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Author B Mark Smithers

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Contemporary management of locoregionally advanced melanoma in Australia and New Zealand and the role of adjuvant systemic therapy.

B Mark Smithers, Robyn P M Saw, David E Gyorki, Richard C W Martin, Victoria Atkinson, Andrew Haydon, Rachel Roberts-Thomson, John F Thompson,

Australia and New Zealand have the highest incidence and mortality rates for melanoma in the world. Local surgery is still the standard treatment of primary cutaneous melanoma, and it is therefore important that surgeons understand the optimal care pathways for patients with melanoma. Accurate staging is critical to ensure a ... Read more >>

ANZ J Surg (ANZ journal of surgery)
[2021, 91 Suppl 2:3-13]

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Increased melanoma recurrence in patients with multiple primary invasive melanomas.

Adele C Green, Maria Celia B Hughes, Gail M Williams, Maryrose Malt, Vanessa L Beesley, Kiarash Khosrotehrani, B Mark Smithers,

J Am Acad Dermatol (Journal of the American Academy of Dermatology)
[2021, :]

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Radiomics Biomarkers Correlate with CD8 Expression and Predict Immune Signatures in Melanoma Patients.

Lauren G Aoude, Bernadette Z Y Wong, Vanessa F Bonazzi, Sandra Brosda, Shaun B Walters, Lambros T Koufariotis, Marjan M Naeini, John V Pearson, Harald Oey, Kalpana Patel, Julia J Bradford, Conor J Bloxham, Victoria Atkinson, Phillip Law, Geoffrey Strutton, Gerard Bayley, Samuel Yang, B Mark Smithers, Nicola Waddell, Kenneth Miles, Andrew P Barbour,

Treatment for metastatic melanoma includes targeted and/or immunotherapy. Although many patients respond, only a subset has complete response. As late-stage patients often have multiple tumors in difficult access sites, non-invasive techniques are necessary for the development of predictive/prognostic biomarkers. PET/CT scans from 52 patients with stage III/IV melanoma were assessed ... Read more >>

Mol Cancer Res (Molecular cancer research : MCR)
[2021, 19(6):950-956]

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Pulmonary metastasectomy in the era of targeted therapy and immunotherapy.

Christopher Y Bong, B Mark Smithers, Terence C Chua,

Metastatic melanoma is a fatal malignancy with a high mortality and morbidity. Since the early 1970s, available medical therapies were limited in improving survival. Surgery represented the best chance for a cure. However, surgery could only be offered to selected patients. The current landscape of treatment has radically evolved since ... Read more >>

J Thorac Dis (Journal of thoracic disease)
[2021, 13(4):2618-2627]

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Preoperative Ultrasound Assessment of Regional Lymph Nodes in Melanoma Patients Does not Provide Reliable Nodal Staging: Results From a Large Multicenter Trial.

John F Thompson, Lauren E Haydu, Roger F Uren, Robert H Andtbacka, Jonathan S Zager, Peter D Beitsch, Doreen M Agnese, Nicola Mozzillo, Alessandro Testori, Tawnya L Bowles, Harald J Hoekstra, Mark C Kelley, Jeffrey Sussman, Schlomo Schneebaum, B Mark Smithers, Gregory McKinnon, Eddy Hsueh, Lisa Jacobs, Erwin Schultz, Douglas Reintgen, John M Kane, Erica B Friedman, Hejing Wang, Lisa Van Kreuningen, Vicki Schiller, David A Elashoff, Robert Elashoff, Alistair J Cochran, Stacey Stern, Mark B Faries, ,

<h4>Objective</h4>To assess whether preoperative ultrasound (US) assessment of regional lymph nodes in patients who present with primary cutaneous melanoma provides accurate staging.<h4>Background</h4>It has been suggested that preoperative US could avoid the need for sentinel node (SN) biopsy, but in most single-institution reports, the sensitivity of preoperative US has been low.<h4>Methods</h4>Preoperative ... Read more >>

Ann Surg (Annals of surgery)
[2021, 273(4):814-820]

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Hospital characteristics associated with better 'quality of surgery' and survival following oesophagogastric cancer surgery in Queensland: a population-level study.

