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Author Baoqing Guo

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Cystathionine gamma-lyase/H2 S signaling facilitates myogenesis under aging and injury condition.

Yanjie Zhang, Laura Masters, Yuehong Wang, Lingyun Wu, Yanxi Pei, Baoqing Guo, Amadeo Parissenti, Simon J Lees, Rui Wang, Guangdong Yang,

Hydrogen sulfide (H<sub>2</sub> S) can be endogenously produced and belongs to the class of signaling molecules known as gasotransmitters. Cystathionine gamma-lyase (CSE)-derived H<sub>2</sub> S is implicated in the regulation of cell differentiation and the aging process, but the involvements of the CSE/H<sub>2</sub> S system in myogenesis upon aging and injury ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(5):e21511]

Cited: 0 times

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Comparison of historical and contemporary isolates of Senecavirus A.

Alexandra C Buckley, David D Michael, Kay S Faaberg, Baoqing Guo, Kyoung-Jin Yoon, Kelly M Lager,

Senecavirus A (SVA) was discovered as a cell culture contaminant in 2002, and multiple attempts to experimentally reproduce disease were unsuccessful. Field reports of porcine idiopathic vesicular disease (PIVD) cases testing PCR positive for SVA in addition to outbreaks of PIVD in Brazil and the United States in 2015 suggested ... Read more >>

Vet Microbiol (Veterinary microbiology)
[2021, 253:108946]

Cited: 0 times

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Single dose combination nanovaccine provides protection against influenza A virus in young and aged mice.

Kathleen Ross, Sujata Senapati, Jessica Alley, Ross Darling, Jonathan Goodman, Matthew Jefferson, Metin Uz, Baoqing Guo, Kyoung-Jin Yoon, David Verhoeven, Marian Kohut, Surya Mallapragada, Michael Wannemuehler, Balaji Narasimhan,

Immunosenescence poses a formidable challenge in designing effective influenza vaccines for aging populations. While approved vaccines against influenza viruses exist, their efficacy in older adults is significantly decreased due to the diminished capabilities of innate and adaptive immune responses. In this work, the ability of a combination nanovaccine containing both ... Read more >>

Biomater Sci (Biomaterials science)
[2019, 7(3):809-821]

Cited: 4 times

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The RNA disruption assay is superior to conventional drug sensitivity assays in detecting cytotoxic drugs.

Jonathan P J Mapletoft, Renée J St-Onge, Baoqing Guo, Phillipe Butler, Twinkle J Masilamani, Lavina D'costa, Laura B Pritzker, Amadeo M Parissenti,

Conventional drug sensitivity assays used to screen prospective anti-cancer agents for cytotoxicity monitor biological processes associated with active growth and proliferation, used as proxies of cell viability. However, these assays are unable to distinguish between growth-arrested (but otherwise viable) cells and non-viable/dead cells. As a result, compounds selected based on ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):8671]

Cited: 0 times

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Utility of a PCR-based method for rapid and specific detection of toxigenic Microcystis spp. in farm ponds.

Jian Yuan, Hyun-Joong Kim, Christopher T Filstrup, Baoqing Guo, Paula Imerman, Steve Ensley, Kyoung-Jin Yoon,

Microcystis is a widespread freshwater cyanobacterium that can produce microcystin, a potent hepatotoxin harmful to animals and humans. Therefore, it is crucial to monitor for the presence of toxigenic Microcystis spp. to provide early warning of potential microcystin contamination. Microscopy, which has been used traditionally to identify Microcystis spp., cannot ... Read more >>

J Vet Diagn Invest (Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc)
[2020, 32(3):369-381]

Cited: 1 time

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High-Speed Railway Intruding Object Image Generating with Generative Adversarial Networks.

Baoqing Guo, Gan Geng, Liqiang Zhu, Hongmei Shi, Zujun Yu,

Foreign object intrusion is a great threat to high-speed railway safety operations. Accurate foreign object intrusion detection is particularly important. As a result of the lack of intruding foreign object samples during the operational period, artificially generated ones will greatly benefit the development of the detection methods. In this paper, ... Read more >>

Sensors (Basel) (Sensors (Basel, Switzerland))
[2019, 19(14):]

Cited: 0 times

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An Adaptive Track Segmentation Algorithm for a Railway Intrusion Detection System.

Yang Wang, Liqiang Zhu, Zujun Yu, Baoqing Guo,

Video surveillance-based intrusion detection has been widely used in modern railway systems. Objects inside the alarm region, or the track area, can be detected by image processing algorithms. With the increasing number of surveillance cameras, manual labeling of alarm regions for each camera has become time-consuming and is sometimes not ... Read more >>

Sensors (Basel) (Sensors (Basel, Switzerland))
[2019, 19(11):]

Cited: 2 times

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Experimental Seneca Valley virus infection in market-weight gilts.

