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Author Barbara Nicol

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Constitutive expression of Steroidogenic factor-1 (NR5A1) disrupts ovarian functions, fertility, and metabolic homeostasis in female mice.

Emmi Rotgers, Barbara Nicol, Karina Rodriguez, Saniya Rattan, Jodi A Flaws, Humphrey Hung-Chang Yao,

Steroid hormones regulate various aspects of physiology, from reproductive functions to metabolic homeostasis. Steroidogenic factor-1 (NR5A1) plays a central role in the development of steroidogenic tissues and their ability to produce steroid hormones. Inactivation of Nr5a1 in the mouse results in a complete gonadal and adrenal agenesis, absence of gonadotropes ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(8):e21770]

Cited: 0 times

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Increased FOXL2 expression alters uterine structures and functions†.

Rong Li, San-Pin Wu, Lecong Zhou, Barbara Nicol, John P Lydon, Humphrey H-C Yao, Francesco J DeMayo,

The transcription factor forkhead box L2 (FOXL2) regulates sex differentiation and reproductive function. Elevated levels of this transcription factor have been observed in the diseases of the uterus, such as endometriosis. However, the impact of elevated FOXL2 expression on uterine physiology remains unknown. In order to determine the consequences of ... Read more >>

Biol Reprod (Biology of reproduction)
[2020, 103(5):951-965]

Cited: 1 time

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Aberrant and constitutive expression of FOXL2 impairs ovarian development and functions in mice.

Barbara Nicol, Karina Rodriguez, Humphrey H-C Yao,

Development and functions of the ovary rely on appropriate signaling and communication between various ovarian cell types. FOXL2, a transcription factor that plays a key role at different stages of ovarian development, is associated with primary ovarian insufficiency and ovarian cancer as a result of its loss-of-function or mutations. In ... Read more >>

Biol Reprod (Biology of reproduction)
[2020, 103(5):966-977]

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In utero exposure to arsenite contributes to metabolic and reproductive dysfunction in male offspring of CD-1 mice.

Karina F Rodriguez, Namya Mellouk, Erica K Ungewitter, Barbara Nicol, Chang Liu, Paula R Brown, Cynthia J Willson, Humphrey H-C Yao,

In utero exposure to arsenite (iAs) is known to increase disease risks later in life. We investigated the effect of in utero exposure to iAs in the drinking water on metabolic and reproductive parameters in male mouse offspring at postnatal and adult stages. Pregnant CD-1 mice were exposed to iAs ... Read more >>

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2020, 95:95-103]

Cited: 1 time

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Canonical Wnt/β-catenin activity and differential epigenetic marks direct sexually dimorphic regulation of Irx3 and Irx5 in developing mouse gonads.

Megan L Koth, S Alexandra Garcia-Moreno, Annie Novak, Kirsten A Holthusen, Anbarasi Kothandapani, Keer Jiang, Makoto Mark Taketo, Barbara Nicol, Humphrey H-C Yao, Christopher R Futtner, Danielle M Maatouk, Joan S Jorgensen,

Members of the Iroquois B (IrxB) homeodomain cluster genes, specifically <i>Irx3</i> and <i>Irx5</i>, are crucial for heart, limb and bone development. Recently, we reported their importance for oocyte and follicle survival within the developing ovary. <i>Irx3</i> and <i>Irx5</i> expression begins after sex determination in the ovary but remains absent in ... Read more >>

Development (Development (Cambridge, England))
[2020, 147(6):]

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Increased FOXL2 Expression Alters Uterine Structures and Functions

Rong Li, San-Pin Wu, Lecong Zhou, Barbara Nicol, John Lydon, Humphrey H-C Yao, Francesco DeMayo,

Transcription factor FOXL2 exhibits an increase in mRNA levels in eutopic endometrial biopsy in endometriosis patients. While FOXL2 is known of regulating sex differentiation and reproductive function, the impact of elevated FOXL2 expression on uterine physiology remains unknown. To answer this question, we generated mice with over expression of FOXL2 ... Read more >>

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RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2.

