Full Text Journal Articles by
Author Baihong Pan

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The role of autophagy in abdominal aortic aneurysm: protective but dysfunctional.

Lei Wang, Shuai Liu, Baihong Pan, Huoying Cai, Haiyang Zhou, Pu Yang, Wei Wang,

Autophagy, an evolutionarily conserved mechanism that promotes cell survival by recycling nutrients and degrading long-lived proteins and dysfunctional organelles, is an important defense mechanism, and its attenuation has been well documented in senescence and aging-related diseases. Abdominal aortic aneurysm (AAA), a well-known aging-related disease, has been defined as a chronic ... Read more >>

Cell Cycle (Cell cycle (Georgetown, Tex.))
[2020, :1-11]

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Peptidylarginine deiminase 2 has potential as both a biomarker and therapeutic target of sepsis.

Yuzi Tian, Shibin Qu, Hasan B Alam, Aaron M Williams, Zhenyu Wu, Qiufang Deng, Baihong Pan, Jing Zhou, Baoling Liu, Xiuzhen Duan, Jianjie Ma, Santanu Mondal, Paul R Thompson, Kathleen A Stringer, Theodore J Standiford, Yongqing Li,

Peptidylarginine deiminases (PADs) are a family of calcium-dependent enzymes that are involved in a variety of human disorders, including cancer and autoimmune diseases. Although targeting PAD4 has shown no benefit in sepsis, the role of PAD2 remains unknown. Here, we report that PAD2 is engaged in sepsis and sepsis-induced acute ... Read more >>

JCI Insight (JCI insight)
[2020, 5(20):]

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LncRNA SENCR suppresses abdominal aortic aneurysm formation by inhibiting smooth muscle cells apoptosis and extracellular matrix degradation.

Zhou Cai, Jianhua Huang, Junxiao Yang, Baihong Pan, Wei Wang, Yangyang Ou, Xianwei Wang, Pu Yang,

Abdominal aortic aneurysm (AAA) is a progressive chronic dilatation of the abdominal aorta without effective medical treatment. This study aims to clarify the potential of long non-coding RNA SENCR as a treatment target in AAA. Angiotensin II (Ang-II) was used to establish AAA mouse model as well as a cell ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, :]

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Inhibition of PAD2 Improves Survival in a Mouse Model of Lethal LPS-Induced Endotoxic Shock.

Zhenyu Wu, Qiufang Deng, Baihong Pan, Hasan B Alam, Yuzi Tian, Umar F Bhatti, Baoling Liu, Santanu Mondal, Paul R Thompson, Yongqing Li,

Endotoxemia induced by lipopolysaccharide (LPS) is an extremely severe syndrome identified by global activation of inflammatory responses. Neutrophil extracellular traps (NETs) play an important role in the development of endotoxemia. Histone hypercitrullination catalyzed by peptidylarginine deiminases (PADs) is a key step of NET formation. We have previously demonstrated that simultaneous ... Read more >>

Inflammation (Inflammation)
[2020, 43(4):1436-1445]

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Inhibition of Phosphatidylinositol 3-Kinase γ by IPI-549 Attenuates Abdominal Aortic Aneurysm Formation in Mice.

Rui Liu, Jianhua Huang, Yingbin Ge, Shuai Liu, Tingting Huang, Huoying Cai, Baihong Pan, Qi Zhang, Pu Yang, Mingmei Liao, Baohui Xu, Wei Wang,

OBJECTIVE:The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signalling pathway plays a pivotal role in abdominal aortic aneurysm (AAA). However, systemic inhibition of this pathway causes serious side effects, thus limiting the clinical use of pan-PI3K inhibitors. In this study, it was hypothesised that the γ subunit of PI3K plays an ... Read more >>

Eur J Vasc Endovasc Surg (European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery)
[2020, 60(2):254-263]

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Spermidine Suppresses Development of Experimental Abdominal Aortic Aneurysms.

Shuai Liu, Tingting Huang, Rui Liu, Huoying Cai, Baihong Pan, Mingmei Liao, Pu Yang, Lei Wang, Jianhua Huang, Yingbin Ge, Baohui Xu, Wei Wang,

Background The protective effects of polyamines on cardiovascular disease have been demonstrated in many studies. However, the roles of spermidine, a natural polyamine, in abdominal aortic aneurysm (AAA) disease have not been studied. In this study, we investigated the influence and potential mechanisms of spermidine treatment on experimental AAA disease. ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, 9(8):e014757]

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An Integrated Plasmo-Photoelectronic Nanostructure Biosensor Detects an Infection Biomarker Accompanying Cell Death in Neutrophils.

Younggeun Park, Byunghoon Ryu, Qiufang Deng, Baihong Pan, Yujing Song, Yuzi Tian, Hasan B Alam, Yongqing Li, Xiaogan Liang, Katsuo Kurabayashi,

Bacterial infections leading to sepsis are a major cause of deaths in the intensive care unit. Unfortunately, no effective methods are available to capture the early onset of infectious sepsis near the patient with both speed and sensitivity required for timely clinical treatment. To fill the gap, the authors develop ... Read more >>

Small (Small (Weinheim an der Bergstrasse, Germany))
[2020, 16(1):e1905611]

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Protective Effect of Tubastatin A in CLP-Induced Lethal Sepsis.