Alexandra Buckley, Vikas Kulshreshtha, Albert van Geelen, Nestor Montiel, Baoqing Guo, Kyoung-Jin Yoon, Kelly Lager,

Seneca Valley virus (SVV) is a picornavirus that causes vesicular disease in swine. Since it is clinically indistinguishable from vesicular disease caused by food-and-mouth disease virus (FMDV), investigations must be performed to rule out this high consequence pathogen. A large portion of these investigations have involved market-weight swine at slaughter ... Read more >>

Vet Microbiol (Veterinary microbiology)
[2019, 231:7-10]

Cited: 2 times

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Efflux inhibition by H2S confers sensitivity to doxorubicin-induced cell death in liver cancer cells.

Eric Stokes, Tian Shuang, Yanjie Zhang, Yanxi Pei, Ming Fu, Baoqing Guo, Amadeo Parissenti, Lingyun Wu, Rui Wang, Guangdong Yang,

<h4>Aims</h4>Hydrogen sulfide (H<sub>2</sub>S), an important gasotransmitter, is involved in a variety of cellular functions and pathophysiologic processes. Drug resistance due to alterations in drug trafficking and metabolism severely limits the effectiveness of cancer therapy. This study examined the role of H<sub>2</sub>S in drug resistance in liver cancer cells.<h4>Materials and methods</h4>Human ... Read more >>

Life Sci (Life sciences)
[2018, 213:116-125]

Cited: 2 times

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Dexamethasone treatment did not exacerbate Seneca Valley virus infection in nursery-age pigs.

Alexandra Buckley, Nestor Montiel, Baoqing Guo, Vikas Kulshreshtha, Albert van Geelen, Hai Hoang, Christopher Rademacher, Kyoung-Jin Yoon, Kelly Lager,

<h4>Background</h4>Senecavirus A, commonly known as Seneca Valley virus (SVV), is a picornavirus that has been infrequently associated with porcine idiopathic vesicular disease (PIVD). In late 2014 there were multiple PIVD outbreaks in several states in Brazil and samples from those cases tested positive for SVV. Beginning in July of 2015, ... Read more >>

BMC Vet Res (BMC veterinary research)
[2018, 14(1):352]

Cited: 1 time

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Genomic Sequence of a Swine Pasivirus Type 1 Strain Identified in U.S. Swine.

Baoqing Guo, Hanjun Kim, Ying Zheng, Huigang Shen, Roman M Pogranichniy, Kent J Schwartz, Ganwu Li, Kyoung-Jin Yoon,

We report for the first time in the United States the identification of a swine pasivirus (SPaV) strain with a genomic sequence identity of less than 80% to other SPaVs reported in Europe and China, using a next-generation sequencing (NGS) technique in sow tissues collected from an animal study conducted ... Read more >>

Genome Announc (Genome announcements)
[2018, 6(6):]

Cited: 0 times

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Alterations in estrogen signalling pathways upon acquisition of anthracycline resistance in breast tumor cells.

Simon Chewchuk, Baoqing Guo, Amadeo Mark Parissenti,

Intrinsic or acquired drug resistance is a major impediment to the successful treatment of women with breast cancer using chemotherapy. We have observed that MCF-7 breast tumor cells selected for resistance to doxorubicin or epirubicin (MCF-7DOX2 and MCF-7EPI cells, respectively) exhibited increased expression of several members of the aldo-keto reductase ... Read more >>

PLoS One (PloS one)
[2017, 12(2):e0172244]

Cited: 3 times

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Role of autophagy and lysosomal drug sequestration in acquired resistance to doxorubicin in MCF-7 cells.

Baoqing Guo, Adam Tam, Stacey A Santi, Amadeo M Parissenti,

<h4>Background</h4>The roles and mechanisms involved in starvation-induced autophagy in mammalian cells have been extensively studied. However, less is known about the potential role for autophagy as a survival pathway in acquired drug resistance in cancer cells under nutrient-rich conditions.<h4>Methods</h4>We selected MCF-7 breast tumor cells for survival in increasing concentrations of ... Read more >>

BMC Cancer (BMC cancer)
[2016, 16(1):762]

Cited: 19 times

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Vesicular Disease in 9-Week-Old Pigs Experimentally Infected with Senecavirus A.