Aaditya Narendra, Peter D Baade, Joanne F Aitken, Jonathan Fawcett, Brandon Leggett, Callum Leggett, Kevin Tian, Theodore Sklavos, B Mark Smithers,

<h4>Background</h4>The impact of hospital characteristics on the quality of surgery and survival following oesophagogastric cancer surgery has not been well established in Australia. We assessed the interaction between hospital volume, service capability and surgical outcomes, with the hypothesis that both the quality of surgery and survival are better following treatment ... Read more >>

ANZ J Surg (ANZ journal of surgery)
[2021, 91(3):323-328]

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Pathogenic germline variants are associated with poor survival in stage III/IV melanoma patients.

Lauren G Aoude, Vanessa F Bonazzi, Sandra Brosda, Kalpana Patel, Lambros T Koufariotis, Harald Oey, Katia Nones, Scott Wood, John V Pearson, James M Lonie, Melissa Arneil, Victoria Atkinson, B Mark Smithers, Nicola Waddell, Andrew P Barbour,

Patients with late stage resected cutaneous melanoma have poor overall survival (OS) and experience irreversible adverse events from systemic therapy. There is a clinical need to identify biomarkers to predict outcome. Performing germline/tumour whole-exome sequencing of 44 stage III/IV melanoma patients we identified pathogenic germline mutations in CDKN2A, CDK4, ATM, ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):17687]

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Oncologic Outcomes After Isolated Limb Infusion for Advanced Melanoma: An International Comparison of the Procedure and Outcomes Between the United States and Australia.

Michael J Carr, James Sun, Hidde M Kroon, John T Miura, Georgia M Beasley, Norma E Farrow, Paul J Mosca, Michael C Lowe, Clara R Farley, Youngchul Kim, Syeda Mahrukh Hussnain Naqvi, Dennis A Kirichenko, Aishwarya Potdar, Hala Daou, Dean Mullen, Jeffrey M Farma, Michael A Henderson, David Speakman, Jonathan Serpell, Keith A Delman, B Mark Smithers, Brendon J Coventry, Douglas S Tyler, John F Thompson, Jonathan S Zager,

<h4>Background</h4>Isolated limb infusion (ILI) is a minimally invasive procedure for delivering high-dose chemotherapy to extremities affected by locally advanced or in-transit melanoma. This study compared the outcomes of melanoma patients treated with ILI in the United States of America (USA) and Australia (AUS).<h4>Methods</h4>Patients with locally recurrent in-transit melanoma treated with ... Read more >>

Ann Surg Oncol (Annals of surgical oncology)
[2020, 27(13):5107-5118]

Cited: 1 time

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Germline and somatic albinism variants in amelanotic/hypomelanotic melanoma: Increased carriage of TYR and OCA2 variants.

Jenna E Rayner, David L Duffy, Darren J Smit, Kasturee Jagirdar, Katie J Lee, Brian De'Ambrosis, B Mark Smithers, Erin K McMeniman, Aideen M McInerney-Leo, Helmut Schaider, Mitchell S Stark, H Peter Soyer, Richard A Sturm,

Amelanotic/hypomelanotic melanoma is a clinicopathologic subtype with absent or minimal melanin. This study assessed previously reported coding variants in albinism genes (TYR, OCA2, TYRP1, SLC45A2, SLC24A5, LRMDA) and common intronic, regulatory variants of OCA2 in individuals with amelanotic/hypomelanotic melanoma, pigmented melanoma cases and controls. Exome sequencing was available for 28 ... Read more >>

PLoS One (PloS one)
[2020, 15(9):e0238529]

Cited: 1 time

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Intraoperative fluid restriction during enhanced recovery after surgery versus liberal fluids for esophagectomy: A single center retrospective pilot study.

