Full Text Journal Articles by
Author B J Bradford

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Effects of sodium salicylate and time postpartum on mammary tissue proliferation, gene transcript profile, and DNA methylation.

C M Ylioja, A J Carpenter, L K Mamedova, K M Daniels, P J Ross, S L Laflin, T H Swartz, B J Bradford,

Previous studies have demonstrated nonsteroidal antiinflammatory drug treatment in early lactation had a positive impact on whole-lactation milk production in older cows. The objective of this study was to evaluate proliferative, transcriptional, and epigenetic changes in the mammary gland that could explain increased production responses due to nonsteroidal antiinflammatory drug ... Read more >>

J Dairy Sci (Journal of dairy science)
[2021, :]

Cited: 0 times

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Invited review: Mechanisms of hypophagia during disease.

W E Brown, B J Bradford,

Suppression of appetite, or hypophagia, is among the most recognizable effects of disease in livestock, with the potential to impair growth, reproduction, and lactation. The continued evolution of the field of immunology has led to a greater understanding of the immune and endocrine signaling networks underlying this conserved response to ... Read more >>

J Dairy Sci (Journal of dairy science)
[2021, :]

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Effects of milk feeding strategies on short- and long-term productivity of Holstein heifers.

M Garcia, S R Montgomery, S J Moisá, G A Hanzlicek, L E Hulbert, B J Bradford,

Research investigating the effects of feeding raw or pasteurized nonsaleable milk (NSM) on heifers' performance beyond the period of supplementation is limited. This study aimed to examine the effects of type of milk [NSM or milk replacer (MR)] and pasteurization of NSM on preweaning and first-lactation performance of heifers born ... Read more >>

J Dairy Sci (Journal of dairy science)
[2021, 104(4):4303-4316]

Cited: 1 time

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First postpartum ovulation, metabolites and hormones in follicular fluid and blood in transition dairy cows supplemented with a Saccharomyces cerevisiae fermentation product.

J A Sauls-Hiesterman, K E Olagaray, S E Sivinski, B J Bradford, J S Stevenson,

We hypothesized that feeding a Saccharomyces cerevisiae fermentation product (SCFP) from -4 through +7 wk (calving = Day 0) facilitates early first postpartum ovulation and alters blood and follicular fluid concentrations of glucose, beta-hydroxybutyrate (BHB), free fatty acids (FFA), and steroid hormones favorable to subsequent fertility. Holstein cows were fed individually a SCFP product (n = 24) ... Read more >>

Theriogenology (Theriogenology)
[2021, 164:12-21]

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Intergenerational cycle of disease: Maternal mastitis is associated with poorer daughter performance in dairy cattle.

T H Swartz, B J Bradford, J S Clay,

Adverse prenatal environments, such as maternal stress and infections, can influence the health and performance of offspring. Mastitis is the most common disease in dairy cattle, yet the intergenerational effects have not been specifically investigated. Therefore, we examined the associations between the dam's mammary gland health and daughter performance using ... Read more >>

J Dairy Sci (Journal of dairy science)
[2021, 104(4):4537-4548]

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Relative availability of metabolizable methionine from 2 ruminally protected sources of methionine fed to lactating dairy cattle.

M Ardalan, C F Vargas-Rodriguez, G I Zanton, M Vázquez-Añón, B J Bradford, E C Titgemeyer,

Our objective was to evaluate the lactational responses of dairy cows to methionine provided from 2 ruminally protected sources of methionine activity. Twenty-one Holstein dairy cows [11 primiparous (634 kg of body weight, 140 d in milk) and 10 second-parity (670 kg of body weight, 142 d in milk)] were ... Read more >>

J Dairy Sci (Journal of dairy science)
[2021, 104(2):1811-1822]

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Acute-phase protein α-1-acid glycoprotein is negatively associated with feed intake in postpartum dairy cows.