Nestor Montiel, Alexandra Buckley, Baoqing Guo, Vikas Kulshreshtha, Albert VanGeelen, Hai Hoang, Christopher Rademacher, Kyoung-Jin Yoon, Kelly Lager,

Senecavirus A has been infrequently associated with vesicular disease in swine since 1988. However, clinical disease has not been reproduced after experimental infection with this virus. We report vesicular disease in 9-week-old pigs after Sencavirus A infection by the intranasal route under experimental conditions. ... Read more >>

Emerg Infect Dis (Emerging infectious diseases)
[2016, 22(7):1246-1248]

Cited: 29 times

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Complete Genome Sequence of Porcine Sapelovirus Strain USA/IA33375/2015 Identified in the United States.

Qi Chen, Ying Zheng, Baoqing Guo, Jianqiang Zhang, Kyoung-Jin Yoon, Karen M Harmon, Rodger G Main, Ganwu Li,

The complete genome of sapelovirus A, formerly known as porcine sapelovirus (PSV), from a diarrheic pig was sequenced for the first time in the United States (designated PSV USA/IA33375/2015). It shares 87.8% to 83.9% nucleotide identities with other reported PSV strains globally and is most closely related to Asia PSV ... Read more >>

Genome Announc (Genome announcements)
[2016, 4(5):]

Cited: 6 times

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Novel Senecavirus A in Swine with Vesicular Disease, United States, July 2015.

Baoqing Guo, Pablo E Piñeyro, Christopher J Rademacher, Ying Zheng, Ganwu Li, Jian Yuan, Hai Hoang, Phillip C Gauger, Darin M Madson, Kent J Schwartz, Paisley E Canning, Bailey L Arruda, Vickie L Cooper, David H Baum, Daniel C Linhares, Rodger G Main, Kyoung-Jin Yoon,

Emerg Infect Dis (Emerging infectious diseases)
[2016, 22(7):1325-1327]

Cited: 19 times

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Full-Length Genome Sequences of Senecavirus A from Recent Idiopathic Vesicular Disease Outbreaks in U.S. Swine.

Jianqiang Zhang, Pablo Piñeyro, Qi Chen, Ying Zheng, Ganwu Li, Christopher Rademacher, Rachel Derscheid, Baoqing Guo, Kyoung-Jin Yoon, Darin Madson, Phillip Gauger, Kent Schwartz, Karen Harmon, Daniel Linhares, Rodger Main,

Since July 2015, vesicular lesions affecting growing pigs and sows accompanied with neonatal mortality have been reported in multiple U.S. states. Senecavirus A has been consistently detected from these cases. The complete genome sequences of 3 recent U.S. Senecavirus A isolates were determined to further characterize this virus. ... Read more >>

Genome Announc (Genome announcements)
[2015, 3(6):]

Cited: 10 times

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RNA disruption is associated with response to multiple classes of chemotherapy drugs in tumor cell lines.

Rashmi Narendrula, Kyle Mispel-Beyer, Baoqing Guo, Amadeo M Parissenti, Laura B Pritzker, Ken Pritzker, Twinkle Masilamani, Xiaohui Wang, Carita Lannér,

<h4>Background</h4>Cellular stressors and apoptosis-inducing agents have been shown to induce ribosomal RNA (rRNA) degradation in eukaryotic cells. Recently, RNA degradation in vivo was observed in patients with locally advanced breast cancer, where mid-treatment tumor RNA degradation was associated with complete tumor destruction and enhanced patient survival. However, it is not ... Read more >>

BMC Cancer (BMC cancer)
[2016, 16:146]

Cited: 4 times

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A phase I/II trial of epirubicin and docetaxel in locally advanced breast cancer (LABC) on 2-weekly or 3-weekly schedules: NCIC CTG MA.22.

Maureen Elizabeth Trudeau, Judith-Anne W Chapman, Baoqing Guo, Mark J Clemons, Rebecca A Dent, Roberta A Jong, Harriette J Kahn, Kathleen I Pritchard, Lei Han, Patti O'Brien, Lois E Shepherd, Amadeo M Parissenti,

This phase I/II neoadjuvant trial (ClinicalTrials.gov identifier NCT00066443) determined maximally-tolerated doses (MTD), dose-limiting toxicities, response-to-therapy, and explored the role of novel response biomarkers. MA.22 accrued T3N0, any N2 or N3, and T4 breast cancer patients. Treatment was 6 cycles of 3-weekly (Schedule A; N = 47) or 8 cycles of 2-weekly (Schedule ... Read more >>

Springerplus (SpringerPlus)
[2015, 4:631]

Cited: 4 times

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Tumor RNA disruption predicts survival benefit from breast cancer chemotherapy.