Barbara Nicol, Sara A Grimm, Frédéric Chalmel, Estelle Lecluze, Maëlle Pannetier, Eric Pailhoux, Elodie Dupin-De-Beyssat, Yann Guiguen, Blanche Capel, Humphrey H-C Yao,

Sex determination of the gonads begins with fate specification of gonadal supporting cells into either ovarian pre-granulosa cells or testicular Sertoli cells. This fate specification hinges on a balance of transcriptional control. Here we report that expression of the transcription factor RUNX1 is enriched in the fetal ovary in rainbow ... Read more >>

Nat Commun (Nature communications)
[2019, 10(1):5116]

Cited: 7 times

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Enhanced Recovery After Surgery to Change Process Measures and Reduce Opioid Use After Cesarean Delivery: A Quality Improvement Initiative.

Monique Hedderson, Derrick Lee, Eric Hunt, Kimberly Lee, Fei Xu, Alex Mustille, Jessica Galin, Cynthia Campbell, Charles Quesenberry, Vivian Reyes, Mengfei Huang, Barbara Nicol, Shirley Paulson, Vincent Liu,

<h4>Objective</h4>To evaluate implementation of an enhanced recovery after surgery (ERAS) program for patients undergoing elective cesarean delivery by comparing opioid exposure, multimodal analgesia use, and other process and outcome measures before and after implementation.<h4>Methods</h4>An ERAS program was implemented among patients undergoing elective cesarean delivery in a large integrated health care ... Read more >>

Obstet Gynecol (Obstetrics and gynecology)
[2019, 134(3):511-519]

Cited: 3 times

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RUNX1 safeguards the identity of the fetal ovary through an interplay with FOXL2

Barbara Nicol, Sara Grimm, Frederic Chalmel, Estelle Lecluze, Maëlle Pannetier, Eric Pailhoux, Elodie Dupin-De-Beyssat, Yann Guiguen, Blanche Capel, Humphrey H.-C. Yao,

Sex determination of the gonads begins with fate specification of gonadal supporting cells into either ovarian granulosa cells or testicular Sertoli cells. This process of fate specification hinges on a balance of transcriptional control. We discovered that expression of the transcription factor RUNX1 is enriched in the fetal ovary in ... Read more >>

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The unusual rainbow trout sex determination gene hijacked the canonical vertebrate gonadal differentiation pathway.

Sylvain Bertho, Amaury Herpin, Adèle Branthonne, Elodie Jouanno, Ayaka Yano, Barbara Nicol, Thomas Muller, Maëlle Pannetier, Eric Pailhoux, Misako Miwa, Goro Yoshizaki, Manfred Schartl, Yann Guiguen,

Evolutionary novelties require rewiring of transcriptional networks and/or the evolution of new gene functions. Sex determination (SD), one of the most plastic evolutionary processes, requires such novelties. Studies on the evolution of vertebrate SD revealed that new master SD genes are generally recruited from genes involved in the downstream SD ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2018, 115(50):12781-12786]

Cited: 8 times

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Genome-wide identification of FOXL2 binding and characterization of FOXL2 feminizing action in the fetal gonads.

Barbara Nicol, Sara A Grimm, Artiom Gruzdev, Greg J Scott, Manas K Ray, Humphrey H-C Yao,

The identity of the gonads is determined by which fate, ovarian granulosa cell or testicular Sertoli cell, the bipotential somatic cell precursors choose to follow. In most vertebrates, the conserved transcription factor FOXL2 contributes to the fate of granulosa cells. To understand FOXL2 functions during gonad differentiation, we performed genome-wide ... Read more >>

Hum Mol Genet (Human molecular genetics)
[2018, 27(24):4273-4287]

Cited: 11 times

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Response to "Comment on 'Effects of in Utero Exposure to Arsenic during the Second Half of Gestation on Reproductive End Points and Metabolic Parameters in Female CD-1 Mice'".