W E Brown, M Garcia, L K Mamedova, K R Christman, M G Zenobi, C R Staples, B M Leno, T R Overton, B K Whitlock, J A Daniel, B J Bradford,

α-1-Acid glycoprotein (AGP) is an acute-phase protein that may suppress dry matter intake (DMI), potentially by acting on the leptin receptor in the hypothalamus. Our objectives were to characterize plasma AGP concentration and associations with DMI during the transition period, and to determine the utility of AGP to identify or ... Read more >>

J Dairy Sci (Journal of dairy science)
[2021, 104(1):806-817]

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Do biological and management reasons for a short or long dry period induce the same effects on dairy cattle productivity?

K E Olagaray, M W Overton, B J Bradford,

The dry period is a well-established factor that determines lactation success. A retrospective observational study used 32,182 lactations from 16 farms to determine whether management versus biological reasons for deviations from the targeted 60-d dry period have the same associations with subsequent lactation performance. Herd inclusion criteria were Holstein cows, ... Read more >>

J Dairy Sci (Journal of dairy science)
[2020, 103(12):11857-11875]

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Development of an in vitro macrophage screening system on the immunomodulating effects of feed components.

S E Sivinski, L K Mamedova, R A Rusk, C C Elrod, T H Swartz, J M McGill, B J Bradford,

<h4>Background</h4>While feed components capable of modulating the immune system are highly sought after and marketed, often little evidence is available to support functional immune response claims. Thus, a high-throughput <i>in vitro</i> cell screening system was developed to test these compounds for innate immune signaling effects, using <i>Saccharomyces cerevisiae</i> and its ... Read more >>

J Anim Sci Biotechnol (Journal of animal science and biotechnology)
[2020, 11:89]

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Effects of a high-protein corn product compared with soy and canola protein sources on nutrient digestibility and production responses in mid-lactation dairy cows.

W E Brown, B J Bradford,

An experiment was conducted to assess the effects of a novel and proprietary high-protein corn product [56% crude protein (CP)] relative to other common sources of protein on the lactation performance of dairy cows. Twenty-four Holstein cows (620 ± 47.7 kg of body weight, 111 ± 34 d in milk, ... Read more >>

J Dairy Sci (Journal of dairy science)
[2020, 103(7):6233-6243]

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Physiologic responses to feeding rumen-protected glucose to lactating dairy cows.

J A Sauls-Hiesterman, S Banuelos, B Atanasov, B J Bradford, J S Stevenson,

It was hypothesized that rumen-protected glucose (RPG) in diets of dairy cows increases concentrations of insulin resulting in greater blood progesterone concentrations because elevated insulin decreases activity of liver enzymes inactivating steroid hormones. Timing of ovulation was synchronized among 64 postpartum Holstein cows using GnRH and PGF<sub>2α</sub> (Day 0 = ... Read more >>

Anim Reprod Sci (Animal reproduction science)
[2020, 216:106346]

Cited: 1 time

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Review: Following the smoke signals: inflammatory signaling in metabolic homeostasis and homeorhesis in dairy cattle.

B J Bradford, T H Swartz,

Inflammatory cascades are a critical component of the immune response to infection or tissue damage, involving an array of signals, including water-soluble metabolites, lipid mediators and several classes of proteins. Early investigation of these signaling pathways focused largely on immune cells and acute disease models. However, more recent findings have ... Read more >>

Animal (Animal : an international journal of animal bioscience)
[2020, 14(S1):s144-s154]

Cited: 2 times

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Diet starch concentration and starch fermentability affect markers of inflammatory response and oxidant status in dairy cows during the early postpartum period.

R I Albornoz, L M Sordillo, G A Contreras, R Nelli, L K Mamedova, B J Bradford, M S Allen,

Our objective was to evaluate the effects of diet starch concentration and starch fermentability on inflammatory response markers and oxidant status during the early postpartum (PP) period and its carryover effects. Fifty-two multiparous Holstein cows were used in a completely randomized block design experiment with a 2 × 2 factorial ... Read more >>

J Dairy Sci (Journal of dairy science)
[2020, 103(1):352-367]

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Associations between body condition score at parturition and microRNA profile in colostrum of dairy cows as evaluated by paired mapping programs.

