Full Text Journal Articles by
Author Barry G Timms


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Fetal bisphenol A and ethinylestradiol exposure alters male rat urogenital tract morphology at birth: Confirmation of prior low-dose findings in CLARITY-BPA.

Kristen S Uchtmann, Julia A Taylor, Barry G Timms, Richard W Stahlhut, Emily A Ricke, Mark R Ellersieck, Frederick S Vom Saal, William A Ricke,

Bisphenol A (BPA) is a contaminant in virtually all Americans. To examine BPA's adverse effects, the FDA-NCTR, NIEHS, and 14 groups of academic scientists formed a consortium: CLARITY-BPA. The purpose of our study was to investigate the effects of a wide range of doses of BPA on fetal development of ... Read more >>

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2020, 91:131-141]

Cited: 2 times

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Development of the human prostate.

Gerald R Cunha, Chad M Vezina, Dylan Isaacson, William A Ricke, Barry G Timms, Mei Cao, Omar Franco, Laurence S Baskin,

This paper provides a detailed compilation of human prostatic development that includes human fetal prostatic gross anatomy, histology, and ontogeny of selected epithelial and mesenchymal differentiation markers and signaling molecules throughout the stages of human prostatic development: (a) pre-bud urogenital sinus (UGS), (b) emergence of solid prostatic epithelial buds from ... Read more >>

Differentiation (Differentiation; research in biological diversity)
[2018, 103:24-45]

Cited: 8 times

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Testosterone and 17β-estradiol induce glandular prostatic growth, bladder outlet obstruction, and voiding dysfunction in male mice.

Tristan M Nicholson, Emily A Ricke, Paul C Marker, Joseph M Miano, Robert D Mayer, Barry G Timms, Frederick S vom Saal, Ronald W Wood, William A Ricke,

Benign prostatic hyperplasia (BPH) and bladder outlet obstruction (BOO) are common in older men and can contribute to lower urinary tract symptoms that significantly impact quality of life. Few existing models of BOO and BPH use physiological levels of hormones associated with disease progression in humans in a genetically manipulable ... Read more >>

Endocrinology (Endocrinology)
[2012, 153(11):5556-5565]

Cited: 51 times

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Prostate development and growth in benign prostatic hyperplasia.

Barry G Timms, Luke E Hofkamp,

The etiology of benign prostatic hyperplasia [BPH] in elderly men has intrigued anatomists, pathologists and scientists for centuries. Studies of morbid anatomy, clinical observations and contemporary cellular biology have contributed to an evolving interpretation of the causality of the disease. Insights into the detailed microanatomy and ductal architecture of the ... Read more >>

Differentiation (Differentiation; research in biological diversity)
[2011, 82(4-5):173-183]

Cited: 26 times

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Atypical fetal prostate development is associated with ipsilateral hypoplasia of the wolffian ducts in the ACI rat.

Luke E Hofkamp, Sarahann Bradley, Jan Geliebter, Barry G Timms,

For over a half century, the ACI (August x Copenhagen) rat has been a primary model for studying renal agenesis and ipsilateral hypoplasia (IHP) of the Wolffian-derived structures (WDS). Because the ACI rat is also used as a model for prostate research, it is important to examine the relationship of ... Read more >>

Anat Rec (Hoboken) (Anatomical record (Hoboken, N.J. : 2007))
[2010, 293(5):747-753]

Cited: 1 time

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Prostate development: a historical perspective.

Barry G Timms,

The regional anatomy of the human prostate has been debated periodically over the last century with various levels of controversy and agreement, beginning with the concept of lobes and replaced by the current model of zones. During this period a variety of classifications have been proposed, based upon the studies ... Read more >>

Differentiation (Differentiation; research in biological diversity)
[2008, 76(6):565-577]

Cited: 47 times

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Implications for human health of the extensive bisphenol A literature showing adverse effects at low doses: a response to attempts to mislead the public.

Frederick S vom Saal, Susan C Nagel, Barry G Timms, Wade V Welshons,

Toxicology (Toxicology)
[2005, 212(2-3):244-52, author reply 253-4]

Cited: 23 times

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The importance of appropriate controls, animal feed, and animal models in interpreting results from low-dose studies of bisphenol A.

Frederick S Vom Saal, Catherine A Richter, Rachel R Ruhlen, Susan C Nagel, Barry G Timms, Wade V Welshons,

Interpreting results of studies that report only negative effects is problematic. A number of published studies to determine whether chemicals with estrogenic activity can cause effects at low doses have not taken into account the possibility that the commercial animal feed being used can mask effects of even potent estrogenic ... Read more >>

Birth Defects Res. Part A Clin. Mol. Teratol. (Birth defects research. Part A, Clinical and molecular teratology)
[2005, 73(3):140-145]

Cited: 28 times

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Estrogenic chemicals in plastic and oral contraceptives disrupt development of the fetal mouse prostate and urethra.

Barry G Timms, Kembra L Howdeshell, Lesley Barton, Sarahann Bradley, Catherine A Richter, Frederick S vom Saal,

Exposure of human fetuses to man-made estrogenic chemicals can occur through several sources. For example, fetal exposure to ethinylestradiol occurs because each year approximately 3% of women taking oral contraceptives become pregnant. Exposure to the estrogenic chemical bisphenol A occurs through food and beverages because of significant leaching from polycarbonate ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2005, 102(19):7014-7019]

Cited: 168 times

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2,3,7,8-tetrachlorodibenzo-p-dioxin interacts with endogenous estradiol to disrupt prostate gland morphogenesis in male rat fetuses.

Barry G Timms, Richard E Peterson, Frederick S vom Saal,

Fetal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) interferes with normal development of the male reproductive system in rats and mice. We examined the effects of TCDD on the initial development of the urogenital system (urethra, prostate, and seminal vesicles) in male rat fetuses on gestation day (GD) 20. The number of prostatic ... Read more >>

Toxicol. Sci. (Toxicological sciences : an official journal of the Society of Toxicology)
[2002, 67(2):264-274]

Cited: 15 times

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The role of smooth muscle in regulating prostatic induction.

Axel A Thomson, Barry G Timms, Lesley Barton, Gerald R Cunha, Oliver C Grace,

We have examined the role that smooth muscle plays during prostatic organogenesis and propose that differentiation of a smooth muscle layer regulates prostatic induction by controlling mesenchymal/epithelial interactions. During development of the rat reproductive tract, an area of condensed mesenchyme involved in prostatic organogenesis is formed. This mesenchyme (the ventral ... Read more >>

Development (Development (Cambridge, England))
[2002, 129(8):1905-1912]

Cited: 55 times

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