Karina F Rodriguez, Erica K Ungewitter, Yasmin Crespo-Mejias, Chang Liu, Barbara Nicol, Grace E Kissling, Humphrey Hung-Chang Yao,

Environ Health Perspect (Environmental health perspectives)
[2016, 124(3):A46-7]

Cited: 7 times

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Effects of in Utero Exposure to Arsenic during the Second Half of Gestation on Reproductive End Points and Metabolic Parameters in Female CD-1 Mice.

Karina F Rodriguez, Erica K Ungewitter, Yasmin Crespo-Mejias, Chang Liu, Barbara Nicol, Grace E Kissling, Humphrey Hung-Chang Yao,

<h4>Background</h4>Mice exposed to high levels of arsenic in utero have increased susceptibility to tumors such as hepatic and pulmonary carcinomas when they reach adulthood. However, the effects of in utero arsenic exposure on general physiological functions such as reproduction and metabolism remain unclear.<h4>Objectives</h4>We evaluated the effects of in utero exposure ... Read more >>

Environ Health Perspect (Environmental health perspectives)
[2016, 124(3):336-343]

Cited: 17 times

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Gonadal Identity in the Absence of Pro-Testis Factor SOX9 and Pro-Ovary Factor Beta-Catenin in Mice.

Barbara Nicol, Humphrey H-C Yao,

Sex-reversal cases in humans and genetic models in mice have revealed that the fate of the bipotential gonad hinges upon the balance between pro-testis SOX9 and pro-ovary beta-catenin pathways. Our central query was: if SOX9 and beta-catenin define the gonad's identity, then what do the gonads become when both factors ... Read more >>

Biol Reprod (Biology of reproduction)
[2015, 93(2):35]

Cited: 20 times

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Heritable targeted inactivation of the rainbow trout (Oncorhynchus mykiss) master sex-determining gene using zinc-finger nucleases.

Ayaka Yano, Barbara Nicol, Elodie Jouanno, Yann Guiguen,

Gene targeting is a powerful tool for analyzing gene function. Recently, new technology for gene targeting using engineered zinc-finger nucleases (ZFNs) has been described in fish species. However, it has not yet been widely used for cold water and slow developing species, such as Salmonidae. Here, we present the results ... Read more >>

Mar Biotechnol (NY) (Marine biotechnology (New York, N.Y.))
[2014, 16(2):243-250]

Cited: 11 times

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Divergent expression regulation of gonad development genes in medaka shows incomplete conservation of the downstream regulatory network of vertebrate sex determination.

Amaury Herpin, Mateus C Adolfi, Barbara Nicol, Maria Hinzmann, Cornelia Schmidt, Johanna Klughammer, Mareen Engel, Minoru Tanaka, Yann Guiguen, Manfred Schartl,

Genetic control of male or female gonad development displays between different groups of organisms a remarkable diversity of "master sex-determining genes" at the top of the genetic hierarchies, whereas downstream components surprisingly appear to be evolutionarily more conserved. Without much further studies, conservation of sequence has been equalized to conservation ... Read more >>

Mol Biol Evol (Molecular biology and evolution)
[2013, 30(10):2328-2346]

Cited: 35 times

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Building an ovary: insights into establishment of somatic cell lineages in the mouse.

Barbara Nicol, Humphrey H-C Yao,

The molecular pathways that drive the differentiation of somatic cell populations in the testis and ovary have been the subjects of intensive research over the past decade. It is now clear that ovarian differentiation is a coordinate event driven by secreted factors including R-spondin1, WNT4, and follistatin and transcriptional regulators ... Read more >>

Sex Dev (Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation)
[2014, 8(5):243-251]

Cited: 13 times

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The sexually dimorphic on the Y-chromosome gene (sdY) is a conserved male-specific Y-chromosome sequence in many salmonids.