C M Ylioja, M M Rolf, L K Mamedova, B J Bradford,

MicroRNA (miRNA) are abundant in milk, and likely have regulatory activity involving lactation and immunity. The objective of this study was to determine the miRNA profile in colostrum of overconditioned cows compared with cows of more moderate body condition score (BCS) at calving. Multiparous cows with either high (≥4.0 on ... Read more >>

J Dairy Sci (Journal of dairy science)
[2019, 102(12):11609-11621]

Cited: 1 time

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Effect of Saccharomyces cerevisiae fermentation product on feed intake parameters, lactation performance, and metabolism of transition dairy cattle.

K E Olagaray, S E Sivinski, B A Saylor, L K Mamedova, J A Sauls-Hiesterman, I Yoon, B J Bradford,

The transition period in dairy cattle is characterized by many stressors, including an abrupt diet change, but yeast product supplementation can alter the rumen environment to increase dairy cattle productivity. Saccharomyces cerevisiae fermentation product (SCFP) was fed from -29 ± 5 to 42 d relative to calving (RTC) to evaluate ... Read more >>

J Dairy Sci (Journal of dairy science)
[2019, 102(9):8092-8107]

Cited: 2 times

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Proteomic analysis reveals greater abundance of complement and inflammatory proteins in subcutaneous adipose tissue from postpartum cows treated with sodium salicylate.

C S Takiya, S R Montgomery, L K Mamedova, G Kra, N Nemes-Navon, Y Levin, S D Fleming, B J Bradford, M Zachut,

This study aimed to investigate sodium salicylate (SS) treatment effects on the proteome of adipose tissue (AT) in postpartum cows. Twenty Holstein cows were assigned to control (CON, n = 10) or SS (n = 10) provided via drinking water (2.3 g/L) during the first 7 d of lactation. Subcutaneous AT was collected on d 7 ... Read more >>

J Proteomics (Journal of proteomics)
[2019, 204:103399]

Cited: 3 times

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Dietary supplementation of Scutellaria baicalensis extract during early lactation decreases milk somatic cells and increases whole lactation milk yield in dairy cattle.

K E Olagaray, M J Brouk, L K Mamedova, S E Sivinski, H Liu, F Robert, E Dupuis, M Zachut, B J Bradford,

Systemic inflammation is common in early lactation dairy cows and is associated with decreased milk production. The Scutellaria baicalensis plant contains flavonoids with anti-inflammatory and anti-oxidative properties, which may counteract the inflammatory state in early lactation dairy cows. The objective of this experiment was to determine whether Scutellaria baicalensis extract ... Read more >>

PLoS One (PloS one)
[2019, 14(1):e0210744]

Cited: 3 times

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Effects of sodium salicylate on glucose kinetics and insulin signaling in postpartum dairy cows.

S R Montgomery, L K Mamedova, M Zachut, G Kra, S Häussler, M Vaughn, J Gonzalez, B J Bradford,

Low-grade inflammation has been implicated as a contributor to metabolic disease during the transition to lactation. In previous work, administration of sodium salicylate (SS) for 7 d led to hypoglycemia in mature dairy cows in early lactation. The purpose of this study was to identify the mode of action underlying ... Read more >>

J Dairy Sci (Journal of dairy science)
[2019, 102(2):1617-1629]

Cited: 0 times

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Effects of fat supplementation to diets high in nonforage fiber on production responses of midlactation dairy cows.