Rachel L Ng, Iain G Thomson, B Mark Smithers, Anton W G Booth,

J Clin Anesth (Journal of clinical anesthesia)
[2020, 67:110030]

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Factors predicting toxicity and response following isolated limb infusion for melanoma: An international multi-centre study.

Timothy J Kenyon-Smith, Hidde M Kroon, John T Miura, Jüri Teras, Georgia M Beasley, Dean Mullen, Norma E Farrow, Paul J Mosca, Michael C Lowe, Clara R Farley, Aishwarya Potdar, Hala Daou, James Sun, Jeffrey M Farma, Michael A Henderson, David Speakman, Jonathan Serpell, Keith A Delman, B Mark Smithers, Andrew Barbour, Brendon J Coventry, Douglas S Tyler, Jonathan S Zager, John F Thompson,

<h4>Introduction</h4>Isolated limb infusion (ILI) is a minimally-invasive procedure for delivering high-dose regional chemotherapy to treat melanoma in-transit metastases confined to a limb. The aim of this international multi-centre study was to identify predictive factors for toxicity and response.<h4>Methods</h4>Data of 687 patients who underwent a first ILI for melanoma in-transit metastases ... Read more >>

Eur J Surg Oncol (European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology)
[2020, 46(11):2140-2146]

Cited: 1 time

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Anxiety and depression after diagnosis of high-risk primary cutaneous melanoma: a 4-year longitudinal study.

Vanessa L Beesley, Maria Celia B Hughes, B Mark Smithers, Kiarash Khosrotehrani, Maryrose K Malt, Lena A von Schuckmann, Adèle C Green,

<h4>Purpose</h4>To quantify the prevalence of anxiety or depression (overall; melanoma-related) among people with high-risk primary melanoma, their related use of mental health services and medications, and factors associated with persistent new-onset symptoms across 4 years post-diagnosis.<h4>Methods</h4>A longitudinal study of 675 patients newly diagnosed with tumor-stage 1b-4b melanoma. Participants completed the Hospital ... Read more >>

J Cancer Surviv (Journal of cancer survivorship : research and practice)
[2020, 14(5):712-719]

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Patterns of Omega-3 and Omega-6 Fatty Acid Dietary Intake and Melanoma Thickness at Diagnosis.

Yahya Mahamat-Saleh, Maria Celia B Hughes, Kyoko Miura, Maryrose K Malt, Lena von Schuckmann, Kiarash Khosrotehrani, B Mark Smithers, Adèle C Green,

<h4>Background</h4>Experimental evidence suggests that dietary intakes of omega-3 and omega-6 polyunsaturated fatty acids have divergent effects on melanoma growth, but epidemiologic evidence on their combined effect is lacking.<h4>Methods</h4>In 634 Australian patients with primary melanoma, we assessed prediagnosis consumption of 39 food groups by food frequency questionnaires completed within 2 months ... Read more >>

Cancer Epidemiol Biomarkers Prev (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology)
[2020, 29(8):1647-1653]

Cited: 1 time

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International Multicenter Experience of Isolated Limb Infusion for In-Transit Melanoma Metastases in Octogenarian and Nonagenarian Patients.

Jüri Teras, Hidde M Kroon, John T Miura, Tim Kenyon-Smith, Georgia M Beasley, Dean Mullen, Norma E Farrow, Paul J Mosca, Michael C Lowe, Clara R Farley, Aishwarya Potdar, Hala Daou, James Sun, Michael Carr, Jeffrey M Farma, Michael A Henderson, David Speakman, Jonathan Serpell, Keith A Delman, B Mark Smithers, Andrew Barbour, Douglas S Tyler, Brendon J Coventry, Jonathan S Zager, John F Thompson,

<h4>Background</h4>Isolated limb infusion (ILI) is used to treat in-transit melanoma metastases confined to an extremity. However, little is known about its safety and efficacy in octogenarians and nonagenarians (ON).<h4>Patients and methods</h4>ON patients (≥ 80 years) who underwent a first ILI for American Joint Committee on Cancer seventh edition stage IIIB/IIIC melanoma between ... Read more >>

Ann Surg Oncol (Annals of surgical oncology)
[2020, 27(5):1420-1429]

Cited: 2 times

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Regional nodal metastasis and 5-year survival in patients with thin melanoma in Queensland: a population-based study.