Ayaka Yano, Barbara Nicol, Elodie Jouanno, Edwige Quillet, Alexis Fostier, René Guyomard, Yann Guiguen,

All salmonid species investigated to date have been characterized with a male heterogametic sex-determination system. However, as these species do not share any Y-chromosome conserved synteny, there remains a debate on whether they share a common master sex-determining gene. In this study, we investigated the extent of conservation and evolution ... Read more >>

Evol Appl (Evolutionary applications)
[2013, 6(3):486-496]

Cited: 88 times

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Characterization of rainbow trout gonad, brain and gill deep cDNA repertoires using a Roche 454-Titanium sequencing approach.

Aurélie Le Cam, Julien Bobe, Olivier Bouchez, Cédric Cabau, Olivier Kah, Christophe Klopp, Jean-Jacques Lareyre, Isabelle Le Guen, Jérôme Lluch, Jérôme Montfort, Francois Moreews, Barbara Nicol, Patrick Prunet, Pierre-Yves Rescan, Arianna Servili, Yann Guiguen,

Rainbow trout, Oncorhynchus mykiss, is an important aquaculture species worldwide and, in addition to being of commercial interest, it is also a research model organism of considerable scientific importance. Because of the lack of a whole genome sequence in that species, transcriptomic analyses of this species have often been hindered. ... Read more >>

Gene (Gene)
[2012, 500(1):32-39]

Cited: 3 times

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An immune-related gene evolved into the master sex-determining gene in rainbow trout, Oncorhynchus mykiss.

Ayaka Yano, René Guyomard, Barbara Nicol, Elodie Jouanno, Edwige Quillet, Christophe Klopp, Cédric Cabau, Olivier Bouchez, Alexis Fostier, Yann Guiguen,

Since the discovery of Sry in mammals [1, 2], few other master sex-determining genes have been identified in vertebrates [3-7]. To date, all of these genes have been characterized as well-known factors in the sex differentiation pathway, suggesting that the same subset of genes have been repeatedly and independently selected ... Read more >>

Curr Biol (Current biology : CB)
[2012, 22(15):1423-1428]

Cited: 176 times

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Ovary-predominant wnt4 expression during gonadal differentiation is not conserved in the rainbow trout (Oncorhynchus mykiss).

Barbara Nicol, Adele Guerin, Alexis Fostier, Yann Guiguen,

The Wnt/β-catenin pathway is crucial for ovarian differentiation in mammals, and WNT4 is an important protein that regulates this process. While the role of Wnt4 in gonadal differentiation is relatively well characterized in mammals, little is known regarding its role in teleost fish. Therefore, we investigated the potential activity of ... Read more >>

Mol Reprod Dev (Molecular reproduction and development)
[2012, 79(1):51-63]

Cited: 20 times

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The duplicated rainbow trout (Oncorhynchus mykiss) T-box transcription factors 1, tbx1a and tbx1b, are up-regulated during testicular development.

Ayaka Yano, Barbara Nicol, Adele Guerin, Yann Guiguen,

Tbx1 is a member of the T-box transcription factor gene family involved in embryogenesis and organogenesis. Recently, within a pan-genomic screen using rainbow trout (Oncorhynchus mykiss) cDNA microarrays, we identified a tbx1 homolog with testicular over-expression during sex differentiation. Here, we characterized two very similar rainbow trout tbx1 paralogs, tbx1a ... Read more >>

Mol Reprod Dev (Molecular reproduction and development)
[2011, 78(3):172-180]

Cited: 10 times

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Involvement of ZFPIP/Zfp462 in chromatin integrity and survival of P19 pluripotent cells.

Julie Massé, Audrey Laurent, Barbara Nicol, Daniel Guerrier, Isabelle Pellerin, Stéphane Deschamps,

Toti- or pluripotent cells proliferation and/or differentiation have been shown to be strongly related to nuclear chromatin organization and structure over the last past years. We have recently identified ZFPIP/Zfp462 as a zinc finger nuclear factor necessary for correct cell division during early embryonic developmental steps of vertebrates. We thus ... Read more >>

Exp Cell Res (Experimental cell research)
[2010, 316(7):1190-1201]

Cited: 3 times

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