sanchez, Si M Pham, Zachary N Kon,

<h4>Objectives</h4>Considerable growth of individual lung transplant programs remains challenging. We hypothesized that the systematic implementation of modular risk components to a lung transplantation program would allow for expeditious growth without increasing mortality.<h4>Methods</h4>All consecutive patients placed on the lung transplantation waitlist were reviewed. Patients were stratified by an 18-month period surrounding ... Read more >>

J Card Surg (Journal of cardiac surgery)
[2020, 35(9):2177-2184]

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