Harrison Theile, Julie Moore, Nathan Dunn, Danica Cossio, Catherine E Forristal, Adele C Green, B Mark Smithers,

<h4>Background</h4>Optimal management of regional lymph nodes for thin cutaneous melanoma is uncertain. We evaluated regional lymph node involvement and 5-year melanoma-specific survival (MSS) in patients with thin (≤1 mm) primary melanoma.<h4>Methods</h4>Patients with a melanoma, American Joint Committee on Cancer Staging 8th Edition pT1a (<0.8 mm) or pT1b (ulceration; and/or 0.8-1.0 mm), diagnosed during ... Read more >>

ANZ J Surg (ANZ journal of surgery)
[2020, 90(4):503-507]

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Prognostic implications of biopsy with tumor transection for patients with high-risk primary melanoma.

Lena A von Schuckmann, Kiarash Khosrotehrani, Maria Celia B Hughes, Jolieke C van der Pols, Maryrose Malt, B Mark Smithers, Adele C Green,

J Am Acad Dermatol (Journal of the American Academy of Dermatology)
[2020, 82(6):1521-1524]

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Accuracy of mobile digital teledermoscopy for skin self-examinations in adults at high risk of skin cancer: an open-label, randomised controlled trial.

Monika Janda, Caitlin Horsham, Dimitrios Vagenas, Lois J Loescher, Nicole Gillespie, Uyen Koh, Clara Curiel-Lewandrowski, Rainer Hofmann-Wellenhof, Allan Halpern, David C Whiteman, Jennifer A Whitty, B Mark Smithers, H Peter Soyer,

<h4>Background</h4>Skin self-examinations supplemented with mobile teledermoscopy might improve early detection of skin cancers compared with naked-eye skin self-examinations. We aimed to assess whether mobile teledermoscopy-enhanced skin self-examination can improve sensitivity and specificity of self-detection of skin cancers when compared with naked-eye skin self-examination.<h4>Methods</h4>This randomised, controlled trial was done in Brisbane ... Read more >>

Lancet Digit Health (The Lancet. Digital health)
[2020, 2(3):e129-e137]

Cited: 1 time

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Impact of hospital resection volume and service capability on post-operative mortality following gastrectomy.

Aaditya Narendra, Peter D Baade, Joanne F Aitken, Jonathan Fawcett, B Mark Smithers,

<h4>Background</h4>Improved post-operative mortality following gastrectomy for cancer in hospitals with higher resection volumes has not been reported in Australia. Using a population-based study in Queensland, we aimed to compare post-operative mortality following gastrectomy between high- and low-volume hospitals stratified by their service capability.<h4>Methods</h4>All patients undergoing gastrectomy for adenocarcinoma in Queensland ... Read more >>

ANZ J Surg (ANZ journal of surgery)
[2020, 90(1-2):86-91]

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Evaluation of the efficacy of 3D total-body photography with sequential digital dermoscopy in a high-risk melanoma cohort: protocol for a randomised controlled trial.