Qiufang Deng, Ting Zhao, Baihong Pan, Isabel S Dennahy, Xiuzhen Duan, Aaron M Williams, Baoling Liu, Nan Lin, Umar F Bhatti, Eric Chen, Hasan B Alam, Yongqing Li,

We have found earlier that Tubastatin A (TubA), a selective inhibitor of histone deacetylase 6 (HDAC6), improves survival in a mouse model of lethal cecal ligation and puncture (CLP)-induced sepsis. However, the underlying mechanisms have not been fully established. This study sought to test the hypothesis that TubA could affect ... Read more >>

Inflammation (Inflammation)
[2018, 41(6):2101-2109]

Cited: 2 times

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Inhibition of peptidylarginine deiminase alleviates LPS-induced pulmonary dysfunction and improves survival in a mouse model of lethal endotoxemia.

Yingjian Liang, Baihong Pan, Hasan B Alam, Qiufang Deng, Yibing Wang, Eric Chen, Baoling Liu, Yuzi Tian, Aaron M Williams, Xiuzhen Duan, Yanming Wang, Jifeng Zhang, Yongqing Li,

Immune cell death caused by neutrophil extracellular traps (NETs), referred to as NETosis, can contribute to the pathogenesis of endotoxemia and organ damage. Although the mechanisms by which infection induces NETosis and how that leads to organ dysfunction remain largely unknown, NET formation is often found following citrullination of histone ... Read more >>

Eur J Pharmacol (European journal of pharmacology)
[2018, 833:432-440]

Cited: 6 times

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CitH3: a reliable blood biomarker for diagnosis and treatment of endotoxic shock.

Baihong Pan, Hasan B Alam, Wei Chong, James Mobley, Baoling Liu, Qiufang Deng, Yinjian Liang, Yanming Wang, Eric Chen, Tianbing Wang, Muneesh Tewari, Yongqing Li,

Current biomarkers for sepsis are limited by their non-specificity, short half-life, and insensitive response to therapy. Recently, we have demonstrated that citrullinated histone H3(CitH3) is released into the blood from neutrophil extracellular traps(NETs) in response to severe infection, and CitH3 may be a potential biomarker for sepsis. In the present ... Read more >>

Sci Rep (Scientific reports)
[2017, 7(1):8972]

Cited: 12 times

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Lung Protective Effects of Low-Volume Resuscitation and Pharmacologic Treatment of Swine Subjected to Polytrauma and Hemorrhagic Shock.

Vahagn C Nikolian, Baihong Pan, Tomaz Mesar, Isabel S Dennahy, Patrick E Georgoff, Xiuzhen Duan, Baoling Liu, Xizi Wu, Michael J Duggan, Hasan B Alam, Yongqing Li,

Hemorrhage is a common cause of death in the battlefield. Valproic acid (VPA) has been associated with improved outcomes in multiple models of trauma, when combined with isotonic fluid resuscitation. However, isotonic fluid administered in this setting is logistically impractical and may be associated with complications. In this study, we ... Read more >>

Inflammation (Inflammation)
[2017, 40(4):1264-1274]

Cited: 1 time

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Protective effect of Cl-amidine against CLP-induced lethal septic shock in mice.

Ting Zhao, Baihong Pan, Hasan B Alam, Baoling Liu, Roderick T Bronson, Qiufang Deng, Erxi Wu, Yongqing Li,

Production of innate and adaptive immune cells from hematopoietic stem cells, and maturation of T lymphocytes are effective immune responses to fight severe microbial infection. In sepsis, this emergency myelopoiesis is damaged, leading to failure of bacterial clearance, and excessive stress-induced steroids cause immature T-lymphocyte apoptosis in thymus. We recently ... Read more >>

Sci Rep (Scientific reports)
[2016, 6:36696]

Cited: 12 times

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Inhibition of histone deacetylase 6 restores intestinal tight junction in hemorrhagic shock.

Zhigang Chang, Yongqing Li, Wei He, Baoling Liu, Xiuzhen Duan, Ihab Halaweish, Ted Bambakidis, Baihong Pan, Yingjian Liang, Vahagn C Nikolian, Patrick Georgoff, Hasan B Alam,

BACKGROUND:We recently discovered that Tubastatin-A, a histone deacetylase (HDAC6) inhibitor, can improve survival in a rodent model of hemorrhagic shock (HS), but mechanisms remain poorly defined. In this study, we investigated whether Tubastatin-A could protect intestinal tight junction (TJ) in HS. METHODS:In an in-vivo study with Wistar-Kyoto rats, the rats ... Read more >>

J Trauma Acute Care Surg (The journal of trauma and acute care surgery)
[2016, 81(3):512-519]

Cited: 6 times

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Inhibition of histone deacetylase 6 restores innate immune cells in the bone marrow in a lethal septic model.

Ting Zhao, Yongqing Li, Baoling Liu, Baihong Pan, Xin Cheng, Patrick Georgoff, Hasan B Alam,

BACKGROUND:We have previously demonstrated that Tubastatin A, a selective inhibitor of histone deacetylase 6 (HDAC6), improves survival and increases circulating monocyte count and bacterial clearance in a lethal model of cecal ligation and puncture (CLP) in mice. The aim of the present study was to characterize the effects of inhibition ... Read more >>

J Trauma Acute Care Surg (The journal of trauma and acute care surgery)
[2016, 80(1):34-40; discussion 40-1]

Cited: 7 times

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