Amadeo M Parissenti, Baoqing Guo, Laura B Pritzker, Kenneth P H Pritzker, Xiaohui Wang, Mu Zhu, Lois E Shepherd, Maureen E Trudeau,

In a prior substudy of the CAN-NCIC-MA.22 clinical trial (ClinicalTrials.gov identifier NCT00066443), we observed that neoadjuvant chemotherapy reduced tumor RNA integrity in breast cancer patients, a phenomenon we term "RNA disruption." The purpose of the current study was to assess in the full patient cohort the relationship between mid-treatment tumor ... Read more >>

Breast Cancer Res Treat (Breast cancer research and treatment)
[2015, 153(1):135-144]

Cited: 5 times

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RNA Disruption and Drug Response in Breast Cancer Primary Systemic Therapy.

Kenneth Pritzker, Laura Pritzker, Daniele Generali, Alberto Bottini, Maria Rosa Cappelletti, Baoqing Guo, Amadeo Parissenti, Maureen Trudeau,

<h4>Background</h4>As there is now evidence that switching clinical nonresponders early in primary systemic therapy to alternate treatment regimens can enhance survival in some breast cancer patients, the need for a robust intermediate endpoint that can guide treatment response across all tumor subtypes is urgent. Recently, chemotherapy drugs have been shown ... Read more >>

J Natl Cancer Inst Monogr (Journal of the National Cancer Institute. Monographs)
[2015, 2015(51):76-80]

Cited: 2 times

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Chinese and Vietnamese strains of HP-PRRSV cause different pathogenic outcomes in United States high health swine.

Baoqing Guo, Kelly M Lager, Sarah N Schlink, Marcus E Kehrli, Susan L Brockmeier, Laura C Miller, Sabrina L Swenson, Kay S Faaberg,

An infectious clone of a highly pathogenic PRRSV strain from Vietnam (rSRV07) was prepared and was demonstrated to contain multiple amino acid differences throughout the genome when compared to Chinese highly pathogenic PRRSV strain rJXwn06. Virus rescued from the rSRV07 infectious clone was compared to rJXwn06 and US Type 2 ... Read more >>

Virology (Virology)
[2013, 446(1-2):238-250]

Cited: 16 times

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Distinct genetic alterations occur in ovarian tumor cells selected for combined resistance to carboplatin and docetaxel.

Stephen R Armstrong, Rashmi Narendrula, Baoqing Guo, Amadeo M Parissenti, Katherine L McCallum, Stephanie Cull, Carita Lannér,

<h4>Unlabelled</h4><h4>Background</h4>Current protocols for the treatment of ovarian cancer include combination chemotherapy with a platinating agent and a taxane. However, many patients experience relapse of their cancer and the development of drug resistance is not uncommon, making successful second line therapy difficult to achieve. The objective of this study was to ... Read more >>

J Ovarian Res (Journal of ovarian research)
[2012, 5(1):40]

Cited: 10 times

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Experimental infection of United States swine with a Chinese highly pathogenic strain of porcine reproductive and respiratory syndrome virus.

Baoqing Guo, Kelly M Lager, Jamie N Henningson, Laura C Miller, Sarah N Schlink, Matthew A Kappes, Marcus E Kehrli, Susan L Brockmeier, Tracy L Nicholson, Han-Chun Yang, Kay S Faaberg,

The pathogenesis of Type 2 highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) in 10-week old swine in the United States was investigated. rJXwn06, rescued from an infectious clone of Chinese HP-PRRSV, replicated in swine with at least 100-fold increased kinetics over U.S. strain VR-2332. rJXwn06 caused significant weight ... Read more >>

Virology (Virology)
[2013, 435(2):372-384]

Cited: 63 times

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Analysis of the swine tracheobronchial lymph node transcriptomic response to infection with a Chinese highly pathogenic strain of porcine reproductive and respiratory syndrome virus.

Laura C Miller, Damarius Fleming, Andrew Arbogast, Darrell O Bayles, Baoqing Guo, Kelly M Lager, Jamie N Henningson, Sarah N Schlink, Han-Chun Yang, Kay S Faaberg, Marcus E Kehrli,

<h4>Background</h4>Porcine reproductive and respiratory syndrome virus (PRRSV) is a major pathogen of swine worldwide. Emergence in 2006 of a novel highly pathogenic PRRSV (HP-PRRSV) isolate in China necessitated a comparative investigation into the host transcriptome response in tracheobronchial lymph nodes (TBLN) 13 days post-infection with HP-PRRSV rJXwn06, PRRSV strain VR-2332 ... Read more >>

BMC Vet Res (BMC veterinary research)
[2012, 8:208]

Cited: 19 times

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