Clare Amy Primiero, Aideen M McInerney-Leo, Brigid Betz-Stablein, David C Whiteman, Louisa Gordon, Liam Caffery, Joanne F Aitken, Elizabeth Eakin, Sonya Osborne, Len Gray, B Mark Smithers, Monika Janda, H Peter Soyer, Anna Finnane,

<h4>Introduction</h4>Melanoma is Australia's fourth most common cancer. Early detection is fundamental in maximising health outcomes and minimising treatment costs. To date, population-based screening programmes have not been justified in health economic studies. However, a skin surveillance approach targeting high-risk individuals could improve the cost-benefit ratio.<h4>Methods and analysis</h4>This paper describes a ... Read more >>

BMJ Open (BMJ open)
[2019, 9(11):e032969]

Cited: 2 times

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New treatment paradigms for clinically apparent metastatic melanoma in regional lymph nodes.

Michael A Henderson, John Spillane, T Michael Hughes, Andrew J Spillane, B Mark Smithers, John F Thompson,

ANZ J Surg (ANZ journal of surgery)
[2019, 89(10):1187-1189]

Cited: 0 times

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IRF4 rs12203592*T/T genotype is associated with nodular melanoma.

Jenna E Rayner, Erin K McMeniman, David L Duffy, Brian De'Ambrosis, B Mark Smithers, Kasturee Jagirdar, Katie J Lee, H Peter Soyer, Richard A Sturm,

Melanoma Res (Melanoma research)
[2019, 29(4):445-446]

Cited: 1 time

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Risk of Melanoma Recurrence After Diagnosis of a High-Risk Primary Tumor.

Lena A von Schuckmann, Maria Celia B Hughes, Reza Ghiasvand, Maryrose Malt, Jolieke C van der Pols, Vanessa L Beesley, Kiarash Khosrotehrani, B Mark Smithers, Adele C Green,

<h4>Importance</h4>With emerging new systemic treatments for metastatic melanoma, early detection of disease recurrence is increasingly important.<h4>Objective</h4>To investigate the risk of melanoma recurrence in patients with a localized melanoma at a high risk of metastasis.<h4>Design, setting, and participants</h4>A total of 1254 patients with newly diagnosed, histologically confirmed tumor category T1b to ... Read more >>

JAMA Dermatol (JAMA dermatology)
[2019, 155(6):688-693]

Cited: 6 times

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The Impact of Signet Ring Cell Differentiation on Outcome in Patients with Esophageal and Gastroesophageal Junction Adenocarcinoma.

Sander J M van Hootegem, B Mark Smithers, David C Gotley, Sandra Brosda, Iain G Thomson, Janine M Thomas, Michael Gartside, Jan J B van Lanschot, Sjoerd M Lagarde, Bas P L Wijnhoven, Andrew P Barbour,

<h4>Background</h4>Little is known about the association between signet ring cell (SRC) differentiation and response to neoadjuvant chemotherapy (nCT) or neoadjuvant chemoradiotherapy (nCRT) in patients with esophageal and junctional adenocarcinoma (EAC). We aimed to assess if SRC differentiation is associated with survival and response to nCT or nCRT in patients with ... Read more >>

Ann Surg Oncol (Annals of surgical oncology)
[2019, 26(8):2375-2384]

Cited: 5 times

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Conclusions from quality of life studies in patients with resected high-risk melanoma: one part of the full story.

B Mark Smithers,

Lancet Oncol (The Lancet. Oncology)
[2019, 20(5):611-612]

Cited: 0 times

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Evaluation of the efficacy and toxicity of upper extremity isolated limb infusion chemotherapy for melanoma: An Australian multi-center study.

Hidde M Kroon, Brendon J Coventry, Michael A Henderson, Andrew Barbour, Jonathan Serpell, B Mark Smithers, John F Thompson,

<h4>Background</h4>Isolated limb infusion (ILI) is a minimally invasive treatment for patients with locally advanced extremity melanoma. Most studies combine results of upper-limb ILI (UL-ILI) and lower-limb ILI (LL-ILI), leaving UL-ILIs relatively underreported as LL-ILIs comprise the vast majority in these reports. However, differences between the two procedures may be clinically ... Read more >>

Eur J Surg Oncol (European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology)
[2019, 45(5):832-837]

Cited: 0 times

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