C M Ylioja, C Abney-Schulte, R Stock, B J Bradford,

The effects of dietary nonforage fiber sources on production responses of lactating dairy cattle have been well described, but interactions with other components of the diet have been less thoroughly explored. We investigated the effects of adding 2 commonly fed fat sources to a ration featuring high levels of nonforage ... Read more >>

J Dairy Sci (Journal of dairy science)
[2018, 101(7):6066-6073]

Cited: 1 time

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Productivity of lactating dairy cows fed diets with teff hay as the sole forage.

B A Saylor, D H Min, B J Bradford,

Groundwater depletion is one of the most pressing issues facing the dairy industry in arid regions. One strategy to improve the industry's drought resilience involves feeding drought-tolerant forage crops in place of traditional forage crops such as alfalfa and corn silage. The objective of this study was to assess the ... Read more >>

J Dairy Sci (Journal of dairy science)
[2018, 101(7):5984-5990]

Cited: 2 times

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Relative bioavailability of carnitine delivered by ruminal or abomasal infusion or by encapsulation in dairy cattle.

K E Olagaray, J E Shaffer, C K Armendariz, A Bellamine, S Jacobs, E C Titgemeyer, B J Bradford,

Two studies were designed to evaluate the relative bioavailability of l-carnitine delivered by different methods in dairy cattle. In experiment 1, 4 Holstein heifers were used in a split-plot design to compare ruminally or abomasally infused l-carnitine. The study included 2 main-plot periods, with infusion routes allocated in a crossover ... Read more >>

J Dairy Sci (Journal of dairy science)
[2018, 101(3):2060-2071]

Cited: 0 times

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Effects of early postpartum sodium salicylate treatment on long-term milk, intake, and blood parameters of dairy cows.

A J Carpenter, C M Ylioja, L K Mamedova, K E Olagaray, B J Bradford,

Previous research has shown that cows who receive treatment with nonsteroidal anti-inflammatory drugs after calving may have increased milk yield beginning near peak lactation, resulting in greater 305-d milk production. It has not been demonstrated whether this response is associated with greater feed intake following the first 3 wk of ... Read more >>

J Dairy Sci (Journal of dairy science)
[2018, 101(2):1437-1447]

Cited: 1 time

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Effects of TNF receptor blockade on in vitro cell survival and response to negative energy balance in dairy cattle.

C A Martel, L K Mamedova, J E Minton, M Garcia, C Legallet, B J Bradford,

Background:Associative data and some controlled studies suggest that the inflammatory cytokine tumor necrosis factor (TNF) α can induce fatty liver in dairy cattle. However, research demonstrating that TNFα is a necessary component in the etiology of bovine fatty liver is lacking. The aim of this work was to evaluate whether ... Read more >>

J Anim Sci Biotechnol (Journal of animal science and biotechnology)
[2018, 9:6]

Cited: 0 times

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Short communication: Sodium salicylate negatively affects rumen fermentation in vitro and in situ.

A J Carpenter, C F Vargas Rodriguez, J A B Jantz, B J Bradford,

Administration of sodium salicylate (SS) to cows in early lactation has a positive effect on whole-lactation milk production but a negative effect on metabolism in some cases. The objective of this trial was to determine whether SS directly affects rumen fermentation. Experiment 1 was designed to investigate the effects of ... Read more >>

J Dairy Sci (Journal of dairy science)
[2017, 100(3):1935-1939]

Cited: 1 time

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A supplement containing multiple types of gluconeogenic substrates alters intake but not productivity of heat-stressed Afshari lambs.

E Mahjoubi, H Amanlou, M Hossein Yazdi, N Aghaziarati, G R Noori, C I Vahl, B J Bradford, L H Baumgard,

Thirty-two Afshari lambs were used in a completely randomized design with a 2 × 2 factorial arrangement of treatments to evaluate a nutritional supplement designed to provide multiple gluconeogenic precursors during heat stress (HS). Lambs were housed in thermal neutral (TN) conditions and fed ad libitum for 8 d to ... Read more >>

J Anim Sci (Journal of animal science)
[2016, 94(6):2497-2505]

Cited: 1 time

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